Efficacy and safety of the Ayurvedic herbal preparation Maharishi Amrit Kalash: a systematic review of randomized controlled trials.

Background: Maharishi Amrit Kalash (MAK) 4 and 5 are Ayurvedic herbal nutritional supplements that are believed to have beneficial effects on overall health and wellbeing. This study aimed to systematically review all available randomized controlled trials (RCTs) investigating the clinical effects and safety of MAK. Methods: We included RCTs on therapy, health promotion, and prevention for patients and healthy volunteers of all ages. We systematically searched MEDLINE (via PubMed), EMBASE (via Ovid), the Cochrane Central Register of Controlled Trials (CENTRAL, The Cochrane Library), DHARA, Clinicaltrials.gov, the World Health Organization (WHO) International Clinical Trials Registry Platform, and Google Scholar from inception through 7 May 2023, with no time or language restrictions. The risk of bias was assessed using the Cochrane Risk of Bias Tool version 1. The protocol was registered with PROSPERO before conducting the review (CRD42023421655). Results: Three RCTs with 418 study participants were included. Two studies were on breast cancer patients and one on healthy adults. The two studies on cancer evaluated the efficacy of MAK in reducing the side effects of chemotherapy in women with breast cancer. The study on healthy adults evaluated whether MAK has an effect on an age-related alertness task as an indicator of cognitive aging. Both studies on breast cancer patients found beneficial effects on performance status, anorexia, vomiting, and body weight. One study reported positive effects regarding stomatitis. Regarding visual alertness, results showed that individuals who received MAK improved in performance. None of the three included studies reported adverse events. The risk of bias was mixed. Due to the small number and heterogeneity of the RCTs, no meta-analysis could be performed. Conclusion: There is evidence that MAK may have supportive effects in chemotherapeutic treatments for breast cancer patients and for healthy individuals regarding visual discrimination. However, it is difficult to verify treatment effects due to the small number of RCTs and the mixed risk of bias. Furthermore, none of the included studies recorded adverse events. Therefore, further high-quality studies are warranted to confirm the potential health benefits of MAK and to determine its optimal dosage and duration of use. Systematic review registration: PROSPERO, CRD42023421655.

Lactation support in neonatal intensive care units in Germany from the mothers' perspective - a mixed-method study of the current status and needs.

BACKGROUND: Establishing successful lactation in mothers of very low birth weight (VLBW, <1500g) infants requires structured lactation support. Little is known about mothers' perspectives on lactation support in German neonatal intensive care units (NICUs). METHODS: This paper features a convergent mixed-method approach that includes a retrospective, cross-sectional questionnaire and interview data to showcase mothers' perceptions of lactation support in NICUs. Content analysis of the interviews (n = 12) and a descriptive analysis of quantitative data (n = 533) were performed to illustrate the current status and need for lactation support in German NICUs. RESULTS: The results show that lactation support in German NICUs is often inadequate and does not comply with recommendations based on the existing literature to encourage pumping and breastfeeding in mothers. The data imply that even if lactation is successfully initiated in most cases, it is often not maintained over time, which may be due to a lack of personal support and consistent information. CONCLUSION: The overall structures and institutional guidelines for lactation support should be encouraged to promote nutrition with mother´s own milk in German NICUs.

Structured lactation support and human donor milk for German NICUs-Protocol on an intervention design based on a multidimensional status quo and needs assessment (Neo-MILK).

INTRODUCTION: Mother's own milk is the best nutrition for every newborn and especially for vulnerable infants such as preterm infants with a very low birth weight below 1,500 grams (VLBW). If no MOM is available, human donor milk is the alternative of choice. Mothers of preterm born infants face challenging conditions that impair sufficient milk production. For this reason, it is particularly important to provide structural lactation support and, at the same time, to promote the establishment of human donor milk banks. METHODS AND ANALYSIS: Via a multidisciplinary approach the Neo-MILK study will develop an intervention for structured breastfeeding and lactation support. This will be based on a comprehensive status quo and needs assessment. In addition, the implementation of human donor milk banks (HDMB) will be supported by the development of standards. ETHICS AND DISSEMINATION: Intervention development is participatory, involving different disciplines and stakeholders. All surveys are subject to approval by the ethics committee. During the course of the project, the results will be communicated to the scientific community and the general public via publications, the project homepage and social media. TRIAL REGISTRATION NUMBER: DRKS00024799 (German Clinical Trials Register).

Diversity Training With Robots: Perspective-Taking Backfires, While Sterotype-Suppression Decreases Negative Attitudes Towards Robots.

The present research investigated the effects of a diversity training intervention on robot-related attitudes to test whether this could help to manage the diversity inherent in hybrid human-robot teams in the work context. Previous research in the human-human context has shown that stereotypes and prejudice, i.e., negative attitudes, may impair productivity and job satisfaction in teams high in diversity (e.g., regarding age, gender, or ethnicity). Relatedly, in hybrid human-robot teams, robots likely represent an "outgroup" to their human co-workers. The latter may have stereotypes towards robots and may hold negative attitudes towards them. Both aspects might have detrimental effects on subjective and objective performance in human-robot interactions (HRI). In an experiment, we tested the effect of an economic and easy to apply diversity training intervention for use in the work context: The so-called enlightenment approach. This approach utilizes perspective-taking to reduce prejudice and discrimination in human-human contexts. We adapted this intervention to the HRI context and explored its impact on participants' implicit and explicit robot-related attitudes. However, contrary to our predictions, taking the perspective of a robot resulted in more negative robot-related attitudes, whereas actively suppressing stereotypes about social robots and their characteristics produced positive effects on robot attitudes. Therefore, we recommend considering potential pre-existing aversions against taking the perspective of a robot when designing interventions to improve human-robot collaboration at the workplace. Instead, it might be useful to provide information about existing stereotypes and their consequences, thereby making people aware of their potential biases against social robots.

Imagine how to behave: the influence of imagined contact on human-robot interaction.

Imagined contact (IC), that is, mentally simulating an interaction with an outgroup member, reduces negative attitudes towards outgroup members, increases contact intentions, and reduces intergroup anxiety in human-human intergroup context. Our experiment tested the effectiveness of IC with a robot to improve human-robot interaction (HRI). Social psychological literature suggested that IC provides a behavioural script for an interaction. Hence, an imagined scenario similar to a real contact scenario should be more effective in eliciting the aforementioned positive effects. We therefore examined the effect of similarity between IC with a robot and the following actual HRI on interaction perception, and behaviours towards the robot. High similarity was expected to lead to a more positive perception of HRI and more positive interaction behaviour towards the robot (e.g. more social behaviour). Results showed that perceived HRI quality was evaluated more positively and participants displayed more social behaviour towards the robot when the imagined task resembled the HRI that followed, compared to when it did not resemble the subsequent HRI. When controlling for covariates, the effects on number of social behaviours and perceived interaction quality remained significant, however, there was no effect on the total amount of time spent producing social behaviours. This article is part of the theme issue 'From social brains to social robots: applying neurocognitive insights to human-robot interaction'.