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1.
J Orthop Surg Res ; 19(1): 649, 2024 Oct 12.
Artículo en Inglés | MEDLINE | ID: mdl-39396015

RESUMEN

Total Knee Arthroplasty (TKA) is a surgery that is commonly performed on older adults to improve their quality of life. However, the increasing use of knee joint prostheses has led to a rise in the incidence of Prosthetic Joint Infections (PJI) in patients after TKA. Different clinical studies have looked at the occurrence of PJI after TKA in different regions, but they have drawn varying conclusions. To better understand this topic, we conducted a meta-analysis and bibliometric study using data from multiple databases. Our research found that the estimated prevalence of PJI after TKA is approximately 1.08% across different regions, but there is still considerable variation. Additionally, our regression analysis of sub-groups shows significant differences in follow-up periods. Furthermore, our comprehensive bibliometric analysis identifies current research trends, "hotspots" related to TKA-related PJI, influential nations, organizations, and noteworthy publications. Our analysis provides valuable insights to guide future research in this area.


Asunto(s)
Artroplastia de Reemplazo de Rodilla , Bibliometría , Infecciones Relacionadas con Prótesis , Artroplastia de Reemplazo de Rodilla/efectos adversos , Humanos , Infecciones Relacionadas con Prótesis/etiología , Infecciones Relacionadas con Prótesis/epidemiología , Incidencia
2.
ACS Appl Mater Interfaces ; 16(35): 45830-45860, 2024 Sep 04.
Artículo en Inglés | MEDLINE | ID: mdl-39178336

RESUMEN

Metal-organic frameworks (MOFs) have attained broad research attention in the areas of sensors, resistive memories, and optoelectronic synapses on the merits of their intriguing physical and chemical properties. In this review, recent progress on the synthesis of MOFs and their electronic applications is introduced and discussed. Initially, the crystal structures and properties of MOFs encompassing optical, electrical, and chemical properties are discussed in brief. Subsequently, advanced synthesis methods for MOFs are introduced, categorized into hydrothermal approach, microwave synthesis, mechanochemical synthesis, and electrochemical deposition. After that, the various roles of MOFs in widespread applications, including sensing, information storage, optoelectronic synapses, machine learning, and artificial intelligence, are discussed, highlighting their versatility and the innovative solutions they provide to long-standing challenges. Finally, an outlook on remaining challenges and a future perspective for MOFs are proposed.

3.
Acad Radiol ; 2024 Aug 21.
Artículo en Inglés | MEDLINE | ID: mdl-39174359

RESUMEN

RATIONALE AND OBJECTIVE: There is a notable absence of robust evidence on the efficacy of ultrasound-based breast cancer screening strategies, particularly in populations with a high prevalence of dense breasts. Our study addresses this gap by evaluating the effectiveness of such strategies in Chinese women, thereby enriching the evidence base for identifying the most efficacious screening approaches for women with dense breast tissue. METHODS: Conducted from October 2018 to August 2022 in Central China, this prospective cohort study enrolled 8996 women aged 35-64 years, divided into two age groups (35-44 and 45-64 years). Participants were screened for breast cancer using hand-held ultrasound (HHUS) and automated breast ultrasound system (ABUS), with the older age group also receiving full-field digital mammography (FFDM). The Breast Imaging Reporting and Data System (BI-RADS) was employed for image interpretation, with abnormal results indicated by BI-RADS 4/5, necessitating a biopsy; BI-RADS 3 required follow-up within 6-12 months by primary screening strategies; and BI-RADS 1/2 were classified as negative. RESULTS: Among the screened women, 29 cases of breast cancer were identified, with 4 (1.3‰) in the 35-44 years age group and 25 (4.2‰) in the 45-64 years age group. In the younger age group, HHUS and ABUS performed equally well, with no significant difference in their AUC values (0.8678 vs. 0.8679, P > 0.05). For the older age group, ABUS as a standalone strategy (AUC 0.9935) and both supplemental screening methods (HHUS with FFDM, AUC 0.9920; ABUS with FFDM, AUC 0.9928) outperformed FFDM alone (AUC 0.8983, P < 0.05). However, there was no significant difference between HHUS alone and FFDM alone (AUC 0.9529 vs. 0.8983, P > 0.05). CONCLUSION: The findings indicate that both HHUS and ABUS exhibit strong performance as independent breast cancer screening strategies, with ABUS demonstrating superior potential. However, the integration of FFDM with these ultrasound techniques did not confer a substantial improvement in the overall effectiveness of the screening process.

4.
Small ; : e2405520, 2024 Aug 11.
Artículo en Inglés | MEDLINE | ID: mdl-39128137

RESUMEN

Over the past decades, tactile sensing technology has made significant advances in the fields of health monitoring and robotics. Compared to conventional sensors, self-powered tactile sensors do not require an external power source to drive, which makes the entire system more flexible and lightweight. Therefore, they are excellent candidates for mimicking the tactile perception functions for wearable health monitoring and ideal electronic skin (e-skin) for intelligent robots. Herein, the working principles, materials, and device fabrication strategies of various self-powered tactile sensing platforms are introduced first. Then their applications in health monitoring and robotics are presented. Finally, the future prospects of self-powered tactile sensing systems are discussed.

5.
J Mech Behav Biomed Mater ; 156: 106599, 2024 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-38820710

RESUMEN

The specific viscoelastic mechanical properties of the human Achilles tendon are strongly dependent on the structural characteristics of collagen. Although research on the deformation mechanisms of the Achilles tendon in various animals is extensive, understanding of these mechanisms in the human Achilles tendon remains largely empirical and macroscopic. In this work, the evolution of D-space, orientation, and average length of voids between fibers are investigated during the stretching using SAXS techniques. Initially, the void length increases marginally, while the misorientation breadth decreased rapidly as the D-space steadily increased. In the second region, D-space and the void length increase sharply under rising stress, even though misorientation width decreased. During the third region, the increases in void length and D-space decelerate, but the misorientation width widens, suggesting the onset of irreversible microscopic fibril failure in the Achilles tendon. In the final region, the fibers undergo macroscopic failure, with D-space and void length returning to their initial states. The macroscopic alterations are elucidated by the nanoscale structural responses, providing a fundamental understanding of the mechanisms driving the complex biomechanics, tissue structural organization, and Achilles tendon regeneration.


Asunto(s)
Tendón Calcáneo , Dispersión del Ángulo Pequeño , Difracción de Rayos X , Tendón Calcáneo/fisiología , Humanos , Soporte de Peso , Fenómenos Biomecánicos , Colágeno/química , Colágeno/metabolismo , Estrés Mecánico , Masculino
6.
Entropy (Basel) ; 26(4)2024 Apr 11.
Artículo en Inglés | MEDLINE | ID: mdl-38667880

RESUMEN

A hot NUT-Kerr-Newman black hole is a general stationary axisymmetric black hole. In this black hole spacetime, the dynamical equations of fermions at the horizon are modified by considering Lorentz breaking. The corrections to the Hawking temperature and Bekenstein-Hawking entropy at the horizon of the black hole are studied in depth. Based on the semiclassical theory correction, the Bekenstein-Hawking entropy of this black hole is quantum-corrected by considering the perturbation effect of the Planck constant ℏ. The latter part of this paper presents a detailed discussion of the obtained results and their physical implications.

7.
Adv Sci (Weinh) ; 11(20): e2307995, 2024 May.
Artículo en Inglés | MEDLINE | ID: mdl-38468444

RESUMEN

Heterogeneous structures and doping strategies have been intensively used to manipulate the catalytic conversion of polysulfides to enhance reaction kinetics and suppress the shuttle effect in lithium-sulfur (Li-S) batteries. However, understanding how to select suitable strategies for engineering the electronic structure of polar catalysts is lacking. Here, a comparative investigation between heterogeneous structures and doping strategies is conducted to assess their impact on the modulation of the electronic structures and their effectiveness in catalyzing the conversion of polysulfides. These findings reveal that Co0.125Zn0.875Se, with metal-cation dopants, exhibits superior performance compared to CoSe2/ZnSe heterogeneous structures. The incorporation of low Co2+ dopants induces the subtle lattice strain in Co0.125Zn0.875Se, resulting in the increased exposure of active sites. As a result, Co0.125Zn0.875Se demonstrates enhanced electron accumulation on surface Se sites, improved charge carrier mobility, and optimized both p-band and d-band centers. The Li-S cells employing Co0.125Zn0.875Se catalyst demonstrate significantly improved capacity (1261.3 mAh g-1 at 0.5 C) and cycle stability (0.048% capacity delay rate within 1000 cycles at 2 C). This study provides valuable guidance for the modulation of the electronic structure of typical polar catalysts, serving as a design directive to tailor the catalytic activity of advanced Li-S catalysts.

8.
Nat Commun ; 14(1): 5420, 2023 Sep 05.
Artículo en Inglés | MEDLINE | ID: mdl-37669964

RESUMEN

Real-time imaging of transient structure of the electronic excited state is fundamentally critical to understand and control ultrafast molecular dynamics. The ejection of electrons from the inner-shell and valence level can lead to the population of different excited states, which trigger manifold ultrafast relaxation processes, however, the accurate imaging of such electronic state-dependent structural evolutions is still lacking. Here, by developing the laser-induced electron recollision-assisted Coulomb explosion imaging approach and molecular dynamics simulations, snapshots of the vibrational wave-packets of the excited (A) and ground states (X) of D2O+ are captured simultaneously with sub-10 picometre and few-femtosecond precision. We visualise that θDOD and ROD are significantly increased by around 50∘ and 10 pm, respectively, within approximately 8 fs after initial ionisation for the A state, and the ROD further extends 9 pm within 2 fs along the ground state of the dication in the present condition. Moreover, the ROD can stretch more than 50 pm within 5 fs along autoionisation state of dication. The accuracies of the results are limited by the simulations. These results provide comprehensive structural information for studying the fascinating molecular dynamics of water, and pave the way towards to make a movie of excited state-resolved ultrafast molecular dynamics and light-induced chemical reaction.

9.
ACS Appl Mater Interfaces ; 15(27): 32475-32486, 2023 Jul 12.
Artículo en Inglés | MEDLINE | ID: mdl-37386799

RESUMEN

Solvent engineering is highly essential for the upscaling synthesis of high-quality metal halide perovskite materials for solar cells. The complexity in the colloidal containing various residual species poses great difficulty in the design of the formula of the solvent. Knowledge of the energetics of the solvent-lead iodide (PbI2) adduct allows a quantitative evaluation of the coordination ability of the solvent. Herein, first-principles calculations are performed to explore the interaction of various organic solvents (Fa, AC, DMSO, DMF, GBL, THTO, NMP, and DPSO) with PbI2. Our study establishes the energetics hierarchy with an order of interaction as DPSO > THTO > NMP > DMSO > DMF > GBL. Different from the common notion of forming intimate solvent-Pb bonds, our calculations reveal that DMF and GBL cannot form direct solvent-Pb2+ bonding. Other solvent bases, such as DMSO, THTO, NMP, and DPSO, form direct solvent-Pb bonds, which penetrate through the top iodine plane and possess much stronger adsorption than DMF and GBL. A strong solvent-PbI2 adhesion (i.e., DPSO, NMP, and DMSO), associated with a high coordinating ability, explains low volatility, retarded precipitation of the perovskite solute, and tendency of a large grain size in the experiment. In contrast, weakly coupled solvent-PbI2 adducts (i.e., DMF) induces a fast evaporation of the solvent, accordingly a high nucleation density and small grains of perovskites are observed. For the first time, we reveal the promoted absorption above the iodine vacancy, which implies the need for pre-treatment of PbI2 like vacuum annealing to stabilize solvent-PbI2 adducts. Our work establishes a quantitative evaluation of the strength of the solvent-PbI2 adducts from the atomic scale perspective, which allows the selective engineering of the solvent for high-quality perovskite films.

10.
J Phys Condens Matter ; 35(20)2023 Mar 16.
Artículo en Inglés | MEDLINE | ID: mdl-36881922

RESUMEN

Hydrogen as the cleanest energy carrier is a promising alternative renewable resource to fossil fuels. There is an ever-increasing interest in exploring efficient and cost-effective approaches of hydrogen production. Recent experiments have shown that single platinum atom immobilized on the metal vacancies of MXenes allows a high-efficient hydrogen evolution reaction (HER). Here usingab initiocalculations, we design a series of substitutional Pt-doped Tin+ 1CnTx(Tin+ 1CnTx-PtSA) with different thicknesses and terminations (n= 1, 2 and 3, Tx= O, F and OH), and investigate the quantum-confinement effect on the HER catalytic performance. Surprisingly, we reveal a strong thickness effect of the MXene layer on the HER performance. Among the various surface-terminated derivatives, Ti2CF2-PtSAand Ti2CH2O2-PtSAare found to be the best HER catalysts with the change of Gibbs free energy ΔGH*∼ 0 eV, complying with the thermoneutral condition. Theab initiomolecular dynamics simulations reveal that Ti2CF2-PtSAand Ti2CH2O2-PtSApossess a good thermodynamic stability. The present work shows that the HER catalytic activity of the MXene is not solely governed by the local environment of the surface such as Pt single atom. We point out the critical role of thickness control and surface decoration of substrate in achieving a high-performance HER catalytical activity.

11.
J Int Med Res ; 51(3): 3000605231164005, 2023 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-36999675

RESUMEN

Primary biliary melanoma arises from proliferating melanocytes in the mucosal surface of the bile duct and is extremely rare. Since the vast majority of biliary melanomas represent metastases of cutaneous origin, accurate preoperative diagnosis of melanoma and exclusion of other primary sources are vital in cases involving primary lesions. Although melanomas with pigmented cells have typical signal characteristics, obtaining a non-invasive pre-treatment diagnosis remains difficult, due to their low incidence. Here, the case of a 61-year-old male Asian patient who presented with upper quadrant abdominal pain, swelling and jaundice for 2 weeks, and who was diagnosed with primary biliary melanoma following extensive preoperative blood analyses, computed tomography (CT) and magnetic resonance imaging (MRI), is described. Post-resection immunohistochemistry confirmed the diagnosis and the patient received six chemotherapy cycles of temozolomide and cisplatin, however, progression of multiple liver metastases was observed at the 18-month follow-up CT. The patient continued with pembrolizumab and died 17 months later. The present case of primary biliary melanoma is the first reported diagnosis based on typical MRI features and the exhaustive exclusion of a separate primary origin.


Asunto(s)
Neoplasias Hepáticas , Melanoma , Masculino , Humanos , Persona de Mediana Edad , Melanoma/diagnóstico por imagen , Melanoma/patología , Tomografía Computarizada por Rayos X/efectos adversos , Imagen por Resonancia Magnética , Neoplasias Hepáticas/diagnóstico por imagen , Neoplasias Hepáticas/complicaciones , Dolor Abdominal/etiología
12.
Cannabis Cannabinoid Res ; 8(3): 445-463, 2023 06.
Artículo en Inglés | MEDLINE | ID: mdl-36745405

RESUMEN

Background: Despite the successful introduction of combined antiretroviral therapy, the prevalence of mild to moderate forms of HIV-associated neurocognitive disorders (HAND) remains high. It has been demonstrated that neuronal injury caused by HIV is excitotoxic and inflammatory, and it correlates with neurocognitive decline in HAND. Endocannabinoid system (ECS) protects the body from excitotoxicity and neuroinflammation on demand and presents a promising therapeutic target for treating HAND. Here, we firstly discuss the potential pathogenesis of HAND. We secondly discuss the structural and functional changes in the ECS that are currently known among HAND patients. We thirdly discuss current clinical and preclinical findings concerning the neuroprotective and anti-inflammatory properties of the ECS among HAND patients. Fourth, we will discuss the interactions between the ECS and neuroendocrine systems, including the hypothalamic-pituitary-adrenocortical (HPA) and hypothalamic-pituitary-gonadal (HPG) axes under the HAND conditions. Materials and Methods: We have carried out a review of the literature using PubMed to summarize the current state of knowledge on the association between ECS and HAND. Results: The ECS may be ideally suited for modulation of HAND pathophysiology. Direct activation of presynaptic cannabinoid receptor 1 or reduction of cannabinoid metabolism attenuates HAND excitotoxicity. Chronic neuroinflammation associated with HAND can be reduced by activating cannabinoid receptor 2 on immune cells. The sensitivity of the ECS to HIV may be enhanced by increased cannabinoid receptor expression in HAND. In addition, indirect regulation of the ECS through modulation of hormone-related receptors may be a potential strategy to influence the ECS and also alleviate the progression of HAND due to the reciprocal inhibition of the ECS by the HPA and HPG axes. Conclusions: Taken together, targeting the ECS may be a promising strategy to alleviate the inflammation and neurodegeneration caused by HIV-1 infection. Further studies are required to clarify the role of endocannabinoid signaling in HIV neurotoxicity. Strategies promoting endocannabinoid signaling may slow down cognitive decline of HAND are proposed.


Asunto(s)
Cannabinoides , Infecciones por VIH , Seropositividad para VIH , VIH-1 , Humanos , Endocannabinoides/metabolismo , VIH-1/metabolismo , Enfermedades Neuroinflamatorias , Receptores de Cannabinoides/metabolismo , Trastornos Neurocognitivos/tratamiento farmacológico , Infecciones por VIH/tratamiento farmacológico
13.
Magn Reson Imaging ; 99: 91-97, 2023 06.
Artículo en Inglés | MEDLINE | ID: mdl-36803634

RESUMEN

PURPOSE: To evaluate the diagnostic performance of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) metrics for glioma grading on a point-to-point basis. METHODS: Forty patients with treatment-naïve glioma underwent DCE-MR examination and stereotactic biopsy. DCE-derived parameters including endothelial transfer constant (Ktrans), volume of extravascular-extracellular space (ve), fractional plasma volume (fpv), and reflux transfer rate (kep) were measured within ROIs on DCE maps accurately matched with biopsies used for histologic grades diagnosis. Differences in parameters between grades were evaluated by Kruskal-Wallis tests. Diagnostic accuracy of each parameter and their combination was assessed using receiver operating characteristic curve. RESULTS: Eighty-four independent biopsy samples from 40 patients were analyzed in our study. Significant statistical differences in Ktrans and ve were observed between grades except ve between grade 2 and 3. Ktrans showed good to excellent accuracy in discriminating grade 2 from 3, 3 from 4, and 2 from 4 (area under the curve = 0.802, 0.801 and 0.971, respectively). Ve indicated good accuracy in discriminating grade 3 from 4 and 2 from 4 (AUC = 0.874 and 0.899, respectively). The combined parameter demonstrated fair to excellent accuracy in discriminating grade 2 from 3, 3 from 4, and 2 from 4 (AUC = 0.794, 0.899 and 0.982, respectively). CONCLUSION: Our study had identified Ktrans, ve and the combination of parameters to be an accurate predictor for grading glioma.


Asunto(s)
Neoplasias Encefálicas , Glioma , Humanos , Neoplasias Encefálicas/patología , Clasificación del Tumor , Medios de Contraste , Glioma/patología , Imagen por Resonancia Magnética/métodos , Biopsia
14.
Polymers (Basel) ; 15(3)2023 Jan 25.
Artículo en Inglés | MEDLINE | ID: mdl-36771917

RESUMEN

Polymer flooding is one of the techniques used to enhance oil recovery from depleted hydrocarbon reservoirs. Although this technology is popular for this application, the shearing effect in the injection process causes poor performance, which is an obstacle to meeting the needs of the formation. An experimental evaluation of the rheological properties, viscoelasticity, hydrodynamic size, static adsorption, and seepage characteristics of the associated polymer solution before and after shearing was conducted to determine the influence of shearing on the polymer solution. The results show that the effect of shear on the polymer was irreversible, and the properties of the polymer solution damaged by shear were attenuated. After the critical associating concentration, the associated polymer can recover its solution properties through hydrophobic association, which can improve the shear resistance of the polymer solution and make its own rheological law and reduce the viscoelastic change. Although the hydrodynamic size, viscoelasticity, and adsorption capacity of the polymer solution after shear failure decreased, strong flow resistance during porous media seepage and mobility control was achieved. Improving the shear resistance of the polymer solution by increasing the intermolecular force is proposed to develop new polymer systems for subsequent oil displacement.

15.
Int J Cancer ; 152(1): 7-14, 2023 01 01.
Artículo en Inglés | MEDLINE | ID: mdl-35362560

RESUMEN

We aimed to determine participation in low-dose computed tomography (LDCT) of individuals with a family history of common cancers in a population-based screening program to provide timely evidence in high-risk populations in China. The analysis was conducted using data from the Cancer Screening Program in Urban China (CanSPUC), which recruited 282 377 participants aged 40 to 74 years from eight cities in the Henan province. Using the CanSPUC risk score system, 55 428 participants were evaluated to have high risk for lung cancer and were recommended for LDCT. We calculated the overall and group-specific participation rates using family history of common cancers and compared differences in participation rates between different groups. Odds ratios (ORs) and 95% confidence intervals were derived by multivariable logistic regression. Of the 55 428 participants, 22 260 underwent LDCT (participation rate, 40.16%). Family history of lung, esophageal, stomach, liver and colorectal cancer was associated with increased participation in LDCT screening. The odds of participants with a family history of one, two, three and four or more cancer cases undergoing LDCT screening were 1.9, 2.7, 2.8 and 3.5 times, respectively, than those without a family history of cancer. Compared to those without a history of cancer, participation in LDCT gradually increased as the number of cancer cases in the family increased (P < .001). Our findings suggest that there is room for improvement in lung cancer screening given the relatively low participation rate. Lung cancer screening in populations with a family history of cancer may improve efficiency and cost-effectiveness; however, this requires further verification.


Asunto(s)
Detección Precoz del Cáncer , Neoplasias Pulmonares , Humanos , Detección Precoz del Cáncer/métodos , Neoplasias Pulmonares/diagnóstico por imagen , Neoplasias Pulmonares/epidemiología , Tomografía Computarizada por Rayos X/métodos , Tamizaje Masivo , China/epidemiología
16.
Ann Transl Med ; 10(18): 994, 2022 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-36267765

RESUMEN

Background: A cluster randomized controlled trial of endoscopy-based screening for esophageal cancer (EC) and gastric cancer (GC) was conducted to evaluate the efficacy and feasibility of this strategy in a non-high-incidence rural area of China. The trial design and baseline findings are presented here. Methods: A total of 33 eligible villages in Luoshan County in Henan Province were assigned randomly to the intervention or control group in a 1:1 ratio by a computer-generated randomization list. Local residents aged 40 to 69 years were enrolled from the villages. Participants in the intervention group were risk-stratified with a questionnaire, and high-risk individuals were subsequently screened by endoscopy. The primary outcomes were EC and GC mortality. The secondary outcomes comprised the detection rate, stage distribution, and the treatment rate. In this study, baseline characteristics were assessed by a questionnaire. Multivariate logistic regression analysis was performed to explore factors associated with endoscopy compliance. Results: Trial recruitment was completed in 2017, and ultimately, there were 12,475 and 11,442 participants allocated to the intervention (17 clusters) and the control group (16 clusters), respectively. We included 23,653 participants in the analysis, with 12,402 in the intervention group and 11,251 in the control group. A total of 6,286 (50.7%) participants in the intervention group were estimated as high-risk individuals, and 2,719 (43.3%) underwent endoscopy. Multivariate logistic regression analysis demonstrated that some factors including age, gender, education, personality and mental health, and upper gastrointestinal diseases or symptoms might affect endoscopy compliance. The detection rates for positive cases of EC and GC were 0.22% and 0.55%, respectively. The rates for esophageal and gastric precancerous lesions were 0.70% and 2.35%, respectively. The early detection rates for EC and GC were 50.0% and 33.3%, respectively. Additionally, the overall treatment rate for positive cases was 90.0%. Conclusions: The diagnostic yield of endoscopy-based screening for EC and GC was relatively low in a non-high-incidence rural area. The study may offer clues for the improvement of endoscopy compliance and the optimization of screening strategies for upper gastrointestinal cancer in non-high-incidence areas. Trial Registration: Chinese Clinical Trial Registry ChiCTR-EOR-16008577.

17.
Ann Transl Med ; 10(16): 899, 2022 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-36111000

RESUMEN

Background: It is great of significance to figure the time-trend of esophageal cancer (EC) and its current status for effective prevention and control, especially in EC high risk areas. As one of world-renowned high-risk areas, the epidemiology of EC in Henan has not been recently updated. Therefore, we aimed to depict the status quo of EC and analyze its time-trend in Henan. Methods: The EC data were extracted from the Henan Provincial Cancer registry database derived from the population based cancer registry system, which covered 30.51% of the whole population in Henan and were qualified according to national and international guidelines. The incidence and mortality of EC were estimated by area (rural/urban), gender, and age groups. The age-standardized rates (ASRs) were calculated according to the Segi's population. Joinpoint regression was used to calculate annual percentage change (APC) and average annual percentage change (AAPC) to evaluate the time-trend of EC. Results: As estimated, there were 29,913 new EC cases in Henan, 2018. The crude incidence and the age-standardized incidence rate by world standard population (ASIRW) was 27.43/105 and 19.96/105, respectively. The incidence in males and rural was 1.83 and 1.51 times higher than that in females and urban areas, respectively. Meanwhile, it was estimated that 22,688 deaths occurred in 2018. The crude mortality and the age-standardized mortality rate by world standard population (ASMRW) were 20.80/105 and 14.47/105, respectively. Similarly, males and rural areas had higher mortality compared with females and urban areas. The age-specific incidence and mortality of EC showed significant increasing after 60-64 years group. In general, the time-trend of incidence (APC: -8.9, P<0.001) and mortality (APC: -7.6, P<0.001) of EC showed a significant decreasing trend since 2014, and downward trend were also observed in rural areas for incidence (APC: -5.2, P<0.001) and mortality (APC: -3.9, P<0.001) from 2010 to 2018. Conclusions: The EC incidence and mortality in Henan has exhibited a significant declining trend in past years. Nonetheless, the disease burden remains high, especially in males and rural areas. Therefore, the ongoing prevention and control strategies of EC should be maintained alongside the establishment of more effective strategies.

18.
ChemSusChem ; 15(15): e202200564, 2022 Aug 05.
Artículo en Inglés | MEDLINE | ID: mdl-35680606

RESUMEN

Existence of van der Waals gaps renders two-dimensional (2D) materials ideal passages of lithium for being used as anode materials. However, the requirement of good conductivity significantly limits the choice of 2D candidates. So far, only graphite is satisfying due to its relatively high conductivity. Recently, a new polymorph of layered germanium selenide (γ-GeSe) was proven to be semimetal in its bulk phase with a higher conductivity than graphite while its monolayer behaves semiconducting. In this work, by using first-principles calculations, the possibility was investigated of using this new group-IV monochalcogenide, γ-GeSe, as anode in Li-ion batteries (LIBs). The studies revealed that the Li atom would form an ionic adsorption with adjacent selenium atoms at the hollow site and exist in cationic state (lost 0.89 e to γ-GeSe). Results of climbing image-nudged elastic band showed the diffusion barrier of Li was 0.21 eV in the monolayer limit, which could activate a relatively fast diffusion even at room temperature on the γ-GeSe surface. The calculated theoretical average voltages ranged from 0.071 to 0.015 V at different stoichiometry of Lix GeSe with minor volume variation, suggesting its potential application as anode of LIBs. The predicted moderate binding energy, a low open-circuit voltage (comparable to graphite), and a fast motion of Li suggested that γ-GeSe nanosheet could be chemically exfoliated via Li intercalation and is a promising candidate as the anode material for LIBs.

19.
Phys Rev Lett ; 128(18): 183202, 2022 May 06.
Artículo en Inglés | MEDLINE | ID: mdl-35594086

RESUMEN

Investigation on structures in the high-harmonic spectrum has provided profuse information of molecular structure and dynamics in intense laser fields, based on which techniques of molecular ultrafast dynamics imaging have been developed. Combining ab initio calculations and experimental measurements on the high-harmonic spectrum of the CO_{2} molecule, we find a novel dip structure in the low-energy region of the harmonic spectrum which is identified as fingerprints of participation of deeper-lying molecular orbitals in the process and decodes the underlying attosecond multichannel coupling dynamics. Our work sheds new light on the ultrafast dynamics of molecules in intense laser fields.

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