The risk characteristics of heavy metals in urban soil of typical developed cities in China.

With the rapid development of China's industrial economy, heavy metals continue to accumulate in the environment, which has created serious threats for the ecological environment and human health. This study collected 50 surface soil samples in Nanjing, a typical developed city in China, and the contents of Al, Ca, Fe, Mg, Mn, Ni, Ti, Cd, Cr, Cu, Pb, and Zn in the samples were determined. Combined with the ecological risk index and the health risk assessment model, the risk of soil heavy metals in Nanjing was comprehensively evaluated. The results show that the variation coefficients of Pb and Cu are distinctly large, and these elements are all slightly polluting. Children are at a high risk of exposure in various ways, among which Pb and Cu elements have a high risk of causing non-carcinogenic issues. The results of the correlation analysis showed that the content changes of Pb, Zn, and Cu had extremely significant correlations, indicating that they may have the same source. The results of the principal component analysis showed that industrial sources in Nanjing contributed the most heavy metals, reaching 34.4%. The second largest source was from parent material and fertilizer, which contributed 32.3% and 19.6%, respectively. The sources with the lowest contributions were from weathering and deposition, which reached 13.7%. The results of this study will provide guidance and reference for risk-source analysis, early warning, and management of soil heavy metals in developed cities.

Radiocolloid-based dynamic sentinel lymph node biopsy in penile cancer with clinically negative inguinal lymph node: an updated systematic review and meta-analysis.

PURPOSE: More literatures regarding radiocolloid-based dynamic sentinel lymph node biopsy (DSNB) in penile cancer with clinically negative groin (cN0) have been published since previous meta-analysis in 2012. This updated meta-analysis was to assess the accuracy of the procedure in penile cancer with cN0 disease and explore its relative factors on the basis of current evidences. MATERIALS AND METHODS: We performed a review of PubMed, Ovid/Embase, and the Cochrane Library in March 2016 according to the Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA) statement. Study quality was evaluated by the use of the Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2). A random effects model was used for statistical pooling. Publication bias was evaluated by the use of funnel plot and Egger's test. Meta-regression, subgroup and sensitivity analysis were conducted to explore the sources of heterogeneity. RESULTS: A total of 27 articles were included. Two articles had two different cohorts and each cohort was considered a separate study. Overall 29 studies were used for sensitivity and negative predictive value (NPV) meta-analysis. The pooled sensitivity and NPV was 88 % (95 % CI 84-90 %) and 99 % (98-99 %), respectively. Meta-regression and subgroup analysis revealed that the use of preoperative ultrasonic scan (USS) ± fine-needle aspiration cytology (FNAC), surgical exploration of wound for suspicious lymph nodes (LN), immunohistochemistry (IHC) and extensive experience were significantly associated with the improved sensitivity of DSNB. CONCLUSIONS: Radiocolloid-based DSNB is a promising staging modality to detect inguinal micrometastasis in penile cancer without clinically positive inguinal LN. Preoperative USS ± FNAC and surgical exploration are effective supplements to exclude potentially clinical involvement, and IHC makes the diagnosis of occult metastasis in SLN more likely. The multidisciplinary and multistep procedure should be performed by skilled teams in specialized centers.