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FEBS Lett ; 579(10): 2137-42, 2005 Apr 11.
Artículo en Inglés | MEDLINE | ID: mdl-15811331

RESUMEN

Eight genes showed significant changes in expression in mice under psychophysiological stress provided by cage-restraint and water-immersion. The transcription level of most of these genes was affected in all the tissues analyzed, and some of them were responsive genes in several different stress systems. Peculiarly, the expression level of one gene, cdc2-like kinase 1 (CLK1), was reduced only in the brain, while the balance of partially- and alternatively-spliced CLK1 mRNA species changed in all the tissues including the brain. These results suggest that some stress-response mechanisms, including transcriptional and post-transcriptional events, are coordinated in the whole body in mice under psychophysiological stress.


Asunto(s)
Regulación de la Expresión Génica , Estrés Psicológico/genética , Animales , ADN Complementario , Proteínas Inmediatas-Precoces , Intrones , Masculino , Ratones , Ratones Endogámicos C57BL , Proteínas Nucleares/genética , Análisis de Secuencia por Matrices de Oligonucleótidos , Proteínas Serina-Treonina Quinasas/genética , Proteínas Tirosina Quinasas/genética , Reacción en Cadena de la Polimerasa de Transcriptasa Inversa , Estrés Psicológico/enzimología , Transcripción Genética
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