Celebrating JSR's 30th anniversary: reminiscences of a Main Editor.

Reminiscences of one of the founding Main Editors of JSR on its 30th anniversary.

Animal Reproduction journal and International Symposium on Animal Biology of Reproduction: Historical and personal reflections on two decades of exciting amalgamation of young and old science and scientists.

In 2024, the Brazilian College of Animal Reproduction (CBRA in Portuguese) is proudly celebrating its golden 50th anniversary. Founded in 1974, CBRA has had a very productive and challenging journey of five decades, achieving many important milestones that have established it as a major society and its journal as a major reference in the field of animal reproduction, both in Brazil and internationally. Coincidentally, the Animal Reproduction journal and the International Symposium on Animal Biology (ISABR), both created and sponsored by CBRA, are also celebrating their 20th and 10th anniversary and edition, respectively, this year. These remarkable events are being celebrated in the city of Fortaleza, Brazil, during the 10th edition of ISABR. As someone who had the privilege of playing a leading role in the creation and establishment of both Animal Reproduction journal and ISABR, I am honored to describe here the favorable circumstances that led to these significant achievements. The crucial steps and combined efforts required to make these institutions successful were unconditionally supported by the CBRA. Additionally, significant global networking and scientific collaborations, both individual and collective, have been pivotal in advancing the science and connecting the scientific community, spanning both young and experienced members, for decades. Finally, I hope that this historical article will inspire future generations of scientists in the field to continue CBRA's journey and leadership, ensuring the growth of Animal Reproduction and ISABR advancement to even higher standards.

Top 20 EGFR+ NSCLC Clinical and Translational Science Papers That Shaped the 20 Years Since the Discovery of Activating EGFR Mutations in NSCLC. An Editor-in-Chief Expert Panel Consensus Survey.

The year 2024 is the 20th anniversary of the discovery of activating epidermal growth factor receptor (EGFR) mutations in non-small cell lung cancer (NSCLC). Since then, tremendous advances have been made in the treatment of NSCLC based on this discovery. Some of these studies have led to seismic changes in the concept of oncology research and spurred treatment advances beyond NSCLC, leading to a current true era of precision oncology for all solid tumors. We now routinely molecularly profile all tumor types and even plasma samples of patients with NSCLC for multiple actionable driver mutations, independent of patient clinical characteristics nor is profiling limited to the advanced incurable stage. We are increasingly monitoring treatment responses and detecting resistance to targeted therapy by using plasma genotyping. Furthermore, we are now profiling early-stage NSCLC for appropriate adjuvant targeted treatment leading to an eventual potential "cure" in early-stage EGFR+ NSCLC which have societal implication on implementing lung cancer screening in never-smokers as most EGFR+ NSCLC patients are never-smokers. All these advances were unfathomable in 2004 when the five papers that described "discoveries" of activating EGFR mutations (del19, L858R, exon 20 insertions, and "uncommon" mutations) were published. To commemorate this 20th anniversary, we assembled a global panel of thoracic medical oncology experts to select the top 20 papers (publications or congress presentation) from the 20 years since this seminal discovery with December 31, 2023 as the cutoff date for inclusion of papers to be voted on. Papers ranked 21 to 30 were considered "honorable mention" and also annotated. Our objective is that these 30 papers with their annotations about their impact and even all the ranked papers will serve as "syllabus" for the education of future thoracic oncology trainees. Finally, we mentioned potential practice-changing clinical trials to be reported. One of them, LAURA was published online on June 2, 2024 was not included in the list of papers to be voted on but will surely be highly ranked if this consensus survery is performed again on the 25th anniversay of the discovery EGFR mutations (i.e. top 25 papers on the 25 years since the discovery of activating EGFR mutations).

The 125th Anniversary of Aspirin-The Story Continues.

The year 2024 marks the 125th anniversary of aspirin, still one of the most frequently used drugs worldwide. Despite its veritable age, it is still relevant in pharmacotherapy and its use has spread to new areas over time. Due to aspirin's multiple pharmacological actions unified in one single molecule (i.e., analgesic, antipyretic, anti-inflammatory, antithrombotic, and antiviral effects), it continues to attract considerable attention in the scientific community and is subject to intense basic and clinical research. In fact, recent results confirmed aspirin's potential role as an antiviral drug and as an agent that can block harmful platelet functions in inflammatory/immunological processes. These features may open up new horizons for this ancient drug. The future of aspirin looks, therefore, bright and promising. Aspirin is not yet ready for retirement; on the contrary, its success story continues. This 125th anniversary paper will concisely review the various therapeutic uses of aspirin with a particular emphasis on the latest research results and their implications (e.g., use as an antiviral agent). In addition, the reader is provided with future perspectives for this remarkable drug.

Forty Years of Inferential Methods in the Journals of the Society for Molecular Biology and Evolution.

We are launching a series to celebrate the 40th anniversary of the first issue of Molecular Biology and Evolution. In 2024, we will publish virtual issues containing selected papers published in the Society for Molecular Biology and Evolution journals, Molecular Biology and Evolution and Genome Biology and Evolution. Each virtual issue will be accompanied by a perspective that highlights the historic and contemporary contributions of our journals to a specific topic in molecular evolution. This perspective, the first in the series, presents an account of the broad array of methods that have been published in the Society for Molecular Biology and Evolution journals, including methods to infer phylogenies, to test hypotheses in a phylogenetic framework, and to infer population genetic processes. We also mention many of the software implementations that make methods tractable for empiricists. In short, the Society for Molecular Biology and Evolution community has much to celebrate after four decades of publishing high-quality science including numerous important inferential methods.

Some Reflections on the 50th Anniversary of Hospice Care in America.

This article celebrates the 50th anniversary of hospice care in America. It also offers a brief recounting of one person's reflections on some aspects of the history, achievements, and current status of American hospice care.

Clinical gait analysis 1973-2023: Evaluating progress to guide the future.

Clinical gait analysis has been used to inform treatment for over 50 years. Over that period there have been significant advances in motion capture technology and software development, driven in part by innovations in biomechanics. The aim of this paper is to review the current state of the art in gait analysis, mapping progress over the last five decades using the collective experience of the community of researchers and clinicians.An online survey was circulated to gait analysts to canvas opinion and responses were received from 229 people from 28 countries.Respondents identified the greatest progress in the areas of hardware, automation of processes, and software development. Despite laboratories being better equipped, many of today's challenges would have been very familiar to those working in 1973. Better algorithms and more evidence are needed to establish a secure link between gait analysis data and clinical decision making. Biomechanical models require further refinement to overcome well known limitations. Despite innovation, clinical gait analysis remains relatively unknown in the wider healthcare field.Growth in the global Gait Analysis communities and advances in remote communication technology have created new opportunities for taking on this challenge over the next 50 years. Hopefully, future innovation will lead to clinical gait analysis becoming more accessible, more flexible to real world mobility and more able to exploit emerging advanced modelling techniques.

Brief history of the Society for Melanoma Research: A community of clinicians, researchers, and friends.

To commemorate the 20th Anniversary of the Society of Melanoma Research and the first International Melanoma Research Congress held in June of 2003, we have described in brief, how the Society for Melanoma Research (SMR) began, the purpose, goals, and governance of the SMR, and how the society has evolved to support new melanoma researchers. In celebration of the immense progress in treating melanoma patients over the last 20 years and the impact of the SMR on these advances, we have highlighted memories and insight from early SMR members and founders.

Anniversary reactions among journalists covering terror: stress reactions and well-being 10 years after the terror in Norway.

Background: Covering terror and catastrophes can be traumatic for journalists, potentially resulting in long-term impairment. This study investigated 10-year anniversary reactions among Norwegian journalists who covered the Oslo/Utöya terror incident in Norway, 2011.Objective: The study aimed to investigate whether level of traumatic exposure and support actions in 2011 were related to anniversary reactions and current psychological well-being in 2021. It also explored if magnitude of anniversary reactions was related to level of current well-being.Method: A cross-sectional survey was sent to journalists who still work within journalism, eight weeks after the 10-year anniversary (N = 200). Participants reported retrospectively on trauma exposure, ethical dilemmas and social support in 2011, as predictors, and attitude to media anniversary coverage, anniversary-related stress, and well-being, as outcome variables.Results: More ethical dilemmas in 2011 (r = .295, p < .001) were related to a larger degree of anniversary-related stress in 2021. Having received less workplace social support in 2011 was related to more stress reactions (r = -.196, p < .05), while the magnitude of overall traumatic exposure in 2011 was not related to stress. Social support also predicted a higher level of current well-being in 2021 (r = .381, p < .001). More severe anniversary-related stress symptoms were significantly associated with decreased level of current well-being (r = -.259, p < .001).Conclusion: Journalists can experience lasting consequences from demanding experiences at work, including fluctuating stress symptoms during incident anniversaries. It is crucial for both journalists and newsrooms to recognize and be aware of the potential impact of anniversaries on the well-being of those involved in the initial coverage.

In a cross-sectional study carried out in 2021, journalists who had faced more ethical dilemmas while covering terror in 2011 had more anniversary-related stress symptoms in 2021. A larger magnitude of overall traumatic exposure in 2011 was not related to stress reactions ten years later.Journalists who had received more workplace social support in 2011 had lower stress levels in 2021.Journalists who had received more support in 2011 had higher levels of current well-being in 2021.Journalists with lower levels of anniversary-related stress symptoms had higher current well-being.

100 years of glucagon anniversary.

The year 2023 marks 100 years since publication of the first report of a hyperglycemic factor in pancreatic extracts which C P Kimball and John R Murlin named glucagon (from GLUCose AGONist). Glucagon has a range of profound effects on metabolism including, but not limited to, stimulation of hepatic glucose production. Dysregulation of glucagon secretion is a key feature of both major forms of diabetes, leading to the concept that diabetes is a bihormonal disorder. Still, the work to fully understand the production and biological effects of glucagon has proceeded at a slower pace compared to that of insulin. A recent resurgence of interest in the islet alpha (α) cell, the predominant site of glucagon production, has been facilitated in part by technological innovations. This work has led to significant developments in the field, from defining how alpha cells develop and how glucagon secretion from pancreatic alpha cells is regulated to determining the role of glucagon in metabolic homeostasis and the progression of both major forms of diabetes. In addition, glucagon is considered to be a promising target for diabetes therapy, with many new potential applications arising from research in this field. This collection of reviews, led by Guest Editors James Cantley, Vincent Poitout and Rebecca Hull-Meichle, is intended to capture the field's current understanding of glucagon and alpha cell biology, as well stimulate additional interest and research on this important hormone.

Claims of priority - The scientific path to the discovery of X-rays.

Shortly after Röntgen's publication about a new kind of rays, a dispute about priority claims began. Röntgen was not the first researcher to produce X-rays nor the first to take X-ray images. An analysis of the history of cathode ray research in the 19th century reveals ample evidence that researchers before Röntgen had already produced X-rays, albeit without knowing this. Most of them, for their part, did not claim any priority, some did so rather casually. The German-Hungarian physicist Philipp Lenard, a co-founder of German Physics, considered himself a "true discoverer". It remains to be said, however, that he, like many others before him, failed to recognize the character of the new radiation. It was Wilhelm Conrad Röntgen, with his three scientific publications on X-rays, who laid the foundations for their physical clarification and paved the way for the success story of their application in a variety of fields that continues to this day.

Spatial- and Temporal-Trajectory Analysis of the Crested Ibis (Nipponia nippon) by Fusing Multiple Sources of Data.

The Crested Ibis (Nipponia nippon) is an endangered animal with an extremely high ecological, humanistic, and scientific value. However, this species still faces survival challenges, due to rapidly shrinking foraging grounds, the serious interference of human behavior, and increased habitat requirements. Geographical environment is a significant factor affecting Crested Ibis behavior-pattern analysis and habitat protection. The spatial and temporal trajectory contains habitat location and period information, a vital record of the Crested Ibis' habits, and the basis of all research. Nevertheless, there are only a handful of studies on the missing trajectory data and fusing multiple sources of environmental data-research methods. We studied the spatial and temporal habitat use of the tracked Crested lbis by fusing multiple data-sources in China. This paper adopts the LSTM (long short-term memory) model to supplement the missing trajectory data and perform cluster mining; and a random forest model is used to predict the habitat of the Crested Ibis with high fitting accuracy (R2 = 84.9%). The results show that the Crested Ibis distribution-pattern is characterized by high altitude and proximity to woodland and rivers. Additionally, the habitat dependence on the village implicates human agricultural activities in positively impacting its reproduction. This paper provides a complete method for analyzing Crested Ibis' spatial and temporal trajectory by fusing multi-source data, which is crucial for protecting the survival and reproduction of the Crested Ibis.

Editorial: The society for environmental geochemistry and health (SEGH): 50 years and beyond.

When the SEGH international board released a short editorial paper back in 2019, we described an aim to increase the membership offering, whilst improving the diversity of input regionally, by scientific discipline and to ensure greater and more regular contact across the regions from 2020 onwards. Wider aspirations described in 2019 (Watts et al. 2019) are discussed within this short communication at the end of 2021 to evaluate progress made. In particular, how the SEGH community adapted to the unprecedented circumstances that have challenged each and every one of us throughout the COVID-19 pandemic since early 2020 and are likely to influence our activities for the foreseeable future.

The Asian Cardiovascular and Thoracic Annals turns 30.

The Asian Cardiovascular and Thoracic Annals turns 30 in 2023. A historical review since it was first published in March 1993 is presented.

On the Occasion of 70th Anniversary of Life and 45 Years of Academic Work of Academician Izet Masic.

In the hilly Balkans, a folk proverb has been circulating for a long time, "It is most difficult to be a prophet in one's own village", which reflects the age-old mistrust of the population towards new ideas. This is not surprising in the least, because since the written history of the peoples of the Balkans has existed, a continuous series of conquerors and local rulers who subjugated the common folks and imposed their world view can be traced. Nevertheless, from time to time, people with great strength appear who not only break the shackles imposed by the powerful, but through their actions find a way to the souls of their compatriots and gain their unreserved trust. One of such spontaneous creators is professor Izet Masic, who achieved a miracle of medical publishing in his Sarajevo and Bosnia and Herzegovina and traced the path of medical science. There may be thousands of medical journals in the world, more or less reputable, and researchers from the Balkans can publish their work in them, but only domestic medical journals can initiate and direct domestic medical research, and educate young researchers in the right way. Professor Masic made it possible for authors from Bosnia and Herzegovina and other Balkan countries to present their results to the world and receive an incentive from impartial experts to continue their work and progress more and more by editing and publishing three domestic journals at once, which are visible in the most important world bases,. The progress in research then translated into improving medical practice and health care of the population. The following details from Professor Masic's biography tell us how this miracle happened. This year, academician Izet Masic, Editor-in-Chief of a few biomedical journals, including Acta Informatica Medica journal, celebrates his 70th birthday and also 45 years of his academic and scientific work.