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Eur Ann Otorhinolaryngol Head Neck Dis ; 139(6): 327-331, 2022 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-35688677

RESUMEN

OBJECTIVES: The main objective of this study was to compare the wound infiltration (peritonsillar fossa) of magnesium sulphate combined with bupivacaine, bupivacaine alone and saline solution on post-tonsillectomy pain in children. The accessory objectives were to evaluate the effect of magnesium sulphate infiltration on prevention of laryngospasm and occurrence of nausea/vomiting. METHODS: This study is a prospective; double blinded and randomized clinical trial. Seventy-five children undergoing tonsillectomy were enrolled. Patients were randomized into three groups using closed envelop technique. Group 1 (N=24) received saline solution (NaCl), group 2 (N=25) received 0.25% bupivacaine (1mg/kg) and group 3 received magnesium sulphate (5mg/kg) and 0.25% bupivacaine (1mg/kg) after tonsillectomy using three-point technique. Pain was evaluated using mCHEOPS scale. The occurrence of laryngospasm, nausea and vomiting was monitored. RESULTS: The mCHEOPS scores of the group 3 were significantly lower than those of the group 2 and 1 (P<0.001). Time to first analgesic administration was longer for the group 3 than for the groups 2 and 1 (P<0.001). The mean consumption of additional analgesic drugs was lower for the group 3 than the other groups (P<0.001). There were no episodes of laryngospasm in the group 3 in comparison with the other groups. The difference of the incidence of nausea and vomiting was not statistically significant (P=0.628). CONCLUSION: The adjunction of magnesium sulphate to bupivacaine proved to provide more efficient pain control than bupivacaine alone. However, the small number of participants and the absence of sampling at the P level of 0.005 do not allow to conclude with absolute certainty.


Asunto(s)
Analgésicos , Bupivacaína , Sulfato de Magnesio , Tonsilectomía , Niño , Humanos , Analgésicos/uso terapéutico , Anestésicos Locales/uso terapéutico , Bupivacaína/uso terapéutico , Método Doble Ciego , Laringismo/complicaciones , Laringismo/tratamiento farmacológico , Sulfato de Magnesio/uso terapéutico , Náusea/complicaciones , Náusea/tratamiento farmacológico , Dimensión del Dolor/efectos adversos , Dimensión del Dolor/métodos , Dolor Postoperatorio/tratamiento farmacológico , Dolor Postoperatorio/prevención & control , Dolor Postoperatorio/etiología , Estudios Prospectivos , Solución Salina/uso terapéutico , Tonsilectomía/efectos adversos , Tonsilectomía/métodos
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