RESUMEN
The outbreak of 2019 novel coronavirus (2019-nCoV) pneumonia was reported in Wuhan, Hubei Province, China in December 2019 and has spread internationally. This article discusses how radiology departments can most effectively respond to this public health emergency.
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Infecciones por Coronavirus/diagnóstico por imagen , Brotes de Enfermedades , Urgencias Médicas , Pulmón/diagnóstico por imagen , Neumonía Viral/diagnóstico por imagen , Salud Pública , Tomografía Computarizada por Rayos X , Betacoronavirus , COVID-19 , Prueba de COVID-19 , China/epidemiología , Técnicas de Laboratorio Clínico , Infecciones por Coronavirus/diagnóstico , Humanos , Neumonía Viral/diagnóstico , Radiología , SARS-CoV-2RESUMEN
Since the beginning of 2020, coronavirus disease 2019 (COVID-19) has spread throughout China. This study explains the findings from lung computed tomography images of some patients with COVID-19 treated in this medical institution and discusses the difference between COVID-19 and other lung diseases.
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Infecciones por Coronavirus/diagnóstico por imagen , Neumonía Viral/diagnóstico por imagen , Tomografía Computarizada por Rayos X , Betacoronavirus/aislamiento & purificación , COVID-19 , Diagnóstico Diferencial , Femenino , Humanos , Masculino , Persona de Mediana Edad , Pandemias , SARS-CoV-2RESUMEN
Two new acylamide metal-organic frameworks (MOFs), based on mixed N- and O-donor ligands, with 4-connected topologies have been obtained, namely poly[[µ2-N(1),N(4)-bis(pyridin-3-yl)terephthalamide]bis(µ3-4,4'-oxydibenzoato)dizinc(II)], [Zn2(C14H8O5)2(C18H14N4O2)]n, (1), and poly[[(µ2-benzene-1,4-dicarboxylato)[µ2-N(4),N(4')-bis(pyridin-3-yl)-[1,1'-biphenyl]-4,4'-dicarboxamide]dicadmium(II)] dihydrate], {[Cd(C8H4O4)(C24H18N4O2)]·2H2O}n, (2). Complex (1) is a 4-connected CdSO4 net with no interpenetration, where the Zn(II) cation is regarded as a 4-connecting node with square geometry. Complex (2) is a 4-connected dia net with threefold interpenetration, where the Cd(II) cation acts as a 4-connecting node with tetrahedral geometry. The results of thermogravimetric and luminescence analyses are described in detail.
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Cadmio/química , Complejos de Coordinación/química , Cristalografía por Rayos X , Enlace de Hidrógeno , Ligandos , LuminiscenciaRESUMEN
The three-dimensional Zn(II) coordination polymer poly[[bis(µ2-benzene-1,4-dicarboxylato){µ4-N(1),N(3),N(5)-tris[(pyridin-3-yl)methyl]benzene-1,3,5-tricarboxamide}dizinc(II)] monohydrate], {[Zn2(C8H4O4)2(C27H24N6O3)]·H2O}n, is characterized by a rare (4,4,4)-connected (4.6(2).7(2).8)(4.6(2).7(3))(4(2).6(2).7(2)) topology. The tricarboxamide ligand adopts an unprecedented tetradentate coordination mode, with one carboxamide O atom participating in the coordination. The polymer was further characterized by thermogravimetric and solid-state luminescence analysis.
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The title compound, [Dy4(C7H4NO4)12(C11H9N5)2] or Dy4(L1)12(L2)2, where HL1 = 3-nitro-benzoic acid and HL2 = 2,6-bis-(1H-pyrazol-1-y1)pyridine, is a linear tetra-nuclear complex possessing inversion symmetry. The two central inversion-related Dy(III) atoms are seven-coordinate, DyO7, with a monocapped triangular-prismatic geometry. The outer two Dy(III) atoms are eight-coordinate, DyO5N3, with a bicapped triangular-prismatic geometry. The outer adjacent Dy(III) atoms are bridged by three L1(-) carboxyl-ate groups, while the inner inversion-related Dy(III) atoms are bridged by four L1(-) carboxyl-ate groups. The L2 ligands are terminally coordinated to the outer Dy(III) atoms in a tridentate manner. In the crystal, mol-ecules are linked via C-Hâ¯O hydrogen bonds, forming a two-dimensional network parallel to (001). Two carboxyl-ate O atoms, and N and O atoms of three nitro groups, are disordered over two positions, with a refined occupancy ratio of 0.552â (6):0.448â (6).
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We demonstrate herein a promising pathway towards low-energy CO2 capture and release triggered by UV and visible light. A photosensitive diarylethene ligand was used to construct a photochromic diarylethene metal-organic framework (DMOF). A local photochromic reaction originating from the framework movement induced by the photoswitchable diarylethene unit resulted in record CO2-desorption capacity of 75% under static irradiation and 76% under dynamic irradiation.
RESUMEN
Three new metal-organic frameworks (MOFs) were prepared by solvo(hydro)thermolysis and further characterized as framework isomers. The structural transformation from non-porous to porous MOFs and the purity of these products can be modulated by controlling the reaction temperature. The periodic-increased porosity observed was further confirmed by CO2 adsorption isotherms. Owing to the presence of acylamide groups in the pore walls and the flexible nature of the skeleton of these MOFs, highly selective CO2 adsorption over N2 was observed, as well as structure-dependent periodic varieties in luminescence properties.
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Dióxido de Carbono/química , Nitrógeno/química , Adsorción , Cristalografía por Rayos X , Isomerismo , Conformación Molecular , Compuestos Organometálicos/química , Porosidad , Espectrometría de FluorescenciaRESUMEN
[µ-N,N'-Bis(pyridin-3-yl)benzene-1,4-dicarboxamide-1:2κ(2)N:N']bis{[N,N'-bis(pyridin-3-yl)benzene-1,4-dicarboxamide-κN]diiodidomercury(II)}, [Hg2I4(C18H14N4O2)3], is an S-shaped dinuclear molecule, composed of two HgI2 units and three N,N'-bis(pyridin-3-yl)benzene-1,4-dicarboxamide (L) ligands. The central L ligand is centrosymmetric and coordinated to two Hg(II) cations via two pyridine N atoms, in a syn-syn conformation. The two terminal L ligands are monodentate, with one uncoordinated pyridine N atom, and each adopts a syn-anti conformation. The HgI2 units show highly distorted tetrahedral (sawhorse) geometry, as the Hg(II) centres lie only 0.34â (2) or 0.32â (2)â Å from the planes defined by the I and pyridine N atoms. Supramolecular interactions, thermal stability and solid-state luminescence properties were also measured.
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OBJECTIVE: To assess the value of diffusion tensor imaging (DTI) in therapeutic effect evaluation of major depression. METHODS: Eighteen patients who met the CCMD-3-R criteria for major depression or bipolar disorder (with depressed episode and total score no less than 18 for 17 items of Hamilton Depression Rating Scale) and 13 aged-matched controls were examined by routine magnetic resonance imaging (MRI) and DTI. DTI were used to determine fractional anisotropy (FA) in the preselected white matter regions. All the patients with major depression received treatment with selective serotonine reuptake inhibitor (SSRI) for 6-8 weeks, and the efficacy were assessed by Hamilton Depression Scale, Hamilton Anxiety Scale (HAMA), and Clinical Global Impression (CGI) scale. RESULTS: The total response rate to fluoxetine was 67%, and significant improvement was observed in 56% of the patients while 33% failed to respond after 8 weeks of treatment. The depressed subjects failing to respond to the treatment had a significant lower FA of the frontal white matter than those responding favorably to the treatment and the healthy control subjects. CONCLUSION: DTI may identify the microstructural abnormality in the white matter, which is associated with a low remission rate of major depression.
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Encéfalo/patología , Trastorno Depresivo Mayor/tratamiento farmacológico , Imagen de Difusión por Resonancia Magnética , Adulto , Trastorno Bipolar/tratamiento farmacológico , Estudios de Casos y Controles , Femenino , Humanos , Masculino , Persona de Mediana Edad , Escalas de Valoración Psiquiátrica , Inhibidores Selectivos de la Recaptación de Serotonina/uso terapéutico , Resultado del TratamientoRESUMEN
OBJECTIVE: To investigate DNA aneuploid and P16 expression in biopsy specimens from lung cancer, and to study genetic instability and the application of flow cytometry in lung cancer pernicious degree diagnosis. METHODS: Blood cells and cancer cells in biopsy specimens were marked simultaneously with anti-CD45 and anti-P16 fluorescent antibody, and the ratio of CD45+ P16+ cells and CD4- P16+ cells was compared. DNA content in biopsy specimens from lung cancer was detected by flow cytometry. RESULTS: Among the 74 cases of lung cancer, there are 46 cases of DNA aneuploid (62.2%). Thirty-seven cases of lung cancer expressed P16 lowly (50%). Twelve cases of lung cancer only expressed P16 lowly (16.22%), 21 cases of lung cancer only expressed DNA aneuploid (28.38%), and 25 cases not only expressed P16 lowly but also expressed DNA aneuploid (33.78%). Indexes of malign degree, such as P16 low expression or DNA aneuploid could be detected in 58 cases among the 74 cases (78.38%) by flow cytometry. CONCLUSION: P16 low expression and DNA aneuploid are the indexes of lung cancer malign degree, and flow cytometry can be used to study genetic instability and evaluate biopsy specimens from lung cancer.
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Aneuploidia , Inestabilidad Cromosómica/genética , ADN/genética , Regulación Neoplásica de la Expresión Génica , Genes p16 , Neoplasias Pulmonares/genética , Animales , Biopsia , Femenino , Citometría de Flujo , Dosificación de Gen , Humanos , Antígenos Comunes de Leucocito/genética , Neoplasias Pulmonares/diagnóstico , Neoplasias Pulmonares/patología , Masculino , Ratones , Persona de Mediana EdadRESUMEN
OBJECTIVE: To study the clinical significance of detecting p53 gene mutation expression in colorectal cancer cells of peripheral blood. METHODS: Flow cytometry (FCM) was used to detect p53 gene mutation expression in peripheral blood cancer cells of 128 patients with colorectal cancer. Experimental data were analyzed by SPSS (v.11.0) software. RESULTS: The lymph node metastasis showed the significant difference statistically (P<0.01) between p53 positive and negative expression in the colorectal cancer patients. The mutation p53 expression associated with existing histological differentiation (r=0.8476, P<0.05). A lymph node metastasis difference was observed between left and right colorectal cancers of mutation p53 positive expression. CONCLUSION: Detecting the mutation p53 expression in cancer cells of peripheral blood might be helpful to the early diagnosis of colorectal cancer.
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Neoplasias Colorrectales/diagnóstico , ADN de Neoplasias/análisis , Genes p53/genética , Células Neoplásicas Circulantes/metabolismo , Proteína p53 Supresora de Tumor/genética , Adulto , Anciano , Anciano de 80 o más Años , Neoplasias Colorrectales/genética , Neoplasias Colorrectales/patología , Femenino , Expresión Génica , Regulación Neoplásica de la Expresión Génica , Humanos , Masculino , Persona de Mediana EdadRESUMEN
OBJECTIVE: To investigate the association of genetic polymorphism Val384Asp in hMLH1 gene with the risk of colorectal, gastric, esophageal and breast carcinomas. METHODS: A case-control study was taken to investigate the role of Val384Asp in hMLH1 gene in developing these four carcinomas. 233 colorectal, 273 gastric, 90 esophageal and 111 breast cancer patients were included, as well as 268 healthy individual served as controls. Peripheral white blood cell DNA was obtained from all subjects. hMLH1 gene Val384Asp was analysed using a PCR-based DHPLC while the existence of Val384Asp were verified by DNA sequencing. RESULTS: 6.34% of the healthy individuals were identified as Val384Asp carriers and significant differences existing between colorectal cancer patients or gastric cancer patients and controls, especially between young aged patients and controls. CONCLUSION: Determination of Val384Asp in hMLH1 gene single nucleotide polymorphism seemed to be suitable for identifying individuals with increased risk of gastrointestinal cancer in the Chinese population.