RESUMEN
In patients with complicated essential hypertension (ischemic stroke) and coronary heart disease, inductors of platelet aggregation in various doses induced "paradoxical" changes in platelet aggregation activity reflecting the degree of decompensation under conditions of persistent endothelial dysfunction. Aggregation inductors in low doses were shown to have a greater diagnostic significance. The content of endothelial dysfunction markers in the blood was persistently elevated under these conditions.
Asunto(s)
Enfermedad Coronaria/sangre , Endotelio Vascular/fisiología , Agregación Plaquetaria/fisiología , Accidente Cerebrovascular/sangre , Adenosina Difosfato , Epinefrina , Femenino , Humanos , Masculino , Persona de Mediana Edad , Estadísticas no Paramétricas , Factor de von Willebrand/análisisRESUMEN
The study designed to estimate the state of the homeostatic system, levels of NAD and NAD-dependent dehydrogenases included 90 patients with complicated hypertensive disease and coronary heart disease following ischemic stroke. Hypercoagulation and enhanced platelet aggregation occurred throughout the entire follow-up period. Acute stage of ischemic stroke was associated with marked changes in bioenergetic and plastic processes.