RESUMEN
Eighteen cadavers of persons, who died of acute and chronic alcohol and drug intoxication (ephedron-addiction), were used to study the changes in the spinal nerve plexuses and external genitals. The activity of acetylcholinesterase and of NADPH-diaphorase was determined histochemically; the adrenergic nerve fibers were detected by a glyoxyl-acid technique. Rectified changes in the relative density of adrenal-cholinergic- and nitroxydergic structures and in the activity of mediators in different intoxications were found. The chronic intoxication by alcohol and ephedron was accompanied by a reduced activity of enzymes involved in the metabolism of acetylcholine, nitric oxide and catecholamines. A lower density was observed in the nerve fibers that contained the examined substances. The results can be used as an additional criterion in evaluating the male sexual-function status.
Asunto(s)
Fibras Adrenérgicas/patología , Fibras Colinérgicas/patología , Genitales/inervación , Trastornos Relacionados con Sustancias/fisiopatología , Adolescente , Fibras Adrenérgicas/enzimología , Adulto , Intoxicación Alcohólica/fisiopatología , Alcoholismo/fisiopatología , Cadáver , Fibras Colinérgicas/enzimología , Femenino , Genitales/patología , Humanos , Masculino , NADPH Deshidrogenasa/metabolismoRESUMEN
The external male genitals (EMG) of male corpses, who abused alcohol and narcotics at lifetime, were examined. The objects were stained according to the common histological and histochemical methods. The study results are indicative of a high frequency rate of pathologic changes of the EMG in persons, who abused alcohol and narcotics at lifetime. The inflammatory, fibrosing and atrophic changes of the EMG as well as a reduced vascular permeability can be a cause for erection malfunction.
Asunto(s)
Alcoholismo/fisiopatología , Genitales Masculinos/patología , Trastornos Relacionados con Sustancias/patología , Adolescente , Adulto , Alcoholismo/patología , Genitales Masculinos/fisiopatología , Humanos , Masculino , Trastornos Relacionados con Sustancias/fisiopatologíaRESUMEN
Biochemical effects of ephedrone and their clinical manifestations are described. Statistical data on the prevalence of ephedrone narcomania in the Primorye territory are compared with the prevalence of use of psychostimulating narcotics in other regions (analysis of the files of thanatological department of Bureau of Forensic Medical Expert Evaluations in Moscow). Morphological changes in the viscera are described detail. The authors come to a conclusion on high incidence and multifactorial toxic effects of ephedrone and multilevel somatic involvement in ephedrone narcomania.
Asunto(s)
Propiofenonas/efectos adversos , Trastornos Relacionados con Sustancias/epidemiología , Adulto , Femenino , Humanos , Masculino , Federación de Rusia/epidemiologíaAsunto(s)
Trastornos Relacionados con Sustancias/patología , Enfermedad Aguda , Autopsia , Enfermedad Crónica , Infecciones por VIH/complicaciones , Infecciones por VIH/patología , VIH-1 , Humanos , Drogas Ilícitas/envenenamiento , Intoxicación/complicaciones , Intoxicación/patología , Abuso de Sustancias por Vía Intravenosa/complicaciones , Abuso de Sustancias por Vía Intravenosa/patología , Trastornos Relacionados con Sustancias/complicacionesAsunto(s)
Cardiopatías/inducido químicamente , Trastornos Respiratorios/inducido químicamente , Trastornos Relacionados con Sustancias/complicaciones , Adolescente , Adulto , Animales , Asma/inducido químicamente , Trastornos Relacionados con Cocaína/complicaciones , Humanos , Enfermedades Pulmonares/inducido químicamente , Abuso de Marihuana/complicaciones , Propiofenonas/efectos adversos , Psicotrópicos/efectos adversos , RatasRESUMEN
Morphological changes of the viscera and skin were examined in the corpses of 8 narcomaniacs who abused ephedrone, a narcotic prepared by ephedrine oxidation. Total systems angiopathies and vasculitides involving mainly the kidneys, heart, and brain were revealed. The mechanisms of the injurious effect of the narcotic are discussed.
Asunto(s)
Adrenérgicos , Efedrina/análogos & derivados , Drogas Ilícitas , Propiofenonas , Abuso de Sustancias por Vía Intravenosa/patología , Adrenérgicos/envenenamiento , Adulto , Autopsia , Enfermedad Crónica , Efedrina/envenenamiento , Humanos , Drogas Ilícitas/envenenamiento , Masculino , Intoxicación/patología , Propiofenonas/envenenamientoAsunto(s)
Perforación del Esófago/etiología , Esófago , Esófago/lesiones , Cuerpos Extraños/complicaciones , Pericardio/lesiones , Taponamiento Cardíaco/etiología , Taponamiento Cardíaco/patología , Niño , Perforación del Esófago/patología , Esófago/patología , Resultado Fatal , Cuerpos Extraños/patología , Humanos , Masculino , Pericardio/patologíaRESUMEN
Time course of the activities of transport enzymes in capillary walls of human spinal cord was studied in various periods after closed injury to the cord, inflicted by hard blunt objects, with the use of histochemical methods for the detection of alkaline phosphatase and Mg-dependent ATPase. Wave-like fluctuations in the activities of the examined enzymes were revealed. The findings may be used to assess the period elapsed since the cord injury.