An Early Stage Researcher's Primer on Systems Medicine Terminology.

Background: Systems Medicine is a novel approach to medicine, that is, an interdisciplinary field that considers the human body as a system, composed of multiple parts and of complex relationships at multiple levels, and further integrated into an environment. Exploring Systems Medicine implies understanding and combining concepts coming from diametral different fields, including medicine, biology, statistics, modeling and simulation, and data science. Such heterogeneity leads to semantic issues, which may slow down implementation and fruitful interaction between these highly diverse fields. Methods: In this review, we collect and explain more than100 terms related to Systems Medicine. These include both modeling and data science terms and basic systems medicine terms, along with some synthetic definitions, examples of applications, and lists of relevant references. Results: This glossary aims at being a first aid kit for the Systems Medicine researcher facing an unfamiliar term, where he/she can get a first understanding of them, and, more importantly, examples and references for digging into the topic.

Active safety systems for powered two-wheelers: A systematic review.

Objective: Active safety systems, of which antilock braking is a prominent example, are going to play an important role to improve powered two-wheeler (PTW) safety. This paper presents a systematic review of the scientific literature on active safety for PTWs. The aim was to list all systems under development, identify knowledge gaps and recognize promising research areas that require further efforts.Methods: A broad search using "safety" as the main keyword was performed on Scopus, Web of Science and Google Scholar, followed by manual screening to identify eligible papers that underwent a full-text review. Finally, the selected papers were grouped by general technology type and analyzed via structured form to identify the following: specific active safety system, study type, outcome type, population/sample where applicable, and overall findings.Results: Of the 8,000 papers identified with the initial search, 85 were selected for full-text review and 62 were finally included in the study, of which 34 were journal papers. The general technology types identified included antilock braking system, autonomous emergency braking, collision avoidance, intersection support, intelligent transportation systems, curve warning, human machine interface systems, stability control, traction control, and vision assistance. Approximately one third of the studies considered the design and early stage testing of safety systems (n. 22); almost one fourth (n.15) included evaluations of system effectiveness.Conclusions: Our systematic review shows that a multiplicity of active safety systems for PTWs were examined in the scientific literature, but the levels of development are diverse. A few systems are currently available in the series production, whereas other systems are still at the level of early-stage prototypes. Safety benefit assessments were conducted for single systems, however, organized comparisons between systems that may inform the prioritization of future research are lacking. Another area of future analysis is on the combined effects of different safety systems, that may be capitalized for better performance and to maximize the safety impact of new technologies.

Feasibility study of a safe sled environment for reclined frontal deceleration tests with human volunteers.

Objective: The goal of the study was to assess the feasibility of a safe crash environment for volunteer tests in reclined seating positions. An iterative multimodal approach was chosen, consisting of full-body human body model (HBM) simulations, anthropomorphic test device (ATD) physical testing, and volunteer testing.Methods: To estimate a noninjurious deceleration pulse, the iterative inclination of the seat was supported through HBM simulations and physical ATD testing. One male volunteer was exposed to 5 low-speed frontal sled impacts with stepwise reclined seat angles. The volunteer was restrained with a non-pretensioned 3-point seat belt. All procedures were approved by the relevant ethics boards.Results: Volunteer sled tests in 3 different seat configurations were performed with one volunteer at noninjurious deceleration levels. Inclination of the seat and the absence of a footrest resulted in elevated axial seat reaction forces and almost pure translational motion of the human body.Conclusions: A maximum speed of 7.1 km/h and peak deceleration of 3.0 g was found to be a safe pulse for volunteer testing in frontal impacts with a rigid reclined seat. Larger soft tissue deformations were observed when reclined, possibly associated with higher shear loads within the soft tissue. Preliminary results highlight trade-offs between the degree of seat angulation, friction force, and restraint capability of a 3-point seat belt, thus causing forward translation and/or axial spinal compression of the occupant that may need to be addressed in the future.

Analysis of the stability of PTW riders in autonomous braking scenarios.

While fatalities of car occupants in the EU decreased remarkably over the last decade, Powered Two Wheelers (PTWs) fatalities still increase following the increase of PTW ownership. Autonomous braking systems have been implemented in several types of vehicles and are presently addressed by research in the field of PTWs. A major concern in this context is the rider stability. Experiments with volunteers were performed in order to find out whether autonomous braking for PTWs will produce a greater instability of the rider in comparison to manual braking. The PTW's braking conditions were simulated in a laboratory with a motorcycle mock-up mounted on a sled, which was accelerated with an average of 0.35 g. The motion of the rider was captured in autonomous braking scenarios with and without pre-warning as well as in manual braking scenarios. No significant differences between the scenarios were found with respect to maximum forward displacement of the volunteer's torso and head (p<0.05). By performing clustering analysis on two kinematic parameters, two different strategies of the volunteers were identified. They were not related to the braking scenarios. A relation of the clusters with the initial posture represented by the elbow angle was revealed (p<0.05). It is concluded that autonomous braking at low deceleration will not cause significant instabilities of the rider in comparison to manual braking in idealized laboratory conditions. Based on this, further research into the development and implementation of autonomous braking systems for PTWs, e.g. by extensive riding tests, seems valuable.