Efficacy of ultrasound-guided cryoablation in treating low-risk breast cancer.

OBJECTIVES: The primary objective of this study to determine whether infiltrating carcinoma is present in surgical specimens obtained after ultrasound-guided cryoablation from patients with HER2-negative luminal breast cancer without positive axillary lymph nodes at ultrasound. The secondary objective is to demonstrate that placing the presurgical seed-marker immediately before cryoablation does not interfere with the disappearance of tumor cells from freezing or in the surgeon's ability to locate the tumor. METHODS: We treated 20 patients diagnosed with unifocal HR-positive HER2-negative infiltrating ductal carcinoma measuring <2cm by means of ultrasound-guided cryoablation (ICEfx Galil, Boston Scientific) using a triple-phase (freezing‒passive thawing‒freezing; 10min each phase) protocol. All patients later underwent tumorectomy according to the routine operating-room agenda. RESULTS: No infiltrating carcinoma cells were detected in the post-cryoablation surgical specimen in 19 patients; a focus of infiltrating carcinoma cells measuring <1mm was detected in the remaining patient. CONCLUSION: In the near future, if confirmed in larger studies with longer follow-up, cryoablation might constitute a safe and efficacious technique for the treatment of early, low-risk infiltrating ductal carcinoma. In our series, marking with ferromagnetic seeds did not interfere with the efficacy of the procedure or of the subsequent surgical intervention.

Correlación ecográfica, mamográfica e histopatológica en el diagnóstico de cáncer de mama en Guantánamo, 2010-2015

RESUMEN Introducción: El cáncer de mama se conoce desde épocas remotas, el tumor de mama es la neoplasia maligna más importante en la mujer. Se considera la primera causa de muerte por cáncer en las mujeres en el mundo. Objetivo: Evaluar la correlación ecográfica, mamográfica e histopatológica del carcinoma de mama en la provincia de Guantánamo. Método: Se realizó un estudio observacional, descriptivo, retrospectivo en 140 pacientes durante el período de 2010 a 2015 en el Hospital General Docente "Dr. Agostinho Neto" de Guantánamo. El dato primario se obtuvo del Registro Provincial de Cáncer con diagnóstico de tumor maligno de mama. Resultados: La mayor incidencia de la enfermedad se registró a partir de los 45 años (80 %), el promedio de edad del diagnóstico fue de 57 más menos 15 años. La mama izquierda tuvo una mayor frecuencia a verse afectada con respecto a la mama la derecha (53 % vs. 46 %), fue poco frecuente que ambas mamas se encontrasen afectadas de forma sincrónica (menos del 1 %). El 53 % presentó una lesión de aspecto espiculado en la mamografía, de aspecto sólido en la ecografía y correspondiente a un carcinoma ductal infiltrante por histología. Conclusiones: Existe correlación entre los diagnósticos ecográficos, mamográficos y el diagnóstico definitivo histopatológico del cáncer de mama.

ABSTRACT Introduction: Since ancient times, breast cancer has been studied. It is current the most important invasive neoplasm in women and considered the leading cause of cancer deaths in women worldwide. Objective: To assess the ultrasound, mammographic and histopathological correlation for the diagnosis of breast cancer in Guantanamo province. Method: An observational, descriptive, and retrospective study was conducted in 140 patients during the period 2010-2015 at the Hospital General Docente "Dr. Agostinho Neto" in Guantánamo. The primary information was obtained from the Provincial Registry Database of Cancer with the diagnosis of malignant breast tumor. Results: The highest incidence of the disease was recorded in patients 45 plus years of age (80%), the average age at diagnosis was 57 ± 15 years. The left breast was more frequently affected than the right breast (53% vs. 46%), it was not common for both breasts be affected synchronously (less than 1%). The 53% of patients presented a lesion with a speculated appearance on mammography, solid appearance on ultrasound. This lesion, as per histology criteria, it corresponded to an infiltrating ductal carcinoma. Conclusions: There is a correlation between ultrasound, mammographic diagnoses and the breast cancer related definitive histopathological diagnosis.

RESUMO Introdução: O câncer de mama é conhecido desde a antiguidade, sendo o tumor de mama a neoplasia maligna mais importante na mulher. É considerada a principal causa de morte por câncer em mulheres no mundo. Objetivo: Avaliar a correlação ecográfica, mamográfica e histopatológica do carcinoma de mama na província de Guantánamo. Método: Estudo observacional, descritivo, retrospectivo, realizado em 140 pacientes durante o período de 2010 a 2015 no Hospital General Docente "Dr. Agostinho Neto" de Guantánamo. Os dados primários foram obtidos do Registro Provincial de Câncer com diagnóstico de tumor maligno de mama. Resultados: A maior incidência da doença foi registrada após 45 anos (80%), a média de idade do diagnóstico foi de 57 anos mais ou menos 15 anos. A mama esquerda teve maior frequência de acometimento em relação à mama direita (53% vs. 46%), sendo raro que ambas as mamas fossem acometidas de forma síncrona (menos de 1%). 53% apresentavam lesão com aspecto espiculado na mamografia, aspecto sólido na ultrassonografia e correspondendo a carcinoma ductal infiltrante pela histologia. Conclusões: Existe correlação entre os diagnósticos ultrassonográfico e mamográfico e o diagnóstico histopatológico definitivo de câncer de mama.

El infiltrado tumoral del carcinoma ductal infiltrante en Holguín, Cuba / Ductal infiltrating carcinoma´s inflammatory tumor infiltrates in Holguín, Cuba

Introducción: el carcinoma ductal infiltrante es la neoplasia maligna mamaria más frecuente. Entre sus características anatomopatológicas se presenta el grado histológico de malignidad, como su factor pronóstico. Existen otras alteraciones histopatológicas, como la presencia e intensidad del infiltrado inflamatorio intratumoral y peritumoral, sobre lo cual es necesario profundizar. Objetivos: determinar la intensidad del infiltrado inflamatorio intraperitumoral y peritumoral, e identificar su relación con el grado histológico de malignidad. Métodos: el estudio de una serie de casos de 392 biopsias, diagnosticadas con carcinoma ductal infiltrante de mama, en el Departamento de Anatomía Patológica del Hospital Lenin, de Holguín, Cuba, desde el año 2011 al 2015. Se determinó la presencia e intensidad del infiltrado inflamatorio intratumoral y peritumoral, y su grado histológico de malignidad. Resultados: se logró diferenciar el 68,1% de los tumores de mama. Predominaron los infiltrados inflamatorios intratumoral y peritumoral ligeros, con 44,9% y 55,4% respectivamente. El 84,6% de los tumores bien diferenciados, mostraron un infiltrado inflamatorio intratumoral ligero. En el 47,2% de los tumores moderadamente diferenciados, y en el 41,7% de los tumores poco diferenciados, con un infiltrado inflamatorio severo; se realizaron infiltrados moderados. En los tumores bien diferenciados se observó un predominio del infiltrado inflamatorio peritumoral ligero, de hasta el 92,3%; mientras que el 48,3% de los tumores con poca diferenciación, mostraron una correlación positiva con el infiltrado inflamatorio severo. Conclusiones: en el infiltrado inflamatorio intratumoral y peritumoral, predominó la intensidad ligera, y apareció un factor pronóstico potencial: la correlación entre la intensidad del infiltrado inflamatorio y el grado histológico de malignidad.

Introduction: among most frequent malignant breast tumors, ductal carcinoma has prevailed. Its malignancy histological level has become the prognosis factor. However, histopathological abnormalities like intra and peritumoral inflammatory infiltrates intensity, still require serious studies. Objectives: to determine intra and peritumoral inflammatory infiltrates intensity, and to identify their relation to malignancy histological levels. Methods: a case series study with 392 infiltrating ductal carcinoma diagnosed biopsies, at Lenin Hospital Pathological Anatomy Department, from 2011 to 2015; in which presence and intensity of intratumoral, and peritumoral inflammatory infiltrates, and malignancy histological level, were found. Results: breast tumors were differentiated up to 68.1%. Intra and peritumoral lights inflammatory infiltrate prevailed, with 44.9% and 55.4% each. Well differentiated lights inflammatory infiltrated tumors reached 84.6%. Moderate differentiated tumors were moderate infiltrated, up to 47.2%; and poor diferentiated with severe inflamatory infíltrate, presented 41.7%. Among well differentiated tumors, peritumoral light inflamatory infiltrate revealed 92.3%. Those poor differentiated were only 48.3% positively related. Conclusions: intra and peritumoral light intensity inflammatory infiltrate was the most frequent, considered as the potential prognosis factor, because of its directly proportional relationship with malignancy histological level.

[From tumour to tumour: Metastasis of invasive ductal breast carcinoma to chromophobe renal cell carcinoma]. / Tumor a tumor: metástasis de carcinoma ductal infiltrante de mama sobre carcinoma de células cromófobas de riñón.

The coexistence of two or more tumours in the same patient is unusual, but even rarer is the metastasis of one tumour to another. Most reports are based on evidence from autopsies; very few refer to surgical specimens. The most common primary tumour is pulmonary carcinoma and most frequent metastatic tumour is renal clear cell carcinoma. We present the case of a 54 year-old female with a past history of infiltrating ductal carcinoma of the breast with metastases in lung, lymph nodes and bone. Three months previously to her referral to us, she had developed a renal mass and underwent nephrectomy. Histopathology revealed a renal chromophobe cell carcinoma with intratumoral breast cancer metastasis. We describe the histopathological, immunohistochemical and molecular features and review the recent literature.

Detección y tipificación de virus del papiloma humano en biopsias de carcinoma ductal infiltrante y lesiones benignas de mama en mujeres venezolanas

Objetivo: Realizar la detección y tipificación del virus del papiloma humano (VPH) en muestras de biopsias de tejido mamario con carcinoma ductal infiltrante. Métodos: Estudio descriptivo de corte transversal de 57 biopsias de carcinoma ductal infiltrante, y 41 biopsias de lesiones benignas de mama de pacientes venezolanas, estas fueron evaluadas utilizando la técnica PCR-RFLP en busca de la presencia del genoma del virus de papiloma humano. El riesgo OR fue evaluado mediante análisis estadístico con el paquete SPSS 12.0. Resultados: Treinta y tres (57,9 %) de las muestras de carcinoma ductal infiltrante tuvieron un resultado positivo para virus de papiloma humano, 19 de ellas pudieron ser tipificadas como: VPH-6b 15,15 %; VPH-11 3,03 %; VPH-18 12,12 %; VPH-33 27,27 %; VPH-45 3,03 % y VPH-58 3,03 %; de este grupo el 42,4 % fueron positivas no determinadas para la presencia de ADN del virus. Seis biopsias de lesiones benignas (14,6 %), presentaron infección por virus de papiloma humano, determinándose para ellas los tipos VPH-6b 33,33 %, VPH-11 16,67%, VPH-33 16,67% y 33,33 % positivas no determinadas. Se determinó estadísticamente que la presencia de virus de papiloma humano en tejido mamario aumenta 10,77 veces la posibilidad de desarrollar carcinoma ductal infiltrante. Conclusiones: Los hallazgos corroboran los resultados de otros investigadores, colocando al virus de papiloma humano como posible agente involucrado en la inmortalización de las células epiteliales de la mama.

Objective: To perform the detection and typing of human papilloma (HPV) virus in biopsy samples of breast tissue invasive ductal cancer. Methods: Cross-sectional study of 57 biopsies of invasive ductal carcinoma, and 41 biopsies of benign breast lesions of Venezuelan patients were evaluated using the PCR-RFLP technique for the presence of the human papillomavirus genome. The OR risk was evaluated by statistical analysis using SPSS package. Results: Thirty-three (57.9%) of invasive ductal carcinoma samples had a positive result for human papillomavirus, 19 of them could be classified as: HPV-6b 15.15%; HPV-11 3.03%; HPV-18 12.12%; HPV-33 27.27%; HPV-45 3.03% and HPV-58 3.03%. This group 42.4% were positive not determined for the presence of virus DNA. Six biopsies of benign lesions (14.6%) had human papillomavirus infection, determining for themselves the types HPV-6b 33.33%, 16.67% HPV-11, HPV-33 16.67% and 33.33% not determined positive. It is statistically determined that the presence of human papillomavirus in breast tissue 10.77 times increases the possibility of developing invasive ductal carcinoma. Conclusions: These findings corroborate the results of other researchers, placing human papillomavirus as a possible agent involved in the immortalization of epithelial cells of the breast.

Supervivencia y seguimiento clínico de mujeres mastectomizadas durante una década / Survival and clinical follow-up of mastectomized women for a decade

Se llevó a cabo una investigación explicativa, de cohorte y aplicada, en 132 pacientes operadas por cáncer de mama, con seguimiento clínico en la consulta de Mastología del Hospital Provincial Docente Clinicoquirúrgico "Saturnino Lora Torres" de Santiago de Cuba, de enero del 2002 a igual mes del 2012, para evaluar la supervivencia en ellas e identificar algunos factores pronósticos asociados a la mortalidad por la entidad clínica. En la casuística el tipo de alteración hística preponderante fue el carcinoma ductal infiltrante, con una supervivencia en las féminas de 60,0 %; en tanto, el de pronóstico más desfavorable fue el carcinoma mixto, que no mostró supervivencia alguna al final del seguimiento, y el de mejor sobrevida, el carcinoma lobulillar. Las afectadas con tumores en estadios 0, I y IIA mostraron mayor supervivencia (100,0; 92,5 y 77,0 %, respectivamente) y entre las que padecieron metástasis a distancia, se obtuvo primacía de las diseminaciones hepática y óseas, y mejor sobrevida en aquellas con lesiones metastásicas locorregionales.

An applied explanatory cohort study was conducted in 132 patients operated for breast cancer, with clinical follow-up at the Mastology Department of "Saturnino Lora Torres" Provincial Teaching Clinical Surgical Hospital of Santiago de Cuba, from January 2002 to the same month of 2012, to assess their survival and identify some predictive factors associated with mortality from this condition. The predominant tissular alteration was infiltrating ductal carcinoma in the case material, with 60.0% of survival in females, while the worst prognosis was mixed carcinoma without survival at the end of follow-up, and that of the best survival was lobular carcinoma. Patients with tumors in stages 0, I and IIA showed improved survival (100.0; 92.5 and 77.0%, respectively) and among women who developed distant metastases were predominance of liver and bone spread and better survival in those with locoregional metastatic lesions.

Carcinoma de mama em mulher com 26 anos / Breast carcinoma in women aged 26

A incidência do câncer de mama vem crescendonas últimas décadas em todo o mundo. É consideradoo segundo tipo de câncer mais comum, sendo o maisfrequente entre as mulheres. Dados do National CancerIn Institute (NCI) mostram que menos de 1% dos cânceresde mama apresentam-se em pacientes com menosde 30 anos. A descrição deste caso tem como objetivocontribuir com mais dados estatísticos para um melhorconhecimento dos tumores de mama em pacientes jovens,que devido a sua baixa prevalência ainda necessitammaiores estudos quanto ao seu comportamento.Paciente feminina, 26 anos, ao auto-exame, palpounódulo em mama esquerdo. Solicitado ultrassonografiaque revelou nódulo em quadrante ínfero-lateral damama esquerda medindo 1,6 X 1,6 X 1,1cm. Submetidaao estadiamento tumoral, classificada como estadio IB(T2N0M0). Realizado ressecção segmentar de mama,evidenciando carcinoma ductal invasivo de 2,3 cm, graude difereciação II. Encaminhada ao serviço de oncologiapara avaliação do tratamento adjuvante.O caso descritoapresenta características clínicas e epidemiológicascompativeis com outros casos da literatura, exceto pelograu histológico e pelo tamanho clínico do nódulo epoderia ter sido diagnosticado, talvez ainda mas precocemente,se a paciente tivesse procurado atendimentomédico quase 1 ano antes, quando relata ter percebidoo nódulo.

The incidence of breast cancer has increased inrecent decades throughout the world. It is consideredthe second most common type of cancer and themost common among women. Data from the NationalCancer Institute (NCI) show that less than 1% of breastcancers present in patients younger than 30 years. Thedescription of this event aims to contribute more statisticaldata to a better understanding of breast tumorsin young patients, who due to their low prevalence stillneed further study as to their behavior. Female patient,26 years, at the self-examination palpated a nodulein the left breast. Ultrasound revealed a nodule in theinferior-lateral quadrant of the left breast measuring1.6 X 1.6 X 1.1 cm. Submitted to the tumor staging wasclassified as stage IB (T2N0M0). Submitted to a directedsegmental resection of the breast, which shows an invasiveductal carcinoma of 2.3 cm, grade II differentiation.Referred to the oncology service for evaluation of treatment.This case report presents clinical and epidemiologicalfeatures compatible with other cases from theliterature, except for histological grade and size of thenodule, which could have been diagnosed even earlier,if the patient had sought medical care almost one yearago, when she reports have noticed the nodule.

Carcinoma adenoide cístico de mama: relato de caso de uma rara neoplasia / Adenoid cystic carcinoma of the breast: a case report of a rare neoplasm

O carcinoma adenoide cístico representa aproximadamente 0,1% dos carcinomas da mama e corresponde a uma neoplasia de baixo grau de malignidade constituída por dois tipos celulares distintos (basaloides/mioepiteliais e ductais/epiteliais). Relacionado com o padrão molecular dos tumores de fenótipo basal, este carcinoma geralmente revela imunoexpressão negativa para os receptores hormonais e HER-2. No presente relato, os autores descrevem as características clinicas e histopatológicas de um carcinoma adenoide cístico originado no quadrante superior lateral da mama direita em uma paciente de 50 anos(

Adenoid cystic carcinoma represents approximately 0.1% of breast carcinomas and corresponds to a neoplasm of low grade malignancy composed of two different cell types (basaloid/myoepithelial and ductal/epithelial). Related to the molecular pattern of basal phenotype tumors, this cancer usually reveals negative immunostaining for hormone receptors and HER-2. In this report the authors describe the clinical and histopathologic features of an adenoid cystic carcinoma originated in the upper side of the right breast in a 50-year-old patient

Expresión de los receptores hormonales (RE/RP) y sobreexpresión de la proteína HER-2/neu en carcinoma ductal infiltrante / Expression of hormone receptors receptors (ER/RP) and overexpression of HER-2/neu protein overexpression in infiltrating ductal carcinoma

Introducción: El grado de diferenciación tumoral, la expresión de los receptores de estrógeno y progesterona y la sobreexpresión de la proteína HER-2/neu son factores de tipo pronóstico y predictivo importantes en la evolución y conducta terapéutica del carcinoma mamario infiltrante. Se ha encontrado en diversos estudios que los inmunofenotipos que no expresan los receptores hormonales o que sobre expresan la proteína HER-2/neu se asocian con pobre diferenciación tumoral. Objetivo: Determinar el perfil inmunofenotípico del carcinoma ductal infiltrante y establecer su relación con el grado de diferenciación tumoral. Metodología: Usando técnicas de inmunohistoquímica se determinaron los receptores de estrógeno (RE) y progesterona (RP), y la sobreexpresión de la proteína HER-2/neu en muestras de carcinoma ductal infiltrante y se identificaron sus fenotipos basados en la clasificación de Cheang. La variedad histológica y el grado de diferenciación tumoral en los carcinomas ductales infiltrantes fueron evaluados en tejido coloreado con hematoxilina-eosina. Resultados: Se incluyeron las muestras de 58 pacientes con carcinoma ductal infiltrante. El 15,5% de los carcinomas eran bien diferenciados, 63,8% moderadamente diferenciados y el 20,7% restante pobremente diferenciados. El inmunofenotipo triple negativo se presentó en 29,3% de las muestras, HER2+ en el 20,7%, luminal/ HER2+ en el 1,7%, luminal A en el 43,1% y ER-/PR+/HER2- en el 5,2%. Conclusión: En nuestro estudio, no se encontró asociación entre el grado de diferenciación tumoral y los inmunofenotipos. Salud UIS 2011; 43 (2): 149-158.

Introduction: The degree of tumor differentiation, the expression of estrogen and progesterone receptors and HER-2/ neu protein overexpressing are important prognostic and predictive factors in the evolution and therapeutic management of invasive breast carcinoma. In different studies were found that the immunophenotypes that do not express hormonal receptors or the HER-2/neu protein overexpressing have been associated with poor tumor differentiation. Purpose: To determine the immunophenotypic profile of invasive ductal carcinoma and establish its relationship with the histological grade. Methodology: Using immunohistochemistry were determined the estrogen receptor (ER) and progesterone (PR) and HER-2/neu protein overexpression in invasive ductal carcinoma samples and their phenotypes were identified based on classification of Cheang. The histological subtype and degree of tumor differentiation in invasive ductal carcinomas were evaluated in tissue stained with hematoxylin-eosin. Results: In this study were included 58 patients with invasive ductal carcinoma. 15.5% of the carcinomas were well differentiated, 63.8% moderately differentiated and the remaining 20.7% poorly differentiated. The triple-negative immunophenotype was show in 29.3% of the samples, HER2+ in the 20.7%, luminal/HER2 + in the 1.7%, luminal A in the 43.1% and the phenotype (ER-/PR+/HER2) in the 5.2%. Conclusion: In this study don't was found association between the degree of tumor differentiation and the immunophenotypes. Salud UIS 2011; 43 (2): 149-158.

Concordancia clínica, mamográfica y anatomopatológica en el cáncer mamario / Clinical mammographic, and pathologic concordance in breast cancer

Se efectuó un estudio observacional, descriptivo y transversal para caracterizar, según variables generales, clínicas, anatomopatológicas e imagenológicas, a las 100 pacientes con cáncer de mama que acudieron a la Consulta de Mastología en el Hospital Oncológico Docente Conrado Bení­tez de Santiago de Cuba, desde agosto de 2009 hasta julio de 2010. Se utilizaron el porcentaje como medida de resumen para validar estadísticamente los resultados y el í­ndice de Kappa para determinar la concordancia diagnóstica. En la casuística primaron las féminas de 40-49 años, con antecedentes de mastopatías fibroquísticas y lesión palpable, así­ como también el nódulo en la mama derecha, cuadrante superior externo y periferia del seno; el tumor mayor de un centímetro de dá¡metro y el carcinoma ductal infiltrante en las etapas III-b y IV.

An observational descriptive and cross-sectional study was carried out in 100 patients with breast cancer, who attended the Breast Care Department at Conrado Benítez Teaching Oncology Hospital in Santiago de Cuba from August 2009 to July 2010, to characterize them according to imaging, pathological, clinical, and general variables. Percentage as summary measure to statically validate the results and Kappa index to determine diagnostic concordance were used. Women between 40-49 years with history of fibrocystic breast disease and palpable lesions, as well as lump in the right breast, upper outer quadrant and periphery of the breast, tumor greater than one centimeter in diameter and infiltrating ductal carcinoma in the stages III-b and IV prevailed in the case material.

Anticuerpo monoclonal KI-67: sobreexpresión en carcinomas mamarios / KI-67 monoclonal antibody: over expresión in breast carcinomas

Tipo de estudio: retrospectivo, descriptivo de enero a junio de 2006 en el Instituto Oncológico Nacional de SOLCA en mujeres con diagnóstico de cáncer mamario. Objetivo: mejorar la evaluación pronóstica en la sobrevida de las pacientes con cáncer de mama, colaborando en su terapéutica y determinar la tasa de proliferación celular a través de técnicas de inmunohistoquímica utilizando el anticuerpo monoclonal KI-67. Resultados: de los 112 pacientes diagnosticados con cáncer de mama, 102 tenían carcinoma ductal infiltrante de los cuales el 68,6 presentaron Sobreexpresión (+ del 50 de células tumorales) del anticuerpo KI-67. Del total de pacientes 92 correspondieron a un grado histológico II de los cuales, 55 presentaron sobreexpresión del anticuerpo. Metástasis ganglionares linfáticas tenían 60 pacientes; y de éstas, 34 sobreexpresaron el anticuerpo. El tamaño tumoral que predominó fue el de mayor de 2 cm. (70 casos) de éstos, 45 presentaron sobreexpresión del KI-67. Conclusión: se concluye que el anticuerpo KI-67 no es suficiente para ser considerado como marcador tumoral con posible valor pronóstico y sobre todo predictivo para el cáncer de mama. La media de los años de presentación luego de la interpretación de los datos es similar a la información obtenida de la revisión bibliográfica, y que en Ecuador el cáncer de mama puede tener presentación precoz (menor de 40 años).

Study type: retrospective, descriptive, from january to june/2006in the National Oncological Institute of SOLCA in women with a breast cancer diagnosis. Objective: to improve the prognosis assessment in survival time of patients with breast cancer, to cooperate with their treatment and set the cell proliferation rate through immunohistochemistry techniques using the KI-67 Monoclonal Antibody. Results: 102 out of the 112 patients with breast cancer diagnosis, had infiltrative ductal carcinoma and 68.6 of them presented KI-67 antibody (+ than 50 of tumoral cells) overexpression. Ninety two patients had a histological grade II, and 55 of them presented the antibody overexpression. Sixty patients had ganglion metastasis and from them, 34 overexpressed the antibody. The predominant tumor size was longer than 0.8” (70 cases). From them 45 presented KI-67 antibody overexpression. Conclusion: KI-67 antibody is not enough to be considered as a tumor marker with a possible prognosis value and specially predictive for breast cancer. The average of years of presentation after data interpretation is similar to the information obtained from bibliographic revision, and that in Ecuador breast cancer may have an early presentation (younger than 40 years).