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1.
Nat Prod Res ; 35(22): 4715-4719, 2021 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-31916461

RESUMEN

Palicourea species has been used in folk medicine in the treatment of some diseases including cancer and inflammatory disorders. This work aimed to evaluate the in vitro antiproliferative and in vivo topical anti-inflammatory activities of the methanolic extract, fractions and two major alkaloids isolated from Palicourea minutiflora. Methanolic extract, non-alkaloidal and alkaloidal fractions exhibited strong growth inhibition for ovarian cell lines (OVCAR-3, GI50 = 3.8 at 16.3 µg mL-1) and the vincosamide alkaloid revealed selective effect on the growth of glioma cell lines (U251, GI50 = 33.0 µg mL-1) compared with doxorubicin (DOX, GI50 = 0.42 and 0.025 µg mL-1, respectively) anticancer drug. Methanolic extract, fractions and strictosidinic acid showed significant inhibitory effect with 62.7% at 77.5% (p < 0.05) to ear edema induced by croton oil and 81% at 100% (p < 0.05) to myeloperoxidase assay compared with indomethacin (positive control) 68.4% and 91.3% (p < 0.05), respectively.


Asunto(s)
Alcaloides , Neoplasias Ováricas , Rubiaceae , Alcaloides/farmacología , Antiinflamatorios/farmacología , Antiinflamatorios/uso terapéutico , Apoptosis , Línea Celular Tumoral , Edema/inducido químicamente , Edema/tratamiento farmacológico , Humanos , Extractos Vegetales/farmacología , Extractos Vegetales/uso terapéutico
2.
Nat Prod Res ; 32(11): 1357-1360, 2018 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-28641452

RESUMEN

The crude extract and fractions from the branches of Ixora brevifolia, a tree found in the Brazilian Cerrado, were tested for anti-inflammatory and in vitro antiproliferative effects. The crude extract and n-hexane fraction exhibited significant inhibition of ear oedema in mice, while n-hexane-precipitated and chloroform fractions strongly inhibited the myeloperoxidase activity in ear tissue. The n-hexane and n-hexane-precipitated fractions showed strong growth inhibition for glioma cell line and the hydromethanolic fraction inhibited the growth of leukaemia cell line.


Asunto(s)
Antiinflamatorios/farmacología , Antineoplásicos Fitogénicos/farmacología , Extractos Vegetales/farmacología , Rubiaceae/química , Animales , Antineoplásicos Fitogénicos/química , Brasil , Línea Celular Tumoral , Cloroformo/química , Ensayos de Selección de Medicamentos Antitumorales , Edema/tratamiento farmacológico , Glioma/tratamiento farmacológico , Glioma/patología , Células Hep G2 , Hexanos/química , Humanos , Ratones , Peroxidasa/metabolismo , Extractos Vegetales/química
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