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Terahertz absorbers are crucial to the cutting-edge techniques in the next-generation wireless communications, imaging, sensing, and radar stealth, as they fundamentally determine the performance of detectors and cloaking capabilities. It has long been a pressing task to find absorbers with customizable performance that can adapt to various environments with low cost and great flexibility. Here, perfect absorption empowered by bound states in the continuum (BICs) is demonstrated, allowing for the tailoring of absorption coefficient, bandwidth, and field of view. The one-port absorbers are interpreted using temporal coupled-mode theory highlighting the dominant role of BICs in the far-field radiation properties. Through a thorough investigation of BICs from the perspective of lattice symmetry, the radiation features of three BIC modes are unraveled using both multipolar and topological analysis. The versatile radiation capabilities of BICs provide ample freedom to meet specific requirements of absorbers, including tunable bandwidth, stable performance in a large field of view, and multiband absorption using a thin and flexible film without extreme geometric demands. These findings offer a systematic approach to developing optoelectronic devices and demonstrate the significant potential of BICs for optical and photonic applications, which will stimulate further studies on terahertz photonics and metasurfaces.
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A low-complexity multi-subcarrier pulse generation scheme is proposed to suppress the interference fading in a phase-sensitive optical time-domain reflectometer (Φ-OTDR) based distributed acoustic sensor (DAS) with heterodyne coherent detection. The multi-subcarrier pulse is generated in the digital domain based on the proper clipping operation of a sine signal. The localization and recovery of the disturbance signal are realized by the spectrum extraction and rotated vector sum (SERVS) method. The experimental results show that the occurrences of interference fading can be significantly reduced. The intensity fluctuation is reduced from â¼75 dB to â¼25 dB. Multiple disturbance signals are successfully demodulated to verify the effectiveness of the proposed method.
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To reduce noise in indoor visible light communication (IVLC), the Pearson correlation coefficient difference (PCCD), a denoising system combining iterative variational mode decomposition (IVMD) and multiple frequency shift keying modulation (MFSK), is proposed. Compared with VMD, the method can directly determine the optimal number of VMD modes and solve the issue of VMD penalty factor selection to some extent. The simulation results show that, when the input SNRs vary from -15 to -8d B, the proposed method can improve the output SNRs of the 2FSK signal by an average of 15.5 dB and reduce the BER by 55.8%, improve the output SNR of the 4FSK signal by an average of 13 dB, and reduce the BER by 54.4%. The proposed method can also effectively suppress noise interference in real IVLC experiments at a distance of 1 m. In addition, the IVMD-MFSK denoising system can be applied to denoise all frequency-modulated signals with high applicability.
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The Bloch band theory and Brillouin zone (BZ) that characterize wave-like behaviors in periodic mediums are two cornerstones of contemporary physics, ranging from condensed matter to topological physics. Recent theoretical breakthrough revealed that, under the projective symmetry algebra enforced by artificial gauge fields, the usual two-dimensional (2D) BZ (orientable Brillouin two-torus) can be fundamentally modified to a non-orientable Brillouin Klein bottle with radically distinct manifold topology. However, the physical consequence of artificial gauge fields on the more general three-dimensional (3D) BZ (orientable Brillouin three-torus) was so far missing. Here, we theoretically discovered and experimentally observed that the fundamental domain and topology of the usual 3D BZ can be reduced to a non-orientable Brillouin Klein space or an orientable Brillouin half-turn space in a 3D acoustic crystal with artificial gauge fields. We experimentally identify peculiar 3D momentum-space non-symmorphic screw rotation and glide reflection symmetries in the measured band structures. Moreover, we experimentally demonstrate a novel stacked weak Klein bottle insulator featuring a nonzero Z2 topological invariant and self-collimated topological surface states at two opposite surfaces related by a nonlocal twist, radically distinct from all previous 3D topological insulators. Our discovery not only fundamentally modifies the fundamental domain and topology of 3D BZ, but also opens the door towards a wealth of previously overlooked momentum-space multidimensional manifold topologies and novel gauge-symmetry-enriched topological physics and robust acoustic wave manipulations beyond the existing paradigms.
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Soliton molecules, a frequently observed phenomenon in most mode-locked lasers, have intriguing characteristics comparable to their matter molecule counterparts. However, there are rare explorations of the deterministic control of the underlying physics within soliton molecules. Here, we demonstrate the bistable response of intramolecular motion to external stimuli and identify a general approach to excite their quasi-periodic oscillations. By introducing frequency-swept gain modulation, the intrinsic resonance frequency of the soliton molecule is observed in the simulation model. Applying stronger modulation, the soliton molecule exhibits divergent response susceptibility to up- and down-sweeping, accompanied by a jump phenomenon. Quasi-periodic intramolecular oscillations appear at the redshifted resonance frequency. Given the leading role of bistability and quasi-periodic dynamics in nonlinear physics, our research provides insights into the complex nonlinear dynamics within dissipative soliton molecules. It may pave the way to related experimental studies on synchronization and chaos at an ultrafast time scale.
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Infectious diseases pose a significant threat to global health, yet traditional microbiological identification methods suffer from drawbacks, such as high costs and long processing times. Raman spectroscopy, a label-free and noninvasive technique, provides rich chemical information and has tremendous potential in fast microbial diagnoses. Here, we propose a novel Combined Mutual Learning Net that precisely identifies microbial subspecies. It demonstrated an average identification accuracy of 87.96% in an open-access data set with thirty microbial strains, representing a 5.76% improvement. 50% of the microbial subspecies accuracies were elevated by 1% to 46%, especially for E. coli 2 improved from 31% to 77%. Furthermore, it achieved a remarkable subspecies accuracy of 92.4% in the custom-built fiber-optical tweezers Raman spectroscopy system, which collects Raman spectra at a single-cell level. This advancement demonstrates the effectiveness of this method in microbial subspecies identification, offering a promising solution for microbiology diagnosis.
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Escherichia coli , Pinzas Ópticas , Espectrometría Raman/métodosRESUMEN
The intriguing and anomalous optical characteristics of exceptional points (EPs) in optical resonators have attracted significant attention. While EP-related phenomena have been observed by perturbing resonators with off-chip components, implementing EPs fully on-chip remains challenging due to their extreme susceptibility to fabrication errors. In this Letter, we propose a succinct and compact approach to reach EP in an on-chip integrated silicon microring resonator by manipulating the evolution of backscatterings with two nanocylinders of disparate diameters. The theoretical analysis unveils that the fabrication constraints could be significantly relieved by increasing the difference in diameters of the nanocylinders. The evolution from non-EP to EP is traced experimentally through the step-by-step tuning of the angular and radial positions of nanocylinders. The proposed method opens a pathway toward the on-chip high-density integration of non-Hermitian devices.
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Optical coherence tomography (OCT) inevitably suffers from the influence of speckles originating from multiple scattered photons owing to its low-coherence interferometry property. Although various deep learning schemes have been proposed for OCT despeckling, they typically suffer from the requirement for ground-truth images, which are difficult to collect in clinical practice. To alleviate the influences of speckles without requiring ground-truth images, this paper presents a self-supervised deep learning scheme, namely, Self2Self strategy (S2Snet), for OCT despeckling using a single noisy image. Specifically, in this study, the main deep learning architecture is the Self2Self network, with its partial convolution being updated with a gated convolution layer. Specifically, both the input images and their Bernoulli sampling instances are adopted as network input first, and then, a devised loss function is integrated into the network to remove the background noise. Finally, the denoised output is estimated using the average of multiple predicted outputs. Experiments with various OCT datasets are conducted to verify the effectiveness of the proposed S2Snet scheme. Results compared with those of the existing methods demonstrate that S2Snet not only outperforms those existing self-supervised deep learning methods but also achieves better performances than those non-deep learning ones in different cases. Specifically, S2Snet achieves an improvement of 3.41% and 2.37% for PSNR and SSIM, respectively, as compared to the original Self2Self network, while such improvements become 19.9% and 22.7% as compared with the well-known non-deep learning NWSR method.
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Raman spectroscopy has tremendous potential for material analysis with its molecular fingerprinting capability in many branches of science and technology. It is also an emerging omics technique for metabolic profiling to shape precision medicine. However, precisely attributing vibration peaks coupled with specific environmental, instrumental, and specimen noise is problematic. Intelligent Raman spectral preprocessing to remove statistical bias noise and sample-related errors should provide a powerful tool for valuable information extraction. Here, we propose a novel Raman spectral preprocessing scheme based on self-supervised learning (RSPSSL) with high capacity and spectral fidelity. It can preprocess arbitrary Raman spectra without further training at a speed of ~1 900 spectra per second without human interference. The experimental data preprocessing trial demonstrated its excellent capacity and signal fidelity with an 88% reduction in root mean square error and a 60% reduction in infinite norm ([Formula: see text]) compared to established techniques. With this advantage, it remarkably enhanced various biomedical applications with a 400% accuracy elevation (ΔAUC) in cancer diagnosis, an average 38% (few-shot) and 242% accuracy improvement in paraquat concentration prediction, and unsealed the chemical resolution of biomedical hyperspectral images, especially in the spectral fingerprint region. It precisely preprocessed various Raman spectra from different spectroscopy devices, laboratories, and diverse applications. This scheme will enable biomedical mechanism screening with the label-free volumetric molecular imaging tool on organism and disease metabolomics profiling with a scenario of high throughput, cross-device, various analyte complexity, and diverse applications.
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The detection of trace cancer markers in body fluids such as blood/serum is crucial for cancer diseases screening and treatment, which requires high sensitivity and specificity of biosensors. In this study, a peanut structure cascaded lasso (PSCL) shaped fiber sensing probe based on fiber laser demodulation method was proposed to specifically detect the carcinoembryonic antigen related cell adhesion molecules 5 (CEACAM5) protein in serum. Thanks for the narrow linewidth and high signal-to-noise ratio (SNR) of the laser spectrum, it is easier to distinguish small spectral changes than interference spectrum. Adding the antibody modified magnetic microspheres (MMS) to form the sandwich structure of "antibody-antigen-antibody-MMS", and amplified the response caused by biomolecular binding. The limit of detection (LOD) for CEACAM5 in buffer could reach 0.11 ng/mL. Considering the common threshold of 5 ng/mL for CEA during medical screening and the cut off limit of 2.5 ng/mL for some kits, the LOD of proposed biosensor meets the actual needs. Human serum samples from a hospital were used to validate the real sensing capability of proposed biosensor. The deviation between the measured value in various serum samples and the clinical value ranged from 1.9 to 9.8 %. This sensing scheme holds great potential to serve as a point of care testing (POCT) device and extend to more biosensing applications.
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Arachis , Neoplasias , Humanos , Microesferas , Moléculas de Adhesión Celular , Rayos Láser , Fenómenos Magnéticos , Antígeno Carcinoembrionario , Proteínas Ligadas a GPIRESUMEN
Carcinoembryonic antigen (CEACAM5), as a broad-spectrum tumor biomarker, plays a crucial role in analyzing the therapeutic efficacy and progression of cancer. Herein, we propose a novel biosensor based on specklegrams of tapered multimode fiber (MMF) and two-dimensional convolutional neural networks (2D-CNNs) for the detection of CEACAM5. The microfiber is modified with CEA antibodies to specifically recognize antigens. The biosensor utilizes the interference effect of tapered MMF to generate highly sensitive specklegrams in response to different CEACAM5 concentrations. A zero mean normalized cross-correlation (ZNCC) function is explored to calculate the image matching degree of the specklegrams. Profiting from the extremely high detection limit of the speckle sensor, variations in the specklegrams of antibody concentrations from 1 to 1000 ng/mL are measured in the experiment. The surface sensitivity of the biosensor is 0.0012 (ng/mL)-1 within a range of 1 to 50 ng/mL. Moreover, a 2D-CNN was introduced to solve the problem of nonlinear detection surface sensitivity variation in a large dynamic range, and in the search for image features to improve evaluation accuracy, achieving more accurate CEACAM5 monitoring, with a maximum detection error of 0.358%. The proposed fiber specklegram biosensing scheme is easy to implement and has great potential in analyzing the postoperative condition of patients.
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Técnicas Biosensibles , Neoplasias , Humanos , Antígeno Carcinoembrionario , Proteínas Ligadas a GPIRESUMEN
We propose a Vernier effect-based sensor for temperature and salinity measurements. This sensor utilizes the correlation speckle pattern generated by spatial multimode interference and has undergone testing to validate its effectiveness. The speckle demodulation method is used to solve the problem of inconsistent envelope measurement when tracking with different upper and lower envelopes. The device consists of two Fabry Perot interferometers (FPIs) created by connecting hole core fiber (HCF) and erbium-doped fiber (EDF) in series. The speckle image produced by the interferometers is analyzed using the Zero means normalized cross-correlation (ZNCC) technique. The ZNCC value demonstrates a linear relationship with salinity and temperature, allowing for the measurement of these parameters. The sensor exhibits a temperature detection sensitivity of -0.0224 /°C and a salinity detection sensitivity of -0.0439/%. The sensor offers several advantageous features, including its compact size, low-cost manufacturing, high sensitivity, stability, and convenient reflection measurements. These characteristics make it a valuable tool for various applications. The proposed Vernier effect-based temperature and salinity sensor shows great potential for simultaneous monitoring and measurement of temperature and salinity in environments such as marine settings or industrial processes where accurate control of these parameters is crucial.
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We have proposed and demonstrated a weak acoustic signal detection technology based on phase-sensitive optical time-domain reflectometry (Φ-OTDR). Non-contact acoustic signals transmitting through air gap between the sound source and the receiver are difficult to detect due to fast attenuation. In order to improve the detection ability of non-contact weak acoustic signals, we demonstrate that multi-mode fiber (MMF) is a better solution than single-mode fiber (SMF) benefiting from its larger core and higher Rayleigh backscattering (RBS) capture coefficient. The frequency signal-to-noise ratio (SNR) has been enhanced by 9.26â dB. Then, with the help of 3D printing technology, elastomers have been designed to further enhance the detection ability due to the high-sensitive response to acoustic signals. Compared with the previous reported "I" type elastomer, the location and frequency SNR enhancement caused by our new proposed "n" type elastomer are 8.39â dB and 11.02â dB in SMF based system. The values are further improved to 10.51â dB and 13.38â dB in MMF and "n" type elastomer integrated system. And a phase-pressure sensitivity of -94.62â dB re rad/µPa has been achieved at 2.5 kHz. This non-contact weak acoustic signal detection technique has great application potential in the quasi-distributed partial discharge (PD) detection of smart grid.
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We have proposed and demonstrated the generation of a high-energy, ultrashort pulse duration, GHz pulse burst polarization-maintaining fiber amplification system that utilizes both chirped-pulse amplification and self-similar amplification techniques. Such hybrid fiber amplification system produces 22 µJ-energy bursts of 200 pulses with a 1.02-GHz intra-burst pulse repetition rate and a 1-MHz inter-burst repetition rate. The center wavelength of the amplified compressed pulse is 1065â nm, with a 3â dB spectral bandwidth of 65â nm. The pulse duration of optimal compression is â¼35 fs, which represents the shortest pulse duration reported to date for any multi-microjoule class amplification system with a repetition rate at the GHz level. At the same time, only common double-cladding Yb3+-doped fiber is used as the gain fiber, without any large-mode-area Yb3+-doped photonic crystal fiber, makes the system compact and reliable by the simple fusion operation.
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Supercontinuum generation via direct pumping of unamplified high-repetition-rate, sub-100 fs pulses with a pulse energy lower than 50 pJ is superior in noise performance and features a high acquisition speed. We demonstrate a novel, to the best of our knowledge, gigahertz-repetition-rate, mode-locked Yb-doped fiber laser, where the hybrid mode-locking approach is employed. The laser has a low initiating threshold of 300 mW and a broad mode-locking range of 600 mW (300-900 mW) in terms of pump power. The shortest obtained pulse width of the laser after compression is 95 fs, and the highest output pulse energy is 92.9 pJ at a fundamental repetition rate of 1.15 GHz. Moreover, the laser's output polarization states are switchable, and it has a polarization extinction ratio of 17.9 dB.
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As a leading cause of blindness worldwide, macular edema (ME) is mainly determined by sub-retinal fluid (SRF), intraretinal fluid (IRF), and pigment epithelial detachment (PED) accumulation, and therefore, the characterization of SRF, IRF, and PED, which is also known as ME segmentation, has become a crucial issue in ophthalmology. Due to the subjective and time-consuming nature of ME segmentation in retinal optical coherence tomography (OCT) images, automatic computer-aided systems are highly desired in clinical practice. This paper proposes a novel loss-balanced parallel decoding network, namely PadNet, for ME segmentation. Specifically, PadNet mainly consists of an encoder and three parallel decoder modules, which serve as segmentation, contour, and diffusion branches, and they are employed to extract the ME's characteristics, the contour area features, and to expand the ME area from the center to edge, respectively. A new loss-balanced joint-loss function with three components corresponding to each of the three parallel decoding branches is also devised for training. Experiments are conducted with three public datasets to verify the effectiveness of PadNet, and the performances of PadNet are compared with those of five state-of-the-art methods. Results show that PadNet improves ME segmentation accuracy by 8.1%, 11.1%, 0.6%, 1.4% and 8.3%, as compared with UNet, sASPP, MsTGANet, YNet, RetiFluidNet, respectively, which convincingly demonstrates that the proposed PadNet is robust and effective in ME segmentation in different cases.
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Edema Macular , Desprendimiento de Retina , Humanos , Tomografía de Coherencia Óptica/métodos , Retina/diagnóstico por imagen , Edema Macular/diagnóstico por imagen , Desprendimiento de Retina/diagnóstico por imagenRESUMEN
A fiber speckle sensor (FSS) based on a tapered multimode fiber (TMMF) has been developed to measure liquid analyte refractive index (RI) in this work. By the lateral and axial offset of input light into TMMF, several high-order modes are excited in TMMF, and the speckle pattern is spatially modulated, which affects an asymmetrical speckle pattern with a random intensity distribution at the output of TMMF. When the TMMF is immersed in the liquid analyte with RI variation, it influences the guided modes, as well as the mode interference, in TMMF. A digital image correlations method with zero-mean normalized cross-correlation coefficient is explored to digitize the speckle image differences, analyzing the RI variation. It is found that the lateral- and axial-offsets-induced speckle sensor can enhance the RI sensitivity from 6.41 to 19.52 RIU-1 compared to the one without offset. The developed TMMF speckle sensor shows an RI resolution of 5.84 × 10-5 over a linear response range of 1.3164 to 1.3588 at 1550 nm. The experimental results indicate the FSS provides a simple, efficient, and economic approach to RI sensing, which exhibits an enormous potential in the image-based ocean-sensing application.
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We propose, what we believe to be, a novel method for high temperature sensing calibration based on the mechanism of alterable interferential fineness in Bragg hollow core fiber (BHCF). To verify the proof-of-concept, the fabricated sensing structure is sandwiched by two sections with different length of BHCF. Two interferential fineness fringes dominate the transmission spectrum, where the high-fineness fringes formed by anti-resonant reflecting optical waveguide (ARROW) plays the role for high temperature measurement. Meanwhile, the low-fineness fringes induced by short Fabry-Perot (F-P) cavity are exploited as temperature calibration. The experimental results show that the ARROW mechanism-based temperature sensitivity can reach 26.03 pm/°C, and the intrinsic temperature sensitivity of BHCF is 1.02 pm/°C. Here, the relatively lower magnitude of the temperature sensitivity is considered as the standard value since it merely relies on the material properties of silicon. Additionally, a large dynamic temperature range from 100 °C to 800 °C presents linear response of the proposed sensing structure, which may shine the light on the sensing applications in the harsh environment.
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Detection of trace tumor markers in blood/serum is essential for the early screening and prognosis of cancer diseases, which requires high sensitivity and specificity of the assays and biosensors. A variety of label-free optical fiber-based biosensors has been developed and yielded great opportunities for Point-of-Care Testing (POCT) of cancer biomarkers. The fiber biosensor, however, suffers from a compromise between the responsivity and stability of the sensing signal, which would deteriorate the sensing performance. In addition, the sophistication of sensor preparation hinders the reproduction and scale-up fabrication. To address these issues, in this study, a straightforward lasso-shaped fiber laser biosensor was proposed for the specific determination of carcinoembryonic antigen (CEA)-related cell adhesion molecules 5 (CEACAM5) protein in serum. Due to the ultra-narrow linewidth of the laser, a very small variation of lasing signal caused by biomolecular bonding can be clearly distinguished via high-resolution spectral analysis. The limit of detection (LOD) of the proposed biosensor could reach 9.6 ng/mL according to the buffer test. The sensing capability was further validated by a human serum-based cancer diagnosis trial, enabling great potential for clinical use. The high reproduction of fabrication allowed the mass production of the sensor and extended its utility to a broader biosensing field.
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Técnicas Biosensibles , Neoplasias , Humanos , Biomarcadores de Tumor , Fibras Ópticas , Neoplasias/diagnóstico , Rayos Láser , Antígeno Carcinoembrionario , Proteínas Ligadas a GPIRESUMEN
Bulk photovoltaic effect (BPVE), a second-order nonlinear optical effect governed by the quantum geometric properties of materials, offers a promising approach to overcome the Shockley-Quiesser limit of traditional photovoltaic effect and further improve the efficiency of energy harvesting. Here, we propose an effective platform, the nano edges embedded in assembled van der Waals (vdW) homo- or hetero-structures with strong symmetry breaking, low dimensionality and abundant species, for BPVE investigations. The BPVE-induced photocurrents strongly depend on the orientation of edge-embedded structures and polarization of incident light. Reversed photocurrent polarity can be observed at left and right edge-embedded structures. Our work not only visualizes the unique optoelectronic effect in vdW nano edges, but also provides an effective strategy for achieving BPVE in engineered vdW structures.