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J Gastroenterol Hepatol ; 39(4): 674-684, 2024 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-38191176

RESUMEN

BACKGROUND AND AIM: More insight into the incidence of and factors associated with progression following a first episode of acute pancreatitis (AP) would offer opportunities for improvements in disease management and patient counseling. METHODS: A long-term post hoc analysis of a prospective cohort of patients with AP (2008-2015) was performed. Primary endpoints were recurrent acute pancreatitis (RAP), chronic pancreatitis (CP), and pancreatic cancer. Cumulative incidence calculations and risk analyses were performed. RESULTS: Overall, 1184 patients with a median follow-up of 9 years (IQR: 7-11) were included. RAP and CP occurred in 301 patients (25%) and 72 patients (6%), with the highest incidences observed for alcoholic pancreatitis (40% and 22%). Pancreatic cancer was diagnosed in 14 patients (1%). Predictive factors for RAP were alcoholic and idiopathic pancreatitis (OR 2.70, 95% CI 1.51-4.82 and OR 2.06, 95% CI 1.40-3.02), and no pancreatic interventions (OR 1.82, 95% CI 1.10-3.01). Non-biliary etiology (alcohol: OR 5.24, 95% CI 1.94-14.16, idiopathic: OR 4.57, 95% CI 2.05-10.16, and other: OR 2.97, 95% CI 1.11-7.94), RAP (OR 4.93, 95% CI 2.84-8.58), prior pancreatic interventions (OR 3.10, 95% CI 1.20-8.02), smoking (OR 2.33, 95% CI 1.14-4.78), and male sex (OR 2.06, 95% CI 1.05-4.05) were independently associated with CP. CONCLUSION: Disease progression was observed in a quarter of pancreatitis patients. We identified several risk factors that may be helpful to devise personalized strategies with the intention to reduce the impact of disease progression in patients with AP.


Asunto(s)
Enfermedades Pancreáticas , Neoplasias Pancreáticas , Pancreatitis Crónica , Humanos , Masculino , Enfermedad Aguda , Progresión de la Enfermedad , Estudios de Seguimiento , Recurrencia Local de Neoplasia/complicaciones , Enfermedades Pancreáticas/complicaciones , Neoplasias Pancreáticas/etiología , Neoplasias Pancreáticas/complicaciones , Pancreatitis Crónica/complicaciones , Pancreatitis Crónica/epidemiología , Estudios Prospectivos , Recurrencia , Factores de Riesgo
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