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1.
Nat Commun ; 15(1): 8587, 2024 Oct 04.
Artículo en Inglés | MEDLINE | ID: mdl-39362899

RESUMEN

Exotic quantum phases, arising from a complex interplay of charge, spin, lattice and orbital degrees of freedom, are of immense interest to a wide research community. A well-known example of such an entangled behavior is the Jahn-Teller effect, where the lifting of orbital degeneracy proceeds through lattice distortions. Here we demonstrate that a highly-symmetrical 5d1 double perovskite Ba2MgReO6, comprising a 3D array of isolated ReO6 octahedra, represents a rare example of a dynamic Jahn-Teller system in the strong spin-orbit coupling regime. Thermodynamic and resonant inelastic x-ray scattering experiments, supported by quantum chemistry calculations, undoubtedly show that the Jahn-Teller instability leads to a ground-state doublet, resolving a long-standing puzzle in this family of compounds. The dynamic state of ReO6 octahedra persists down to the lowest temperatures, where a multipolar order sets in, allowing for investigations of the interplay between a dynamic JT effect and strongly correlated electron behavior.

2.
Artículo en Inglés | MEDLINE | ID: mdl-39276001

RESUMEN

BACKGROUND: The optimal exercise regimen for alleviating sarcopenia remains uncertain. This study aimed to investigate the efficacy of high-intensity interval training (HIIT) over moderate-intensity continuous training (MICT) in ameliorating sarcopenia. METHODS: We conducted a randomized crossover trial to evaluate plasma proteomic reactions to acute HIIT (four 4-min high-intensity intervals at 70% maximal capacity alternating with 4 min at 30%) versus MICT (constant 50% maximal capacity) in inactive adults. We explored the relationship between a HIIT-specific protein relative to MICT, identified via comparative proteomic analysis, eukaryotic translation elongation factor 1 epsilon 1 (EEF1E1) and sarcopenia in a paired case-control study of elderly individuals (aged over 65). Young (3 months old) and aged (20 months old) mice were randomized to sedentary, HIIT and MICT groups (five sessions/week for 4 weeks; n = 8 for each group). Measurements included skeletal muscle index, hand grip strength, expression of atrophic markers Atrogin1 and MuRF1 and differentiation markers MyoD, myogenin and MyHC-II via western blotting. We examined the impact of EEF1E1 siRNA and recombinant protein on D-galactose-induced myoblast senescence, measuring senescence-associated ß-galactosidase and markers like p21 and p53. RESULTS: The crossover trial, including 10 sedentary adults (32 years old, IQR 31-32) demonstrated significant alterations in the abundance of 21 plasma proteins after HIIT compared with MICT. In the paired case-control study of 84 older adults (84 years old, IQR 69-81; 52% female), EEF1E1 was significantly increased in those with sarcopenia compared to those without (14.68 [95%CI, 2.02-27.34] pg/mL, p = 0.03) and was associated with skeletal muscle index (R2 = 0.51, p < 0.001) and hand grip strength (R2 = 0.54, p < 0.001). In the preclinical study, aged mice exhibited higher EEF1E1 mRNA and protein levels in skeletal muscle compared to young mice, accompanied by a lower muscle mass and strength, increased cellular senescence and protein degradation markers and reduced muscle differentiation efficiency (all p < 0.05). HIIT reduced EEF1E1 expression and mitigated age-related muscle decline and atrophy in aged mice more effectively than MICT. Notably, EEF1E1 downregulation via siRNA significantly counteracted D-galactose-induced myoblast senescence as evidenced by reduced markers of muscle protein degradation and improved muscle differentiation efficiency (all p < 0.05). Conversely, treatments that increased EEF1E1 levels accelerated the senescence process (p < 0.05). Further exploration indicated that the decrease in EEF1E1 was associated with increased SIRT1 level and enhanced autophagy. CONCLUSIONS: This study highlights the potential of HIIT as a promising approach to prevent and treat sarcopenia while also highlighting EEF1E1 as a potential intervention target.

3.
Comput Struct Biotechnol J ; 23: 3104-3116, 2024 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-39219717

RESUMEN

Extracellular microRNA (miRNA) expression data generated by different laboratories exhibit heterogeneity, which poses challenges for biologists without bioinformatics expertise. To address this, we introduce ExomiRHub (http://www.biomedical-web.com/exomirhub/), a user-friendly database designed for biologists. This database incorporates 191 human extracellular miRNA expression datasets associated with 112 disease phenotypes, 62 treatments, and 24 genotypes, encompassing 29,198 and 23 sample types. ExomiRHub also integrates 16,012 miRNA transcriptomes of 156 cancer subtypes from The Cancer Genome Atlas. All the data in ExomiRHub were further standardized and curated with annotations. The platform offers 25 analytical functions, including differential expression, co-expression, Weighted Gene Co-Expression Network Analysis (WGCNA), feature selection, and functional enrichment, enabling users to select samples, define groups, and customize parameters for analyses. Moreover, ExomiRHub provides a web service that allows biologists to analyze their uploaded miRNA expression data. Four additional tools were developed to evaluate the functions and targets of miRNAs and miRNA variations. Through ExomiRHub, we identified extracellular miRNA biomarkers associated with angiogenesis for monitoring glioma progression, demonstrating its potential to significantly accelerate the discovery of extracellular miRNA biomarkers.

4.
ACS Appl Mater Interfaces ; 16(40): 54316-54327, 2024 Oct 09.
Artículo en Inglés | MEDLINE | ID: mdl-39318355

RESUMEN

The electrode optimization and rational design are of great significance for the performance enhancement of self-powered electrochromic devices (ECDs). It can be effectively enhanced by developing interfacial properties of electrodes, which can promote the internal ion transport within functional components consisting of an electrode, electrochromic layer, and electrolyte layer and thus obtain performance improvement of fabricated devices. This work aims to construct the electrode of poly(3,4-ethylenedioxythiophene): polystyrenesulfonate (PEDOT:PSS) on different substrates and promote interface performance of the prepared electrodes via inheriting the surface topography of substrates. Besides, the prepared PEDOT:PSS electrodes as a dual-function layer including the electrochromic and electrode layer are employed to assemble the ECDs. It is found that the intrinsic roughness of the paper substrate can facilitate the electrochemical performance of the prepared PEDOT:PSS electrode on it effectively, thereby showing a superior electrochemical surface area and diffusion coefficient as well as a lower charge-transfer resistance of 13.56 Ω. Similarly, for the prepared self-powered ECD on the paper substrate, it also indicates a high light absorption property (0.413), well-defined electrochromic contrast (33.09), fast switching (τc = 4.0 s, τb = 6.8 s), high coloration efficiency (92.275 cm2 C-1), high areal capacity (10.93 mAh m-2) at 0.01 mA cm-2, and lower equivalent series resistance (176.2 Ω) in comparison to parallel ECDs on the PET and glass substrate. Leveraging the intrinsic roughness of the substrate is able to enhance the electrochemical performance of electrodes, which can also provide a new strategy for the construction of high-performance self-powered ECDs.

5.
Langmuir ; 40(36): 19116-19124, 2024 Sep 10.
Artículo en Inglés | MEDLINE | ID: mdl-39177968

RESUMEN

The progress of industrialization has led to a notable elevation in selenium (Se) levels within aquatic environments, surpassing established thresholds and posing significant risks to both human health and ecological equilibrium. Chitosan (CS) exhibits considerable potential in mitigating waterborne pollutants owing to its nontoxic nature, cost-effectiveness, and the presence of abundant hydroxyl and amino functional groups along its backbone. However, its subpar mechanical and thermal stability, susceptibility to acidic dissolution, and challenges in recycling impede its widespread use in water pollution mitigation. To address the aforementioned issues, this study employs a liquid nitrogen-directed freezing process to synthesize chitosan aerogel, aiming to enhance the adsorption efficiency of Se(IV). Morphological and adsorption tests demonstrate that the compact and closely interconnected porous structure facilitates diffusion of Se(IV) into the aerogel, thereby enhancing its adsorption efficiency. The theoretical adsorption capacity of the CS aerogel for Se(IV) is 56.45 mg/g, surpassing that of numerous natural and composite adsorbents, with adsorption equilibrium achieved within 2.5 h. Moreover, the CS aerogel demonstrates substantial potential in remediating Se(IV)-contaminated wastewater and improving circulation stability. A series of characterization results demonstrate that the primary adsorption mechanism of the CS aerogel onto Se(IV) involves electrostatic interactions, complemented by hydrogen bonding between the amino and hydroxyl groups of the CS aerogel and Se(IV), thereby augmenting the adsorption efficacy. This study introduces innovative avenues for tailoring the functionality of 3D macroscopic materials to address the remediation of heavy metals in aquatic environments.

6.
Adv Mater ; 36(38): e2310668, 2024 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-39101291

RESUMEN

Strongly-correlated transition-metal oxides are widely known for their various exotic phenomena. This is exemplified by rare-earth nickelates such as LaNiO3, which possess intimate interconnections between their electronic, spin, and lattice degrees of freedom. Their properties can be further enhanced by pairing them in hybrid heterostructures, which can lead to hidden phases and emergent phenomena. An important example is the LaNiO3/LaTiO3 superlattice, where an interlayer electron transfer has been observed from LaTiO3 into LaNiO3 leading to a high-spin state. However, macroscopic emergence of magnetic order associated with this high-spin state has so far not been observed. Here, by using muon spin rotation, x-ray absorption, and resonant inelastic x-ray scattering, direct evidence of an emergent antiferromagnetic order with high magnon energy and exchange interactions at the LaNiO3/LaTiO3 interface is presented. As the magnetism is purely interfacial, a single LaNiO3/LaTiO3 interface can essentially behave as an atomically thin strongly-correlated quasi-2D antiferromagnet, potentially allowing its technological utilization in advanced spintronic devices. Furthermore, its strong quasi-2D magnetic correlations, orbitally-polarized planar ligand holes, and layered superlattice design make its electronic, magnetic, and lattice configurations resemble the precursor states of superconducting cuprates and nickelates, but with an S→1 spin state instead.

7.
Bioinformatics ; 40(8)2024 08 02.
Artículo en Inglés | MEDLINE | ID: mdl-39128019

RESUMEN

MOTIVATION: High-throughput technologies yield a broad spectrum of multi-omics datasets, which offer unparalleled insights into complex biological systems. However, effectively analyzing this diverse array of data presents challenges, considering factors such as species diversity, data types, costs, and limitations of the available tools. RESULTS: Herein, we present ExpOmics, a comprehensive web platform featuring 7 applications and 4 toolkits, with 28 customizable analysis functions spanning various analyses of differential expression, co-expression, Weighted Gene Co-expression Network Analysis (WGCNA), feature selection, and functional enrichment. ExpOmics allows users to upload and explore multi-omics data without organism restrictions, supporting various expression data, including genes, mRNAs, lncRNAs, miRNAs, circRNAs, piRNAs, and proteins and is compatible with diverse gene nomenclatures and expression values. Moreover, ExpOmics enables users to analyze 22 427 transcriptomic datasets of 196 cancer subtypes sourced from 63 projects of The Cancer Genome Atlas Program (TCGA) to identify cancer biomarkers. The analysis results from ExpOmics are presented in high-quality graphical formats suitable for publication and are available for free download. A case study using ExpOmics identified two potential oncogenes, SERPINE1 and SLC43A1, that may regulate colorectal cancer through distinct biological processes. In summary, ExpOmics can serves as a robust platform for global researchers to explore multi-omics data, gain biological insights, and formulate testable hypotheses. AVAILABILITY AND IMPLEMENTATION: ExpOmics is available at http://www.biomedical-web.com/expomics.


Asunto(s)
Programas Informáticos , Humanos , Internet , Biología Computacional/métodos , Redes Reguladoras de Genes , Neoplasias/genética , Neoplasias/metabolismo , Bases de Datos Genéticas , Perfilación de la Expresión Génica/métodos , Genómica/métodos , Transcriptoma/genética , Multiómica
8.
Phys Chem Chem Phys ; 26(28): 19460-19468, 2024 Jul 17.
Artículo en Inglés | MEDLINE | ID: mdl-38973766

RESUMEN

Vibrationally-resolved resonant inelastic X-ray scattering (VR-RIXS) at the O K-edge is emerging as a powerful tool for identifying embedded molecules in lithium-ion battery cathodes. Here, we investigate two known oxygen redox-active cathode materials: the commercial LixNi0.90Co0.05Al0.05O2 (NCA) used in electric vehicles and the high-capacity cathode material Li1.2Ni0.13Co0.13Mn0.54O2 (LRNMC) for next-generation Li-ion batteries. We report the detection of a novel vibrational RIXS signature for Li-ion battery cathodes appearing in the O K pre-peak above 533 eV that we attribute to OH-groups. We discuss likely locations and pathways for OH-group formation and accumulation throughout the active cathode material. Initial-cycle behaviour for LRNMC shows that OH-signal strength correlates with the cathodes state of charge, though reversibility is incomplete. The OH-group RIXS signal strength in long-term cycled NCA is retained. Thus, VR-RIXS offers a path for gaining new insights to oxygen reactions in battery materials.

9.
Artículo en Inglés | MEDLINE | ID: mdl-38614212

RESUMEN

OBJECTIVE: Limited evidence exists regarding the efficacy of preoperative exercise in reducing short-term complications after minimally invasive surgery in patients with non-small cell lung cancer. This study aims to investigate the impact of preoperative exercise on short-term complications after minimally invasive lung resection. METHODS: In this prospective, open-label, randomized (1:1) controlled trial at Xiangya Hospital, China (September 2020 to February 2022), patients were randomly assigned to a preoperative exercise group with 16-day alternate supervised exercise or a control group. The primary outcome assessed was short-term postoperative complications, with a follow-up period of 30 days postsurgery. RESULTS: A total of 124 patients were recruited (preoperative exercise group n = 62; control n = 62). Finally, 101 patients (preoperative exercise group; n = 51 and control; n = 50) with a median age of 56 years (interquartile range, 50-62 years) completed the study. Compared with the control group, the preoperative exercise group showed fewer postoperative complications (preoperative exercise 3/51 vs control 10/50; odds ratio, 0.17; 95% CI, 0.04-0.86; P = .03) and shorter hospital stays (mean difference, -2; 95% CI, -3 to -1; P = .01). Preoperative exercise significantly improved depression, stress, functional capacity, and quality of life (all P < .05) before surgery. Furthermore, preoperative exercise demonstrated a significantly lower minimum blood pressure during surgery and lower increases in body temperature on day 2 after surgery, neutrophil-to-lymphocyte ratio, and neutrophil count after surgery (all P < .05). Exploratory research on lung tissue RNA sequencing (5 in each group) showed downregulation of the tumor necrosis factor signaling pathway in the preoperative exercise group compared with the control group. CONCLUSIONS: Preoperative exercise training decreased short-term postoperative complications in patients with non-small cell lung cancer.

10.
Front Neurosci ; 18: 1265630, 2024.
Artículo en Inglés | MEDLINE | ID: mdl-38298913

RESUMEN

Color blindness is a retinal disease that mainly manifests as a color vision disorder, characterized by achromatopsia, red-green color blindness, and blue-yellow color blindness. With the development of technology and progress in theory, extensive research has been conducted on the genetic basis of color blindness, and various approaches have been explored for its treatment. This article aims to provide a comprehensive review of recent advances in understanding the pathological mechanism, clinical symptoms, and treatment options for color blindness. Additionally, we discuss the various treatment approaches that have been developed to address color blindness, including gene therapy, pharmacological interventions, and visual aids. Furthermore, we highlight the promising results from clinical trials of these treatments, as well as the ongoing challenges that must be addressed to achieve effective and long-lasting therapeutic outcomes. Overall, this review provides valuable insights into the current state of research on color blindness, with the intention of informing further investigation and development of effective treatments for this disease.

11.
ACS Omega ; 9(7): 7958-7966, 2024 Feb 20.
Artículo en Inglés | MEDLINE | ID: mdl-38405544

RESUMEN

As a greenhouse gas with strong global warming potential, the use of SF6 needs to be reduced as much as possible. Researching environmentally friendly insulation (EFI) gases to replace SF6 in power electrical equipment is an effective way to reduce its usage. CF3SO2F/N2, as a newly proposed EFI gas, has certain potential to replace SF6. Compatibility of CF3SO2F/N2 gas with rubber sealing materials commonly used in electrical equipment is still unknown. In this article, the compatibility of CF3SO2F/N2 with the ethylene-propylene-diene monomer (EPDM) and chloroprene rubber (CR) was investigated experimentally. It was found that CF3SO2F/N2 would slightly decompose under the influence of EPDM and CR rubber under certain conditions. The surface morphology of EPDM changed slightly under the influence of CF3SO2F/N2, and it was similar to the influence of SF6. While the surface morphology of CR deteriorated significantly with obvious defects. The mechanical properties of EPDM were not significantly affected by CF3SO2F, which is similar to the influence of SF6. But CR was affected greatly by CF3SO2F gas. Permanent deformation compression and surface morphology are two effective indicators for characterizing the compatibility between gas and rubber sealing materials. This research provides a reference for the application of CF3SO2F/N2 as a new EFI gas in power equipment.

12.
J Mater Chem A Mater ; 12(4): 2465-2478, 2024 Jan 23.
Artículo en Inglés | MEDLINE | ID: mdl-38269086

RESUMEN

The rising demand for high-performance lithium-ion batteries, pivotal to electric transportation, hinges on key materials like the Ni-rich layered oxide LiNixCoyAlzO2 (NCA) used in cathodes. The present study investigates the redox mechanisms, with particular focus on the role of oxygen in commercial NCA electrodes, both fresh and aged under various conditions (aged cells have performed >900 cycles until a cathode capacity retention of ∼80%). Our findings reveal that oxygen participates in charge compensation during NCA delithiation, both through changes in transition metal (TM)-O bond hybridization and formation of partially reversible O2, the latter occurs already below 3.8 V vs. Li/Li+. Aged NCA material undergoes more significant changes in TM-O bond hybridization when cycling above 50% SoC, while reversible O2 formation is maintained. Nickel is found to be redox active throughout the entire delithiation and shows a more classical oxidation state change during cycling with smaller changes in the Ni-O hybridization. By contrast, Co redox activity relies on a stronger change in Co-O hybridization, with only smaller Co oxidation state changes. The Ni-O bond displays an almost twice as large change in its bond length on cycling as the Co-O bond. The Ni-O6 octahedra are similar in size to the Co-O6 octahedra in the delithiated state, but are larger in the lithiated state, a size difference that increases with battery ageing. These contrasting redox activities are reflected directly in structural changes. The NCA material exhibits the formation of nanopores upon ageing, and a possible connection to oxygen redox activity is discussed. The difference in interaction of Ni and Co with oxygen provides a key understanding of the mechanism and the electrochemical instability of Ni-rich layered transition metal oxide electrodes. Our research specifically highlights the significance of the role of oxygen in the electrochemical performance of electric-vehicle-grade NCA electrodes, offering important insights for the creation of next-generation long-lived lithium-ion batteries.

13.
Phys Rev Lett ; 132(1): 016501, 2024 Jan 05.
Artículo en Inglés | MEDLINE | ID: mdl-38242670

RESUMEN

We use resonant inelastic x-ray scattering (RIXS) at the Fe-L_{3} edge to study the spin excitations of uniaxial-strained and unstrained FeSe_{1-x}S_{x} (0≤x≤0.21) samples. The measurements on unstrained samples reveal dispersive spin excitations in all doping levels, which show only minor doping dependence in energy dispersion, lifetime, and intensity, indicating that high-energy spin excitations are only marginally affected by sulfur doping. RIXS measurements on uniaxial-strained samples reveal that the high-energy spin-excitation anisotropy observed previously in FeSe is also present in the doping range 0200 K in x=0.18 and reaches a maximum around the nematic quantum critical doping (x_{c}≈0.17). Since the spin-excitation anisotropy directly reflects the existence of nematic spin correlations, our results indicate that high-energy nematic spin correlations pervade the regime of nematicity in the phase diagram and are enhanced by the nematic quantum criticality. These results emphasize the essential role of spin fluctuations in driving electronic nematicity and highlight the capability of uniaxial strain in tuning spin excitations in quantum materials hosting strong magnetoelastic coupling and electronic nematicity.

15.
Sci Rep ; 13(1): 15430, 2023 09 18.
Artículo en Inglés | MEDLINE | ID: mdl-37723197

RESUMEN

The strength of evidence regarding long-term changes to fitness resulting from the coronavirus disease 2019 (COVID-19) lockdowns is deficient. This two-site retrospective study aimed to investigate the long-term changes in physical fitness among young adults a year after the onset of the pandemic using a robust historical control. University freshmen who underwent physical fitness tests in 2019 and completed a follow-up in 2020 (study group) were included. The primary focus was to compare the current cohort with a historical control group who completed the same tests a year prior (2018). A total of 5376 individuals were recruited, of which 2239 were in the study group. Compared with the control, the study group exhibited a decrease in anaerobic fitness, with an overall difference of -0.84 (95% confidence interval [CI], [-1.33 to -0.36]); declines in aerobic fitness, with a difference of -2.25 [-3.92 to -0.57] for males and -4.28 [-4.97 to -3.59] for females; a reduced explosive fitness (-2.68 [-3.24 to -2.12]); and a decreased upper-body strength in females (-1.52 [-2.16 to -0.87]). The fitness of young adults has been considerably compromised by COVID-19 lockdowns, highlighting the importance of promoting physical activity to prevent long-term health implications.


Asunto(s)
COVID-19 , Pandemias , Femenino , Masculino , Humanos , Adulto Joven , Estudio Históricamente Controlado , Estudios Retrospectivos , COVID-19/epidemiología , Control de Enfermedades Transmisibles , Aptitud Física
16.
Front Bioeng Biotechnol ; 11: 1254861, 2023.
Artículo en Inglés | MEDLINE | ID: mdl-37711450

RESUMEN

Nanoparticles (NPs) can be extremely effective in the early diagnosis and treatment of cancer due to their properties. The nanotechnology industry is developing rapidly. The number of multifunctional NPs has increased in the market and hundreds of NPs are in various stages of preclinical and clinical development. Thus, the mechanism underlying the effects of NPs on biological systems has received much attention. After NPs enter the body, they interact with plasma proteins, tumour cell receptors, and small biological molecules. This interaction is closely related to the size, shape, chemical composition and surface modification properties of NPs. In this review, the effects of the size, shape, chemical composition and surface modification of NPs on the biological effects of NPs were summarised, including the mechanism through which NPs enter cells, the resulting oxidative stress response, and the interaction with proteins. This review of the biological effects of NPs can not only provide theoretical support for the preparation of safer and more efficient NPs but also lay the foundation for their clinical application.

17.
Adv Colloid Interface Sci ; 320: 102988, 2023 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-37690330

RESUMEN

In recent years, flexible devices have gained rapid development with great potential in daily life. As the core component of wearable devices, flexible tactile sensors are prized for their excellent properties such as lightweight, stretchable and foldable. Consequently, numerous high-performance sensors have been developed, along with an array of innovative fabrication processes. It has been recognized that the improvement of the single performance index for flexible tactile sensors is not enough for practical sensing applications. Therefore, balancing and optimization of overall performance of the sensor are extensively anticipated. Furthermore, new functional characteristics are required for practical applications, such as freeze resistance, corrosion resistance, self-cleaning, and degradability. From a bionic perspective, the overall performance of a sensor can be optimized by constructing bionic microstructures which can deliver additional functional features. This review briefly summarizes the latest developments in bionic microstructures for different types of tactile sensors and critically analyzes the sensing performance of fabricated flexible tactile sensors. Based on this, the application prospects of bionic microstructure-based tactile sensors in human detection and human-machine interaction devices are introduced.


Asunto(s)
Biomimética , Dispositivos Electrónicos Vestibles , Humanos , Tacto
18.
Small ; 19(46): e2302827, 2023 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-37403285

RESUMEN

High-performance porous materials with a low carbon footprint provide sustainable alternatives to petroleum-based lightweight foams and can help meet carbon neutrality goals. However, these materials generally face a trade-off between thermal management capabilities and structural strength. Here, a mycelium composite with a hierarchical porous structure, including both macro- and microscale pores, produced from multiple and advanced mycelial networks (elastic modulus of 1.2 GPa) binding loosely distributed sawdust is demonstrated. The morphological, biological, and physicochemical properties of the filamentous mycelium and composites are discussed in terms of how they are influenced by the mycelial system of the fungi and the way they interact with the substrate. The composite shows a porosity of 0.94, a noise reduction coefficient of 0.55 at a frequency range of 250-3000 Hz (for a 15 mm thick sample), a thermal conductivity of 0.042 W m-1  K-1 , and an energy absorption of 18 kJ m-3 at 50% strain. It is also hydrophobic, repairable, and recyclable. It is expected that the hierarchical porous structural composite with excellent thermal and mechanical properties can make a significant impact on the future development of highly sustainable alternatives to lightweight plastic foams.

19.
J Exp Med ; 220(5)2023 05 01.
Artículo en Inglés | MEDLINE | ID: mdl-36930174

RESUMEN

Retinitis pigmentosa (RP) is an inherited retinal dystrophy causing progressive and irreversible loss of retinal photoreceptors. Here, we developed a genome-editing tool characterized by the versatility of prime editors (PEs) and unconstrained PAM requirement of a SpCas9 variant (SpRY), referred to as PESpRY. The diseased retinas of Pde6b-associated RP mouse model were transduced via a dual AAV system packaging PESpRY for the in vivo genome editing through a non-NGG PAM (GTG). The progressing cell loss was reversed once the mutation was corrected, leading to substantial rescue of photoreceptors and production of functional PDE6ß. The treated mice exhibited significant responses in electroretinogram and displayed good performance in both passive and active avoidance tests. Moreover, they presented an apparent improvement in visual stimuli-driven optomotor responses and efficiently completed visually guided water-maze tasks. Together, our study provides convincing evidence for the prevention of vision loss caused by RP-associated gene mutations via unconstrained in vivo prime editing in the degenerating retinas.


Asunto(s)
Retina , Retinitis Pigmentosa , Ratones , Animales , Retinitis Pigmentosa/genética , Electrorretinografía , Células Fotorreceptoras de Vertebrados , Edición Génica
20.
Molecules ; 28(4)2023 Feb 06.
Artículo en Inglés | MEDLINE | ID: mdl-36838555

RESUMEN

The increase in the insecticide resistance of pests, such as Mythimna separata, Aphis craccivora Koch, and Tetranychus cinnabarinus, necessitates the development of new heterocyclic compounds with high insecticidal activity. A series of novel 2-phenylpyridine derivatives containing N-phenylbenzamide moieties were designed and synthesised with Suzuki-Miyaura cross-coupling, nucleophilic substitution, and amidation reactions. The reaction conditions in each step are mild, and the product is easy to separate (yield is about 85%). The structures of the compounds were characterised using 1H and 13C NMR spectroscopy and HRMS. Moreover, the insecticidal activity of the compounds was analysed using the leaf dipping method. The compounds 5a, 5d, 5g, 5h, and 5k at 500 mg/L exhibited 100% inhibition against Mythimna separata. Therefore, the 2-phenylpyridine moieties have the potential to lead to the discovery of novel and effective insecticides.


Asunto(s)
Áfidos , Insecticidas , Mariposas Nocturnas , Tetranychidae , Animales , Insecticidas/química , Piridinas/farmacología , Estructura Molecular , Relación Estructura-Actividad
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