Pompon mum-like ionic covalent organic framework nanocomposites for efficient solid-phase extraction of nonsteroidal anti-inflammatory drugs.

Molecularly imprinted ionic covalent organic framework nanocomposites (MI-IC-COF@SnO2) were prepared as potential adsorbents for the enhanced adsorption of nonsteroidal anti-inflammatory drugs (NSAIDs) from aqueous solution. The resulting material exhibited a pompon mum-like structure, featuring a large surface area, and well-defined mesopores. The presence of uniform positive ions within the three-dimensional skeleton of MI-IC-COF@SnO2 facilitated a rapid adsorption rate and high adsorption capacity for target analytes. Thermodynamic fitting revealed the adsorption process of NSAIDs to be feasible, endothermic, and spontaneous. Additionally, the adsorbent material exhibited respectable selectivity, as evidenced by imprinting factor values ranging from 2.8 to 6.7. Utilizing MI-IC-COF@SnO2 as the sorbent, a solid-phase extraction method coupled with high-performance liquid chromatography-ultraviolet detection (SPE-HPLC-UV) was developed and optimized. The proposed method demonstrated good linear range with determination coefficients of 0.998-0.999, and low limit of detection (0.18-1.35 µg L-1). Recoveries of NSAIDs in urine and river water samples were 78.1 %-106.1 %, with relative standard deviations lower than 12.5 %. This rapid and sensitive method enables the determination of NSAIDs at trace levels in complex matrices, providing reliable and reproducible results.

Anatomy and variation of right posterior portal vein in Chinese population.

BACKGROUND/AIMS: Our assessment of the segmental anatomy of the liver will allow more systematic and limited segmentectomies, as well as a safer harvesting for liver sectors in LDLT. METHODOLOGY: We have examined 104 patients with normal intrahepatic vascular anatomy by helical CT scans and another 12 cases of cadaveric livers dissected to examine their bifurcation characteristics. RESULTS: In 61 out of 104 (59%) cases, we have found out that the right posterior portal vein does not have obvious isolated bifurcation branches which can determine the boundary between the 6th and the 7th graft. In 8 out of 12 (66.6%) cadaveric livers cases, the RPV runs through the right posterior segment without any other large branches while the rest of them form an actinomorphic bifurcation. CONCLUSION: Because of the major discrepancies that occurred in determining the boundary between the 6th and 7th segment, we propose a creative assessment of the segment of the right hemiliver and consider the right posterior graft as a unique segment.