A Winning New Combination? Toward Clinical Application in Oncology.

Immunotherapy has substantial attention in oncology due to the success of CTLA-4 and PD-1 inhibitors in the treatment of melanoma, lung cancer, head and neck cancer, renal cell carcinoma, and Hodgkin's lymphoma. A deeper understanding of interaction of tumor with its environment and the immune system provides best guide for oncology research. Recent studies in oncology have explained how a tumor alters antigen presentation, avoids detection, and activation of the host immune system to live and develop. Understanding the connections between the tumor and the immune system has resulted in several innovative therapy options. The extensive field of gene therapy has provided a number of cutting-edge medicines that are expected to play an important role in lowering cancer-related mortality. This article explains the history, important breakthroughs, and future prospects for three separate gene therapy treatment modalities: immunotherapy, oncolytic virotherapy, and gene transfer. Immunotherapies have completely changed how cancer is treated, especially for individuals whose condition was previously thought to be incurable. Examples include ACT (adoptive cell therapy) and ICB (immune checkpoint blockade). This review article will discuss the relationship between the immune response to cancer and the mechanisms of immunotherapy resistance. It will cover combination drugs authorized by the US Food and Drug Administration and provide a thorough overview of how these drugs are doing clinically right now. Cytokines, vaccines, and other soluble immunoregulatory agents, innate immune modifiers, ACT, virotherapy, and other treatment modalities will all be covered in detail.

Palpable Penile Metastases: A Bizarre Presentation of Rectal Adenocarcinoma.

Metastasis to the penis is an uncommon occurrence, with only about 370 cases reported in the literature to date. The majority of the primary tumors are genitourinary in origin. We report on a patient with undiagnosed disseminated rectal adenocarcinoma, who first presented with lesions of the corporal bodies. A review of the literature indicates that corporeal metastasis as an initial presentation of malignancy is an extremely rare occurrence and carries a very poor prognosis.

Techniques for laparoscopic and robotic localization of intraluminal ureteral pathology.

OBJECTIVES: Improvements in endoscopic technology have made open ureteral surgery uncommon. There remain cases of ureteral disease not amenable to ureteroscopic treatment, but laparoscopy allows even these complicated cases to be treated in a minimally invasive fashion. Laparoscopic and robotic surgical treatment of the ureter requires the ability to localize the diseased segment laparoscopically, even when the defect is within the lumen and cannot be seen externally or palpated as in open surgery. We describe 3 techniques to localize the disease within the ureter during laparoscopy and robotic surgery and the benefits and limitations of each technique. METHODS: Three cases of laparoscopic and robotic ureteral surgery illustrate 3 different techniques used to localize disease within the ureteral lumen. The first case illustrates a ureteral occlusion balloon catheter used to identify a stricture by distending the collecting system proximal to the obstruction and cinching the balloon against the stricture. The second case illustrates a flexible ureteroscope introduced through a 5-mm port and into the incised ureter to guide excision of extensive polyposis. The third case, involving a polyp and stricture, illustrates a technique involving retrograde ureteroscopy with "cutting to the light" laparoscopically. RESULTS: Three techniques are demonstrated to successfully localize intraluminal ureteral disease that could not be identified visually by laparoscopic inspection alone. These techniques also can minimize the extent of ureteral dissection to preserve blood supply. CONCLUSIONS: Laparoscopy and robotic surgery can be successfully applied to benign ureteral disease not amenable to ureteroscopic treatment. Three cases are presented to illustrate 3 techniques for laparoscopic or robotic localization of intraluminal ureteral disease.

Robot-assisted laparoscopic adrenalectomy for adrenocortical carcinoma: initial report and review of the literature.

We report the first robot-assisted laparoscopic adrenalectomy for adrenocortical carcinoma. This patient was referred to our center for extirpation of an incidentally discovered 8-cm adrenal mass. The patient underwent robot-assisted laparoscopic adrenalectomy. Surgical margins were negative for malignancy, and the patient was discharged home on the first postoperative day. We review the literature regarding robot-assisted laparoscopic adrenalectomy and discuss the potential benefits of this technique as compared with standard laparoscopy in the management of adrenocortical carcinoma.

The assessment and management of the dizzy patient.

A significant number of individuals are affected by symptoms of dizziness. It is the most common complaint among patients over 75 years of age. A large number of these patients seek counsel from their physicians. It is imperative for the evaluating physician to obtain a thorough history and perform a complete physical exam. The proper diagnostic studies must also be obtained to confirm or rule out particular diagnoses. The physician should never assume that the dizziness is the result of normal aging prior to ruling out pathologic conditions.