No effects of post-activation performance enhancement in elite male volleyball players under complex training.

The aim of this study was to establish reliability of post-activation performance enhancement in three manners: (1) interday morning and afternoon reliability; (2) intraday morning and afternoon reliability; (3) intraday set-to-set reliability. Twelve elite male volleyball players experienced in resistance training performed four identical experimental sessions-two in the morning and two in the afternoon. During each session participants performed a mini complex training session-three sets of a conditioning activity (CA) (3 repetitions of a trap bar deadlift at 80% 1RM with 15% of accommodating resistance) and 90 s after a CA performed squat jump (SJ) with 4 min intra-set rest interval. The ANOVA with repeated measures was used to assess significance of the effect of a CA and ICC to assess reliability of measurements. The PAPE protocol was found to be ineffective to subsequently enhance JH on various occasions. Also, the results of this study suggest that the practitioners may effectively implement appropriately organized complex training as both intraday set-to-set (0.87 and 0.82 for morning sessions; 0.83 and 0.58 for afternoon sessions) and interday morning (0.67) and afternoon (0.8) reliabilities seem to be acceptable. However, introducing two CT sessions within one day is highly questionable as at the moment intraday morning and afternoon reliability is vague (0.88 and 0.48).

Bench Press Range-of-Motion and Velocity-based Repetition Control: Effects on Ballistic Push-up Performance in Males.

The purpose of this study was to investigate whether the ballistic push-up (BPU) is responsive to post-activation performance enhancement (PAPE) after a bench press conditioning exercise using velocity-based repetition control. Additionally, we aimed to evaluate the effects of range of motion (ROM) conditions on subsequent BPU performance. In a randomized crossover design, 18 males performed two conditions (full ROM and self-selected partial ROM) of bench press at 80% of their 1RM until mean concentric velocity dropped 10%. Each participant performed two pre- and six post-test BPUs to assess the PAPE effect. Paired sample t-tests assessed bench press performance measures. Multiple two-way repeated measures ANOVAs assessed differences in flight time, impulse, and peak power for the pre- and post-test BPUs. No significant differences existed between ROM conditions for total repetitions, volume load, or peak velocity. Compared to partial ROM, full ROM showed greater displacement (0.42 ± 0.05 vs. 0.34 ± 0.05 m), work (331.99 ± 67.72 vs. 270.92 ± 61.42 J), and mean velocity (0.46 ± 0.09 vs. 0.44 ± 0.08 m/s). Neither bench press ROM condition enhanced the BPU and were detrimental in some cases. Several time points showed partial ROM (flight time: 2 min post, impulse: 12 min post, peak power: 12 min post) significantly greater than full ROM, possibly indicating less fatigue accumulation. The BPU may require a different stimulus or may not be practical for PAPE effects in college-aged males. Partial ROM can be an alternative that achieves similar peak velocities while requiring less overall work.

Does the sequence of plyometric and dynamic stretching exercises influence subsequent sprint performance? A randomized crossover intervention study.

The objectives of this study were to evaluate the acute effects of the sequence order of drop jumps (DJ) and dynamic stretching (DS) on sprinting performances in competitive athletes and to investigate the relationships between post-activation performance enhancement (PAPE) in sprint performance and lower limb power. Thirteen male jumpers and sprinters participated in this study (19 ± 2 years; 177 ± 7 cm; 71.7 ± 5.6 kg). Through a randomized crossover design, the athletes were exposed to three different conditions after a standardized warm-up: DS+DJ, DJ+DS, and control. Sprinting performance over 40 m was analysed with consideration of initial (0 to 20 m) and final acceleration (20 to 40 m) phases. The effect of intervention was examined by two-way repeated-measures of ANOVA. Pearson's correlation test was used to determine the association between PAPE during sprinting and jump performance. There was no effect of any factor on 40-m sprint performance. Meanwhile, the performance at 20-40 m was higher after the DS+DJ condition when compared to baseline (8.79 ± 0.43 vs. 8.91 ± 0.35 m/s; p = 0.015). However, the initial acceleration was worsened in the DJ+DS condition when compared to baseline (6.26 ± 0.25 vs. 6.22 ± 0.26 m/s; p = 0.002). There was a negative correlation between CMJ height and the improvement in final acceleration (r = -0.741; p = 0.004). The use of DS prior to DJ is an effective strategy to improve performance in the final acceleration phase (20-40 m). The athletes with lower levels of lower limb power benefited the most from this PAPE strategy.

The acute effects of a stretching and conditioning exercise protocol for the lower limbs on gait performance- a proof of concept and single-blind study.

Background: Due to improvement in movement performance, post-activation performance enhancement (PAPE) may open new possibilities to improve gait performance. However, no study has attempted to translate this phenomenon into walking. Therefore, the study aimed to test whether acute stretching followed by a conditioning exercise can improve subsequent gait performance in healthy adults. Research question: Can an exercise protocol subsequently improve gait performance? Methods: Sixteen individuals walked four 10-m trials (in each period) before and after 7 min of an exercise protocol composed of stretching (focusing on the lower limb) and a conditioning exercise (standing calf-raise wearing a vest of 20 kg). Gait spatialtemporal parameters and muscle activity of tibialis anterior and gastrocnemius medialis and lateralis muscles were obtained by a 3D-motion system and wireless electromyography, respectively. Before and after the exercise protocol, kinematic and muscle activity parameters were compared by a one-way ANOVA and the Wilcoxon signed-rank test, respectively. Results: After the exercise protocol, the participants walked with a faster step velocity (p < 0.018) and with a lower step duration (p < 0.025). Also, higher peak muscle activity (p < 0.008) and low-frequency (p < 0.034) activation of the anterior tibial muscle after the exercise protocol were observed. Significance: In conclusion, the protocol improves the stability and the muscles' efficiency during gait, contributing to a new approach to enhancing gait rehabilitation programs.

Post-Activation Performance Enhancement (PAPE) Increases Jumping Power in Elite Female Volleyball Athletes.

This study investigated PAPE effects of two conditioning activities (CA) and recovery times on the peak jumping power (PP) of elite female volleyball athletes. Players performed CA separately: three sets of three repetitions of back squats with 85% of 1RM (BS) or one set of five depth drops (DD). PP was measured with countermovement (CMJ) and squat jumps (SJ) before (pre-test) and two minutes (post-test 1) and six hours (post-test 2) after each CA. BS significantly reduced PP at post-test 1 (CMJ and SJ: p < 0.04, d between -0.36 and -0.28). At post-test 2, following BS, PP for both jump forms was significantly greater than at post-test 1 (p < 0.001, d between 0.54 and 0.55) and at pre-test (p < 0.048, d between 0.21 and 0.30). DD increased PP significantly (CMJ and SJ p < 0.05, d between 0.40 and 0.41) relative to pre-test at post-test 2 (there was no significant difference between pre-test and post-test 1). Comparing BS with DD, there were no significant differences (p > 0.05). The greatest PAPE effects were observed six hours after BS. CA are recommended for female athletes to improve jumping performance, but individual responses should be determined prior to use.

The Influence of Unstable Load and Traditional Free-Weight Back Squat Exercise on Subsequent Countermovement Jump Performance.

The purpose of the present study was to examine the effects of a back squat exercise with unstable load (UN) and traditional free-weight resistance (FWR) on subsequent countermovement jump (CMJ) performance. After familiarisation, thirteen physically active males with experience in resistance training visited the laboratory on two occasions during either experimental (UN) or control (FWR) conditions separated by at least 72 h. In both sessions, participants completed a task-specific warm-up routine followed by three maximum CMJs (pre-intervention; baseline) and a set of three repetitions of either UN or FWR back squat exercise at 85% 1-RM. During the UN condition, the unstable load was suspended from the bar with elastic bands and accounted for 15% of the total load. Post-intervention, three maximum CMJs were performed at 30 s, 4 min, 8 min and 12 min after the last repetition of the intervention. The highest CMJ for each participant was identified for each timepoint. No significant increases (p > 0.05) in jump height, peak concentric power, or peak rate of force development (RFD) were found after the FWR or UN conditions at any timepoint. The lack of improvements following both FWR and UN conditions may be a consequence of the low percentage of unstable load and the inclusion of a comprehensive task-specific warm-up. Further research is required to explore higher UN load percentages (>15%) and the chronic effects following the implementation of a resistance training programme.

Acute Effects of Complex Conditioning Activities on Athletic Performance and Achilles Tendon Stiffness in Male Basketball Players.

The goal of this study was to compare the effects of a bilateral conditioning activity consisting of back squats and drop jumps with a unilateral one consisting of split squats and depth jumps to lateral hop over sequentially performed countermovement jump (CMJ), modified t-agility test (MAT), and Achilles tendon stiffness. Twenty-six basketball players participated in this study and were randomly and equally assigned to one of two different test groups: bilateral (B - CA) or unilateral (U - CA) conditioning activity group. The B - CA group completed 2 sets of 4 repetitions of back squats at 80% of one-repetition maximum (1RM), then 10 drop jumps, while the U - CA group performed 2 sets of 2 repetitions of split squats on each leg at 80%1RM, followed by 5 depth jumps to lateral hop on each leg as conditioning activity (CA) complexes. After a warm-up and 5 min before the CA the baseline Achilles tendon stiffness, CMJ, and MAT time measurement were performed. In the 6th min after the CA, all tests were re-tested in the same order. The two-way repeated measures mixed ANOVAs revealed that both B - CA and U - CA failed to produce significant improvements in CMJ and MAT performance. In addition, a significant increase in Achilles stiffness was demonstrated with both protocols (a main effect of time: p = 0.017; effect size = 0.47; medium). This study revealed that combining back squats and drop jumps, as well as split squats and depth jumps to a lateral hop, had no effect on subsequent CMJ and MAT performance in basketball players. Based on these results, it can be assumed that combinations of exercises, even if they have similar movement patterns, may cause excessive fatigue, resulting in no PAPE effect.

Post flywheel squat vs. flywheel deadlift potentiation of lower limb isokinetic peak torques in male athletes.

The present study investigated the post-activation performance enhancement (PAPE) of isokinetic quadriceps and hamstrings torque after flywheel (FW)-squat vs. FW-deadlift in comparison to a control condition. Fifteen male athletes were enrolled in this randomised, crossover study. Each protocol consisted of 3 sets of 6 repetitions, with an inertial load of 0.029 kg.m2. Isokinetic quadriceps (knee extension) and hamstrings (knee flexion) concentric peak torque (60º/s) and hamstring eccentric peak torque (-60º/s) were measured 5 min after experimental or control conditions. A significant condition (PAPE) effect was reported (f = 4.067, p = 0.008) for isokinetic hamstrings eccentric peak torque following FW-squat and FW-deadlift, but no significant differences were found for quadriceps and hamstrings concentric peak torques. The significant difference averaged 14 Nm between FW-squat vs. control (95% CI: 2, 28; d = 0.75, moderate; p = 0.033), and 13 Nm between FW-deadlift vs. control (95% CI: 1, 25; d = 0.68, moderate; p = 0.038). This study reported that both FW-squat and FW-deadlift exercises are equivalently capable of generating PAPE of isokinetic hamstrings eccentric torque. Practitioners may use these findings to inform strength and power development during complex training sessions consisting of flywheel-based exercises prior to a sport-specific task.

Metabolic mechanism of nitrogen modified atmosphere storage on delaying quality deterioration of rice grains.

Nitrogen modified atmosphere was an effective way to control pest infestation in grains. In this study, the quality changes of rice during nitrogen modified atmosphere packaging storage (N2-MAPS) were monitored. An un-targeted metabolomics method was used to detect the rice metabolites and explore the mechanism of N2-MAPS for delaying rice deterioration. In this study, two rice species were studied under N2-MAPS and conventional storage at 30 °C for 150 days. The quality changes of rice during storage were monitored. The results showed that N2-MAPS could retard the increase of fatty acid value and amylose content, and defer the decrease of enzyme activities. And N2-MAPS had no significant influence on texture characteristics of rice. The metabolomics results suggested some metabolites and pathways were affected by N2-MAPS and revealed that N2-MAPS could protect rice cells from oxidative damage, maintain cell integrity and stability by regulating the metabolism to delay the rice deterioration.

Post-Isometric Back Squat Performance Enhancement of Squat and Countermovement Jump.

The effectiveness of isometric conditioning activity (CA) is not well described in terms of the level of performance enhancement and the presence of a stretch and shortening cycle in subsequent explosive tasks. Therefore, the aim of this study was to evaluate the effect of a maximum isometric squat as the CA and a subsequent squat jump (SJ) and countermovement jump (CMJ) height. A total of 31 semi-professional handball and soccer players were randomly assigned to two different conditions: (i) 3 sets of 3 repetitions (each lasting 3 s) of maximum isometric back squats (EXP), and (ii) no CA (CTRL). The jump height measurements were performed 5 min before the CA and approximately at the 4th and 8th minute following the completion of the CA. Due to the high inter-individual variability in the potentiation responses, the best value obtained post-CA was also analyzed. The SJ height significantly increased from baseline to the 8th minute post-CA (p = 0.004; ES = 0.31; Δ = +3.1 ± 5.0%) in the EXP condition. On the other hand, the CMJ height was significantly higher in the 4th (p = 0.001; ES = 0.23; Δ = +2.7 ± 3.7%) and 8th minute post-CA (p = 0.005; ES = 0.32; Δ = +3.6 ± 5.7%) in comparison to baseline during the EXP condition. Furthermore, SJ height significantly increased from baseline to the best time-point during the EXP (p < 0.001; ES = 0.47; Δ = +4.9 ± 4.9%) and CTRL (p = 0.038; ES = 0.21; Δ = +2.5 ± 5.8%) condition. Moreover, the CMJ height was significantly higher at the best time-points than at the baseline during EXP (p < 0.001; ES = 0.53; Δ = +5.6 ± 4.7%) and CTRL (p = 0.002; ES = 0.38; Δ = +3.1 ± 5.2%) condition. The findings from this study indicate that a maximum isometric squat, used as a CA, effectively improved SJ and CMJ height. This suggests that the presence or absence of a stretch and shortening cycle in both CA and post-CA tasks does not significantly impact the post-activation performance enhancement response.

Swimming Warm-Up and Beyond: Dryland Protocols and Their Related Mechanisms-A Scoping Review.

In swimming, the beneficial effects of the in-water warm-up are often undermined by the long transition periods before competition (≥ 20 min). For that reason, studies comparing the effects of in-water warm-ups followed by dryland activities have been conducted in the swimming literature. This has brought conflicting evidence due to large combinations of supervised and unsupervised warm-up procedures used. Therefore, a scoping review was performed to discuss (1) why warm-up strategies are important for competitive swimming; to identify (2) what are the different warm-up approaches available in the literature, and; to establish (3) what are the main conclusions, considerations and gaps that should be addressed in further research to provide clearer guidance for interventions. The search was conducted on PubMed, Web of Science, Scopus, and SPORTDiscus databases. To be considered eligible, studies must have assessed acute short-term responses of warm-up procedures in swimmers by using randomized controlled trials or pre-post study designs. A total of 42 articles were included in this review. The effectiveness of warm-up responses was evaluated based on the inclusion or not of warm-up, the type of conditioning activity (in-water exercise, in-water exercise combined with dryland or dryland exercise only), its duration, and intensity. (1) Warm-up mechanisms have been mainly related to temperature changes associated to cardiovascular adaptations and short-term specific neuromuscular adaptations. Thus, maintaining muscle activity and body temperature during the transition phase immediately prior to competition could help swimmers' performance; (2) the most common approach before a race usually included a moderate mileage of in-water warm-up (~ 1000 m) performed at an intensity of ≤ 60% of the maximal oxygen consumption, followed by dryland protocols to keep the muscle activity and body temperature raised during the transition phase. Dryland activities could only optimize performance in sprint swimming if performed after the in-water warm-up, especially if heated clothing elements are worn. Using tethered swimming and hand-paddles during warm-ups does not provide superior muscular responses to those achieved by traditional in-water warm-ups, possibly because of acute alterations in swimming technique. In contrast, semi-tethered resisted swimming may be considered as an appropriate stimulus to generate post-activation performance enhancements; (3) nothing has yet been investigated in backstroke, butterfly or individual medley, and there is a paucity of research on the effects of experimental warm-ups over distances greater than 100 m. Women are very under-represented in warm-up research, which prevents conclusions about possible sex-regulated effects on specific responses to the warm-up procedures.

The impact of resistance exercise range of motion on the magnitude of upper-body post-activation performance enhancement.

BACKGROUND: Various studies have used different exercise protocols as post-activation performance enhancement (PAPE) stimulus; however, little attention has been given to the effects of exercise range of motion on the PAPE effect and subsequent performance enhancement. This study aimed to compare the PAPE responses induced by the bench press performed with different ranges of motion on subsequent bench press throw performance. METHODS: Ten resistance-trained males (age: 26 ± 3 years; body mass: 93.2 ± 9.4 kg; height: 181 ± 6 cm; experience in resistance training: 6.3 ± 2.4 years; relative bench press one-repetition maximum (1RM) 1.54 ± 0.2 kg/body mass) performed four experimental sessions consisting of a single set of the bench press at 80%1RM until mean barbell velocity dropped by 10% as the conditioning activity (CA) with a (1) standard, (2) cambered, (3) and reversed cambered barbell or a control condition in which the participants did not perform any CA. To assess the PAPE effect, single-sets of 2 repetitions of the bench press throw at 30%1RM were performed before and after the CA at the following time points: 2, 4, 6, 8, 10 min. RESULTS: The two-way ANOVA (4 conditions × 2time points) showed a significant interaction for peak power (p < 0.001; η2 = 0.556) and peak velocity (p = 0.001; η2 = 0.457). The standard barbell bench press CA led to the greatest performance enhancement in peak power (p = 0.001; ES = 0.54) and in peak velocity (p = 0.002; ES = 0.71) within the examined conditions. CONCLUSIONS: The results of this study indicate that the range of motion of the CA has a significant impact on the magnitude of the PAPE response, and the greatest effect can be reached when the range of motion of the CA and the subsequent explosive task is similar.

Does caffeine ingestion affect the lower-body post-activation performance enhancement in female volleyball players?

BACKGROUND: Post-activation performance enhancement (PAPE) is a physiological phenomenon that acutely improves voluntary muscular performance following a conditioning activity. A large and growing body of literature has investigated different strategies to induce a PAPE stimulus; however, little attention has been given to whether acute caffeine ingestion could augment the effect of PAPE on subsequent performance. This study evaluated the acute effects of caffeine ingestion and back squat conditioning activity on subsequent countermovement jump (CMJ) performance in female semi-professional volleyball players. METHODS: Fourteen resistance-trained female volleyball players (26 ± 3 years) performed 3 different testing conditions in randomized order: where each ingested 6 mg/kg of caffeine (CAF) or placebo (PLAC) and performed a single set of back squats at 80%1RM until mean movement velocity dropped by 10% as the conditioning activity or a control (CTRL) condition where participants did not ingest any supplement and did not perform the conditioning activity. CMJ height was examined at baseline and in 2 min intervals until 10 min postconditioning activity. Furthermore, due to the wide inter-individual variation in optimal recovery time of PAPE response, the baseline and best post-conditioning activity performance were also analyzed. RESULTS: The Friedman test revealed a significant difference in jump height within CTRL (p = 0.002) and CAF (p = 0.001) conditions, but no significant difference was found within the PAP condition. The post hoc showed a significant decrease in jump height in 8th min in CTRL condition (p = 0.022, effect size [ES] = -0.31), a significant increase in jump height in 2nd min in CAF condition (p = 0.013, ES = 0.3), without differences in PLAC condition in comparison to baseline values. Moreover, a significant jump height increases from baseline to best performance post conditioning activity value for CAF (p = 0.001, ES = 0.39) and PLAC (p = 0.001, ES = 0.3) condition, but no significant difference was found for the CTRL condition. CONCLUSIONS: The single set of heavy-loaded back squats with controlled velocity used as a conditioning activity in the current study enhanced subsequent CMJ performance in female volleyball players with no additional effect of caffeine.

Acute Effects of Different Activity Types and Work-To-Rest Ratio on Post-Activation Performance Enhancement in Young Male and Female Taekwondo Athletes.

The study assessed conditioning activities' (CAs') effects involving different work-to-rest ratios (WRR) on taekwondo athletes' physical performance. Adolescent taekwondo athletes (age: 16 ± 1 years) randomly participated in the control six experimental conditions. Each condition was composed of standard warm-up and CA composed of plyometrics (P) or repeated high-intensity techniques (RHIT) performed using three different WRR: 1:6, 1:7, self-selected rest time (SSRT). After rest, athletes performed countermovement jump (CMJ), taekwondo specific agility test (TSAT), 10 s frequency speed kick test (FSKT-10s), multiple frequency speed kick test (FSKT-mult). P1:7, SSRT induced techniques higher number in FSKT-10s (p < 0.001 for all comparisons) and lower TSAT time (p < 0.01 for all comparisons) compared with control. Kicks-number recorded during FSKT-mult was lower in the control compared with RHIT1:6 (p = 0.001), RHIT1:7 (p < 0.001), RHITSSRT (p < 0.05), P1:7 (p < 0.001), and SSRT (p < 0.001). Kicking decrement index (DI) during FSKT-mult was lower after RHIT1:6 compared with control (p = 0.008), RHIT1:7 (p = 0.031), P 1:6 (p = 0.014), PSSRT (p = 0.041). (1) P1:7 and PSSRT can be used to improve taekwondo-specific agility and kicks-number, (2) RHIT1:6 is beneficial to maintain low DI, and (3) plyometric and different WRR-repeated-techniques can enhance kicks-number.

Time Duration of Post-Activation Performance Enhancement (PAPE) in Elite Male Sprinters with Different Strength Levels.

(1) Purpose: This study aimed to explore the time duration of post-activation performance enhancement (PAPE) in elite male sprinters with different strength levels. (2) Methods: Thirteen elite male sprinters were divided into a strong group (relative strength: 1RM squat normalized by body mass of ≥2.5; n = 6) and a weak group (relative strength of <2.5; n = 7). All sprinters performed one static squat jump (SSJ) at baseline and 15 s, 3 min, 6 min, 9 min, and 12 min following an exercise protocol including three reps of a 90% 1RM back squat. Two force plates were used to determine the vertical jump height, the impulse output, and the power output for all SSJs. (3) Results: Significant improvements in vertical jump height and peak impulse were observed (p < 0.05) at 3, 6, and 9 min, without significant between-group differences. The peak power had a significant increase in 3 min (p < 0.01) and 6 min (p < 0.05), with also no significant difference between-group differences. Moreover, the stronger subjects induced a greater PAPE effect than the weaker counterparts at 3, 6, and 9 min after the intervention. The maximal benefit following the intervention occurred at 6 min and 3 min after the intervention in the stronger and weaker subjects, respectively. (4) Conclusions: The findings indicated that three reps of a 90% 1RM back squat augmented the subsequent explosive movement (SSJ) for 3−9 min in elite male sprinters, especially in stronger sprinters.

Postactivation performance enhancement (PAPE) of sprint acceleration performance.

Postactivation performance enhancement (PAPE) is a principle that an acute bout of high-intensity voluntary exercise is followed by an enhancement in strength, speed or power production. This study intended to show a direct correlation between intensity, specificity and the outcome of a maximal task of sprint accelerations compared to a previously defined weighted plyometric intervention. In a randomised controlled, double-blind trial, professional footballers undertook 20 m maximal sprint accelerations at a baseline and at 2 and 6 min post-intervention after 1 of 3 interventions; 2 repetitions of 20 m sprint accelerations (S), 3 × 10 alternative leg weighted bounding (P) and control (C). Relative to the baseline there was a significant improvement for S over 10 and 20 m at 2 min of 0.12m.s-1 and 0.11m.s-1 and 6 min of 0.11m.s-1 and 0.12m.s-1. Relative to the baseline P also had a significant improvement over 10 and 20 m at 2 min 0.09m.s-1 and 0.09m.s-1 and 6 min of 0.11m.s-1 and 0.09m.s-1. There was a significant improvement in C between 2 and 6 min post-intervention at 10 and 20 m of 0.06m.s-1 and 0.08m.s-1. This finding suggests a maximal sprint acceleration may enhance the outcome of a subsequent maximal sprint acceleration at 2 min, but the latter results could not be directly attributed to the interventions as previous testing is likely to have influenced these outcomes.

Pathway Preferential Estrogens Prevent Hepatosteatosis Due to Ovariectomy and High-Fat Diets.

About 20-30% of premenopausal women have metabolic syndrome, and the number is almost double in postmenopausal women, and these women have an increased risk of hepatosteatosis. Postmenopausal women with metabolic syndrome are often treated with hormone replacement therapy (HRT), but estrogens in currently available HRTs increase the risk of breast and endometrial cancers and Cardiovascular Disease. Therefore, there is a critical need to find safer alternatives to HRT to improve postmenopausal metabolic health. Pathway preferential estrogen 1 (PaPE-1) is a novel estrogen receptor ligand that has been shown to favorably affect metabolic tissues without adverse effects on reproductive tissues. In this study, we have examined the effects of PaPE-1 on metabolic health, in particular, examining its effects on the liver transcriptome and on plasma metabolites in two different mouse models: diet-induced obesity (DIO) and leptin-deficient (ob/ob) mice. PaPE-1 significantly decreased liver weight and lipid accumulation in both DIO and ob/ob models and lowered the expression of genes associated with fatty acid metabolism and collagen deposition. In addition, PaPE-1 significantly increased the expression of mitochondrial genes, particularly ones associated with the electron transport chain, suggesting an increase in energy expenditure. Integrated pathway analysis using transcriptomics and metabolomics data showed that PaPE-1 treatment lowered inflammation, collagen deposition, and pathways regulating fatty acid metabolism and increased metabolites associated with glutathione metabolism. Overall, our findings support a beneficial metabolic role for PaPE-1 and suggest that PaPE-1 may protect postmenopausal women from fatty liver disease without increasing reproductive cancer risk.

Post Flywheel Squat Potentiation of Vertical and Horizontal Ground Reaction Force Parameters during Jumps and Changes of Direction.

(1) Background: The aim of the study was to determine the post-activation performance enhancement (PAPE) of vertical and horizontal ground reaction force parameters during jumps and change of direction following flywheel squat exercise using two different flywheel inertias. (2) Methods: Eleven male athletes performed a countermovement jump (CMJ), standing broad jump (SBJ), and "modified 505" change of direction (COD) in a control condition and 6 minutes following three sets of six repetitions of flywheel half squats at one of two inertias (0.029 kg·m2 and 0.061 kg·m2). Peak directional ground reaction force, power, and rate of force development were calculated for each test. (3) Results: Higher inertia flywheel squats were able to acutely enhance CMJ peak vertical force (Bayes Factor (BF10) = 33.5, very strong; δ = 1.66; CI: 0.67, 2.70), whereas lower inertia flywheel squats were able to acutely enhance CMJ peak vertical power (BF10 = 3.65, moderate; δ = 0.93; CI: 0.11, 1.88). The vertical squat exercise induced no PAPE effect on resultant SBJ or horizontal COD ground reaction force parameters, nor were any differences observed between the inertias. (4) Conclusions: Researchers and practitioners should consider the kinetic and kinematic correspondence of a pre-load stimulus to the subsequent sport-specific activity (i.e., flywheel squat to CMJ).

The Effects of Plyometric Conditioning on Post-Activation Bench Press Performance.

The present study aimed to determine the effects of plyometric push-ups as a conditioning activity (CA) on high-loaded bench press performance. Two groups of resistance-trained males age (24.5 ± 2.6 years, body mass 84.8 ± 8 kg) performed one of two CA protocols: 3 sets of 5 repetitions of plyometric push-ups with a 1 min rest interval between sets (PAPE; n=12) or equal time aerobic warm-up (CONT; n=12). Four minutes after completion of the CA protocols the participants performed 3 sets of 3 repetitions of the bench press exercise at 70%1RM and 4 min rest interval between sets to assess post-activation differences in peak power output (PP), mean power output (MP), peak bar velocity (PV), and mean bar velocity (MV) between conditions. The two-way ANOVA revealed significant condition × set interaction effect for PP (p<0.01), MP (p<0.05), PV (p<0.01), and MV (p=0.02). The post hoc for condition × set interaction showed that PAPE caused a significant decrease in PP and PV for P-Set2 and P-Set3 when compared to baseline (BA). The MP and MV for the PAPE condition decreased significantly during the P-Set3 compared to BA and to P-Set1. The t-test comparisons for delta values showed significant differences between PAPE and CONT in PP for P-Set1 - BA (p<0.01), in MP for P-Set2 - P-Set1 (p<0.03) and for P-Set3 - P-Set1 (p=0.04). Furthermore, there were significant differences in PV for P-Set3 - BA; P-Set2 - P-Set1; P-Set3 - P-Set1 (p<0.01; p<0.01; p<0.02 respectively). Finally, there were significant differences in MV for P-Set1 - BA; P-Set2 - P-Set1 and P-Set3 - P-Set1 (p<0.01; p<0.01; p<0.02 respectively). This study demonstrated that plyometric push-ups lead to performance enhancement of the bench press exercise at 70%1RM. The increases in performance were observed only in the first set following the CA, while a significant decrease of these variables was registered in P-Set2 and P-Set3.

Postactivation performance enhancement: Does conditioning one arm augment performance in the other?

The purpose was to determine whether postactivation performance enhancement is specific to the muscle being conditioned or if it is also observed within the homologous muscles of the contralateral limb (after accounting for the warm-up and random error). We also investigated whether this differed based on training status or muscle size. One hundred seven participants (75 untrained; 32 trained) participated in four sessions. Visit 1 included baseline measurements and familiarization. Visits 2-4 included the completion of one of the three experimental conditions: (a) control, (b) same side and (c) crossover completed in a randomized order. The control condition completed all testing except for the conditioning contraction. The same side condition completed the conditioning contraction on the same side as the strength test. The crossover condition completed the conditioning on the arm opposite to the strength test. The variable of interest was the change from baseline in isokinetic strength. Our analysis indicated that of the hypotheses compared, the posterior probabilities (posterior probability of 0.506) favoured the hypothesis that the effect was local and greatest in those who were resistance trained [mean (SD) of 1.4 (2.2) Nm over the control in those resistance trained]. We found no relationship between muscle size and postactivation performance enhancement. In conclusion, there is an influence of training status pertaining to the postactivation performance enhancement effect but no influence from baseline muscle size. It appears unlikely that the effect is due to a systemic mechanism.