1.
J Org Chem
; 84(4): 2316-2324, 2019 02 15.
Artículo
en Inglés
| MEDLINE
| ID: mdl-30642180
RESUMEN
Base-catalyzed efficient hydroxylation of isoquinoline-1,3(2 H,4 H)-diones with air under transition-metal-free and reductant-free conditions was established. This methodology is essentially mild and compatible with a broad range of substrates, including aryl, heteroaryl, and alkyl groups. Also, the product could be simply transformed into a hydroxylated tetrahydroisoquinoline core structure through a reductive process.