Asunto(s)
Enfermedad Celíaca/complicaciones , Esclerodermia Sistémica/etiología , Adulto , Enfermedad Celíaca/diagnóstico , Femenino , Humanos , Microcirculación , Angioscopía Microscópica , Uñas/irrigación sanguínea , Enfermedad de Raynaud/diagnóstico , Enfermedad de Raynaud/etiología , Esclerodermia Sistémica/diagnósticoAsunto(s)
Antihipertensivos/uso terapéutico , Isquemia/tratamiento farmacológico , Pierna/irrigación sanguínea , Lupus Eritematoso Cutáneo/tratamiento farmacológico , Sulfonamidas/uso terapéutico , Vasculitis/tratamiento farmacológico , Enfermedad Aguda , Adulto , Bosentán , Femenino , Humanos , Isquemia/complicaciones , Lupus Eritematoso Cutáneo/complicaciones , Vasculitis/complicacionesAsunto(s)
Antirreumáticos/efectos adversos , Artritis Reumatoide/patología , Dipirona/efectos adversos , Isoxazoles/efectos adversos , Metotrexato/efectos adversos , Síndromes Mielodisplásicos/inducido químicamente , Síndromes Mielodisplásicos/inmunología , Anciano , Artritis Reumatoide/complicaciones , Artritis Reumatoide/tratamiento farmacológico , Artritis Reumatoide/inmunología , Femenino , Humanos , Leflunamida , Persona de Mediana Edad , Inducción de Remisión , Resultado del TratamientoAsunto(s)
Anticuerpos Monoclonales/efectos adversos , Antirreumáticos/efectos adversos , Síndrome de Schnitzler/inducido químicamente , Factor de Necrosis Tumoral alfa/antagonistas & inhibidores , Adalimumab , Anticuerpos Monoclonales Humanizados , Etanercept , Femenino , Humanos , Inmunoglobulina G/efectos adversos , Persona de Mediana Edad , Receptores del Factor de Necrosis TumoralRESUMEN
We report the case of a 41-year-old man diagnosed with Still's disease. Multiple disease-modifying anti-rheumatic drug (DMARD) therapies failed to induce disease remission or to prevent progressive joint destruction. The man presented with active arthritis and classical Still's rash accompanied by fever. Anti-tumour necrosis factor-alpha (TNFalpha) therapy was planned but during the medical check-up prior to the biological therapy, renal insufficiency with marked proteinuria (PU) was discovered. With PU of 912 mg/24 h a renal biopsy was performed and a histopathological evaluation revealed the diagnosis of a residual mesangio-proliferative immunocomplex-based glomerulonephritis (GN). After excluding contraindications, infliximab therapy was initiated and a good response of the arthritis was documented after 6 weeks. A significant decrease in PU (279 mg/24 h) was noted after the third infliximab infusion. Because of an allergic reaction during the fifth dose, the infliximab was discontinued. During the time frame without anti-TNFalpha therapy, active joint disease reoccurred and the proteinuria increased significantly. Because of the active disease entanercept therapy was initiated. The arthritis diminished and the PU was reduced markedly within 4 weeks. In the follow-up period of 12 months a good response to therapy was sustained. As described by other investigators, the joint disease showed a rapid and sustained response to anti-TNFalpha therapy. The decrease in proteinuria during biological therapy was notable. It was concluded that the significant decrease in PU in this patient was achieved by eliminating the inflammatory activity of the underlying kidney disease.
Asunto(s)
Anticuerpos Monoclonales/uso terapéutico , Glomerulonefritis Membranoproliferativa/tratamiento farmacológico , Proteinuria/tratamiento farmacológico , Enfermedad de Still del Adulto/tratamiento farmacológico , Factor de Necrosis Tumoral alfa/inmunología , Adulto , Glomerulonefritis Membranoproliferativa/etiología , Humanos , Infliximab , Masculino , Enfermedad de Still del Adulto/complicacionesAsunto(s)
Antirreumáticos/efectos adversos , Artritis Reumatoide/tratamiento farmacológico , Linfoma de Células B/inducido químicamente , Regresión Neoplásica Espontánea , Neoplasias de los Senos Paranasales/inducido químicamente , Anticuerpos Monoclonales/efectos adversos , Anticuerpos Monoclonales/uso terapéutico , Antirreumáticos/uso terapéutico , Artritis Reumatoide/inmunología , Quimioterapia Combinada , Femenino , Humanos , Infliximab , Linfoma de Células B/inmunología , Metotrexato/efectos adversos , Metotrexato/uso terapéutico , Persona de Mediana Edad , Neoplasias de los Senos Paranasales/inmunologíaRESUMEN
Diffuse hemangiomatoses are extremely rare in adults. The etiology and natural history of the disease are not well understood. A case of diffuse hemangiomatosis of the liver and spleen associated with progressive liver failure, thrombocytopenia, and disturbance of blood coagulation (comparable to Kasabach-Merritt syndrome) is presented in a 62-year-old male. We describe the histopathological and immunohistochemical findings and illustrate the morphological aspects of differential diagnosis, distinguishing the disease from other vascular proliferations.