Takotsubo cardiomyopathy and cardiogenic shock due to hypokalaemic rhabdomyolysis.

A woman with a history of chronic idiopathic constipation and remote eating disorders presented to our hospital with generalised weakness and confusion due to severe hypokalaemic rhabdomyolysis. Her initial ECG showed down-sloping ST segment elevations consistent with the 'shark fin' sign, and initial echocardiography was consistent with Takotsubo cardiomyopathy (TCM). She later developed hypotension, hypoxaemia and low central venous oxygen saturation consistent with cardiogenic shock. A repeat ECG demonstrated the 'spiked helmet' sign, and repeat echocardiography showed new global hypokinesis. She was successfully supported with dobutamine on recognition of her worsening cardiomyopathy. This case highlights how the combination of recognised triggers of TCM such as hypokalaemia and rhabdomyolysis may predispose patients to a more morbid cardiac course and how the severity of such triggers may also influence cardiac morbidity. We additionally highlight the prognostic significance of two ECG patterns associated with TCM.

Quantitative Advantages of Corrosion Sensing Using Fluorescence, Microscopy, and Single-Molecule Detection.

The corrosion of metals and alloys is a fundamental issue in modern society. Understanding the mechanisms that cause and prevent corrosion is integral to saving millions of dollars each year and to ensure the safe use of infrastructure subject to the hazardous degrading effects of corrosion. Despite this, corrosion detection techniques have lacked precise, quantitative information, with industries taking a top-down, macroscale approach to analyzing corrosion with tests that span months to years and yield qualitative information. Fluorescence, a well-established optical method, can fill the niche of early-stage, quantitative corrosion detection and can be employed for both bulk and localized testing over time. The latter, fluorescence microscopy, can be pushed to greater levels of detail with single-molecule microscopy, achieving nanometer spatial and subsecond temporal resolutions of corrosion that allow for the extraction of dynamic information and kinetics. This review will present how fluorescence microscopy can provide researchers with a molecular view into the chemical mechanisms of corrosion at interfaces and allow for faster, quantitative studies of how to detect and prevent corrosion.

Editorial Commentary: Microfragmented Adipose Tissue May Provide an Effective Injection Treatment Modality for Arthritic Knee Pain With 1-Year Improvement in Pain and Function.

Injectable treatments for arthritic knee pain continue to evolve. This is significant, considering that osteoarthritis is the most common orthopaedic pathology in adult patients. The Centers for Disease Control and Prevention report that 16.9% of all adults are affected, and by age 65 years, almost one-half of the population will experience pain related to cartilage degradation. Steroid injections show only short-term improvements. Both viscosupplementation using hyaluronates and platelet-rich plasma injection show inconsistent long-term results. Recently microfragmented adipose tissue injections in the office setting have been shown to provide symptomatic improvement at 6 and 12 months in patients with knee pain from degenerative joint disease. Additional studies are needed to confirm the reproducibility of this finding. Most of all, study of injections for knee arthritis must include a placebo control (saline injection) to truly demonstrate efficacy.

Disaggregation Should Extend to Race and Ethnicity: The Missing Pieces in the SAGER Guidelines.

The SAGER recommendations on the inclusion of sex and gender as reportable variables in medical trials are a significant advancement. There is an oversight and failure to include race and ethnicity in medical research trials that has profound implications for the development of effective health care treatment. Previous orthopaedic studies have proven that different racial/ethnic population groups have differences that affect the epidemiology of injury and response to surgery. It is only by including and desegregating data from these diverse patient populations will results accurately reflect treatment outcomes.

Editorial Commentary: Published Literature on Platelet-Rich Plasma Is Extensive but Flawed in Methodology.

Recent research shows that most orthopaedic published investigations on platelet-rich plasma (PRP) lack reporting of preparation methods or PRP composition. The studies are thus unreproducible and the outcomes cannot be verified. Unfortunately, this is not surprising. A PubMed search reveals more than 500 orthopaedic PRP publications from 2023 alone, almost 42 musculoskeletal PRP papers per month, and unfortunately, despite peer review, Nature reports that 44% of published research is flawed and 26% of studies cannot be trusted. PubMed citation does not ensure quality. Guidelines and checklists such as the CONSORT statement (Consolidated Standards of Reporting Trails) can result in quality.

Artificial Intelligence and Machine Learning May Resolve Health Care Information Overload.

Biomedical information doubles almost every 2 months, and this very rate is expected to double by 2025. The result is information overload for clinicians and researchers. Today, artificial intelligence (AI) and machine learning (ML) research contribute to the deluge of information. In addition, AI large language models, although capable of automating scientific writing, are flawed. They hallucinate (make things up), are trained primarily on non-peer-reviewed content, raise ethical and legal issues, and lack human empathy. Still, when it comes to AI including ML, we are optimistic. The technology is improving rapidly. In the future, AI will help us manage unwieldy information by processing data, determining diagnoses, recommending treatments, and predicting outcomes. In research, AI and ML similarly promise efficient data analysis and literature review and will create new content in response to our instructions. Human touch will be required, and we will disclose use of AI proactively, including rationale for its use, our data input, our level of confidence in the output, and the patients or populations to whom the output may be applied. In addition, we will ensure data quality is high and bias is minimized. Most of all, we will provide essential reasoning, clinical and research guidance, and diligent oversight. Humans will remain accountable.

Editorial Commentary: Women Do Not Return to Sport at the Same Level After Anterior Cruciate Ligament Reconstruction as Often as Men: This May Be Associated With Lower Risk Tolerance-and Not Necessarily a Bad Thing!

It has been established that women do not return to preinjury sports (RTS) at the same level after anterior cruciate ligament reconstruction at the same rate as men. Normalization of strength parameters does influence the return to sports in men, but not women. Lower RTS rates may be associated with lower risk tolerance, and this is not necessarily a bad thing. Neither lower RTS rates nor lower risk tolerance is maladaptive or in need of correction. Awareness of the psychological diversity between the sexes does help in understanding this difference. Appreciation of this perspective will improve the relationship with the female athlete during her recovery.

Editorial Commentary: When Performing Proximal Tibial Slope Decreasing Osteotomies in Patients Undergoing Primary or Revision Anterior Cruciate Ligament Reconstruction, Surgeons Must Be Cautious to Avoid Overcorrection of the Posterior Tibial Slope: Teeter-Totter Tibial Translation.

An excessive or large proximal tibial posterior slope is directly correlated with the risk of knee joint injury. This includes anterior cruciate ligament (ACL) graft reconstruction failure and meniscal tear. Correction of the excessive posterior slope seems prudent in patients whose prior surgical procedures have not succeeded in restoring normal knee stability including anterior tibial translation. Such an approach has been presented through techniques involving tibial osteotomy. By decreasing the tibial slope, there will be a decrease in the rate of ACL graft failure. When one is performing a corrective osteotomy, the correction should be neither too little nor too much. Too little a correction will not sufficiently alter the mechanics, resulting in a limited effect. Too great a change will produce negative static anterior tibial translation. Moreover, recent research has shown that after slope-correcting osteotomy, achieving the target slope occurs in fewer than 50% of cases. Surgeons must be cautious to avoid overcorrection of the posterior tibial slope.

Evidence-Based Practice Should Supersede Evidence-Based Medicine Through Consideration of Clinical Experience and Patient Characteristics in Addition to the Published Literature.

On the surface, the benefits of evidence-based medicine (EBM) seem self-evident. However, reliance on the scientific literature alone has limitations. Studies may be biased, statistically fragile, and/or not reproducible. Reliance solely on EBM may ignore physician clinical experience and individual patient characteristics and input. Reliance solely on EBM may overvalue quantitative, statistical significance, resulting in a false sense of certainty. Reliance solely on EBM may fail to consider lack of generalizability of published studies to individually unique patients. The concept of evidence-based practice goes beyond EBM and incorporates (1) EBM, (2) clinical expertise, and (3) individual patient characteristics, values, and preferences. Even if branded as evidence-based, a suggested treatment may not be the best treatment. Evidence-based practice must be considered before determining what is best for our patients.

Imaging in the Intensive Care Unit.

Radiology plays an important role in the management of the most seriously ill patients in the hospital. Over the years, continued advances in imaging technology have contributed to an improvement in patient care. However, even with such advances, the portable chest radiograph (CXR) remains one of the most commonly requested radiographic examinations. While they provide valuable information, CXRs remain relatively insensitive at revealing abnormalities and are often nonspecific. Chest computed tomography (CT) can display findings that are occult on CXR and is particularly useful at identifying and characterizing pleural effusions, detecting barotrauma including small pneumothoraces, distinguishing pneumonia from atelectasis, and revealing unsuspected or additional abnormalities which could result in increased morbidity and mortality if left untreated. CT pulmonary angiography is the modality of choice in the evaluation of pulmonary emboli which can complicate the hospital course of the ICU patient. This article will provide guidance for interpretation of CXR and thoracic CT images, discuss some of the invasive devices routinely used, and review the radiologic manifestations of common pathologic disease states encountered in ICU patients. In addition, imaging findings and complications of more specific clinical scenarios in which the incidence has increased in the ICU setting, such as patients who are immunocompromised, have interstitial lung disease, or COVID-19, will also be discussed. Communication between the radiologist and intensivist, particularly on complicated cases, is important to help increase diagnostic accuracy and leads to an improvement in the management of the most critically ill patients.

Reflections on New Evidence on Crisis Standards of Care in the COVID-19 Pandemic.

Crisis standards of care have been widely developed by healthcare systems and states in the United States during the COVID-19 pandemic, and in some rare cases have actually been used to allocate medical resources. All publicly available U.S. crisis standards of care with a mechanism for allocating scarce resources make use of the Sequential Organ Failure Assessment (SOFA) score in hopes of assigning scarce resources to those patients who are more likely to survive. We reflect on the growing body of evidence suggesting that the SOFA score has limited accuracy in predicting mortality among patients hospitalized with COVID-19 and that the SOFA score systematically disfavors Black patients. Use of the SOFA score for allocating scarce resources may therefore result in Black patients with equal likelihood of survival being deprived of life-saving medical resources. There is also a risk of injustice for patients with non-COVID-19 diagnoses, for whom the SOFA score may be a more accurate prognostic score, but who might nevertheless be unfairly (de)prioritized when assessed alongside COVID-19 patients using the same scoring system. For these reasons we recommend that the SOFA score not be used for triage purposes during the COVID pandemic, and that a national effort be made to develop and empirically test crisis standards of care in advance of the next public health emergency.

Editorial Commentary: If Individual Treatments Are Potentiated, Multimodal Therapy Including Cells and Platelet-Rich Plasma May Beneficially Treat Cartilage Degeneration and Arthritis.

Multimodal therapies may optimize treatments if individual treatments are potentiated. In an attempt to obtain the elusive cure for cartilage degeneration, combined biologic injectable therapy might improve results. Due to the multipotent mesenchymal stem cells in adipose tissue, microfat containing adipose-derived stem cells may assist in cartilage repair. Platelet-rich plasma (PRP) has been similarly shown to be an effective biologic therapy through the release of growth factors affecting chondrocyte metabolism and decreasing inflammation. These 2 different products might be synergistic. Recent study, however, shows no significant differences when evaluating microfat with or without PRP, and importantly also shows that PRP with microfat does provide improvement in knee arthritic pain. This improvement may not correlate with the development of new cartilage, but it does improve function. Each biologic has beneficial effects on knee joint function through different mechanisms.

Challenges in interpreting cytokine data in COVID-19 affect patient care and management.

Challenges in using cytokine data are limiting Coronavirus Disease 2019 (COVID-19) patient management and comparison among different disease contexts. We suggest mitigation strategies to improve the accuracy of cytokine data, as we learn from experience gained during the COVID-19 pandemic.

Articular Cartilage Restoration Requires Cells, Scaffolds, Growth Factors, and Mechanical Stimulation.

Tissue engineering requires cells, scaffolds, growth factors, and mechanical stimulation. In terms of cartilage restoration or repair, various innovative approaches are evolving, using host or allograft cells, biomimetic scaffolds, matrices, or membranes including hyaluronic acid, as well as diverse biological and growth factors. A current approach for the treatment of chondral or osteochondral defects enhances a microfracture procedure (introducing autologous, mesenchymal stem cells) with dehydrated micronized allograft extracellular matrix (scaffold), platelet-rich plasma (containing anabolic, anticatabolic, and anti-inflammatory growth factors), a fibrin glue sealant, and careful rehabilitation providing mechanical stimulation. Early results are encouraging; long-term outcomes including a larger number of study subjects remain to be reported.

Short-Term Outcomes After Multisystem Inflammatory Syndrome in Children Treatment.

This is a retrospective chart review of 20 patients treated with a consensus-driven treatment algorithm in multisystem inflammatory syndrome in children patients across a wide clinical spectrum. Their treatments and clinical status are described as well as their favorable return to functional baseline by 30 days post presentation.

Malignant hyperthermia in severe COVID-19: 2 case reports.

Malignant hyperthermia is a rare but potentially fatal condition. We present 2 cases of young patients with coronavirus disease 2019 (COVID-19) requiring intubation for hypoxic respiratory failure who both developed significant hyperthermia post intubation and were suspected to have malignant hyperthermia. However, the 2 patients had different responses to conservative management and dantrolene. These cases highlight the increased challenge imposed by intubation complications when managing patients with COVID-19.