Synergistic effects of thermosensitive liposomal doxorubicin, mild hyperthermia, and radiotherapy in breast cancer management: an orthotopic mouse model study.

Liposome formulations of the cancer drug doxorubicin have been developed to address the severe side effects that result from administration of this drug in a conventional formulation. Among them, thermosensitive liposomal doxorubicin presents enhanced tumor targeting and efficient drug release when combined with mild hyperthermia localized to the tumor site. Exploiting the radiosensitizing benefits of localized thermal therapy, the integration of radiation therapy with the thermally activated liposomal system is posited to amplify the anti-tumor efficacy. This study explored a synergistic therapeutic strategy that combines thermosensitive liposomal doxorubicin, mild hyperthermia, and radiotherapy, using an orthotopic murine model of breast cancer. The protocol of sequential multi-modal treatment, incorporating low-dose chemotherapy and radiotherapy, substantially postponed the progression of primary tumor growth in comparison to the application of monotherapy at elevated dosages. Improvements in unheated distant lesions were also observed. Furthermore, the toxicity associated with the combination treatment was comparable to that of either thermosensitive liposome treatment or radiation alone at low doses. These outcomes underscore the potential of multi-modal therapeutic strategies to refine treatment efficacy while concurrently diminishing adverse effects in the management of breast cancer, providing valuable insight for the future refinement of thermosensitive liposomal doxorubicin applications.

Emergence of genetic diversity and multi-drug resistant Clostridium perfringens from wild birds.

BACKGROUND: Clostridium perfringens (C. perfringens) is an important zoonotic microorganism that can cause animal and human infections, however information about the prevalence status in wild birds of this pathogenic bacterium is currently limited. RESULT: In this study, 57 strains of C. perfringens were isolated from 328 fecal samples of wild birds. All the isolates were identified as type A and 70.18% of the isolates carried the cpb2 gene. Antimicrobial susceptibility testing showed that and 22.80% of the isolates were classified as multidrug-resistant strains. The MLST analysis of the 57 isolates from wild birds was categorized into 55 different sequence types (STs) and clustered into eight clonal complexes (CCs) with an average of 20.1 alleles and the Simpson Diversity index (Ds) of 0.9812, and revealed a high level of genetic diversity within the C. perfringens populations. Interestingly, the isolates from swan goose were clustered in the same CC while isolates from other bird species were more scattered suggesting that a potential difference in genetic diversity among the C. perfringens populations associated with different bird species. CONCLUSION: C. perfringens exhibits a wide range of host adaptations, varying degrees of antimicrobial resistance, and a high degree of genetic diversity in wild birds. Understanding the prevalence, toxin type, antimicrobial resistance, and genetic diversity of C. perfringens in wildlife populations is essential for developing effective strategies for disease control and management.

Aerosol in global oceanic regions: Four-decade trends, spatial patterns, and policy implications.

High aerosol loadings are observed not only in megacities on continents but also in oceanic regions like the Bohai Sea. This work provides a comprehensive analysis of the spatial and temporal variations in Aerosol Optical Depth (AOD) across different ocean regions worldwide over the past four decades, using remote sensing reanalysis data. The mean AOD value across all oceanic grids is approximately 0.112, with higher levels recorded in the Central Atlantic (~0.206), followed by the North Indian Ocean (~0.201), and the Western North Pacific (~0.197). A latitudinal analysis reveals that high AOD values are predominantly found in the Northern Hemisphere's oceanic regions, especially between latitudes 0° and 70° N. Except for the Gulf of California and Hudson Bay, AOD values in the other fourteen surveyed inland seas surpass the mean levels found at similar latitudes in oceanic regions. Among which, the Bohai Sea stands out as the most polluted oceanic region with AOD value of 0.35. Over the last four decades, AOD trends have revealed a significant decrease across about 89.5 % of global oceanic grids, while an increase in AOD is observed in low-latitude oceanic areas (30° S-30° N). Investigation into inland seas shows that nearly two-thirds have experienced a declining AOD trend, while sharply upward trends in AOD are primarily found in Asia. The Bohai Sea shows the largest increase in AOD, with an annual growth rate of 1.4 %. The turning-points of the AOD in each inland sea confirm the success of regional emission control policies initiated on the adjacent continents. To improve air quality in inland seas like the Bohai Sea, adjusting industrial layouts, such as relocating heavy industries from the surrounding coastal cities' proximities to areas near open seas, could significantly benefit public health.

Causality of genetically proxied immunophenotypes on cardiovascular diseases: a Mendelian randomization study.

Background: Cardiovascular diseases (CVDs) stand as the foremost global cause of mortality, prompting a growing interest in using the potential of immune cells for heart injury treatment. This study aims to assess the causal association between immune cells and CVDs. Methods: A total of 731 immune cells were derived from a previously published genome-wide association study (GWAS), which included approximately 22 million genetic variants among 3,757 individuals of Sardinian ancestry. Genetic associations with atrial fibrillation (AF), heart failure, coronary artery disease, myocardial infarction and stroke were extracted from large-scale GWAS. A two-sample Mendelian randomization (MR) analysis was used to assess the causal association between immune cells and CVDs. Replication MR analysis based on FinnGen dataset and meta-analysis are sequentially conducted to validate causal relationships. Results: Collectively, genetically predicted 4 immune cell traits were associated with AF and 5 immune cell traits were associated with stroke. Increased levels of IgD- CD38dim absolute count were associated with a higher susceptibility to AF, while increased expression of CD14+ CD16+ monocytes, CD62L on CD62L+ myeloid dendritic cells, and CD16 on CD14- CD16+ monocytes were linked to a decreased susceptibility to AF. Additionally, an elevated susceptibility to stroke was linked to an increase in the percentage of CD39+ resting Tregs and heightened CD27 expression on IgD- CD38+ cells. Conversely, a decreased susceptibility to stroke was associated with increased CD40 expression on monocytes, particularly on CD14+ CD16+ and CD14+ CD16- monocytes, with the latter two showing the most compelling evidence. Conclusion: This study identified several immune cell traits that have a causal relationship with CVDs, thus confirming that immune cells play an important role in the pathogenesis of these diseases.

Dry Electrode Processing Technology and Binders.

As a popular energy storage equipment, lithium-ion batteries (LIBs) have many advantages, such as high energy density and long cycle life. At this stage, with the increasing demand for energy storage materials, the industrialization of batteries is facing new challenges such as enhancing efficiency, reducing energy consumption, and improving battery performance. In particular, the challenges mentioned above are particularly critical in advanced next-generation battery manufacturing. For batteries, the electrode processing process plays a crucial role in advancing lithium-ion battery technology and has a significant impact on battery energy density, manufacturing cost, and yield. Dry electrode technology is an emerging technology that has attracted extensive attention from both academia and the manufacturing industry due to its unique advantages and compatibility. This paper provides a detailed introduction to the development status and application examples of various dry electrode technologies. It discusses the latest advancements in commonly used binders for different dry processes and offers insights into future electrode manufacturing.

Synthesis and Characterization of Phenazine-Based Redox Center for High-Performance Polymer Poly(aryl ether sulfone)-5,10-Diphenyl-dihydrophenazine.

Phenazine-based redox-active centers are capable of averting chemical bond rearrangements by coupling during the reaction process, leading to enhanced stabilization of the material. When introduced into a high-performance polymer with excellent physicochemical properties, they can be endowed with electrochemical properties and related prospective applications while maintaining the capabilities of the materials. In this study, a facile C-N coupling method was chosen for the synthesis of serial poly(aryl ether sulfone) materials containing phenazine-based redox-active centers and to explore their electrochemical properties. As expected, the cyclic voltammetry curves of PAS-DPPZ-60, which basically overlap after thousands of cycles, indicate the stability of the electrochemical properties. As an electrochromic material, the transmittance change in PAS-DPPZ-60 exhibits only a slight attenuation after as long as 600 cycles. Meanwhile, as an organic battery cathode material, PAS-DPPZ has a theoretical specific capacity of 126 mAh g-1, and the capacity retention rate is 82.6% after 100 cycles at a 0.1 C current density. The perfect combination of advantageous features between phenazine and poly(aryl ether sulfone) is considered to be the reason for the favorable electrochemical performance of the material series.

Navigating Aged Care Services with GIS: Trends, Developments, and Future Directions.

BACKGROUND: With the growing challenge of an aging population, emerging technologies are increasingly being integrated into the production, organization, and delivery of aged care services. Geographic Information System (GIS), a computer-based tool for spatial information analysis and processing, has made significant strides in the allocation of care recources and service delivery for older adults, a notably vulnerable group. Despite its growing importance, cross-disciplinary literature reviews on this theme are scare. This scoping review was conducted to encapsulate the advancements and discern the future trajectory of GIS applications in aged care services. METHODS: A comprehensive search across nine databases yielded 5941 articles. Adhering to specific inclusion and exclusion criteria, 61 articles were selected for a detailed analysis. RESULTS: The 61 articles span from 2003 to 2022, with a notable increase in publications since 2018, comprising 41 articles (67% of the total) published between 2018-2022. Developed countries contributed 66% of the papers, with 45% focusing on accessibility issues. In the domain of aged care services, GIS has been predominantly utilized for model construction, mapping, and site selection, with a growing emphasis on addressing the unique needs of different subgroups of older adults. CONCLUSION: The past two decades have seen substantial growth in the application of GIS in aged care services, reflecting its increasing importance in this field. This scoping review not only charts the historical development of GIS applications in aged care services but also underscores the need for innovative research approaches. Future directions should emphasize the integration of GIS with diverse methodologies to address the heterogeneous needs of older adults and improve the overall delivery of aged care services. Such advancements in GIS applications have the potential to significantly enhance the efficiency, accessibility, and quality of care for the aging population.

Quantification of NOx sources contribution to ambient nitrate aerosol, uncertainty analysis and sensitivity analysis in a megacity.

Dual isotopes of nitrogen and oxygen of NO3- are crucial tools for quantifying the formation pathways and precursor NOx sources contributing to atmospheric nitrate. However, further research is needed to reduce the uncertainty associated with NOx proportional contributions. The acquisition of nitrogen isotopic composition from NOx emission sources lacks regulation, and its impact on the accuracy of contribution results remains unexplored. This study identifies key influencing factors of source isotopic composition through statistical methods, based on a detailed summary of δ15N-NOx values from various sources. NOx emission sources are classified considering these factors, and representative means, standard deviations, and 95 % confidence intervals are determined using the bootstrap method. During the sampling period in Tianjin in 2022, the proportional nitrate formation pathways varied between sites. For suburban and coastal sites, the ranking was [Formula: see text] (NO2 + OH radical) > [Formula: see text] (N2O5 + H2O) > [Formula: see text] (NO3 + DMS/HC), while the rural site exhibited similar fractional contributions from all three formation pathways. Fossil fuel NOx sources consistently contributed more than non-fossil NOx sources in each season among three sites. The uncertainties in proportional contributions varied among different sources, with coal combustion and biogenic soil emission showing lower uncertainties, suggesting more stable proportional contributions than other sources. The sensitivity analysis clearly identifies that the isotopic composition of 15N-enriched and 15N-reduced sources significantly influences source contribution results, emphasizing the importance of accurately characterizing the localized and time-efficient nitrogen isotopic composition of NOx emission sources. In conclusion, this research sheds light on the importance of addressing uncertainties in NOx proportional contributions and emphasizes the need for further exploration of nitrogen isotopic composition from NOx emission sources for accurate atmospheric nitrate studies.

Identification of lignans as ATP citrate lyase (ACLY) inhibitors from the roots of Pouzolzia zeylanica.

A new lignan, named pouzolignan P (1), together with 14 known ones (2 - 15) were isolated from the roots of Pouzolzia zeylanica (L.) Benn. Their structures were deduced based on the detailed spectroscopic analysis. All the isolates were evaluated for their inhibitory activities toward the ATP citrate lyase (ACLY). Among them, four lignans, isopouzolignan K (3), gnemontanins E (5), gnetuhainin I (6), and styraxlignolide D (15) showed excellent ACLY inhibitory effect with IC50 values of 9.06, 0.59, 2.63, and 7.62 µM, respectively. These compounds were further evaluated for their cholesterol-lowing effects on ox-LDL-induced high-cholesterol HepG2 cells. Compound 15 emerges as the most potent ACLY inhibitor, which significantly decreased the TC level in a dose-dependent manner. In addition, molecular docking simulations elucidated that 15 formed a strong hydrogen-bond interaction with Glu599 of ACLY, which was an important site responsible for the enzyme catalytic activity.

High aerosol loading over the Bohai Sea: Long-term trend, potential sources, and impacts on surrounding cities.

Air pollution over the oceans has received less attention compared to densely populated urban areas of continents. The Bohai Sea, a semi-enclosed sea in northern China, is surrounded by thirteen industrial cities that have experienced significant improvements in air quality over the past decade. However, the changes in air pollution over the Bohai Sea and its impacts on surrounding cities remain poorly understood. To address this, this study investigated the evolution of air pollution and its chemical composition in the Bohai Sea over four decades, utilizing satellite remote sensing data, reanalysis datasets, emissions inventories, and statistical modeling. Historically, the region has suffered from severe air pollution, resulting from a combination of continental emissions and marine inputs (e.g., sea salt, ports and maritime vessel activities). The aerosol optical depth (AOD) over the sea was higher than the mean levels observed in its surrounding coastal cities. Statistically, 45% of the air masses reaching the Bohai Sea are associated with natural sources (dust- and marine-rich), while the remainder carry anthropogenic pollutants from continental regions. With the exception of Cangzhou city, these coastal cities suffer from air pollutants originating from the Bohai Sea. Cities in the northern region of the sea, spanning from Tianjin to Yingkou, are particularly impacted. The majority of the surrounding cities are affected by a large proportion of anthropogenic aerosol types transported through air masses from the Bohai Sea, including those from biomass burning and industrial activities. These findings emphasize the considerable influence of human-induced sources in the Bohai Sea on neighboring urban areas. Furthermore, being a maritime region, natural sources like sea salt and dust from the sea may also exert a discernible impact on the neighboring environment.

A Polytetrafluoroethylene-Based Solvent-Free Procedure for the Manufacturing of Lithium-Ion Batteries.

Lithium-ion batteries (LIBs) have recently become popular for energy storage due to their high energy density, storage capacity, and long-term cycle life. Although binders make up only a small proportion of LIBs, they have become the key to promoting the transformation of the battery preparation process. Along with the development of binders, the battery manufacturing process has evolved from the conventional slurry-casting (SC) process to a more attractive solvent-free (SF) method. Compared with traditional LIBs manufacturing method, the SF method could dramatically reduce and increase the energy density due to the reduced preparation steps and enhanced electrode loading. Polytetrafluoroethylene (PTFE), as a typical binder, has played an important role in fabricating high-performance LIBs, particularly in regards to the SF technique. In this paper, the development history and application status of PTFE binder was introduced, and then its contributions and the inherent problems involved in the SF process were described and analyzed. Finally, the viewpoints concerning the future trends for PTFE-based SF manufacturing methods were also discussed. We hope this work can inspire future research concerning high-quality SF binders and assist in promoting the evolution of the SF manufacturing technology in regards to LIBs.

NIR to MIR ultra-broadband supercontinuum laser source based on all-silica fibers.

We demonstrated an ultra-broadband supercontinuum (SC) laser source with a wavelength range spanning the near-infrared (NIR) to mid-infrared (MIR) region. The SC spectrum was generated in a very short piece of highly nonlinear silica fiber (HNLF) which has a zero-dispersion wavelength (ZDW) of 1.55 µm. The pump source used has a spectral coverage of 1.5∼2.4 µm which covers the ZDW of HNLF, resulting in a dramatic blue and red shift of the spectrum through strong non-linear effects. As the pump laser pulse launched into HNLF, a SC spectrum with broadband range of 0.92∼2.92 µm and maximum average power of 5.09 W was achieved, which sets record coverage of HNLF-based watts magnitude SC laser sources for now, to the best of the authors' knowledge. The setup consists of silica fiber that can be considered easy-to-implement and with a cost-effectiveness scheme for ultra-broadband SC generation that could be easily applied to optical fiber sensing and spectral imaging technology.

Data demonstrating the in vivo anti-tumor efficacy of thermosensitive liposome formulations of a drug combination in pre-clinical models of breast cancer.

Thermosensitive liposomes in combination with localized mild hyperthermia can improve the delivery of drug to solid tumor sites. For this reason, thermosensitive liposome formulations of a range of chemotherapy drugs have been designed. Our group previously developed and characterized a thermosensitive liposome formulation of the heat shock protein 90 inhibitor alvespimycin as a companion therapeutic to a thermosensitive liposome formulation equivalent in composition to ThermoDox (i.e., ThermoDXR), with the goal of increasing the therapeutic index of doxorubicin as the combination was revealed to be highly synergistic in a panel of human breast cancer cell lines including MDA-MB-231 (Dunne et al., 2019). The data presented here further describes the effect of the doxorubicin (DXR) and alvespimycin (ALV) combination in vitro and in vivo. Specifically, the combination effect in mouse breast cancer 4T1 cells and the in vivo efficacy of this heat-activated chemotherapy combination in both immunocompromised (MDA-MB-231 tumor bearing female SCID mice) and immunocompetent (4T1 tumor bearing female BALB/c mice) models of breast cancer.

Efficacy of autologous platelet-rich plasma combined with a non-cross-linked hyaluronic acid compound in the treatment of female androgenetic alopecia: A retrospective, case-series study.

BACKGROUND: Female androgenetic alopecia (FAGA) is a condition that affects women and involves the gradual loss of terminal hair in specific areas of the scalp. The limited treatment options for FAGA necessitate the development of new strategies. This study aimed to evaluate the potential benefit of using a combination therapy composed of autologous platelet-rich plasma (PRP) and a non-cross-linked hyaluronic acid (HA) compound in the treatment of FAGA. METHODS: This was a retrospective, case-series study, which enrolled nine female patients with FAGA between September 2021 and December 2022. The non-cross-linked HA compound (Hearty®, Imeik Technology Development Co., Ltd.) and PRP were implanted into the areas of hair loss over four treatment sessions separated by 4-week intervals. Patients were monitored for overall improvement in their hair loss, hair count, treatment satisfaction, and adverse events at 1, 3, and 6 months follow-up. RESULTS: The improvement rates, subjectively evaluated by the study physician, were 88.89% at the 1-month and 100% at the 3-month follow-up, relative to baseline. Moreover, the quantitative evaluation results showed that the FAGA patients' hair density increased by 54.51% at the 1-month and by 77.25% at the 3-month follow-up. CONCLUSION: The combination of PRP and non-cross-linked HA compound appeared to be a certain positive effective procedure for FAGA without serious adverse event. We envisage that this work will contribute to the development of new treatment options for women suffering from this condition.

Non-invasive detection and differentiation of apoptotic and necroptotic cell death in vitro.

Cell death plays an important role in the development of multicellular organisms and the maintenance of adult homeostasis. However, traditional methods of cell death detection can damage cells and tissues. Here, we report the use of near-infrared (NIR) spectroscopy for non-invasively distinguishing between cell death types. We found a difference between normal, apoptotic, and necroptotic mouse dermal fibroblast cells in the wavelength range of 1100-1700 nm. In particular, the differences in scattering of NIR light between cells at different states are enough to be distinguished. This feature was exploited by measuring the attenuation coefficient (δµ), which specifies the ease at which light can pass through a substance. The results showed that δµ can be used to distinguish between different types of cell death. Therefore, this study proposes a new, non-invasive, and fast method to differentiate cell death types without the additional fluorescent labeling.

Chitosan-based composite hydrogel with a rigid-in-flexible network structure for pH-universal ultra-efficient removal of dye.

Polysaccharide-based hydrogel adsorbents become popular because of their high adsorption capacity and fast adsorption rate, but their low removal rate and poor pH resistance have always been fatal shortcomings. Herein, a feasible strategy was proposed to strengthen the ability of hydrogel adsorbent to remove organic pollutants (i.e., dye) by incorporating natural rectorite (REC) into chitosan-g-poly (2-acrylamido-2-methyl-propane-sulfonic-acid) hydrogel network to form a rectorite-in-polymer network structure. The introduction of less dosage of REC (1.2 wt%) into the hydrogel facilitates to improve its adsorption capacities toward methylene blue (MB) in deionized water, tap water, seawater, Yangtze River water, and Yellow River water (1083.39-1303.49 mg/g); while incorporating higher content of REC (15.8 wt% REC) helps to improve the removal rate (99.6% for MB in real waters), which are greatly superior to commercial activated carbons. The adsorbent keeps high adsorption efficiency in a broad pH range (2-11), and can be reused for >4 times.

Trends of source apportioned PM2.5 in Tianjin over 2013-2019: Impacts of Clean Air Actions.

A long-term (2013-2019) PM2.5 speciation dataset measured in Tianjin, the largest industrial city in northern China, was analyzed with dispersion normalized positive matrix factorization (DN-PMF). The trends of source apportioned PM2.5 were used to assess the effectiveness of source-specific control policies and measures in support of the two China's Clean Air Actions implemented nationwide in 2013-2017 and 2018-2020, respectively. Eight sources were resolved from the DN-PMF analysis: coal combustion (CC), biomass burning (BB), vehicular emissions, dust, steelmaking and galvanizing emissions, a mixed sulfate-rich factor and secondary nitrate. After adjustment for meteorological fluctuations, a substantial improvement in PM2.5 air quality was observed in Tianjin with decreases in PM2.5 at an annual rate of 6.6%/y. PM2.5 from CC decreased by 4.1%/y. The reductions in SO2 concentration, PM2.5 contributed by CC, and sulfate demonstrated the improved control of CC-related emissions and fuel quality. Policies aimed at eliminating winter-heating pollution have had substantial success as shown by reduced heating-related SO2, CC, and sulfate from 2013 to 2019. The two industrial source types showed sharp drops after the 2013 mandated controls went into effect to phaseout outdated iron/steel production and enforce tighter emission standards for these industries. BB reduced significantly by 2016 and remained low due to the no open field burning policy. Vehicular emissions and road/soil dust declined over the Action's first phase followed by positive upward trends, showing that further emission controls are needed. Nitrate concentrations remained constant although NOX emissions dropped significantly. The lack of a decrease in nitrate may result from increased ammonia emissions from enhanced vehicular NOX controls. The port and shipping emissions were evident implying their impacts on coastal air quality. These results affirm the effectiveness of the Clean Air Actions in reducing primary anthropogenic emissions. However, further emission reductions are needed to meet global health-based air quality standards.

Efficient removal of hexavalent chromium from water by Bacillus sp. Y2-7 with production of extracellular polymeric substances.

Bioremediation is an environmentally friendly technology for the treatment of chromium-contaminated sites. Here, a hexavalent chromium [Cr(VI)]-resistant strain was isolated from oil-contaminated soil and designated as Bacillus sp. Y2-7 based on 16S rDNA sequence characterization. The effects of various factors including inoculation dose, pH value, glucose concentration, and temperature on Cr(VI) removal rates were then evaluated. Based on the response surface methodology, optimal Cr(VI) removal efficiency (above 90%) could be achieved at an initial Cr(VI) concentration of 155.0 mg·L-1, glucose concentration of 11.479 g·L-1, and pH of 7.1. The potential removal mechanisms of Cr(VI) by strain Y2-7 were also supposed. The contents of polysaccharide and protein in extracellular polymer (EPS) of strain Y2-7 decreased slowly after cultured with Cr(VI) of 15 mg·L-1 from 1 to 7 days. We thus inferred that EPS bonded with Cr(VI) and underwent morphological changes in water. Molecular operating environment (MOE) analysis suggested that macromolecular protein complexes in Bacillus sp. Y2-7 and hexavalent chromium could establish hydrogen bonds. Collectively, our findings indicate that Bacillus sp. Y2-7 is an excellent bacterial candidate for chromium bioremediation.

Efficient Raman pulse fiber laser pumped by a dissipative soliton resonance pulse near 2 µm.

A high-efficiency Raman conversion from 1.987 µm to 2.177 µm is demonstrated experimentally in 45 m GeO2-doped silica fiber, adopting a dissipative soliton resonance (DSR) rectangular pulse as the pump. Over the entire spectral distribution, the spectral purity of the first-order Raman pulse is up to 96.8%, suggesting a nearly complete pump depletion before the onset of cascaded Raman shifts. The corresponding pump-to-Raman conversion efficiency of 67.4% is the highest up to date in this spectral region. Meanwhile, a large Raman pulse energy of 1.03 µJ was obtained at the repetition rate near MHz level, corresponding to 0.893 W average power. In the total output, the Raman-dominated spike has a Full Width Half Maximum (FWHM) of 1.18 ns far narrower than DSR's pulse duration of 10.25 ns. The results indicate that DSR is a promising candidate for developing efficient Raman nanosecond pulse fiber laser in mid-infrared (MIR) region.

Renal Safety of Sacubitril/Valsartan: A Meta-Analysis of Randomized Controlled Trials.

ABSTRACT: As a first-line therapy, sacubitril/valsartan (S/V) plays a significant role in the treatment of heart failure. However, its effect on renal function is still uncertain. We searched PubMed, EMBASE, the Cochrane Library, and Clinical Trials for randomized controlled trials to evaluate the effect of S/V on renal function in patients. The results are reported as the mean difference, relative ratio, and 95% confidence intervals. A total of 13 randomized controlled trials were included (19,367 patients). Among them, 11 studies focused on patients with heart failure, 1 on patients with acute myocardial infarction, and 1 on patients with chronic kidney disease. We found that fewer worsening renal function events, elevated creatine level events, and severe hyperkalemia events (blood potassium >6.0 mmol/L) occurred in the S/V group than those in the renin-angiotensin-aldosterone system inhibitor (RASi) group. The estimated glomerular filtration rate decreased in both the S/V group and the RASi group, but the change was more obvious in the RASi group. There was no significant difference in hyperkalemia events (blood potassium >5.5 mmol/L) between the 2 groups. Subgroup analysis showed that with the extension of follow-up time (>6 months), worsening renal function events occurred less frequently in the S/V group than in the RASi group. Existing evidence has shown that S/V is superior to RASi in general renal safety. Perhaps with the prolongation of treatment time, the advantages of S/V are more obvious.