1.
Environ Toxicol Chem
; 32(12): 2866-9, 2013 Dec.
Artículo
en Inglés
| MEDLINE
| ID: mdl-23996615
RESUMEN
Ceriodaphnia dubia were tested to evaluate the acute and chronic interactive effects of diphenhydramine and sertraline. Observed effects were compared with 2 reference toxicity models, the concentration addition model and the independent action model. Results indicate that the 2 drugs exhibit additive toxicity in C. dubia. In some cases, individually sublethal concentrations of the chemicals resulted in 100% mortality when combined, demonstrating the potentially severe impact of trace environmental contaminants.