RESUMEN
Background. Transarterial chemoembolization (TACE) has been investigated in patients with liver metastases from colorectal cancer (LMCRC). Limited experience and available data suggest that TACE can achieve disease stabilization or improvement, even in heavily pretreated patients. Methods. Patients with LMCRC, ECOG 0-2, who failed at least 1 line of systemic chemotherapy, received embolizations with 2 mL of microspheres preloaded with 100 mg of irinotecan. Beads were delivered selectively into hepatic arteries. Primary endpoint was overall survival (OS), analyzed using the Kaplan-Meier method. Secondary endpoint was safety, assessed using CTCAE version 4.0. Results. 27 patients were treated using DEBIRI. Patient median age was 57 years (range was 45-82 years). The median number of total embolizations was 1.3 (range 1-3). The median OS was 5.4 months (95% CI; 1.1-22.7 months). The most reported postembolization events were nausea (8/27), vomiting (6/27), right upper quadrant pain (16/27), fatigue (9/27), and the development of ascites (6/27). 5/26 patients required hospitalization after TACE for severe pain. Hospitalization was also required for 1 case of allergic reaction and 1 case of infection. Conclusion. Our data suggest that TACE with DEBIRI could be efficacious in a palliative setting for patients with LMCRC, but they do not necessarily support routine use in clinical practice.
RESUMEN
A Hereford bull from a test station, routinely treated for footrot and not responding, was further examined at the Large Animal Clinic at the Western College of Veterinary Medicine. A slight arthropathy of the right shoulder was radiographically visible. The bull was found to have a marginally low plasma copper level of 0.52 ppm. All bulls in the test station were subsequently sampled for an initial plasma copper determination. At this time 76% of the bulls at the station had plasma copper levels below 0.50 ppm. A mineral mix containing 0.2% copper was added to provide 15 ppm copper in the final ration. All bulls were sampled 28 days later with less than 1% of the bulls showing plasma copper levels below 0.50 ppm.Correlation coefficients between plasma copper levels and average daily gain were +0.067 for the presupplementation period, -0.255 for the supplementation period and -0.085 for the relationship between the change in plasma copper levels and the change in average daily gain. None of these correlations were significant (P > 0.05).During the copper supplementation period plasma copper levels increased for all breeds of bulls studied. However, there was no concomitant improvement in rate of gain by the bulls.