RESUMEN
The rising incidence rate of food allergy is attracting more intention. The pathogenesis of food allergy is complex and its definite regulatory mechanism is not utterly understood. Exploring the molecular mechanism of food allergy to help find effective methods that can prevent or treat food allergy is widely necessary. Recently, targeting cellular signaling pathways have been employed as novel approaches to discover food allergy therapy. Supplementing probiotics and bioactive compounds with anti-allergic property are believed feasible approaches for food allergy therapy. These probiotics or bioactive compounds affect food allergy by regulating cellular signaling pathways, and ultimately alleviate food allergy. This review aims to report systematic information about the knowledge of signaling pathways participated in food allergy, the alterations of these signaling pathways during food allergy that treated with probiotics and bioactive compounds are discussed as well. Further studies on the mechanism of signaling pathway network regulating food allergy and the precise action mechanism of probiotics and bioactive compounds are in the urgent need to help develop efficient treatment or complete prevention. We hope to help scientists understand food allergy systematically.
RESUMEN
The carbon fiber reinforced plastic (CFRP) is widely used in the aerospace industry due to its high strength and lightweight characteristics, making it crucial to ensure the reliability of these materials. This has led to an increasing focus on research on the health monitoring technologies of aerospace materials. Electrical impedance tomography (EIT) is a non-invasive and cost-effective technology that has the potential to realize real-time health monitoring of materials by measuring changes in electrical parameters. This paper investigates the application of EIT for direct 3D reconstruction of damage in CFRP laminates with significant conductivity anisotropy distribution. Based on the corrected sensitivity matrix formula, the direct 3D image reconstruction method combined with the fast iterative shrinkage-thresholding algorithm (FISTA) is proposed to achieve damage imaging of CFRP laminates in the inverse problem. The fast convergence of the FISTA makes it possible to solve complex inverse problems. The numerical simulation results indicate that, compared with 2D EIT, the proposed method is more capable of providing damage information, especially in the depth direction. This research plays a constructive role in realizing 3D image reconstruction of CFRP material damage and has significant implications for improving the reliability and safety of CFRP materials in aerospace applications.
RESUMEN
Seafood allergy, mainly induced by fish, shrimp, crab, and shellfish, is a food safety problem worldwide. The non-thermal processing technology provides a new method in reducing seafood allergenicity. Based on the structural and antigenic properties of allergenic proteins, this review introduces current methods for a comprehensive analysis of the allergenicity changes of seafood allergens induced by non-thermal processing. The IgE-binding capacities/immunoreactivity of seafood allergens are reduced by the loss of conformation during non-thermal processing. Concretely, the destruction of native structure includes degradation, aggregation, uncoiling, unfolding, folding, and exposure, leading to masking of the epitopes. Moreover, most studies rely on IgE-mediated assays to evaluate the allergenic potential of seafood protein. This is not convincing enough to assess the effect of novel food processing techniques. Thus, further studies must be conducted with functional assays, in vivo assays, animal trials, simulated digestion, and intestinal microflora to strengthen the evidence. It also enables us to better identify the effects of non-thermal processing treatment, which would help further analyze its mechanism.