Tumores del sistema nervioso central. Clasificación de la Organización Mundial de la Salud 2021. Hacia un cambio de paradigma / Tumors of the central nervous system. Classification of the World Health Organization 2021. Towards a paradigm shift

El estudio de los tumores del sistema nervioso central (SNC) resulta ser un tema de gran consideración y su conocimiento reviste una alta importancia en la práctica médica. Las clasificaciones de las neoplasias del SNC comenzaron a mediados del siglo XIX hasta que en 1979 la Organización Mundial de la Salud (OMS) publicó la primera edición de una sistemática útil con el objetivo de establecer un lenguaje común para todas las especialidades médicas. Al día de hoy, 5 ediciones actualizaron la taxonomía neoplásica. La quinta edición del año 2021 consolida el cambio de paradigma dado por los avances moleculares, si bien todavía la transición se encuentra en proceso entre la caracterización morfológica y la biológica molecular. En este artículo, se analizan las nuevas modificaciones incorporadas en las diferentes familias tumorales más frecuentes en pediatría haciendo hincapié en aquella información de utilidad para el médico pediatra en su práctica diaria y la consulta multidisciplinaria.

The study of central nervous system (CNS) tumors is a subject of great interest and such knowledge is of great importance in medical practice. The classifications of CNS neoplasms began in the mid-19 th century, until the World Health Organization (WHO) published, in 1979, the first edition of a useful systematic review for the purpose of establishing a common language for all medical specialties. To date, 5 updated editions of neoplastic taxonomy have been published.The fifth edition, from 2021, consolidates the paradigm shift brought about by molecular advances, although the transition between morphological and molecular biological characterization is still in progress. In this article, the new modifications introduced in the different most frequent families of tumors in pediatrics are analyzed, emphasizing useful information for pediatricians in their daily practice and multidisciplinary consultations.

Effectiveness and safety of neoadjuvant therapy in triple-negative breast cancer in a real-world population. / [Artículo traducido] Efectividad y seguridad del tratamiento neoadyuvante del cáncer de mama triple negativo en la vida real.

OBJECTIVE: Triple-negative breast cancer is a subtype of aggressive breast cancer. Our aim is to evaluate the effectiveness and safety of neoadjuvant treatment in early-stage triple-negative breast cancer and to identify predictors of pathological complete response. METHODS: This is a single-center, retrospective study involving 79 patients with triple-negative breast cancer who initiated neoadjuvant treatment between January 2017 and October 2022. Descriptive analyses were performed as appropriate. Statistical analysis utilized bivariate logistic regression to explore the presence of factors related to pathological complete response, and the Kaplan-Meier method was employed for survival analysis. RESULTS: In the overall population, 27 patients (n = 78; 34.6%) achieved pathological complete response in the breast and axillary lymph nodes, and 31 (n = 73; 42.5%) achieved a grade 5 pathological complete response in the breast, according to the Miller and Payne classification. The addition of platinum to standard therapy improved both breast and axillary lymph node pathological complete response rates. Age less than 40 years was identified as a predictor of pathological complete response in our study population through bivariate analysis, while Ki67 levels lower than 70% were associated with a lower pathological complete response rate. Adverse events were reported in 72 patients (91.1%), with grade 3-5 adverse events observed in 33 (41.8%). There was a particularly notable increase in gastrointestinal and hematological adverse events when platinum was added. CONCLUSIONS: In this population, we observed moderate rates of pathological complete response with acceptable chemotherapy tolerance. Platinum-based chemotherapy appears to enhance the likelihood of achieving pathological complete response, albeit with a less favorable safety profile. Therefore, evaluating the benefit-risk balance is crucial when selecting the optimal chemotherapy regimen for individual patients.

Resumen: Consenso internacional para la nomenclatura y clasificación de la válvula aórtica bicúspide congénita y su aortopatía, con fines clínicos, quirúrgicos, intervencionistas y de investigación / Summary: International consensus statement on nomenclature and classification of the congenital bicuspid aortic valve and its aortopathy, for clinical, surgical, interventional and research purposes

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Abstract This consensus of nomenclature and classification for congenital bicuspid aortic valve and its aortopathy is evidence-based and intended for universal use by physicians (both pediatricians and adults), echocardiographers, advanced cardiovascular imaging specialists, interventional cardiologists, cardiovascular surgeons, pathologists, geneticists, and researchers spanning these areas of clinical and basic research. In addition, as long as new key and reference research is available, this international consensus may be subject to change based on evidence-based data1.

Funcionalidade familiar por meiodo instrumento APGAR: avaliaçãodas produções / Family functionality through the APGAR instrument: evaluation of productions

Objetivo: Sintetizar e descrever o que há produzido referente a funcionalidade familiar por meio do uso do instrumento APGAR familiar. Método: O estudo se sustenta na revisão do tipo integrativa de literatura de cunho narrativo, possibilitando a análise do conhecimento científico já produzido sobre o tema investigado. Resultados: A partir dos resultados da revisão integrativa, foi possível a formação de 02 (duas) categorias, como: Categoria 1-APGAR familiar na avaliação das relações cuidadores/familiares do idoso (60 a 100 anos). Categoria 2-Função familiar no cuidado a portadores de situações crônicas, como patologias oncológicas e patologias psiquiátricas. Conclusão: O estudo conseguiu concluir seus objetivos uma vez que os achados sugerem questões significativa concernente à família, pois, detém notoriedade, propiciando a conservação da integridade do ser humano em seus profusos aspectos.(AU)

Objective: To synthesize and describe what has been produced regarding family functionality through the use of the family APGAR instrument. Method: The study is based on an integrative review of narrative literature, enabling the analysis of scientific knowledge already produced on the topic investigated. Results: Based on the results of the integrative review, it was possible to form 02 (two) categories, such as: Category 1-Family APGAR in the assessment of caregiver/family relationships of the elderly (60 to 100 years old). Category2-Family role in caring for people with chronic conditions, such as oncological pathologies and psychiatric pathologies. Conclusion: The study managed to complete its objectives since the findings suggest significant issues concerning the family, as it holds notoriety, enabling the conservation of the integrity of the human being in its profuse aspects.(AU)

Objetivo: Sintetizar y describir lo producido sobre la funcionalidad familiar mediante el uso del instrumento APGAR familiar. Método: El estudio se basa en una revisión integradora de la literatura narrativa, posibilitando el análisis del conocimiento científico ya producido sobre el tema investigado. Resultados: Con base en los resultados de la revisión integradora, fue posible formar 02 (dos) categorías, tales como: Categoría 1-APGAR Familiar en la evaluación de las relaciones cuidador/familiar del anciano (60 a 100 años). Categoría2-Papel familiar en el cuidado de personas con enfermedades crónicas, como patologías oncológicas y patologías psiquiátricas. Conclusión: El estudio logró cumplir sus objetivos ya que los hallazgos sugieren cuestiones significativas relativas a la familia, ya que ésta goza de notoriedad, permitiendo la conservación de la integridad del ser humano en sus aspectos profusos.(AU)

IgG4-related disease: Effectiveness evaluation through Umehara-Okazaki 2011 and ACR/EULAR 2019 diagnostic criteria.

BACKGROUND: IgG4-related disease (IgG4-RD) is a rare, systemic immune-mediated fibro-inflammatory condition with an unclear etiology and pathophysiology, potentially affecting multiple organs. It presents with common clinical, radiological, and serological characteristics. This study aims to compare the latest two IgG4-RD classification and diagnostic criteria: Umehara-Okazaki 2011 and ACR/EULAR 2019. MATERIAL AND METHODS: In a retrospective cross-sectional study conducted across two centers from January 2010 to July 2023, we included patients suspected of having IgG4-RD from various hospital departments. Patients finally diagnosed with other pathologies were excluded. The remaining suspected IgG4-RD cases were evaluated using both Umehara-Okazaki 2011 and ACR/EULAR 2019 criteria. RESULTS: Out of 34 patients with a clinical diagnosis of IgG4-RD, the Umehara-Okazaki 2011 classified 20 patients: 5 as definitive, 7 as probable, and 8 as possible cases. Applying the ACR/EULAR 2019 criteria to the same cohort resulted in the diagnosis of 9 patients. Notably, retroperitoneal fibrosis and aortitis were the most prevalent form of presentation, accounting for 25% and 22.2% of cases classified under the 2011 and 2019 criteria, respectively. DISCUSSION: The more recent and stringent ACR/EULAR 2019 criteria focus on histopathology, various forms of presentation, and analytical data, allow for a more accurate classification of patients.

Effectiveness and safety of neoadjuvant therapy in triple-negative breast cancer in a real-world population.

OBJECTIVE: Triple-negative breast cancer is a subtype of aggressive breast cancer. Our aim is to evaluate the effectiveness and safety of neoadjuvant treatment in early-stage triple-negative breast cancer and to identify predictors of pathological complete response. METHODS: This is a single-center, retrospective study involving 79 patients with triple-negative breast cancer who initiated neoadjuvant treatment between January 2017 and October 2022. Descriptive analyses were performed as appropriate. Statistical analysis utilized bivariate logistic regression to explore the presence of factors related to pathological complete response, and the Kaplan-Meier method was employed for survival analysis. RESULTS: In the overall population, 27 patients (n=78; 34.6%) achieved pathological complete response in the breast and axillary lymph nodes, and 31 (n=73; 42.5%) achieved a grade 5 pathological complete response in the breast, according to the Miller and Payne classification. The addition of platinum to standard therapy improved both breast and axillary lymph node pathological complete response rates. Age less than 40 years was identified as a predictor of pathological complete response in our study population through bivariate analysis, while Ki67 levels lower than 70% were associated with a lower pathological complete response rate. Adverse events were reported in 72 patients (91.1%), with grade 3-5 adverse events observed in 33 (41.8%). There was a particularly notable increase in gastrointestinal and hematological adverse events when platinum was added. CONCLUSIONS: In this population, we observed moderate rates of pathological complete response with acceptable chemotherapy tolerance. Platinum-based chemotherapy appears to enhance the likelihood of achieving pathological complete response, albeit with a less favorable safety profile. Therefore, evaluating the benefit-risk balance is crucial when selecting the optimal chemotherapy regimen for individual patients.

Comparison and combination of three data sources from patient medical records to determine optimal quantification of postoperative morbidity according to the Clavien Dindo Classification and the Comprehensive Complication Index. A prospective study.

INTRODUCTION: It is currently unknown which data sources from the clinical history, or combination thereof, should be evaluated to achieve the most complete calculation of postoperative complications (PC). The objectives of this study were: to analyze the morbidity and mortality of 200 consecutive patients undergoing major surgery, to determine which data sources or combination collect the maximum morbidity, and to determine the accuracy of the morbidity reflected in the discharge report. METHODS: Observational and prospective cohort study. The sum of all PC found in the combined review of medical notes, nursing notes, and a specific form was considered the gold standard. PC were classified according to the Clavien Dindo Classification and the Comprehensive Complication Index (CCI). RESULTS: The percentage of patients who presented PC according to the gold standard, medical notes, nursing notes and form were: 43.5%, 37.5%, 35% and 18.7% respectively. The combination of sources improved CCI agreement by 8%-40% in the overall series and 39.1-89.7 % in patients with PC. The correct recording of PC was inversely proportional to the complexity of the surgery, and the combination of sources increased the degree of agreement with the gold standard by 35 %-67.5% in operations of greater complexity. The CDC and CCI of the discharge report coincided with the gold-standard values in patients with PC by 46.8% and 18.2%, respectively. CONCLUSIONS: The combination of data sources, particularly medical and nursing notes, considerably increases the quantification of PC in general, most notably in complex interventions.

[Disability Degree Assessment: A Comprehensive Approach According to Royal Decree 888/2022]. / Evaluación del grado de discapacidad: un enfoque integral según el Real Decreto 888/2022.

BACKGORUND AND OBJECTIVE: Royal Decree 888/2022 establishes that the evaluation of disability situations is carried out by multiprofessional teams responsible for assessing and recognizing the degree of disability. The participation of professionals in the healthcare and social fields can be valuable in providing reports from which the necessary data for the proper assessment of disability can be obtained, with the ultimate goal of providing comprehensive assistance to people with disabilities. MATERIALS AND METHODS: An analysis and summary of Royal Decree 888/2022, which has recently come into effect, is performed, focusing on the most relevant aspects for professionals in the healthcare and social fields. RESULTS: The recognition and classification of the degree of disability are the responsibility of the autonomous communities, and the assessments are issued by multiprofessional teams. To do this, four components are evaluated using the criteria outlined in the annexes of the Royal Decree itself. Each criterion generates a score that is combined to obtain a single score, the Final Disability Degree of the Person. CONCLUSIONS: The pathology that causes the disability must have been previously diagnosed by the Healthcare System and considered permanent. Its evaluation is based on the evidence of objective clinical findings that are documented and supported by clinical reports. For this reason, it is important to maintain an accurate medical history, document reviews, and provide all relevant evidence.

Lesiones de la vía biliar

La finalidad de esta revisión es mostrar el estado actual de las lesiones de vía biliar (LVB), producidas especialmente durante la colecistectomía laparoscópica. Revisaremos la etiopatogenia, los grados de compromiso biliar, las lesiones vasculares asociadas, las clasificaciones utilizadas y los factores de riesgo. Además la forma como evaluar oportunamente la magnitud de la lesión, tanto en la misma cirugía como en el postoperatorio. Igualmente se muestran las diversas alternativas terapéuticas empleadas. Todo con la finalidad de evitar graves complicaciones.

The purpose of this review is to show the current status of bile duct injury, specially produced during laparoscopic cholecystectomy. We will review etiopathogenesis, degrees of bile commitment, associated vascular lesions, classifications used and risk factors. In addition, how to assess the extent of the injury in a timely manner, both in the same surgery and in the postoperative surgery. The various therapeutic alternatives used are also shown. All in order to avoid serious complications.

Escoliosis idiopática del adolescente / Adolescent idiopathic scoliosis

La escoliosis idiopática del Adolescente (EIA) es una deformidad tridimensional de la columna vertebral que aqueja de diversas formas la condición de vida de quien la padece, afectando el desarrollo físico y psicológico del paciente. Proponemos evaluar el resultado clínico, radiológico y el componente de calidad de vida de pacientes tratados quirúrgicamente con EIA, en el servicio de Neurocirugía, Hospital Jesús Yerena del Lídice. Se evaluó patrón de la curva, clasificación según Lenke, ángulo de Cobb pre y postquirúrgico, edad de tratamiento quirúrgico, gradode corrección, calidad de vida según cuestionario SRS-22 pre y postquirúrgica, valoración funcional mediante la escala de discapacidad de Oswestry (ODI) y complicaciones postoperatorias. Se estudiaron 22 casos (95 % femenino), el principal grupo etario fue de 11-14 años (55 %), la escoliosis tipo 1 fue la predominante (60 %), el ángulo de Cobb inicial fue mayor a 50° (50 %) y la madurez esquelética principal fue Risser 3 (55 %). La edad de resolución quirúrgica predominante fue entre 15-18 años (60 %), el grado de corrección postoperatorio fue de 75-100 % (73 %) y la densidad de los tornillos pediculares fue de 1.4-1.7 (64 %). En el cuestionario SRS-22, hubo mayor afectación en las dimensiones de autoimagen con una media de 1.8 y la valoración por ODI mostró un índice de incapacidad mínima, que fue mejorando en los controles sucesivos. Nuestra principal complicación fueron las infecciones (36 %). Concluimos que la cirugía correctiva temprana en la EIA ofrece a una mejoría clínica, radiológica y de la calidadde vida de estos paciente(AU)

Adolescent idiopathic scoliosis (AIS) is a three-dimensional deformity of the spine that affects the living condition of those who suffer from it in various ways, affecting the physical and psychological development of the patient. We propose to evaluate the clinical and radiological outcome and the quality-of-life component of patients treated surgically with EIA, in the Neurosurgery Service, Hospital Jesús Yerena del Lídice. Curve pattern, Lenke classification, pre-and post-surgical Cobb angle, age at surgical treatment, degree of correction, quality of life according to pre-and post-surgical SRS-22 questionnaire, functional assessment using the Oswestry Disability Scale (ODI) and postoperative complications were evaluated. 22 cases were studied (95% female), the main age group was 11-14 years (55%), type 1 scoliosis was predominant (60%), the initial Cobb angle was greater than 50° (50%) and the main skeletal maturity was Risser 3 (55%). The predominant age of surgical resolution was between 15-18 years (60%), the degree of postoperative correction was 75-100% (73%) and the density of pedicle screws was 1.4-1.7 (64%). In the SRS-22 questionnaire, there was greater impairment in the self-image dimensions with a mean of 1.8 and the ODI assessment showed aminimal disability index, which improved in successive controls. Our main complication was infections (36%). We conclude that early corrective surgery in AIS offers clinical, radiological and quality of life improvement for these patient(AU)

Reflexiones para optimizar el triaje en cirugía / Reflections to optimize triage in surgery

Introducción: La categorización de las urgencias quirúrgicas es una necesidad en razón al continuo desequilibrio entre la oferta y la demanda de servicios quirúrgicos en la mayoría de las instituciones donde se encuentra habilitada la prestación del servicio. Hay abordajes en el tema, con estrategias de priorización de los casos quirúrgicos, que consideran escalas y flujogramas, pero su ausente validez externa y las particularidades de las instituciones y aseguradores, han limitado una generalización de los resultados. Métodos: Se efectúa una conceptualización del triaje de las urgencias quirúrgicas con planteamientos críticos y reflexivos soportados en la evidencia. Se identifican, asimismo, las posibles oportunidades para la investigación. Discusión: Los beneficios potenciales de un triaje quirúrgico en situaciones de urgencia, son extensivos a todos los actores del sistema de salud, disminuyen la posibilidad de desenlaces y repercusiones económicas negativas para las instituciones y los aseguradores. La teoría de las colas ofrece el soporte para un entendimiento del tema y contribuye en las soluciones. Su adopción es escasa como parte de una estrategia local de priorización quirúrgica en un contexto de urgencia. Conclusión:La creación de estrategias que establezcan el triaje para el paciente con una urgencia quirúrgica están influenciadas por la participación continua y efectiva de los actores involucrados en el proceso y en su impacto en los desenlaces clínicos

Introduction: Categorizing surgical emergencies is necessary due to the continued imbalance between the supply and demand of surgical services in most institutions where the service is enabled. There are approaches to the subject, with strategies for prioritizing surgical cases, which consider scales and flowcharts, but their lack of external validity and the particularities of the institutions and insurers have limited the generalization of the results. Methods: A conceptualization of the triage of surgical emergencies is carried out with critical and reflective approaches supported by evidence. Potential research opportunities are also identified. Discussion: The potential benefits of surgical triage in emergent situations are extensive to all health system actors, reducing the possibility of adverse outcomes and economic repercussions for institutions and insurers. Queuing theory offers support for understanding the issue and contributes to solutions. However, its adoption is scarce in an emergency as part of a local surgical prioritization strategy. Conclusion: The creation of strategies that establish triage for the patient with a surgical emergency is influenced by the continuous and effective participation of the actors involved in the process and its impact on clinical outcomes

Caracterización histológica del melanoma cutáneo en reportes de patología en la ciudad de Cali, 2016-2021 / Histological characterization of cutaneous melanoma in pathology reports in the city of Cali, 2016-2021

Introducción. El melanoma es la proliferación maligna de melanocitos asociado a un comportamiento agresivo. El objetivo de este estudio fue determinar las variables histológicas del melanoma cutáneo. Métodos. Estudio observacional retrospectivo, transversal descriptivo, realizado con reportes de patologías de pacientes con diagnóstico de melanoma cutáneo en un laboratorio de patología en Cali, Colombia, entre 2016-2021. Se incluyeron las variables edad, sexo, localización, subtipo, espesor de Breslow, ulceración, márgenes, mitosis, invasión linfovascular, neurotrofismo, regresión tumoral, nivel de Clark e infiltración tumoral por linfocitos. Resultados. Se obtuvieron 106 reportes y fueron excluidos 54 por duplicación. Se incluyeron 52 registros, la media de edad fue de 61 años, con una mayor frecuencia de mujeres (55,8 %). De los 33 casos donde se especificó el subtipo histológico, el más frecuente fue el de extensión superficial (66,6 %), seguido del acral lentiginoso (18,1 %) y nodular con (15,2 %). La localización más frecuente fue en extremidades (61,5 %). El espesor de Breslow más común fue IV (34,6 %) y el nivel de Clark más frecuente fue IV (34,6 %). La ulceración estuvo en el 40,4 %. El subtipo nodular fue el de presentación más agresiva, donde el 100 % presentaron espesor de Breslow IV. Conclusiones. El subtipo de melanoma más común en nuestra población fue el de extensión superficial; el segundo en frecuencia fue el subtipo acral lentiginoso, que se localizó siempre en extremidades. Más del 50 % de los melanomas tenían espesor de Breslow mayor o igual a III, lo que impacta en el pronóstico.

Background. Melanoma is the malignant proliferation of melanocytes associated with aggressive behavior. The objective of this study was to determine the histological variables of cutaneous melanoma. Methods. Observational, cross-sectional, descriptive, retrospective study carried out with reports of pathologies with a diagnosis of cutaneous melanoma in a pathology laboratory in Cali between 2016-2021. The variables were age, sex, location, subtype, Breslow thickness, ulceration, margins, mitosis, lymphovascular invasion, neurotropism, tumoral regression, Clark level and tumor infiltration by lymphocytes. Results. One hundred and six reports were obtained and 54 were excluded due to duplication. A descriptive analysis was made on the 52 records that were included, the mean age was 61 years, with a higher frequency in women with 55.8%. Of the 33 cases where the histological subtype was specified, the most frequent was superficial extension with 66.6%, followed by acral lentiginous with 18.1% and nodular with 15.2%. The most frequent location was in the extremities (61.5%); the most common Breslow was IV (34.6%), and the most frequent Clark was IV (34.6%). Ulceration was in 40.4%. The nodular subtype was the most aggressive presentation where 100% presented Breslow IV. Conclusions. The most common subtype of melanoma was that of superficial extension. In our population, the second most frequent was the acral lentiginous subtype, which was always located on the extremities. More than 50% of the melanomas had Breslow greater than or equal to III, which affects the prognosis.

Avaliação de incapacidade em pessoas com doença falciforme / Disability assessment in people with sickle cell / Evaluación de la discapacidad en personas con enfermedad de células falciformes

A expectativa de vida das pessoas com doença falciforme (DF) é baixa, e o agravamento da condição de saúde é frequente, gerando incapacidades. Todavia, pouco é conhecido sobre tais incapacidades com base na Classificação Internacional de Funcionalidade, Incapacidade e Saúde (CIF). Assim, o objetivo do estudo foi descrever as incapacidades de adultos com DF. Realizou-se um estudo transversal descritivo, com 60 adultos com DF, de ambos os sexos. Informações sociodemográficas, fatores clínicos relacionados ao tipo de DF foram autorreferidos pelos participantes. As incapacidades foram avaliadas por meio da Escala de Avaliação de Incapacidade da Organização Mundial da Saúde (WHODAS 2.0) nos seguintes domínios: cognição, mobilidade, autocuidado, relações interpessoais (convivência com as pessoas), atividades de vida e participação na sociedade. Em cada domínio, foi definida incapacidade quando o sujeito relatou dificuldade leve, moderada, grave ou extrema de desempenhar a tarefa. Os dados foram analisados por estatística descritiva (frequências relativas). Os resultados mostraram valores elevados em todos os domínios avaliados, com destaque para dificuldades de concentração (90%) e desempenho nas tarefas domésticas (93,3%) e impacto da situação de saúde nas finanças do sujeito/família (96,7%). Os dados deste estudo mostraram que adultos com DF apresentam elevados índices de incapacidade, especialmente no domínio cognitivo, nas atividades de vida e na participação social.

Life expectancy of people living with sickle cell disease (SCD) is in general low and the worsening of their health condition is frequent, resulting in disabilities. However, knowledge about those disabilities based on the International Classification of Functioning, Disability and Health (ICF) is scarce. Thus, this study aimed to describe the disabilities of adults with SCD. A descriptive cross-sectional study was carried out with 60 adults with SCD of both sexes. Sociodemographic and clinical factors related to the type of SCD were self-reported by the participants. Disabilities were assessed by the World Health Organization Disability Assessment Schedule (WHODAS 2.0), in the following domains: cognition, mobility, selfcare, getting along with people, life activities, and participation in society. In each domain, disability was defined when the participant self-reported light, moderate, severe, extreme difficulty, or inability to perform the task. Data analysis included descriptive statistics (relative frequencies). The results showed high values in all domains evaluated, with emphasis on difficulties on concentrating (90%) and performing household chores (93.3%) and on the impact of health condition on subject/family's financial situation (96.7%). The data from this study shows that adults with SCD present high disability levels, especially on the cognitive domain, on life activities, and on social participation.

Las personas con enfermedad de células falciformes (ECF) tienen una baja esperanza de vida, y el empeoramiento de su estado de salud es frecuente, generando discapacidades. Sin embargo, estas discapacidades son poco conocidas según la Clasificación Internacional del Funcionamiento, de la Discapacidad y de la Salud (CIF). El objetivo de este estudio fue describir las discapacidades de adultos con ECF . Se realizó un estudio transversal, descriptivo, con 60 adultos con ECF, de ambos sexos. Los factores sociodemográficos y clínicos relacionados con el tipo de ECF fueron autoinformados. Las discapacidades se evaluaron mediante la Escala de Evaluación de la Discapacidad de la Organización Mundial de la Salud (WHODAS 2.0), en los dominios de cognición, movilidad, autocuidado, convivencia con personas, actividades de la vida y participación en la sociedad. La discapacidad se definió mediante un reporte de dificultad o incapacidad leve, moderada, grave, extrema del individuo para realizar una tarea. Los datos fueron analizados por estadística descriptiva (frecuencias relativas). Los resultados mostraron altos valores de discapacidad en todos los dominios evaluados, con énfasis en las dificultades de concentración (90%), el desempeño en las tareas domésticas (93,3%) y el impacto de la situación de salud en las finanzas del sujeto/familia (96,7%). Los datos de este estudio mostraron que los adultos con ECF tienen altas tasas de discapacidad, especialmente en los dominios cognitivo, actividades de la vida y participación social.

Results of surgical treatment of lymph node metastases in patients with cutaneous squamous cell carcinoma of the head and neck.

INTRODUCTION: Out of all cutaneous squamous cell carcinomas originating in the head and neck (HNCSCC), 2-4% are associated with parotid or cervical lymph node metastasis. The aim of this study is to analyse the prognostic factors of patients with HNCSCC with lymph node involvement treated surgically. Additionally, we aim to compare the prognostic capacity of the classification of these patients according to the 8th edition of the TNM, and an alternative classification proposed by O'Brien et al. PATIENTS AND METHODS: Retrospective review of 65 patients with HNCSCC with lymph node metastasis treated surgically during the period 2000-2020. RESULTS: During the study period we carried out 13 neck dissections and 52 parotidectomies + neck dissection in patients with lymph node metastases from a HNCSCC. The great majority of patients (89.2%) received post-operative radiotherapy. The 5 year disease-specific survival was 69.9%, and the overall survival it was 42.8%. The classification proposed by O'Brien et al., based on the parotid or cervical location of the lymph node metastases, and the size and number of the metastatic lymph nodes, had a better prognostic capacity than the TNM classification. CONCLUSIONS: The surgical treatment of lymph node metastases in patients with HNCSCC achieved a high disease control. The classification based on the location, size and number of lymph node metastases proposed by O'Brien et al had better prognostic capacity than the TNM classification.

Gluteal Hidradenitis Suppurativa: Analysis of 83 Patients.

BACKGROUND: In 2013, Canoui-Poitrine et al. identified three hidradenitis suppurativa (HS) phenotypes by a latent class (LC) analysis, based on anatomical sites of involvement. OBJECTIVE: To improve the classification of the gluteal phenotype (LC3) patients given their diverse lesion types and differences in clinical profile. MATERIAL AND METHODS: We designed a bicentric study gathering all LC3 patients (n=83) from two hospitals. We conducted a two-step cluster analysis among them and also compared their characteristics with the rest of the HS patients (n=661). RESULTS: Compared with global HS series, LC3 patients were more frequently non-obese men, with smoking habit, an associated arthropathy, and a more frequent history of pilonidal sinus. The analysis of LC3 patients yielded two clusters: cluster 1 (38.3%) included elderly female patients, with later diagnosis of the disease and more sinus tracts; cluster 2 (61.7%) encompassed more men with earlier disease onset and more nodules and folliculitis lesions. LIMITATIONS: The study's limitations include its retrospective nature, bicentric design, and small sample size. CONCLUSION: The heterogeneous clinical presentation of HS makes it essential to have a good classification of the patients. Gluteal phenotype could actually be classified into two "subphenotypes" with a different clinical profiles and management.

Gluteal Hidradenitis Suppurativa: Analysis of 83 Patients. / [Artículo traducido] Hidradenitis supurativa con afectación glútea: análisis de 83 pacientes.

BACKGROUND: In 2013, Canoui-Poitrine et al. identified three hidradenitis suppurativa (HS) phenotypes by a latent class (LC) analysis, based on anatomical sites of involvement. OBJECTIVE: To improve the classification of the gluteal phenotype (LC3) patients given their diverse lesion types and differences in clinical profile. MATERIAL AND METHODS: We designed a bicentric study gathering all LC3 patients (n=83) from two hospitals. We conducted a two-step cluster analysis among them and also compared their characteristics with the rest of the HS patients (n=661). RESULTS: Compared with global HS series, LC3 patients were more frequently non-obese men, with smoking habit, an associated arthropathy, and a more frequent history of pilonidal sinus. The analysis of LC3 patients yielded two clusters: cluster 1 (38.3%) included elderly female patients, with later diagnosis of the disease and more sinus tracts; cluster 2 (61.7%) encompassed more men with earlier disease onset and more nodules and folliculitis lesions. LIMITATIONS: The study's limitations include its retrospective nature, bicentric design, and small sample size. CONCLUSION: The heterogeneous clinical presentation of HS makes it essential to have a good classification of the patients. Gluteal phenotype could actually be classified into two "subphenotypes" with a different clinical profiles and management.

Workplace barrier's questionnaire: creation and reliability analysis / Cuestionario para evaluar las barreras en el entorno laboral: desarrollo y análisis de fiabilidad / Questionário de avaliação de barreiras no ambiente de trabalho: elaboração e análise da confiabilidade

ABSTRACT Workers' functioning is related to the environmental conditions that influence their activities, favoring or hindering their fulfilment. The Work Rehabilitation Questionnaire (WORQ) was based on a core set of the Classification of Functioning (ICF) to assess workers. It has a validated Portuguese version for use with active Brazilian workers but it only assesses function body limitations, activities, and participation. This study developed a questionnaire to assess environmental barriers at work following the WORQ format and tested its reliability. This study reached a consensus (10 professionals and 11 workers) to choose environmental categories in the CIF core set that originated the WORQ to be integrated into the questionnaire. This research selected elements if at least 85% of participants reported it. Categories were transformed into questions. For reliability analysis, the questionnaire was applied to a random sample of 123 active workers at a public university in Brazil. The questionnaire had 20 questions based on the ICF core set for vocational rehabilitation and WORQ. This study evaluated its reliability, finding an r=0.855 (test-retest) and Cronbach's alpha=0.936 (internal consistency). This study developed an ICF-based questionnaire to assess environmental barriers in the workplace. The analysis of psychometric characteristics showed strong test-retest reliability and the internal consistency of the instrument.

RESUMEN La funcionalidad del trabajador está relacionada con las condiciones ambientales que influyen en sus actividades, favoreciendo o dificultando su desempeño. El Cuestionario de Rehabilitación Profesional (WORQ) se basa en un core set de la Clasificación de Funcionalidad (CIF) para evaluar a los trabajadores y cuenta con una versión en portugués validada para aplicar a trabajadores brasileños en actividad; sin embargo, esta herramienta está circunscrita a evaluar solo las limitaciones en las funciones corporales, las actividades y la participación. Este estudio tuvo por objetivo desarrollar un cuestionario, con base en el formato del WORQ, para evaluar las barreras en el entorno laboral y comprobar su fiabilidad. La elección de las categorías ambientales que serán incluidas en el cuestionario -y que constan en el core set de la CIF que dio origen al WORQ- se realizó por consenso (10 profesionales y 11 trabajadores). Se seleccionaron las categorías elegidas por aproximadamente el 85% de los participantes para convertirlas en preguntas. Para evaluar la fiabilidad, el cuestionario se aplicó a una muestra aleatoria de 123 trabajadores en actividad de una universidad pública de Brasil. El cuestionario constaba de un total de 20 preguntas. Su fiabilidad se evaluó con r=0,855 (test-retest) y alfa de Cronbach=0,936 (consistencia interna). Este estudio desarrolló un cuestionario basado en la CIF para evaluar las barreras ambientales en el entorno laboral que, mediante el análisis de las características psicométricas, indicó una fuerte fiabilidad test-retest y consistencia interna de esta herramienta.

RESUMO A funcionalidade do trabalhador está relacionada às condições ambientais que influenciam suas atividades, favorecendo ou prejudicando a realização delas. O Questionário de Reabilitação Profissional (WORQ) foi baseado em um core set da Classificação de Funcionalidade (CIF) para avaliar trabalhadores, ele apresenta versão em português validada para uso com trabalhadores brasileiros ativos, porém, se restringe à avaliação de limitações em funções corporais, atividades e participação. Este estudo teve como objetivo elaborar um questionário de avaliação de barreiras ambientais no trabalho, seguindo o formato do WORQ, e testar sua confiabilidade. A escolha das categorias ambientais - constantes no core set da CIF que originou o WORQ - para integrar o questionário foi realizada em consenso (10 profissionais e 11 trabalhadores). Foram selecionadas aquelas apontadas por pelo menos 85% dos participantes e, dessa forma, transformadas em questões. Para análise da confiabilidade, o questionário foi aplicado em uma amostra aleatória de 123 trabalhadores ativos de uma universidade pública do Brasil. O questionário elaborado teve o total de 20 questões. A sua confiabilidade foi avaliada com r=0,855 (teste-reteste) e alfa de Cronbach=0,936 (consistência interna). Este estudo elaborou um questionário baseado na CIF para avaliar barreiras ambientais nos locais de trabalho, que, por meio da análise das características psicométricas, apontou forte confiabilidade teste-reteste e consistência interna para o instrumento.

Murciélagos como vectores de enfermedades virales e impacto en la salud humana

Introducción: Los murciélagos se destacan por ser los únicos mamíferos voladores, con alrededor de 1 400 especies que cumplen un rol fundamental como controladores de plagas y polinizadores de plantas nocturnas. Sin embargo, su influencia sobre la salud humana se ha evidenciado cada vez más, en particular después del surgimiento de brotes epidémicos de enfermedades virales asociadas a estos mamíferos. Objetivo: Analizar la influencia de los murciélagos en la salud humana, centrándose en su papel como portadores de enfermedades virales y su potencial como reservorios y vectores de enfermedades. Métodos: Se realizó una revisión bibliográfica de la literatura utilizando descriptores MeSH y términos como: Animals, Wild Chiroptera, Virus Diseases, Zoonoses, Disease Vectors, Disease Reservoirs, Public Health, bats, Communicable Disease Control, Disease Outbreaks, Prevention and Control. Se revisaron 1 442 artículos en bases de datos y documentos oficiales, se seleccionaron las fuentes relevantes con Mendeley Desktop 1.19.4. y se obtuvieron al final 47 artículos. Resultados: Existen varias especies de murciélagos que pueden afectar la salud del ser humano y que albergan en especial virus de las familias Filoviridae, Coronaviridae y Paramixoviridae. Los murciélagos se consideran incubadoras óptimas para la propagación de virus debido a su sistema inmune único que lo hace resistente a estos agentes infecciosos. Conclusiones: La vigilancia y monitoreo de los murciélagos, junto con acciones de educación pública y una gestión adecuada de sus hábitats, son fundamentales para la detección temprana y prevención de la transmisión de nuevos virus de estos mamíferos a los humanos.

Introduction: Bats are the only flight mammals, with around 1,400 species playing critical roles as pest controllers and nocturnal plant pollinators. However, its impact on human health has become increasingly evident, especially after the appearance of epidemic outbreaks of viral diseases related to these mammals. Objetive: To analyze the influence of bats on human health, focusing on their role as carriers of viral diseases and their potential as reservoirs and vectors of diseases. Methods: A literature bibliographical review was conducted using MeSH descriptors and keywords such as: Animals, Wild Chiroptera, Virus Diseases, Zoonosis, Disease Vectors, Disease Reservoirs, Public Health, bats, Communicable Disease Control, Disease Outbreaks, Prevention and Control. 1442 articles in databases and official documents were reviewed, selecting the relevant sources with Mendeley Desktop 1.19.4., obtaining 47 articles at the end. Results: There are several species of bats that can affect human health and that mainly harbor viruses from the Filoviridae families, Coronaviridae and Paramyxoviridae. Bats are considered optimal incubators for the spread of the virus due to their unique immune system that makes them particularly resistant to these infectious agents. Conclusions: Surveillance and monitoring of bats, together with public education actions and proper management of their habitats, are essential for early detection and prevention of transmission of new viruses from these mammals to humans.

Perfil dos atendimentos às gestantes com ameaça de abortamento em um hospital universitário do norte Paraná / Profile of care for pregnant women with threat of abortion at a university hospital in Paraná / Perfil de la atención a embarazada con amenaza de aborto en un hospital universitario de Paraná

Objetivo: Descrever o perfil dos atendimentos de gestantes com ameaça de abortamento atendidas em um Pronto Socorro Obstétrico de um Hospital Universitário do Norte do Paraná. Métodos: Pesquisa descritiva, retrospectiva e documental com abordagem quantitativa, desenvolvida com dados obtidos das fichas de classificação de risco obstétrico do Pronto Socorro Obstétrico do Hospital Universitário Regional do Norte do Paraná, referentes aos meses de junho a setembro de 2022. Incluiu-se pacientes gestantes com menos de 20 semanas de gestação e com queixa de sangramento vaginal, chegando-se ao número total de 440 atendimentos. Os dados foram processados, tabulados e submetidos à estatística descritiva através de frequência simples. Resultados: As ameaças de abortamento caracterizaram 16,3% dos atendimentos, predominando pacientes com idade entre 19 e 29 anos, classificações de riscos verde e azul, a maioria provenientes do próprio município e encaminhada via Serviço de Atendimento Móvel de Urgência. Das gestantes atendidas, somente 8,6% precisaram de internação e as demais foram liberadas após consulta. Conclusão: Evidenciou que os atendimentos às gestantes com ameaça de abortamento concentrou-se na faixa etária de 19 a 29 anos, provenientes do próprio município, encaminhadas via Serviço de Atendimento Móvel de Urgência e com classificação de risco na cor verde (pouco urgente), dessa forma, pode-se entender que são casos que em sua maioria poderiam ter sido encaminhados aos seus respectivos hospitais de referência, não sendo necessário o encaminhamento ao hospital referência para o alto risco.

Objective: To describe the profile of care for pregnant women threatened with miscarriage treated in an Obstetric Emergency Room at a University Hospital in Northern Paraná. Methods: Descriptive, retrospective and documentary research with a quantitative approach, developed with data obtained from the obstetric risk classification forms of the Obstetric Emergency Room of the Hospital Universitário Regional do Norte do Paraná, referring to the months of June to September 2022. Patients included pregnant women with less than 20 weeks of gestation and complaining of vaginal bleeding, reaching a total number of 440 consultations. The data was processed, tabulated and subjected to descriptive statistics using simple frequency. Results: Threats of abortion characterized 16.3% of consultations, with a predominance of patients aged between 19 and 29 years, with green and blue risk classifications, the majority coming from the municipality itself and referred via the Mobile Emergency Care Service. Of the pregnant women treated, only 8.6% required hospitalization and the rest were released after consultation. Conclusion: It showed that care for pregnant women with threatened abortion was concentrated in the age group of 19 to 29 years, coming from the municipality itself, sent via the Mobile Emergency Care Service and with a risk classification in green (not very urgent), therefore, it can be understood that most of these cases could have been referred to their respective reference hospitals, with no need to refer them to the high-risk reference hospital.

Objetivo: Describir el perfil de atención a mujeres embarazadas con riesgo de aborto atendidas en una Sala de Emergencia Obstétrica de un Hospital Universitario del Norte de Paraná. Métodos: Investigación descriptiva, retrospectiva y documental con enfoque cuantitativo, desarrollada con datos obtenidos de los formularios de clasificación de riesgo obstétrico del Servicio de Emergencia Obstétrica del Hospital Universitário Regional do Norte do Paraná, referidos a los meses de junio a septiembre de 2022. Pacientes incluidas mujeres embarazadas con menos de 20 semanas de gestación y que refieren sangrado vaginal, alcanzando un total de 440 consultas. Los datos fueron procesados, tabulados y sometidos a estadística descriptiva mediante frecuencia simple. Resultados: Las amenazas de aborto caracterizaron el 16,3% de las consultas, con predominio de pacientes con edades entre 19 y 29 años, con clasificaciones de riesgo verde y azul, la mayoría provenientes del propio municipio y remitidas a través del Servicio Móvil de Atención de Urgencias. De las gestantes atendidas, sólo el 8,6% requirió hospitalización y el resto fue dada de alta tras consulta. Conclusión: Se demostró que la atención a las mujeres embarazadas con amenaza de aborto se concentró en el grupo etario de 19 a 29 años, provenientes del propio municipio, enviadas a través del Servicio Móvil de Atención de Emergencias y con clasificación de riesgo en color verde (poco urgente), por lo que se puede entender que la mayoría de estos casos podrían haber sido derivados a sus respectivos hospitales de referencia, sin necesidad de derivarlos al hospital de referencia de alto riesgo.

Vulnerabilidade clínico funcional e condições de saúde de idosos com doença de Parkinson / Clinical functional vulnerability and health conditions of elderly people with Parkinson's disease / Vulnerabilidad clínica funcional y condiciones de salud de personas mayores con enfermedad de Parkinson

Objetivo: caracterizar a vulnerabilidade clinico funcional e as condições de saúde de idosos com Parkinson de um serviço de atenção especializada de um município de grande porte brasileiro. Método: trata-se de um estudo documental, transversal, realizado com 230 idosos com diagnóstico de Doença de Parkinson. Foram avaliados os prontuários dos pacientes com enfoque nos instrumentos.: Índice de Vulnerabilidade Clínico Funcional-20 e o Plano de Cuidados da avaliação multidimensional. As análises estatísticas foram realizadas utilizando o software R. Resultados: predomínio de idosos entre 80 e 89 anos, sexo feminino e baixa escolaridade. Apresentaram como principais marcadores de vulnerabilidade clinico funcional o comprometimento da mobilidade, incontinência urinária, sarcopenia, marcha/quedas, distúrbio de humor, comorbidade múltipla e polifarmácia. Conclusão: os achados mostraram alta prevalência de comprometimento funcional na doença de Parkinson. Acredita-se que os resultados possam contribuir na melhoria do cuidado a essa população, possibilitando aos profissionais da enfermagem atuarem na promoção do autocuidado

Objective: to characterize the clinical-functional vulnerability and health conditions of elderly people with Parkinson's in a specialized care service in a large Brazilian city. Method: this is a documentary, cross-sectional study, carried out with 230 elderly people diagnosed with Parkinson's disease. Patient records were evaluated focusing on the instruments: Functional Clinical Vulnerability Index-20 and the multidimensional assessment Care Plan. Statistical analyzes were carried out using the R software. Results: predominance of elderly people between 80 and 89 years old, female and with low education. The main markers of clinical-functional vulnerability were mobility impairment, urinary incontinence, sarcopenia, gait/falls, mood disorder, multiple comorbidities and polypharmacy. Conclusion: the findings showed a high prevalence of functional impairment in Parkinson's disease. It is believed that the results can contribute to improving care for this population, enabling nursing professionals to work to promote self-care

Objetivos:caracterizar la vulnerabilidad clínico-funcional y las condiciones de salud de personas mayores con Parkinson en un servicio de atención especializada de una gran ciudad brasileña. Método: se trata de un estudio documental, transversal, realizado con 230 personas mayores diagnosticadas con Enfermedad de Parkinson. Se evaluaron los expedientes de los pacientes centrándose en los instrumentos: Índice de Vulnerabilidad Clínica Funcional-20 y Plan de Cuidados de la evaluación multidimensional. Los análisis estadísticos se realizaron mediante el software R. Resultados: predominio de personas mayores entre 80 y 89 años, del sexo femenino y con baja escolaridad. Los principales marcadores de vulnerabilidad clínico-funcional fueron la alteración de la movilidad, la incontinencia urinaria, la sarcopenia, la marcha/caídas, los trastornos del estado de ánimo, las comorbilidades múltiples y la polifarmacia. Conclusión: los hallazgos mostraron una alta prevalencia de deterioro funcional en la enfermedad de Parkinson. Se cree que los resultados pueden contribuir para mejorar la atención a esta población, permitiendo a los profesionales de enfermería trabajar para promover el autocuidado