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Bioorg Med Chem Lett
; 19(1): 158-62, 2009 Jan 01.
Artículo
en Inglés
| MEDLINE
| ID: mdl-19019676
RESUMEN
Aryl aminopyrazole amides capped with N-alkylbenzamides 13-16 are selective glucocorticoid receptor agonists. 2,6-Disubstituted benzamides have prednisolone-like potency or better in vitro. Good oral exposure was demonstrated in the rat, with compounds with lower lipophilicity, for example N-hydroxyethyl benzamides (e.g., 16e).