METHODS OF TREATMENT OF LEGG-СALVÉ-PERTHES DISEASE (REVIEW).

This Literature Review presents various treatments, including operative and conservative therapies, of Legg - Calvé - Perthes Disease. The problem is relevant because of the prevalence of the disease. The authors presented a review of literature, which managed to classify the main methods of treatment by the principles of action, practical application, and presented the interpretation of the effectiveness of modern research from the point of view of evidence-based medicine.

TRANS-ILIAC DYNAMIC NAIL FOR MINIMALLY INVASIVE FIXATION OF THE POSTERIOR PELVIC RING INJURY: A BIOMECHANICAL STUDY.

The treatment of posterior pelvic ring fracture with the early mobilization purpose is surgery, which traditionally uses screws and sacral bar. We have created a new trans-iliac dynamic nail (TIDN) for fixation of the posterior pelvic ring. The advantage of TIDN is minimally invasion due to combination of interlocking nailing with the possibility of compression and decompression. Exam the biomechanical properties of a new trans-iliac dynamic nail (TIDN). The current biomechanical study investigated: dynamic tensile and compression tests; static torsional, compression, tensile tests. The study yielded equivalent results for the static torsional test and in dynamic tests, but found the TIDN superior in the static compression test and static tensile test in comparison with other researchers. Based upon the results of this biomechanical study, we conclude that the TIDN proved to be an effective device for posterior pelvic ring injury fixation. The clinical trial should be next.

CLINICAL AND PHARMACEUTICAL ASPECTS OF THE USE OF ANTITHROMBOTIC DRUGS IN PATIENTS SUFFERING FROM ISCHEMIC HEART DISEASE (REVIEW).

The review article discusses the possibilities and evidence base of the use of antithrombotic drugs in common clinical practice. Presents information about the basic clinical trials of the effectiveness of antithrombotic medications (CAPRIE, CURE, VA, RISC, ISIS2, PLATO) in the treatment and secondary prevention of the consequences of atherothrombosis. Also presents the algorithms for prescription of antithrombotic drugs and the principles of rational use of antiplatelet agents.

OPTIMUM APPLICATION OF MODERN ANTITHROMBOTIC DRUGS AMONG PATIENTS WITH THE ACUTE CORONARY SYNDROME WITH THE RISK OF STRICTURE FORMATION OF CORONARY ARTERIES.

The purpose of the research is to give the effectiveness and safety of ticagrelor in combination with acetylsalicylic acid as preoperative treatment of primary stenting in patients with ACS. We have investigated 42 patients with ACS, 3 of which were diagnosed with cardiogenic shock, age from 38 to 82 years (63 ± 6.5 years). The ACS diagnosis was verified using the results of the ECG, a troponin test and x-ray contrast coronary angiography. The purpose of preoperative antiplatelet treatment prior to primary PCI ticagrelor was administered in the dose of 180 mg and aspirin at a dose of 200 mg. Emergency coronary angiography and primary PCI was performed 15-90 minutes from the time of diagnosis. TIMI III flow in the infarct-related coronary arteries was achieved in all patients. None of the patients the phenomenon of "No-Reflow" has not developed. The appointment of the antiplatelet drug ticagrelor before primary PCI contributes to the achievement of full blood flow restoration in the infarct-related coronary artery, and also reduces the risk of intraoperative and postoperative complications.