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1.
J Neuroimmunol ; 309: 41-46, 2017 08 15.
Artículo en Inglés | MEDLINE | ID: mdl-28601286

RESUMEN

Autoantibodies to nodal/paranodal proteins have been reported in patients with chronic inflammatory demyelinating polyneuropathy (CIDP) and multifocal motor neuropathy (MMN). To determine the frequency of anti-paranodal antibodies in our cohort of CIDP patients and to validate the presence anti-nodal antibodies in MMN, sera were screened for IgG against human neurofascin 155, contactin-1, neurofascin 186 and gliomedin using ELISA. In CIDP patients, 7% were anti-NF155 IgG4 positive and 7% were anti-CNTN1 IgG4 positive. Positive results were confirmed using cell based assays and indirect immunofluorescence on teased nerve fibres. We did not detect IgG autoantibodies against these nodal/paranodal antigens in MMN patients.


Asunto(s)
Autoanticuerpos/sangre , Polineuropatías/sangre , Polineuropatías/diagnóstico , Polirradiculoneuropatía Crónica Inflamatoria Desmielinizante/sangre , Polirradiculoneuropatía Crónica Inflamatoria Desmielinizante/diagnóstico , Adulto , Anciano , Animales , Autoanticuerpos/inmunología , Moléculas de Adhesión Celular/sangre , Moléculas de Adhesión Celular/inmunología , Femenino , Células HeLa , Humanos , Inmunoglobulina G/sangre , Inmunoglobulina G/inmunología , Masculino , Proteínas de la Membrana/sangre , Proteínas de la Membrana/inmunología , Persona de Mediana Edad , Factores de Crecimiento Nervioso/sangre , Factores de Crecimiento Nervioso/inmunología , Proteínas del Tejido Nervioso/sangre , Proteínas del Tejido Nervioso/inmunología , Polineuropatías/inmunología , Polirradiculoneuropatía Crónica Inflamatoria Desmielinizante/inmunología , Ratas , Ratas Endogámicas Lew
2.
Eur J Neurol ; 20(3): 509-514, 2013 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-23078293

RESUMEN

BACKGROUND AND PURPOSE: Thalidomide was marketed for the treatment of morning sickness and resulted in foetal death and physical deformities. The exact mechanism of action of thalidomide in its teratogenicity is still actively debated in the literature. METHODS: This study reviewed 16 of the confirmed Australasian victims of in utero exposure to thalidomide who now presented with new-onset neurological symptoms in the fourth and fifth decades. RESULTS: Clinical neurological examination and neurophysiological investigations revealed that new symptoms were due in part to compressive neuropathies, often exacerbated by the adaptations made to accommodate the disability and poor mobility arising from the limb deformities. Other subjects were found to have musculoskeletal symptoms due to compensatory postures employed to perform tasks of daily living. CONCLUSIONS: The study provides no evidence of ongoing loss of neurons or late reactivated neural degeneration and no evidence of a generalized peripheral neuropathy. Rather, the development of new symptoms in subjects can be explained by compressive neuropathies and compensatory postures employed to perform tasks of daily living.


Asunto(s)
Antieméticos/efectos adversos , Enfermedades del Sistema Nervioso Periférico/inducido químicamente , Efectos Tardíos de la Exposición Prenatal/fisiopatología , Talidomida/efectos adversos , Australasia , Australia , Estudios de Cohortes , Progresión de la Enfermedad , Femenino , Humanos , Masculino , Persona de Mediana Edad , Enfermedades del Sistema Nervioso Periférico/fisiopatología , Embarazo , Tiempo
3.
Neurology ; 68(4): 298-300, 2007 Jan 23.
Artículo en Inglés | MEDLINE | ID: mdl-17242338

RESUMEN

We describe two immunocompetent patients with tuberculous cranial pachymeningitis. Both patients underwent biopsy after focal dural thickening was identified on MRI. Histopathologic examination of tissue revealed necrotizing granulomatous inflammation. PCR for Mycobacterium tuberculosis DNA was negative on CSF but positive on tissue. Both patients responded to antituberculous therapy. Although uncommon as a cause of cranial pachymeningitis, tuberculosis should be considered, since it responds well to treatment.


Asunto(s)
Duramadre/diagnóstico por imagen , Duramadre/patología , Tuberculosis Meníngea/diagnóstico por imagen , Tuberculosis Meníngea/patología , Adulto , Antituberculosos/uso terapéutico , Femenino , Humanos , Masculino , Persona de Mediana Edad , Radiografía , Tuberculosis Meníngea/tratamiento farmacológico
4.
Neurology ; 62(4): 612-8, 2004 Feb 24.
Artículo en Inglés | MEDLINE | ID: mdl-14981179

RESUMEN

BACKGROUND: There are a number of distal and generalized small-fiber neuropathies. The neuropathologic basis is poorly understood as somatic and autonomic C fibers are not usually studied in the same region of the body. OBJECTIVE: To evaluate prospective somatic and autonomic C-fiber function in 11 healthy control subjects and 38 patients with different clinical patterns of neuropathy. METHODS: Distal small-fiber neuropathy (DSFN), peripheral neuropathy (PN), diabetic neuropathy (DN), neuropathic postural tachycardia syndrome (POTS), and idiopathic autonomic neuropathy (IAN) were evaluated. Intraepidermal nerve fiber density was used to evaluate distal somatic C fibers. Both quantitative sudomotor axon reflex test and skin norepinephrine content were measured for the biopsy site to assess distal autonomic C-fiber function. Postganglionic sudomotor, adrenergic, and cardiovagal functions were evaluated by autonomic reflex testing and quantified using a Composite Autonomic Severity Scale. RESULTS: Skin norepinephrine concentration was significantly related to CASS. DN was associated with somatic and autonomic C-fiber impairment with good agreement. POTS was associated with selective distal autonomic deficit. DSFN had combined distal somatic and C-fiber impairment. IAN showed combined and selective distal and generalized autonomic C-fiber impairment. The somatic neuropathies had C-fiber impairment affecting both populations to varying degrees. CONCLUSION: Although a general agreement exists between the loss of somatic C fibers and autonomic deficits, selective involvement occurs for specific autonomic neuropathies.


Asunto(s)
Enfermedades del Sistema Nervioso Autónomo/patología , Vías Autónomas/patología , Fibras Nerviosas Amielínicas/patología , Adulto , Anciano , Neuropatías Diabéticas/patología , Femenino , Humanos , Masculino , Persona de Mediana Edad , Norepinefrina/análisis , Fenotipo , Estudios Prospectivos , Índice de Severidad de la Enfermedad , Piel/química , Taquicardia/patología
5.
BioDrugs ; 15(3): 173-83, 2001.
Artículo en Inglés | MEDLINE | ID: mdl-11437683

RESUMEN

The autoimmune pathogenesis of myasthenia gravis is relatively well understood. The current options for treatment of this disease are acute and long term immunotherapies, acetylcholinesterase inhibitors and thymectomy. Many factors influence the timing of initiation of immunomodulatory therapy in myasthenia gravis and both disease factors, such as stage and severity, and patient factors, such as age, pregnancy and intercurrent illness, must be considered. Decisions regarding the choice of therapy can be difficult because of the limited number of randomised controlled trials that have been performed in myasthenic patients. In general, acetylcholinesterase inhibitors alone are used only in mild ocular disease, and in the majority of other patients immunomodulatory therapy is begun early. Corticosteroids are the most commonly used initial therapy, followed by azathioprine. In refractory cases, the available options include immunosuppressants such as cyclosporin, mycophenolate mofetil and cyclophosphamide. Plasmapheresis and intravenous immunoglobulin are important in the treatment of acute exacerbations and myasthenic crisis and in the perioperative setting. Despite many years of experience, the role of thymectomy in improving long term outcome in nonthymomatous myasthenia gravis remains controversial.


Asunto(s)
Adyuvantes Inmunológicos/uso terapéutico , Miastenia Gravis/terapia , Animales , Autoinmunidad/inmunología , Humanos , Miastenia Gravis/inmunología , Miastenia Gravis/patología , Miastenia Gravis/cirugía , Timectomía
6.
Med J Aust ; 174(11): 598-604, 2001 Jun 04.
Artículo en Inglés | MEDLINE | ID: mdl-11453336

RESUMEN

An acute polyneuropathy developing over days to several weeks is most likely to be Guillain-Barré syndrome or a toxic neuropathy, although vasculitis can also present acutely. This presentation should be referred immediately for further investigation. A subacute to chronic (ie, developing over months) neuropathy with significant proximal weakness and prominent loss of reflexes is highly suggestive of chronic inflammatory demyelinating polyradiculoneuropathy. If there is a clear stepwise onset of symptoms, suggestive of multiple mononeuropathies, or significant asymmetry, vasculitic neuropathy should be considered, even in the absence of systemic vasculitis. Idiopathic chronic axonal neuropathy is an indolent, predominantly sensory neuropathy that typically occurs in older patients. Neuropathies occurring in young or middle age or with more subacute onset always warrant further investigation.


Asunto(s)
Enfermedades de los Nervios Craneales/diagnóstico , Enfermedades de los Nervios Craneales/terapia , Enfermedades del Sistema Nervioso Periférico/diagnóstico , Enfermedades del Sistema Nervioso Periférico/terapia , Algoritmos , Árboles de Decisión , Diagnóstico Diferencial , Electrofisiología , Medicina Basada en la Evidencia , Humanos , Masculino , Persona de Mediana Edad , Guías de Práctica Clínica como Asunto , Resultado del Tratamiento
7.
Expert Rev Neurother ; 1(1): 119-29, 2001 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-19811053

RESUMEN

Guillain-Barré syndrome is now the most common cause of acute flaccid paralysis. Although modern intensive care facilities have significantly reduced the mortality associated with this monophasic immune mediated neuropathy, up to 5% of patients do not survive and 10% are left unable to walk unaided. Supportive medical care remains the most important aspect of management but both plasmapheresis and iv. immunoglobulin have been shown to hasten recovery when given in the early stages of the illness. This article summarizes the current management of Guillain-Barré syndrome, including both supportive measures and immune modulating therapy.

8.
Am J Med Sci ; 317(2): 124-33, 1999 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-10037116

RESUMEN

Patients with the postural orthostatic tachycardia syndrome (POTS) have symptoms of orthostatic intolerance despite having a normal orthostatic blood pressure (BP), which suggests some impairment of cerebrovascular regulation. Cerebrovascular autoregulation refers to the maintenance of normal cerebral blood flow in spite of changing BP. Mechanisms of autoregulation include myogenic, metabolic and neurogenic vasoregulation. Beat-to-beat recording of blood-flow velocity (BFV) is possible using transcranial Doppler imaging. It is possible to evaluate autoregulation by regressing deltaBFV to deltaBP during head-up tilt. A number of dynamic methods, relating deltaBFV to deltaBP during sudden induced changes in BP by occluding then releasing peripheral arterial flow or by the Valsalva maneuver. The deltaBFV to deltaBP provides an index of autoregulation. In orthostatic hypotension, the autoregulated range is typically expanded. In contrast, paradoxical vasoconstriction occurs in POTS because of an increased depth of respiration, resulting in hypocapnic cerebrovascular constriction, and impaired autoregulation.


Asunto(s)
Circulación Cerebrovascular , Postura , Taquicardia/etiología , Taquicardia/fisiopatología , Velocidad del Flujo Sanguíneo , Humanos , Reproducibilidad de los Resultados , Taquicardia/diagnóstico por imagen , Ultrasonografía Doppler Transcraneal
9.
Stroke ; 29(9): 1876-81, 1998 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-9731612

RESUMEN

BACKGROUND AND PURPOSE: Orthostatic and other stresses trigger tachycardia associated with symptoms of tremulousness, shortness of breath, dizziness, blurred vision, and, often, syncope. It has been suggested that paradoxical cerebral vasoconstriction during head-up tilt might be present in patients with orthostatic intolerance. We chose to study middle cerebral artery (MCA) blood flow velocity (BFV) and cerebral vasoregulation during tilt in patients with orthostatic intolerance (OI). METHODS: Beat-to-beat BFV from the MCA, heart rate, CO2, blood pressure (BP), and respiration were measured in 30 patients with OI (25 women and 5 men; age range, 21 to 44 years; mean age, 31.3+/-1.2 years) and 17 control subjects (13 women and 4 men; age range, 20 to 41 years; mean age, 30+/-1.6 years); ages were not statistically different. These indices were monitored during supine rest and head-up tilt (HUT). We compared spontaneous breathing and hyperventilation and evaluated the effect of CO2 rebreathing in these 2 positions. RESULTS: The OI group had higher supine heart rates (P<0.001) and cardiac outputs (P<0.01) than the control group. In response to HUT, OI patients underwent a greater heart rate increment (P<0.001) and greater reductions in pulse pressure (P<0.01) and CO2 (P<0.001), but total systemic resistance failed to show an increment. Among the cerebrovascular indices, all BFVs (systolic, diastolic, and mean) decreased significantly more, and cerebrovascular resistance (CVR) was increased in OI patients (P<0.01) compared with control subjects. In both groups, hyperventilation induced mild tachycardia (P<0.001), a significant reduction of BFV, and a significant increase of CVR associated with a fall in CO2. Hyperventilation during HUT reproduced hypocapnia, BFV reduction, and tachycardia and worsened symptoms of OI; these symptoms and indices were improved within 2 minutes of CO2 rebreathing. The relationships between CO2 and BFV and heart rate were well described by linear regressions, and the slope was not different between control subjects and patients with OI. CONCLUSIONS: Cerebral vasoconstriction occurs in OI during orthostasis, which is primarily due to hyperventilation, causing significant hypocapnia. Hypocapnia and symptoms of orthostatic hypertension are reversible by CO2 rebreathing.


Asunto(s)
Circulación Cerebrovascular , Hipocapnia/fisiopatología , Hipotensión Ortostática/fisiopatología , Adulto , Presión Sanguínea , Dióxido de Carbono/sangre , Femenino , Frecuencia Cardíaca , Humanos , Hiperventilación/fisiopatología , Hipocapnia/diagnóstico por imagen , Hipotensión Ortostática/diagnóstico por imagen , Masculino , Pruebas de Mesa Inclinada , Ultrasonografía Doppler Dúplex , Sistema Vasomotor/fisiopatología
10.
Stroke ; 29(1): 104-11, 1998 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-9445337

RESUMEN

BACKGROUND AND PURPOSE: We sought to evaluate cerebral autoregulation in patients with orthostatic hypotension (OH). METHODS: We studied 21 patients (aged 52 to 78 years) with neurogenic OH during 80 degrees head-up tilt. Blood flow velocities (BFV) from the middle cerebral artery were continuously monitored with transcranial Doppler sonography, as were heart rate, blood pressure (BP), cardiac output, stroke volume, CO2, total peripheral resistance, and cerebrovascular resistance. RESULTS: All OH patients had lower BP (P<.0001), BFV_diastolic (P<.05), CVR (P<.007), and TPR (P<.02) during head-up tilt than control subjects. In control subjects, no correlations between BFV and BP were found during head-up tilt, suggesting normal autoregulation. OH patients could be separated into those with normal or expanded autoregulation (OH_NA; n=16) and those with autoregulatory failure (OH_AF; n=5). The OH_NA group showed either no correlation between BFV and BP (n=8) or had a positive BFV/BP correlation (R2>.75) but with a flat slope. An expansion of the "autoregulated" range was seen in some patients. The OH_AF group was characterized by a profound fall in BFV in response to a small reduction in BP (mean deltaBP <40 mm Hg; R2>.75). CONCLUSIONS: The most common patterns of cerebral response to OH are autoregulatory failure with a flat flow-pressure relationship or intact autoregulation with an expanded autoregulated range. The least common pattern is autoregulatory failure with a steep flow-pressure relationship. Patients with patterns 1 and 2 have an enhanced capacity to cope with OH, while those with pattern 3 have reduced capacity.


Asunto(s)
Circulación Cerebrovascular/fisiología , Homeostasis/fisiología , Hipotensión Ortostática/fisiopatología , Anciano , Análisis de Varianza , Velocidad del Flujo Sanguíneo/fisiología , Presión Sanguínea/fisiología , Dióxido de Carbono/metabolismo , Gasto Cardíaco/fisiología , Cardiografía de Impedancia , Arterias Cerebrales/diagnóstico por imagen , Arterias Cerebrales/fisiopatología , Femenino , Frecuencia Cardíaca/fisiología , Humanos , Hiperventilación/fisiopatología , Hipotensión Ortostática/diagnóstico por imagen , Masculino , Persona de Mediana Edad , Respiración , Volumen Sistólico/fisiología , Pruebas de Mesa Inclinada , Ultrasonografía Doppler Transcraneal , Resistencia Vascular/fisiología
11.
Brain ; 119 ( Pt 5): 1441-8, 1996 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-8931569

RESUMEN

The clinical, electrophysiological and pathological features and prognosis of 25 patients with vasculitis selectively affecting the peripheral nervous system were evaluated. Although most patients had a history of mononeuritis multiplex or an asymmetrical neuropathy six out of 25 had a symmetrical neuropathy, both clinically and on neurophysiological testing, by the time of presentation. There were no signs of accompanying systemic vasculitis in any of the patients and serological abnormalities were limited to an elevated erythrocyte sedimentation rate (ESR) in nine out of 21 patients and low titre anti-nuclear antibodies in four out of 20 patients. Most patients had a necrotizing vasculitis on nerve biopsy, although in some cases the diagnosis was made on the association of inflammatory cell infiltrates with extensive axonal degeneration and immune complex deposition on immunofluorescence studies. The mean time from symptom onset to diagnosis was 46 weeks. All patients were treated with corticosteroids and most with additional immunosuppressive therapy. In contrast to vasculitic neuropathy associated with systemic vasculitis the prognosis was good with 24 out of 25 survivors at a mean of 176 weeks follow-up having a mean improvement of 1.4 units on a six-point disability scale.


Asunto(s)
Enfermedades del Sistema Nervioso Periférico/patología , Nervio Sural/patología , Vasculitis/patología , Adulto , Anciano , Femenino , Humanos , Masculino , Persona de Mediana Edad , Pronóstico , Nervio Sural/ultraestructura , Vasculitis/fisiopatología
12.
Brain ; 118 ( Pt 4): 857-68, 1995 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-7655884

RESUMEN

Experiments were conducted to investigate the effect of activated T cells on the blood-nerve barrier (BNB) in experimental allergic neuritis (EAN). T cells reactive to the P2 component of myelin (P2 T cells) and known to cause EAN were injected into the sciatic nerve of Lewis rats. Animals were then given daily intraperitoneal (i.p.) injections of serum with known demyelinating activity (rabbit EAN serum) or control serum. Serial nerve conduction studies across the injected segment were performed and nerves were removed at various stages for histology. Focal conduction block and perivascular demyelination were evidence in T cell injected nerves of animals treated with EAN serum. In animals treated with control serum no conduction block was seen and only perivascular infiltrates without demyelination were present. Similar results were obtained with T cells reactive to non-neural antigens, although the effect was less marked. Systemically administered rabbit immunoglobulin (Ig) was demonstrated within the endoneurium of P2 T cell injected nerves by immunofluorescence and the endoneurial blood vessels showed increased permeability to circulating horseradish peroxidase (HRP). These findings demonstrate that activated T cells cause focal breakdown of the BNB, allowing circulating antimyelin antibody to enter the endoneurium with consequent focal demyelination. P2 reactive EAN producing T cells do not cause significant demyelination when injected intraneurally (i.n.) in the absence of circulating antimyelin antibody. Intraneural injection of tumour necrosis factor alpha (TNF-alpha) yielded similar results, causing conduction block and perivascular demyelination in the presence of circulating antimyelin antibody but not in control serum treated animals.


Asunto(s)
Fenómenos Fisiológicos Sanguíneos , Activación de Linfocitos , Neuritis Autoinmune Experimental/inmunología , Nervio Ciático/fisiología , Linfocitos T/inmunología , Animales , Linfocitos , Proteínas de la Mielina/inmunología , Proteínas de la Mielina/metabolismo , Proteínas de la Mielina/farmacología , Vaina de Mielina/inmunología , Conducción Nerviosa/efectos de los fármacos , Neuritis Autoinmune Experimental/fisiopatología , Permeabilidad , Ratas , Nervio Ciático/citología , Linfocitos T/citología , Factor de Necrosis Tumoral alfa/farmacología , Factor de Necrosis Tumoral alfa/fisiología
13.
Ann Neurol ; 37(4): 467-75, 1995 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-7717683

RESUMEN

Recent studies from our laboratory and by other investigators have shown that autoreactive CD4+ cells specific for peripheral nerve P2 protein have a powerful effect on blood-nerve barrier permeability. In this study we injected CD4+ T cells reactive to a nonneural antigen (ovalbumin) systemically and achieved their accumulation in the tibial nerve of Lewis rats by previous intraneural injection of ovalbumin. Selected rats were given systemic demyelinating antibody (antigalactocerebroside) to provide an indicator of changes in the permeability of the blood-nerve barrier, and the animals were monitored by sequential neurophysiological studies and histology. Circulating ovalbumin-specific T cells accumulated at sites of intraneural ovalbumin injection without inducing demyelination in control animals. In rats with circulating galactocerebroside antibodies, local conduction block and demyelination were seen in the region of T-cell accumulation. Electron microscopy demonstrated dissolution of some tight junctions between endothelial cells in areas of T-cell accumulation, and T cells traversing the endothelium between endothelial cells and through their cytoplasm. Endothelial cell damage was evident in these areas. This study demonstrates breakdown of the blood-nerve barrier by activated T cells, even of nonneural specificity, allowing the development of focal conduction block and demyelination in the presence of circulating antimyelin antibodies.


Asunto(s)
Linfocitos T CD4-Positivos/fisiología , Permeabilidad Capilar/inmunología , Nervios Periféricos/inmunología , Potenciales de Acción/fisiología , Animales , Activación de Linfocitos , Masculino , Microscopía Electrónica , Músculos/fisiología , Ovalbúmina/inmunología , Nervios Periféricos/fisiología , Nervios Periféricos/ultraestructura , Conejos , Ratas , Ratas Endogámicas Lew
14.
J Neuroimmunol ; 57(1-2): 77-84, 1995 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-7535792

RESUMEN

Studies were conducted in experimental allergic neuritis (EAN) to evaluate the possible interaction of cellular and humoral immune mechanisms in the demyelinating process. EAN was induced in Lewis rats by passive transfer of T cells reactive to P2 myelin protein or by active immunisation with whole myelin. Animals were then given systemic antimyelin antibody or control serum and assessed clinically, electrophysiologically and with semiquantitative histological studies. Animals given intraperitoneal (i.p.) P2-reactive T cells and systemic antimyelin antibody developed much more severe disease than those given i.p. T cells alone (P < 0.001). In actively immunised animals, the addition of systemic antimyelin antibody did not significantly alter disease severity. We believe the more severe disease in animals receiving T cells and antimyelin antibody reflects synergy between cellular and humoral immune mechanisms whereby neural antigen-specific T cells breach the blood-nerve barrier, allowing demyelinating antibody access to the endoneurium. In EAN induced by active immunisation with whole myelin it is likely that both B and T cell activation occurs and that the more severe demyelination characteristic of this disease reflects the involvement of both humoral and cellular immunity.


Asunto(s)
Sueros Inmunes/inmunología , Proteína Básica de Mielina/inmunología , Vaina de Mielina/inmunología , Neuritis Autoinmune Experimental/etiología , Linfocitos T/inmunología , Animales , Bovinos , Enfermedades Desmielinizantes/patología , Femenino , Inmunoterapia Adoptiva , Proteína P2 de Mielina , Neuritis Autoinmune Experimental/patología , Conejos , Ratas , Ratas Endogámicas Lew
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