[A Case of Mucosal Gastric Cancer with Lymph Node Metastasis Successfully Treated with Chemotherapy].

A 64-year-old man was found to have an irregular region in the stomach by medical examinations. Upper gastrointestinal fiberscopy(GIF)revealed a reddish lesion in the lesser curvature of the upper stomach. Biopsy showed moderately differentiated adenocarcinoma. CT revealed swollen lymph nodes from the lesser curvature of the stomach to the para-aortic region. EUS-FNA was performed twice; however, histology revealed few atypical cells. A definitive diagnosis could not be obtained. Endoscopic findings revealed that the gastric cancer had invaded as far as the mucosa. Moreover, the swollen lymph nodes were considered to have originated from a different disease, such as lymphoma. The lesion of the stomach was an indication for ESD. On April 2016, ESD was performed, and histology revealed the following: Ⅱc, 31×23 mm, tub2, T1a(M), UL-, ly-, v-, VM0, and HM0. Incisional biopsy of the lymph nodes of the para-aorta was performed the followingmonth, and histology revealed poorly differentiated adenocarcinoma, which metastasized from gastric cancer. SOX therapy was performed in 10 courses. The para-aortic lymph nodes disappeared, and the number of lesser curvature lymph nodes decreased. On August 2018, follow-up GIF endoscopy was performed. A depressed mucosa was found in the lesser curvature of the gastric body, which was away from the ESD scar. Biopsy showed moderately differentiated adenocarcinoma. Total gastrectomy with lymph node dissection was performed on November 2018. Metastasis of the lesser curvature lymph nodes was positive; however, curative resection was performed histologically.

[A Case of Lung Metastasis Occurring Four Years after Pancreaticoduodenectomy for Pancreatic Cancer].

The patient was a 68-year-old man who underwent pancreaticoduodenectomy for pancreatic cancer in 2011(T3N1M0, Stage Ⅲ). Fifty-one months after surgery, 2tumors measuring about 8mm in diameter were detected in the right lung. Thus, partial resection of the right lung was performed. Histological examination of both tumors revealed a tubular adenocarcinoma, with positive staining for CA19-9 and cytokeratin 7 and negative staining for cytokeratin 20, TTF-1, and napsin A, which were diagnosed as metastasis of pancreatic cancer. Twenty-nine months after the lung operation, he died because of peritoneal dissemination. Recurrent pancreatic cancer with metastasis has a particularly poor prognosis; however, surgical resection of lung metastasis in pancreatic cancer might result in a better prognosis.