AI-Powered Identification of Osteoporosis in Dental Panoramic Radiographs: Addressing Methodological Flaws in Current Research.

Background: Osteoporosis, a systemic skeletal disorder, is expected to affect 60% of women over 50. While dual-energy X-ray absorptiometry (DXA) scans are the current gold standard for diagnosis, they are typically used only after fractures occur, highlighting the need for early detection tools. Initial studies have shown panoramic radiographs (PRs) to be a potential medium, but these have methodological flaws. This study aims to address these shortcomings by developing a robust AI application for accurate osteoporosis identification in PRs. Methods: A total of 348 PRs were used for development, 58 PRs for validation, and 51 PRs for hold-out testing. Initially, the YOLOv8 object detection model was employed to predict the regions of interest. Subsequently, the predicted regions of interest were extracted from the PRs and processed by the EfficientNet classification model. Results: The model for osteoporosis detection on a PR achieved an overall sensitivity of 0.83 and an F1-score of 0.53. The area under the curve (AUC) was 0.76. The lowest detection sensitivity was for the cropped angulus region (0.66), while the highest sensitivity was for the cropped mental foramen region (0.80). Conclusion: This research presents a proof-of-concept algorithm showing the potential of deep learning to identify osteoporosis in dental radiographs. Furthermore, our thorough evaluation of existing algorithms revealed that many optimistic outcomes lack credibility when subjected to rigorous methodological scrutiny.

Enhanced Osteoporosis Detection Using Artificial Intelligence: A Deep Learning Approach to Panoramic Radiographs with an Emphasis on the Mental Foramen.

Osteoporosis, a skeletal disorder, is expected to affect 60% of women aged over 50 years. Dual-energy X-ray absorptiometry (DXA) scans, the current gold standard, are typically used post-fracture, highlighting the need for early detection tools. Panoramic radiographs (PRs), common in annual dental evaluations, have been explored for osteoporosis detection using deep learning, but methodological flaws have cast doubt on otherwise optimistic results. This study aims to develop a robust artificial intelligence (AI) application for accurate osteoporosis identification in PRs, contributing to early and reliable diagnostics. A total of 250 PRs from three groups (A: osteoporosis group, B: non-osteoporosis group matching A in age and gender, C: non-osteoporosis group differing from A in age and gender) were cropped to the mental foramen region. A pretrained convolutional neural network (CNN) classifier was used for training, testing, and validation with a random split of the dataset into subsets (A vs. B, A vs. C). Detection accuracy and area under the curve (AUC) were calculated. The method achieved an F1 score of 0.74 and an AUC of 0.8401 (A vs. B). For young patients (A vs. C), it performed with 98% accuracy and an AUC of 0.9812. This study presents a proof-of-concept algorithm, demonstrating the potential of deep learning to identify osteoporosis in dental radiographs. It also highlights the importance of methodological rigor, as not all optimistic results are credible.

AI-Assisted Diagnostics in Dentistry: An Eye-Tracking Study on User Behavior.

Background: Artificial Intelligence (AI) has increasingly been integrated into dental practices, notably in radiographic imaging like Orthopantomograms (OPGs), transforming diagnostic protocols. Eye tracking technology offers a method to understand how dentists' visual attention may differ between conventional and AI-assisted diagnostics, but its integration into daily clinical practice is challenged by the cost and complexity of traditional systems. Material and Methods: Thirty experienced practitioners and dental students participated to evaluate the effectiveness of two low-budget eye-tracking systems, including the Peye Tracker (Eye Tracking Systems LTD, Southsea, UK) and Webgazer.js (Brown University, Providence, Rhode Island) in a clinical setting to assess their utility in capturing dentists' visual engagement with OPGs. The hardware and software setup, environmental conditions, and the process for eye-tracking data collection and analysis are illustrated. Results: The study found significant differences in eye-tracking accuracy between the two systems, with Webgazer.js showing higher accuracy compared to Peye Tracker (p<0.001). Additionally, the influence of visual aids (glasses vs. contact lenses) on the performance of eye-tracking systems revealed significant differences for both Peye Tracker (p<0.05) and Webgazer.js (p<0.05). Conclusions: Low-budget eye-tracking devices present challenges in achieving the desired accuracy for analyzing dentists' visual attention in clinical practice, highlighting the need for continued innovation and improvement in this technology. Key words:Artificial intelligence, Eye-tracking device, low-budget, dentistry.

3D-Printed Temporary Wing Bride as a Temporary Restoration in the Posterior.

The fear of a missing tooth often leads to postponing the visit at the dentist. While extraction itself is a major stressful experience for the patient, the presence of visible gaps or missing teeth inside or outside the aesthetic zone is a deal breaker for a lot of patients. Bridging the time spent until inserting any final restoration with a provisional enables the patients to still take part in everyday life. This case report shows a new approach for a fixed dental provisional in the anterior region using a printed wing bridge approach to replace an extracted tooth. The provisional was prefabricated, and extraction and integration of the provisional could be placed in a single visit. The chosen approach shows the integrability of 3D printing in everyday practice providing immediate economical and aesthetic treatment.

TESTING OF ZIRCONIA FPD FRAMEWORKS FOR FIXED PROSTHESES: MODEL DESIGN AND EVALUATION OF FRACTURE LOAD.

In our previous test model, the abutment teeth and the model base were printed with resin and bonded with a polyether material. Some abutment teeth were fractured during the mechanical load test. Therefore, the aim was to develop and evaluate a new model under mechanical loading until fracture with zirconia FPD frameworks. At a fracture load of up to 1,636 N, neither the artificial abutment teeth nor the base model fractured. Furthermore, the artificial abutment teeth did not detach from the base model. Therefore, the model should be suitable for mechanical testing of most ceramic-based framework materials for three-unit FPDs.

Removal of broken abutment screws using ultrasonic tip - a heat development in-vitro study.

BACKGROUND: Dental implants can cause complications, including the loosening of the abutment screw or fracture. However, there is no standardized technique for removing broken abutment screws. This necessitates further research. OBJECTIVE: This study aimed to measure heat generation during screw removal to better understand its implications for dental implant procedures. MATERIAL AND METHODS: The experimental setup involved using synthetic bone blocks and titanium implants. An ultrasonically operated instrument tip was utilized for screw removal. Infrared thermometry was employed for accurate temperature measurement, considering factors such as emissivity and distance. Statistical analysis using linear regression and ANOVA was conducted. RESULTS: The findings revealed an initial rapid temperature increase during the removal process, followed by a gradual decrease. The regression model demonstrated a strong correlation between time and temperature, indicating the heat generation pattern. CONCLUSION: Heat generation during screw removal poses risks such as tissue damage and integration issues. Clinicians should minimize heat risks through an intermittent approach. The lack of a standardized technique requires further research and caution. Understanding the generated heat optimizes implant procedures.

Comparison of temperature changes in different irrigation methods used in guided piezosurgery: in vitro study.

PURPOSE: The study aimed to investigate the cooling performance of three different surgical methods for bone splitting during implant dentistry procedures. METHODS: An in vitro study was conducted on bovine ribs to test the cooling performance of three osteotomy methods: conventional osteotomy with standard cooling irrigation, template-assisted osteotomy with standard cooling irrigation, and modified template-assisted osteotomy with additional cooling fluid through internal irrigation channels in the surgical guide. A negative control group without cooling was also included. Temperature measurements were taken during the procedures using a contactless infrared thermometer. RESULTS: The results showed that the conventional osteotomy without cooling resulted in the highest mean of the peak temperatures (114.7 °C ± 45.4), while the modified template-assisted osteotomy with additional cooling achieved the lowest mean of the peak temperatures (29.4 °C ± 7). Statistically significant differences in temperature were observed among the groups (p < 0.001). CONCLUSION: The study rejected the null hypothesis and demonstrated that the cooling method used during bone splitting procedures significantly affected the temperature development at the surgical site. The modified template-assisted osteotomy with additional cooling provided the best cooling performance. However, caution should be exercised in interpreting the results due to the limitations of the in vitro study. Further research with stronger external validity is needed to confirm these findings and explore their applicability in clinical settings to benefit patients.

The fracture resistance of 3D-printed versus milled provisional crowns: An in vitro study.

BACKGROUND: CAD/CAM has considerably transformed the clinical practice of dentistry. In particular, advanced dental materials produced via digital technologies offer unquestionable benefits, such as ideal mechanical stability, outstanding aesthetics and reliable high precision. Additive manufacturing (AM) technology has promoted new innovations, especially in the field of biomedicine. AIMS: The aim of this study is to analyze the fracture resistance of implant-supported 3D-printed temporary crowns relative to milled crowns by compression testing. METHODS: The study sample included 32 specimens of temporary crowns, which were divided into 16 specimens per group. Each group consisted of eight maxillary central incisor crowns (tooth 11) and eight maxillary molar crowns (tooth 16). The first group (16 specimens) was 3D printed by a mask printer (Varseo, BEGO, Bremen, Germany) with a temporary material (VarseoSmile Temp A3, BEGO, Bremen, Germany). The second group was milled with a millable temporary material (VitaCAD Temp mono-color, Vita, Bad Säckingen, Germany). The two groups were compression tested until failure to estimate their fracture resistance. The loading forces and travel distance until failure were measured. The statistical analysis was performed using SPSS Version 24.0. We performed multiple t tests and considered a significance level of p <0.05. RESULTS: The mean fracture force of the printed molars was 1189.50 N (±250.85) with a deformation of 1.75 mm (±0.25). The milled molars reached a mean fracture force of 1817.50 N (±258.22) with a deformation of 1.750 mm (±0.20). The printed incisors fractured at 321.63 N (±145.90) with a deformation of 1.94 mm (±0.40), while the milled incisors fractured at 443.38 N (±113.63) with a deformation of 2.26 mm (±0.40). The milled molar group revealed significantly higher mechanical fracture strength than the 3D-printed molar group (P<0.001). However, no significant differences between the 3D-printed incisors and the milled incisors were found (p = 0.084). There was no significant difference in the travel distance until fracture for both the molar group (p = 1.000) and the incisor group (p = 0.129). CONCLUSION: Within the limits of this in vitro investigation, printed and milled temporary crowns withstood masticatory forces and were safe for clinical use.

Augmented reality in orthodontics for bracket placement using conventional mobile devices: Technical note.

BACKGROUND: Improving bracket placement accuracy through computer-aided design and a bracket navigation set supported by augmented reality (AR). METHODS: A technical workflow was developed for implementing AR-assisted orthodontic bracket positioning through a smartphone application. This innovative approach eliminates the need for three-dimensional radiation imaging or physical guides, making it a safe and convenient option for clinical use by overlapping the digitally planned bracket position over the patient clinical crown for a precise recommendation of bracket positioning. RESULTS: It was found that it is achievable and can be easily recognized from all view angles, and this proves that new techniques with new opportunities could be considered. CONCLUSIONS: AR smartphone applications can potentially be used for the accurate placement of dental brackets; thus, such applications show promise for use in the field of orthodontics.

Influence of Multiple Used Implant Drills on Their Cutting Performance and Fracture Resistance.

This study aimed to analyze the influence of multiple uses of zirconia implant drills on their cutting performance and bending strength. The hypothesis was that drill usage and sterilization cycles would not affect drilling time or flexural strength. Sixty zirconia twist drills from Z-Systems were used to drill in the angulus mandibulae region of fresh porcine jaws. The drills were divided into four groups based on the cycle count, and the drilling time was measured. Bending strength tests were conducted using a universal testing machine, and statistical analysis was performed using ANOVA tests. The results showed that drilling times followed a normal distribution, and significant differences were observed in drilling times between group 1 and the other groups for the pilot drill. However, no significant differences were found for ø3.75 mm and ø4.25 mm drills, and drilling times also varied significantly among different drill diameters, regardless of the cycle count. Flexural strength did not significantly differ among drill diameters or sterilization cycles. Overall, using and sterilizing zirconia implant drills had no significant impact on drilling time or flexural strength. Nevertheless, drilling times did vary depending on the diameter of the drill. These findings provide valuable insights into the performance and durability of zirconia implant drills, contributing to the optimization of dental implant procedures.

F-quad helix for simultaneous maxillary expansion and tooth alignment in patients with unilateral cleft lip and/or palate.

Illustrating F-quad helix with extension arms that simultaneously expand maxillary arch and rotate its central incisor adjacent to the alveolar cleft while aligning palatally ectopic canines. Incisor rotation occurred before alveolar grafting, while canine traction was performed after alveolar grafting. The construction of this appliance is shown in detail.

Fracture strength test of digitally produced ceramic-filled and unfilled dental resin restorations via 3d printing: An in vitro study.

Background: Purpose of this study was to investigate the mechanical efficiency of 3D-printed permanent and provisional implant cemented fixed bridges produced via CAD/CAM technology using an interim and a permanent ceramic filled hybrid material. Material and Methods: Two groups with twenty specimens each were designed and 3D-printed via digital light processing technology (DLP). A fracture strength test was performed. Statistical analysis was performed (p>0.05) for impression distance and force. Results: For the fracture resistance and impression distance no significant difference (p = 0.643) were detected. The specimens of interim resin showed a mean value of 365.90 ± 86.67 N. Whereas specimens of permanent ceramic filled hybrid material showed a mean value of 363.45 ± 87.57 N. Conclusions: In this in vitro study 3D-printed ceramic filled hybrid material and interim resin based on methacrylic acid esters showed an acceptable resistance to bite forces with no differences in fracture mechanism. Key words:CAD-CAM, dental resin, 3D printing.

AFM Analysis of a Three-Point Flexure Tested, 3D Printing Definitive Restoration Material for Dentistry.

BACKGROUND: Three-dimensional printing is a rapidly developing technology across all industries. In medicine recent developments include 3D bioprinting, personalized medication and custom prosthetics and implants. To ensure safety and long-term usability in a clinical setting, it is essential to understand material specific properties. This study aims to analyze possible surface changes of a commercially available and approved DLP 3D printed definitive restoration material for dentistry after three-point flexure testing. Furthermore, this study explores whether Atomic Force Microscopy (AFM) is a feasible method for examination of 3D printed dental materials in general. This is a pilot study, as there are currently no studies that analyze 3D printed dental materials using an AFM. METHODS: The present study consisted of a pretest followed by the main test. The resulting break force of the preliminary test was used to determine the force used in the main test. The main test consisted of atomic force microscopy (AFM) surface analysis of the test specimen followed by a three-point flexure procedure. After bending, the same specimen was analyzed with the AFM again, to observe possible surface changes. RESULTS: The mean root mean square (RMS) roughness of the segments with the most stress was 20.27 nm (±5.16) before bending, while it was 26.48 nm (±6.67) afterward. The corresponding mean roughness (Ra) values were 16.05 nm (±4.25) and 21.19 nm (±5.71) Conclusions: Under three-point flexure testing, the surface roughness increased significantly. The p-value for RMS roughness was p = 0.003, while it was p = 0.006 for Ra. Furthermore, this study showed that AFM surface analysis is a suitable procedure to investigate surface changes in 3D printed dental materials.

Comparing Original and Universal Screwdrivers and How They Affect Friction in the Screw.

The present study focused on investigating whether universal screwdriver kits cause less friction between the screwdriver and the abutment screw than original screwdrivers. For this purpose, 2 original screwdrivers (Straumann and BEGO) and a universal screwdriver kit (bredent) were investigated. On 1 implant per screwdriver, 26 abutments were properly attached one after the other with the corresponding abutment screws. After tightening the abutment screw, the force required to pull the screwdriver off the screw head was determined with a spring balance. For both manufacturers, greater pull-off forces were measured when using the original screwdrivers than when using the universal screwdriver. The pull-off force (mean ± SD) required for the Straumann original screwdriver was 3.7 ± 1.4 N, while that required for the universal screwdriver was 0.1 ± 0.1 N (P < .001). The pull-off force was 1.5 ± 1.5 N for the BEGO original screwdriver and 0.7 ± 0.9 N for the universal screwdriver (P = .19). Using original manufacturer-supplied screwdrivers could thus minimize the risk of the screwdriver slipping out of the screw head during dental treatment and being swallowed or aspirated by the patient.

Tunnel Fenestration of the Mandibula after Unsuccessful Post Traumatic Treatment: A Case Report of the One Year Follow-Up.

Particularly severe cases with tunneled defects are rarely reported and are described only in a few case reports. This case report describes the treatment of a tunnel fenestration in the lower central jaw after unsuccessful endodontic treatment following trauma of incisors 31 and 41 over the course of six years, which led to the development of an internal granuloma and a radicular cyst in the lower jaw. The patient presented with a 2.67 cm3 radicular cyst displacing the surrounding tissue at regio 31 and 41, which resulted in a tunnel-like bony defect. Endodontic treatment and periapical root tip resection on teeth 31 and 41 with cystectomy, and with a 12 month follow-up, were successful in the healing of the bone defect. The preserved teeth received lithium disilicate crowns for definite restoration one year postoperatively. This treatment can be an option for the therapy of large cysts.

Artificial intelligence system for training diagnosis and differentiation with molar incisor hypomineralization (MIH) and similar pathologies.

OBJECTIVES: Molar incisor hypomineralization (MIH) is a difficult-to-diagnose developmental disorder of the teeth, mainly in children and adolescents. Due to the young age of the patients, problems typically occur with the diagnosis of MIH. The aim of the present technical note was to investigate whether a successful application of a neural network for diagnosis of MIH and other different pathologies in dentistry is still feasible. MATERIALS AND METHODS: For this study, clinical pictures of four different pathologies were collected (n = 462). These pictures were categorized in caries (n = 118), MIH (n = 115), amelogenesis imperfecta (n = 112) and dental fluorosis (n = 117). The pictures were anonymized and a specialized dentist taking into account all clinical data did the diagnosis. Then, well-investigated picture classifier neural networks were selected. All of these were convolutional neural networks (ResNet34, ResNet50, AlexNet, VGG16 and DenseNet121). The neural networks were pre-trained and transfer learning was performed on the given datasets. RESULTS: For the vgg16 network, the precision is the lowest with 83.98% as for the dense121 it shows the highest values with 92.86%. Comparing the different pathologies between the investigated neural networks, there is no trend detectable. CONCLUSION: In the long term, an implementation of artificial intelligence for the detection of specific dental pathologies is conceivable and sensible. CLINICAL RELEVANCE: Finally, this application can be integrated in the area of training and teaching in order to teach dental students as well as general practitioners for MIH and similar dental pathologies.

Comparative mechanical testing for different orthodontic aligner materials over time - in vitro study.

Background: The purpose of the present study is to mechanically evaluate and compare the forces over 12 hours on different orthodontic aligners manufactured by Polyethylene terephthalate glycol (PETG). Material and Methods: Twelve orthodontic aligner specimens will be produced by a thermoforming laboratory vacuum machine. All specimens will be divided into two equal groups, group A representing Duran (Scheu Dental GmbH, Iserlohn, Germany) and group B representing Erkodur (Erkodent, Pfalzgrafenweiler, Germany). These specimens will be fabricated via CAD/CAM technology by scanning a Frasaco model (Henry Schein Dental, Gallin, Germany) using D 800 (3Shape, Copenhagen, Denmark) and printed via a Varseo S machine using Varseo ModelWax material (BEGO, Bremen, Germany). Group A specimens are manufactured by a Twinster thermoforming machine (Scheu Dental GmbH, Iserlohn, Germany) while group B is produced using Erkoform thermoforming machine (Erkodent, Pfalzgrafenweiler, Germany). Afterwards, a tooth will be removed from the printed model and replaced by an ivory tooth (Henry Schein Dental, Gallin, Germany) to apply forces at a predicted measured centre of resistance. The universal testing machine Z010 (ZwickRoell, Ulm, Germany) will be used for mechanical testing with 0.3 mm displacement over 12 hours. Statistical analysis was performed using Sigmaplot 13.0 (Systat Software GmbH, Erkrath, Germany). Behaviours over time were analysed using R2-regression analysis (SPSS 26.0, IBM SPSS Statistics, Armonk, USA). Results: There is no statistically significant difference in the maximum force between both groups (p=0.071). The mechanical testing over 12 hours showed cubic properties. Conclusions: The PETG material has no influence on the produced mechanical forces regardless of the manufacturing company. The forces over time showed no tendency towards a lower boundary of force. Key words:Mechanical testing, CAD/CAM, orthodontics, thermoplastic aligner materials.

Implant Placement in the Esthetic Zone: More Efficiency in Guided Surgery.

The aim of this case report is to describe the combination of a surgical guide with a temporary restoration to streamline the implant process. A 54-year-old male patient presenting with partial edentulism underwent computer-aided template-guided implant placement for the replacement of the missing upper second right incisor. The presented technique was used during the surgical procedures; it introduced the integration of a surgical guide into the temporary fixed partial denture. Using computer-aided design, computer-aided manufacturing technology and virtual implant planning, a temporary-implantation fixed partial denture was constructed, and a guidance sleeve was implemented into it. The implant bed preparation was then performed using the bridge as a surgical guide. After osteotomy, the guidance sleeve within the bridge was sealed, and the bridge was temporarily incorporated for submerged healing of the implant. The use of a temporary restoration as a surgical guide seems to make the digital workflow of guided implant placement more efficient by achieving a representative clinical outcome.

Mechanical evaluation for three-dimensional printed orthodontic springs with different heights-in vitro study.

BACKGROUND: The orthodontic spring materials in use have a significant influence on the applied forces. The prerequisite to identify the in vitro< force deflection of the CAD/CAM fabricated springs is considered mandatory to identify the material characteristics. The purpose of the present investigation was to evaluate the mechanical load on 3D printed springs using different coil heights. MATERIAL AND METHODS: The springs were digitally designed with different coil heights using Autodesk Netfabb CAD software (San Rafael, CA, USA). Test specimens were manufactured using 3D printable experimental flexible material (Code: BM2008, GC, Tokyo, Japan). The specimens were divided according to the coil height into five groups, group A (n=4mm), group B (n=6mm), group C (n=8mm), group D (n=10mm) and group E (n=12mm). All group specimens were mechanically tested using a universal testing machine. Statistical analysis was performed using K-S-Test to compare the values of each to the control group (p< 0.001). RESULTS: The highest value in all groups was achieved by 5.43 N/mm in group A, while the lowest value was achieved by 0.11 N/mm in group E. CONCLUSIONS: 3D printed springs are mechanically affected by the coil heights and there is a direct correlation to the resulting force. Furthermore, the variations within the investigated groups must be thoroughly investigated prior to clinical application. Key words:CAD/CAM, 3D printing, Orthodontics, mechanical testing, material evaluation.

Pull-off resistance of a screwless implant-abutment connection and surface evaluation after cyclic loading.

PURPOSE: The aim of this study was to investigate to what extent cyclic load affects the screwless implant-abutment connection for Morse taper dental implants. MATERIALS AND METHODS: 16 implants (SICvantage max) and 16 abutments (Swiss Cross) were used. The screwless implant-abutment connection was subjected to 10,000 cycles of axial loading with a maximum force of 120 N. For the pull-off testing, before and after the same cyclic loading, the required force for disconnecting the remaining 6 implant-abutment connections was measured. The surface of 10 abutments was examined using a scanning electron microscope 120× before and after loading. RESULTS: The pull-off test showed a significant decrease in the vertical force required to pull the abutment from the implant with mean 229.39 N ± 18.23 before loading, and 204.30 N ± 13.51 after loading (P<.01). Apart from the appearance of polished surface areas and slight signs of wear, no visible damages were found on the abutments. CONCLUSION: The deformation on the polished abutment surface might represent the result of micro movements within the implant-abutment connection during loading. Although there was a decrease of the pull-off force values after cyclic loading, this might not have a notable effect on the clinical performance.