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1.
JMIR Aging ; 7: e55693, 2024 Aug 01.
Artículo en Inglés | MEDLINE | ID: mdl-39088803

RESUMEN

BACKGROUND: Digital technologies can assist and optimize health care processes. This is increasingly the case in the musculoskeletal health domain, where digital platforms can be used to support the self-management of musculoskeletal conditions, as well as access to services. However, given a large proportion of the population with musculoskeletal conditions are older adults (aged ≥60 years), it is important to consider the acceptability of such platforms within this demographic. OBJECTIVE: This study aims to explore participants' opinions and perceptions on the use of digital platforms for supporting the self-management of musculoskeletal conditions within older adult (aged ≥60 years) populations and to gather their opinions on real examples. METHODS: A total of 2 focus groups (focus group 1: 6/15, 40%; focus group 2: 9/15, 60%) were conducted, in which participants answered questions about their thoughts on using digital health platforms to prevent or manage musculoskeletal conditions. Participants were further presented with 2 example scenarios, which were then discussed. Interviews were audio recorded, transcribed, and analyzed thematically. Participants were aged ≥60 years and with or without current musculoskeletal conditions. Prior experience of using smartphone apps or other digital health platforms for musculoskeletal conditions was not required. Focus groups took place virtually using the Teams (Microsoft Corp) platform. RESULTS: A total of 6 themes were identified across both focus groups: "experiences of digital health platforms," "preference for human contact," "barriers to accessing clinical services," "individual differences and digital literacy," "trust in technology," and "features and benefits of digital health technologies." Each theme is discussed in detail based on the interview responses. The findings revealed that most participants had some existing experience with digital health platforms for preventing or managing musculoskeletal conditions. Overall, there was a lack of trust in and low expectations of quality for digital platforms for musculoskeletal health within this age group. While there was some concern about the use of digital platforms in place of in-person health consultations, several benefits were also identified. CONCLUSIONS: Results highlighted the need for better communication on the benefits of using digital platforms to support the self-management of musculoskeletal conditions, without the platforms replacing the role of the health care professionals. The concerns about which apps are of suitable quality and trustworthiness lead us to recommend raising public awareness around the role of organizations that verify and assess the quality of digital health platforms.


Asunto(s)
Grupos Focales , Enfermedades Musculoesqueléticas , Automanejo , Humanos , Anciano , Masculino , Femenino , Enfermedades Musculoesqueléticas/terapia , Persona de Mediana Edad , Automanejo/métodos , Aplicaciones Móviles , Investigación Cualitativa , Percepción , Telemedicina , Anciano de 80 o más Años , Salud Digital
2.
PLoS One ; 19(8): e0308623, 2024.
Artículo en Inglés | MEDLINE | ID: mdl-39116051

RESUMEN

PURPOSE: To culturally adapt the Musculoskeletal Health Questionnaire (MSK-HQ) to European Portuguese and evaluate its reliability in individuals with musculoskeletal conditions. MATERIALS AND METHODS: The study was carried out in two phases. In the first phase, the MSK-HQ was translated and culturally adapted. In the second phase, a longitudinal observational study was carried out with a convenience sample of participants with musculoskeletal conditions. Data collection began at the start of physiotherapy treatments by filling in the MSK-HQ and Numeric Pain Rating Scale (NPRS). After 4-7 days, the participants were asked to fill out the MSK-HQ once again, as well as the Patient Global Improvement Change (PGIC) scale. The data collected was used to study internal consistency, test-retest reliability, and measurement error. Floor and ceiling effects were also analysed. RESULTS: The MSK-HQ was successfully translated and adapted into European Portuguese. The second phase of the study had a sample of 191 participants. This study demonstrated high internal consistency (Cronbach's α = 0.885) and excellent test-retest reliability (ICC(2,1) = 0.908). The analysis of measurement error resulted in an SEM of 2.818 and an SDC at 7.811. No floor or ceiling effect was observed. CONCLUSIONS: The MSK-HQ-PT is a reliable instrument for measuring musculoskeletal health. Further studies on its validity and responsiveness are needed.


Asunto(s)
Comparación Transcultural , Enfermedades Musculoesqueléticas , Humanos , Femenino , Masculino , Encuestas y Cuestionarios , Persona de Mediana Edad , Adulto , Enfermedades Musculoesqueléticas/terapia , Reproducibilidad de los Resultados , Portugal , Anciano , Estudios Longitudinales
3.
Musculoskeletal Care ; 22(3): e1924, 2024 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-39134408

RESUMEN

BACKGROUND: Musculoskeletal (MSK) conditions affect over 20.3 million people in the UK, presenting a substantial economic impact on health and social services. Physiotherapy can alleviate MSK conditions, especially if delivered in the acute or sub-acute period. However, patients often present after significant waiting times. OBJECTIVES: Our analysis examined how waiting times and the number of treatments influenced physiotherapy outcomes for MSK conditions. DESIGN: Retrospective analysis of the Data for Impact, Physio First dataset. METHODS: Logistic regression models assessed the effects of symptom duration, treatment frequency, and other variables on pain, Patient-Specific Functional Scores (PSFSs), and Goal Achievement (GA). RESULTS: Analysis of 15,624 patient records showed that patients treated within two weeks of symptom onset were more likely to have favourable outcomes in pain (odds ratio [OR] = 2.01, 95% Confidence Interval [95% CI] = 1.65-2.45), PSFS (OR = 1.80, 95% CI = 1.55-2.08), and GA (OR = 1.74, 95% CI = 1.51-2.01) compared to those treated after longer durations. Receiving four or more treatment sessions significantly improved outcomes compared with only one session (pain: OR = 4.64, PSFS: OR = 5.72, GA: OR = 1.94, all p's < 0.001), with no additional benefits beyond four sessions. Younger age was associated with better outcomes (approximately OR = 0.99 per year age difference). Other findings included better outcomes in males and in those with fewer previous episodes of the condition. CONCLUSIONS: Shorter waiting times, a greater number of treatments, and younger patient age are associated with better physiotherapy outcomes for MSK conditions.


Asunto(s)
Enfermedades Musculoesqueléticas , Modalidades de Fisioterapia , Humanos , Modalidades de Fisioterapia/estadística & datos numéricos , Masculino , Femenino , Persona de Mediana Edad , Adulto , Estudios Retrospectivos , Factores de Edad , Enfermedades Musculoesqueléticas/terapia , Enfermedades Musculoesqueléticas/rehabilitación , Anciano , Resultado del Tratamiento , Listas de Espera , Bases de Datos Factuales , Tiempo de Tratamiento/estadística & datos numéricos
4.
Medicine (Baltimore) ; 103(31): e38936, 2024 Aug 02.
Artículo en Inglés | MEDLINE | ID: mdl-39093793

RESUMEN

Musculoskeletal urgent care centers (MUCCs) are an increasingly common alternative to emergency departments for patients with orthopedic injuries. As there is a lack of longitudinal data regarding MUCCs' impact on the emergency health care system, our study seeks to understand recent trends in MUCC growth and their acceptance of Medicaid insurance. Over the last 6 years, at 2-year intervals (2019, 2021, and 2023), we performed a search to identify all MUCCs in the United States. We determined the affiliation and Medicaid acceptance status of all MUCCs, including those that closed/opened between 2019, 2021, and 2023, to analyze trends in MUCC availability and Medicaid acceptance. In 2019, there were 558 MUCCs, which increased to 596 MUCCs in 2021 and then decreased to 555 MUCCs in 2023, representing a growth and then decline of approximately 7%. Overall, since June 2019, 90 MUCCs have opened and 95 MUCCs have closed. Medicaid acceptance increased nationally between 2019 and 2023, from 58% to 71%. Medicaid acceptance increased for both nonaffiliated and privately affiliated MUCCs. Medicaid acceptance has increased nationally from 2019 to 2023, while MUCC availability has gone through a period of growth and then reversion to 2019 levels. As MUCCs have demonstrated limited Medicaid acceptance previously, it is promising that Medicaid acceptance has improved and MUCCs are providing patients with an additional avenue to access orthopedic care.


Asunto(s)
Instituciones de Atención Ambulatoria , Accesibilidad a los Servicios de Salud , Medicaid , Estados Unidos , Medicaid/estadística & datos numéricos , Medicaid/tendencias , Humanos , Accesibilidad a los Servicios de Salud/tendencias , Accesibilidad a los Servicios de Salud/estadística & datos numéricos , Instituciones de Atención Ambulatoria/estadística & datos numéricos , Instituciones de Atención Ambulatoria/tendencias , Enfermedades Musculoesqueléticas/terapia
6.
Sci Rep ; 14(1): 18740, 2024 08 13.
Artículo en Inglés | MEDLINE | ID: mdl-39138217

RESUMEN

Musculoskeletal disorders (MDs) represent a global health issue, which can lead to disability. Physical activity (PA) reduces pain and increases physical function among patients with MDs. To promote behavioural changes, it seems important to focus on modifiable factors, such as motivation. Thus, this review aims to assess effects of interventions targeting PA on motivation towards PA. Searches used terms referring to "physical activity", "motivation" and "chronic musculoskeletal disorders" on the databases PubMed, PsychINFO, MEDLINE, EMBASE, PEDro and Web of Science. All types of intervention-including but not limited to RCTs-were eligible for inclusion. Risk of bias was assessed with the Quality Assessment Tool for Studies with Diverse Designs (QATSDD). Among 6 489 abstracts identified, there were 387 eligible studies and 19 were included, reporting in total 34 effect sizes. The meta-analysis concerned 1 869 patients and indicated a small effect of interventions on change in motivation towards PA (d = 0.34; 95% CI [0.15; 0.54]; p < .01; k = 33). Behavioural interventions positively impact PA motivation in patients with MDs. In the literature, most studies focused on intervention's effect on fear of movement. Future research should assess other explicit motivational constructs, as well as implicit processes.


Asunto(s)
Ejercicio Físico , Motivación , Enfermedades Musculoesqueléticas , Humanos , Ejercicio Físico/psicología , Enfermedades Musculoesqueléticas/terapia , Enfermedades Musculoesqueléticas/psicología , Enfermedad Crónica , Terapia Conductista/métodos
7.
Medicina (Kaunas) ; 60(7)2024 Jun 27.
Artículo en Inglés | MEDLINE | ID: mdl-39064491

RESUMEN

Regenerative medicine, encompassing various therapeutic approaches aimed at tissue repair and regeneration, has emerged as a promising field in the realm of physical therapy. Aim: This comprehensive review seeks to explore the evolving role of regenerative medicine within the domain of physical therapy, highlighting its potential applications, challenges, and current trends. Researchers selected publications of pertinent studies from 2015 to 2024 and performed an exhaustive review of electronic databases such as PubMed, Embase, and Google Scholar using the targeted keywords "regenerative medicine", "rehabilitation", "tissue repair", and "physical therapy" to screen applicable studies according to preset parameters for eligibility, then compiled key insights from the extracted data. Several regenerative medicine methods that are applied in physical therapy, in particular, stem cell therapy, platelet-rich plasma (PRP), tissue engineering, and growth factor treatments, were analyzed in this research study. The corresponding efficacy of these methods in the recovery process were also elaborated, including a discussion on facilitating tissue repair, alleviating pain, and improving functional restoration. Additionally, this review reports the challenges concerning regenerative therapies, among them the standardization of protocols, safety concerns, and ethical issues. Regenerative medicine bears considerable potential as an adjunctive therapy in physiotherapy, providing new pathways for improving tissue repair and functional results. Although significant strides have been made in interpreting the potential of regenerative techniques, further research is warranted to enhance protocols, establish safety profiles, and increase access and availability. Merging regenerative medicine into the structure of physical therapy indicates a transformative alteration in clinical practice, with the benefit of increasing patient care and improving long-term results.


Asunto(s)
Modalidades de Fisioterapia , Medicina Regenerativa , Humanos , Medicina Regenerativa/métodos , Medicina Regenerativa/tendencias , Medicina Regenerativa/normas , Plasma Rico en Plaquetas , Enfermedades Musculoesqueléticas/terapia , Ingeniería de Tejidos/métodos
8.
BMJ Open ; 14(7): e085778, 2024 Jul 18.
Artículo en Inglés | MEDLINE | ID: mdl-39025825

RESUMEN

BACKGROUND: Musculoskeletal injuries can cause distress, and distress is associated with delayed recovery. Numerous interventions have been developed to facilitate recovery from injury, and several systematic reviews evaluate the efficacy of these interventions for reducing psychological distress. OBJECTIVES: This scoping review aims to map the synthesised evidence for the relationship between treatment interventions and distress-related outcomes following acute injury. The objectives were (1) to describe the types of interventions that have been evaluated in relation to distress-related outcomes following accidental injury, (2) to examine the scope of distress-related outcomes that have been measured in relation to these interventions and (3) to explore the range of clinical professions that deliver these interventions. DESIGN: We searched nine electronic databases and grey literature (to 21 April 2022). We included any systematic review reporting on the relationship between interventions delivered in the time following injury and distress-related outcomes. Data relevant to the specific objectives of this scoping review were extracted and described using narrative synthesis. RESULTS: From 8412 systematic reviews imported for screening, 8266 unique records were screened. 179 were selected for full-text review. 84 systematic reviews were included in the study. Interventional types were pharmacological, psychological, exercise based, physical/manual therapies, virtual reality based, multimodal and workplace based. Interventions were delivered digitally, face to face and using virtual reality by a variety of healthcare professionals, including doctors, nurses, psychologists and physiotherapists. The most frequently reported distress-related variables included anxiety, depression, post-traumatic stress disorder diagnosis. CONCLUSION: A wide range of interventions may help to mitigate distress following acute accidental musculoskeletal or orthopaedic injury. Even interventions that were not designed to reduce distress were found to improve distress-related outcomes. In view of the important role of distress in recovery from injury, it is recommended that distress-related variables are measured as core outcomes in the evaluation of treatments for acute injuries.


Asunto(s)
Revisiones Sistemáticas como Asunto , Humanos , Enfermedades Musculoesqueléticas/terapia , Enfermedades Musculoesqueléticas/psicología , Sistema Musculoesquelético/lesiones , Distrés Psicológico , Estrés Psicológico/terapia , Estrés Psicológico/psicología
9.
Eur J Med Res ; 29(1): 398, 2024 Jul 31.
Artículo en Inglés | MEDLINE | ID: mdl-39085932

RESUMEN

Musculoskeletal disorders encompass a wide range of conditions that impact the bones, joints, muscles, and connective tissues within the body. Despite the ongoing debate on toxicity and administration, ozone demonstrated promise in managing several musculoskeletal disorders, modulating pain and inflammation. A literature search was conducted. The research design, methods, findings, and conclusions of the studies were then examined to evaluate the physiological effects, clinical application, controversies, and safety of the application of ozone in musculoskeletal medicine. Ozone application demonstrates considerable therapeutic applications in the management of musculoskeletal disorders, including fractures, osteoarthritis, and chronic pain syndromes. Despite these advantages, studies have raised concerns regarding its potential toxicity and emphasized the importance of adhering to stringent administration protocols to ensure safety. Additionally, heterogeneities in patient reactions and hazards from oxidizing agents were observed. Given its anti-inflammatory and analgesic qualities, ozone therapy holds potential in the management of several musculoskeletal disorders. Additional high-quality research with long follow-up is required to refine indications, efficacy and safety profile. Finally, for wider clinical acceptability and utilization, the development of international recommendations is essential.


Asunto(s)
Enfermedades Musculoesqueléticas , Ozono , Ozono/uso terapéutico , Humanos , Enfermedades Musculoesqueléticas/tratamiento farmacológico , Enfermedades Musculoesqueléticas/terapia
10.
Rev Med Suisse ; 20(882): 1360-1364, 2024 Jul 17.
Artículo en Francés | MEDLINE | ID: mdl-39021106

RESUMEN

The use of Kinesiotaping (KT) has become common in the treatment and prevention of musculoskeletal injuries. This article covers the ten main myths encountered on a daily basis, examining the evidence from recent data (systematic reviews and meta-analyses). With current available data, there is a relative evidence regarding some effect upon short-term pain relief, improved mobility, better joint stability, drainage of edema, and improve muscle function. Concerning the prevention of musculoskeletal injuries, it seems that the effectiveness of KT is still questionable. Overall, there are few publications with a high-level of evidence that can support all myths surrounding K-taping.


L'utilisation de kinésiotaping (KT) est devenue courante dans le traitement et la prévention des blessures musculosquelettiques. Cet article reprend les dix principaux mythes rencontrés au quotidien, en examinant les preuves à partir de données récentes (revues systématiques et méta-analyses) qui nous semblent, à ce jour, les plus pertinentes. Avec les données disponibles actuellement, il existe des preuves partielles d'un soulagement de la douleur à court terme, d'une amélioration de la mobilité, de la stabilité articulaire, de l'œdème et de la fonction musculaire. Concernant la prévention des lésions musculosquelettiques, il semble que l'efficacité du KT soit encore discutable. Dans l'ensemble, il y a peu de publications avec un haut niveau de preuves à ce sujet qui permettent d'étayer l'ensemble des mythes gravitant autour du KT.


Asunto(s)
Cinta Atlética , Humanos , Enfermedades Musculoesqueléticas/prevención & control , Enfermedades Musculoesqueléticas/terapia , Enfermedades Musculoesqueléticas/etiología
11.
South Med J ; 117(7): 353-357, 2024 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-38959960

RESUMEN

OBJECTIVES: This study aimed to analyze the association between physical therapists' recommended number of visits for a full recovery from common orthopedic injuries/surgeries and the extent of insurance coverage for these visits. METHODS: A prospective observational study was conducted with board-certified physical therapists. A qualitative questionnaire was used to gather physical therapists' demographics and the recommended number of physical therapy visits to achieve a full recovery after 11 common orthopedic diagnoses. Physical therapists also were asked to report whether they believe that insurance provides an adequate number of visits overall. In addition to the qualitative survey, insurance coverage details of major Alabama companies were obtained for comparison. Descriptive statistics of the participating therapists were analyzed for sex, age, degree/training, and years of experience. Kruskal-Wallis statistics were used to analyze variance between the aforementioned groupings when compared with the reported average number of sessions. RESULTS: The survey (N = 251) collected data on the average number of physical therapy sessions that are necessary for a complete recovery as recommended by physical therapists for 11 common orthopedic diagnoses. From this survey, the average number of necessary visits ranged from 11.3 visits (ankle sprains) to 37.3 visits (anterior cruciate ligament reconstruction), with the overall average number of visits being 23.8. Only 24% of physical therapists believed that insurance companies provided enough coverage. Insurance coverage varied but often required additional procedures to allocate the adequate number of visits for the studied orthopedic pathologies. CONCLUSIONS: The majority of practicing physical therapists in Alabama perceive insufficient insurance coverage for physical therapy visits for most orthopedic diagnoses. This study has implications for healthcare decision making and patient-centered rehabilitation goals. Physicians and physical therapists can use this information to optimize treatment decisions and rehabilitation goals. Patients will benefit from improved physical and economic well-being. This study has the potential to drive further research and influence national insurance policies to better serve patients' needs.


Asunto(s)
Cobertura del Seguro , Modalidades de Fisioterapia , Humanos , Femenino , Masculino , Modalidades de Fisioterapia/estadística & datos numéricos , Modalidades de Fisioterapia/economía , Cobertura del Seguro/estadística & datos numéricos , Adulto , Estudios Prospectivos , Encuestas y Cuestionarios , Alabama , Persona de Mediana Edad , Seguro de Salud/estadística & datos numéricos , Fisioterapeutas/estadística & datos numéricos , Enfermedades Musculoesqueléticas/terapia , Enfermedades Musculoesqueléticas/economía
12.
Perspect Med Educ ; 13(1): 368-379, 2024.
Artículo en Inglés | MEDLINE | ID: mdl-38948401

RESUMEN

Background and need for innovation: The process to design mobile apps for learning are infrequently reported and focus more on evaluation than process. This lack of clear process for health professional education mobile apps may explain the lack of quality mobile apps to support medical student learning. Goal of innovation: The goal of this project was to develop a student informed ready for production wireframe model of a minimally viable mobile app to support learning of musculoskeletal (MSK) clinical skills. Steps taken for development and implementation of innovation: The Information Systems Research (ISR) framework and Design Thinking were combined for the mobile app design. The process followed the cycles and modes of the combined framework to; systematically review available apps, use a focus group to identify attributes of the app valued by students, define the initial plan for the mobile app, develop an app prototype, and test and refine it with students. Outcomes of innovation: The student focus group data had five themes: 1) interactive usability, 2) environment, 3) clear and concise layout, 4) anatomy and pathology, 5) cultural safety and 'red flags'. The prototyping of the app went through three cycles of student review and improvement to produce a final design ready for app development. Critical reflection on our process: We used a student-centred approach guided by design frameworks to design a minimally viable product mobile app to support learning of MSK clinical skills in ten weeks with a small team. The framework supported nonlinear, iterative, rapid prototyping. Student data converged and diverged with the MSK teaching methods literature. Of note our students requested cultural safety learning in the app design, suggesting mobile apps could support cultural safety learning.


Asunto(s)
Competencia Clínica , Grupos Focales , Aplicaciones Móviles , Humanos , Aplicaciones Móviles/normas , Grupos Focales/métodos , Competencia Clínica/normas , Estudiantes de Medicina/psicología , Enfermedades Musculoesqueléticas/terapia
13.
J Pak Med Assoc ; 74(6): 1199-1201, 2024 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-38949004

RESUMEN

Musculoskeletal (MSK) disorders encompass various conditions impacting bones, muscles, tendons, ligaments, and nerves. An estimated 1.71 billion individuals globally have MSK disorders, causing disability and reduced quality of life. Literature contradicts the notion that musculoskeletal pain and disability solely arise from physical impairments; psychological, behavioural, and social factors contribute significantly. These facets influence pain perception and chronic impairment development. Common interventions-medication, exercise, manual and hydrotherapy, electro-thermal modalities, behavioural and alternative therapies-address pain individually, yet lack the comprehensive response required. In contrast, a multimodal approach combines diverse therapies tailored to individual needs. It ensures lasting symptom relief, prevents recurrence, and improves function. Although proven effective, clinical implementation of this approach remains limited. This mini-review discusses the reasons behind this gap, underscores multimodal approach importance, and enlightens rehabilitation professionals on its potential for managing chronic musculoskeletal issues.


Asunto(s)
Enfermedades Musculoesqueléticas , Humanos , Enfermedades Musculoesqueléticas/terapia , Terapia Combinada , Dolor Musculoesquelético/terapia , Enfermedad Crónica , Terapia por Ejercicio/métodos
14.
BMC Med Educ ; 24(1): 735, 2024 Jul 08.
Artículo en Inglés | MEDLINE | ID: mdl-38977986

RESUMEN

BACKGROUND: There is a need to increase the capacity and capability of musculoskeletal researchers to design, conduct, and report high-quality clinical trials. The objective of this study was to identify and prioritise clinical trial learning needs of musculoskeletal researchers in Australia and Aotearoa New Zealand. Findings will be used to inform development of an e-learning musculoskeletal clinical trials course. METHODS: A two-round online modified Delphi study was conducted with an inter-disciplinary panel of musculoskeletal researchers from Australia and Aotearoa New Zealand, representing various career stages and roles, including clinician researchers and consumers with lived experience of musculoskeletal conditions. Round 1 involved panellists nominating 3-10 topics about musculoskeletal trial design and conduct that they believe would be important to include in an e-learning course about musculoskeletal clinical trials. Topics were synthesised and refined. Round 2 asked panellists to rate the importance of all topics (very important, important, not important), as well as select and rank their top 10 most important topics. A rank score was calculated whereby higher scores reflect higher rankings by panellists. RESULTS: Round 1 was completed by 121 panellists and generated 555 individual topics describing their musculoskeletal trial learning needs. These statements were grouped into 37 unique topics for Round 2, which was completed by 104 panellists. The topics ranked as most important were: (1) defining a meaningful research question (rank score 560, 74% of panellists rated topic as very important); (2) choosing the most appropriate trial design (rank score 410, 73% rated as very important); (3) involving consumers in trial design through to dissemination (rank score 302, 62% rated as very important); (4) bias in musculoskeletal trials and how to minimise it (rank score 299, 70% rated as very important); and (5) choosing the most appropriate control/comparator group (rank score 265, 65% rated as very important). CONCLUSIONS: This modified Delphi study generated a ranked list of clinical trial learning needs of musculoskeletal researchers. Findings can inform training courses and professional development to improve researcher capabilities and enhance the quality and conduct of musculoskeletal clinical trials.


Asunto(s)
Ensayos Clínicos como Asunto , Técnica Delphi , Enfermedades Musculoesqueléticas , Investigadores , Humanos , Nueva Zelanda , Australia , Enfermedades Musculoesqueléticas/terapia , Investigadores/educación , Investigación Biomédica/educación , Evaluación de Necesidades , Proyectos de Investigación , Educación a Distancia
15.
Adv Colloid Interface Sci ; 331: 103232, 2024 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-38889626

RESUMEN

Despite critical advances in regenerative medicine, the generation of definitive, reliable treatments for musculoskeletal diseases remains challenging. Gene therapy based on the delivery of therapeutic genetic sequences has strong value to offer effective, durable options to decisively manage such disorders. Furthermore, scaffold-mediated gene therapy provides powerful alternatives to overcome hurdles associated with classical gene therapy, allowing for the spatiotemporal delivery of candidate genes to sites of injury. Among the many scaffolds for musculoskeletal research, hydrogels raised increasing attention in addition to other potent systems (solid, hybrid scaffolds) due to their versatility and competence as drug and cell carriers in tissue engineering and wound dressing. Attractive functionalities of hydrogels for musculoskeletal therapy include their injectability, stimuli-responsiveness, self-healing, and nanocomposition that may further allow to upgrade of them as "intelligently" efficient and mechanically strong platforms, rather than as just inert vehicles. Such functionalized hydrogels may also be tuned to successfully transfer therapeutic genes in a minimally invasive manner in order to protect their cargos and allow for their long-term effects. In light of such features, this review focuses on functionalized hydrogels and demonstrates their competence for the treatment of musculoskeletal disorders using gene therapy procedures, from gene therapy principles to hydrogel functionalization methods and applications of hydrogel-mediated gene therapy for musculoskeletal disorders, while remaining challenges are being discussed in the perspective of translation in patients. STATEMENT OF SIGNIFICANCE: Despite advances in regenerative medicine, the generation of definitive, reliable treatments for musculoskeletal diseases remains challenging. Gene therapy has strong value in offering effective, durable options to decisively manage such disorders. Scaffold-mediated gene therapy provides powerful alternatives to overcome hurdles associated with classical gene therapy. Among many scaffolds for musculoskeletal research, hydrogels raised increasing attention. Functionalities including injectability, stimuli-responsiveness, and self-healing, tune them as "intelligently" efficient and mechanically strong platforms, rather than as just inert vehicles. This review introduces functionalized hydrogels for musculoskeletal disorder treatment using gene therapy procedures, from gene therapy principles to functionalized hydrogels and applications of hydrogel-mediated gene therapy for musculoskeletal disorders, while remaining challenges are discussed from the perspective of translation in patients.


Asunto(s)
Técnicas de Transferencia de Gen , Terapia Genética , Hidrogeles , Enfermedades Musculoesqueléticas , Hidrogeles/química , Humanos , Enfermedades Musculoesqueléticas/terapia , Enfermedades Musculoesqueléticas/genética , Terapia Genética/métodos , Animales , Ingeniería de Tejidos/métodos
16.
Lancet Rheumatol ; 6(8): e560-e572, 2024 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-38876128

RESUMEN

Rheumatic and musculoskeletal diseases often affect individuals of childbearing age. The incidence and prevalence of rheumatic and musculoskeletal diseases is rising. More pregnancies in patients with rheumatic and musculoskeletal diseases are anticipated and some rheumatic and musculoskeletal diseases are associated with pregnancy complications (eg, miscarriages, fetal deaths, preterm births, and hypertensive disorders in pregnancy). Despite the need to understand the use of drugs to treat rheumatic and musculoskeletal diseases in pregnancy, clinical trials in pregnancy are rare, therapeutics in pregnancy are understudied, and pregnant individuals are routinely excluded as premarketing trial participants. Data on the effectiveness and safety of disease-modifying antirheumatic drugs are most often based on post-marketing observational data. Observational studies assessing the bidirectional relationship between rheumatic and musculoskeletal diseases and pregnancy, as well as interventional studies of treatments during pregnancy, are scarce. Historical reluctance to perform studies in what was deemed an at-risk group persists in pharmaceutical companies, regulatory bodies, and ethics boards. Additionally, patients must be engaged partners, which requires trust that the research respects the needs and interests of the patient and complies with the rules intended to protect the pregnant person and the fetus from harm. In this Series paper, we share challenges we have encountered in conducting prospective cohort studies and interventional trials of postmarketing approved medications, assessing pregnancy specific outcomes in pregnant women with rheumatic and musculoskeletal diseases in the EU, the UK, and the USA. We discuss the changing landscape around trials in pregnancy and present possible solutions to our challenges.


Asunto(s)
Ensayos Clínicos como Asunto , Complicaciones del Embarazo , Proyectos de Investigación , Humanos , Embarazo , Femenino , Complicaciones del Embarazo/tratamiento farmacológico , Complicaciones del Embarazo/epidemiología , Estudios de Cohortes , Enfermedades Reumáticas/tratamiento farmacológico , Enfermedades Musculoesqueléticas/tratamiento farmacológico , Enfermedades Musculoesqueléticas/terapia , Antirreumáticos/uso terapéutico
17.
Pediatr Rheumatol Online J ; 22(1): 60, 2024 Jun 05.
Artículo en Inglés | MEDLINE | ID: mdl-38840147

RESUMEN

BACKGROUND: Many children with rheumatic and musculoskeletal diseases are unrecognized. Identifying these children requires health care provider awareness, knowledge, and skills to recognize disease features and how (and when) to refer to specialist care. The aim of this paper is to highlight the need for better access to health care, review the essential role that education and virtual care play to address unmet need in low resource areas and especially to expand workforce capacity. Using collaborative partnerships, virtual platforms, and innovative assessment methods, musculoskeletal care and education can be delivered to reach a greater audience than ever before. Increased awareness through multiple initiatives and readily available resources are imperative to improve global rheumatology care. CONCLUSION: The needs of children with rheumatic diseases and musculoskeletal conditions are vastly underserved around the world resulting in preventable morbidity and mortality. Expanded implementation of virtual education and e-health care platforms provides an opportunity to increase access to care for children globally.


Asunto(s)
Pediatría , Reumatología , Humanos , Reumatología/educación , Niño , Pediatría/educación , Pediatría/métodos , Accesibilidad a los Servicios de Salud , Enfermedades Reumáticas/terapia , Enfermedades Musculoesqueléticas/terapia , Telemedicina
18.
Geriatr Nurs ; 58: 416-429, 2024.
Artículo en Inglés | MEDLINE | ID: mdl-38901307

RESUMEN

BACKGROUND: The literature lacks a consistent review of musculoskeletal symptoms in postmenopausal women. AIM: To identify features, measurements, determinants, treatments, and outcomes of musculoskeletal symptoms in postmenopausal women. METHOD: A scoping review was completed using six databases: Embase, Medline, Cochrane, CINAHL, Web of Science, and Scopus up to December 2022. Sixty-three articles were identified. RESULTS: Musculoskeletal symptoms in postmenopausal women include somatic symptoms of non-specific origin, upper and lower limb symptoms, spinal pain, and decline in physical performance. Measurements were categorized into four groups: musculoskeletal symptoms for menopause, general musculoskeletal symptoms, menopause-specific quality of life, and general quality of life questionnaires. The determinants were grouped into four themes: demographics, physical determinants, psychosocial determinants, and lifestyle. Pharmacological interventions, supplementation options, and exercise regimens exist for postmenopausal women with musculoskeletal symptoms. CONCLUSION: A comprehensive policy is needed to address musculoskeletal symptoms in postmenopausal women, promoting diverse treatments for improved quality of life.


Asunto(s)
Enfermedades Musculoesqueléticas , Posmenopausia , Calidad de Vida , Humanos , Femenino , Enfermedades Musculoesqueléticas/terapia , Encuestas y Cuestionarios
19.
Musculoskeletal Care ; 22(3): e1914, 2024 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-38943044

RESUMEN

BACKGROUND: Advanced practice physiotherapy (APP) models of care are promising to alleviate pressure in emergency departments (EDs) where physiotherapists' new roles include being a first-contact practitioner and leading the overall care and management of patients with minor musculoskeletal disorders (MSKDs) to alleviate ED physicians' caseload. PURPOSE: To explore patients' acceptability, experience, satisfaction, and perception of a new APP-led model of care in the ED. METHODS: Patients presenting to the ED with a minor MSKD and who agreed to participate in a multicenter, pan-Canadian randomized controlled trial assessing the efficacy and costs of an APP model of care were invited to participate in this qualitative study. Semi-structured interviews were performed to identify themes related to their experiences with this model. Verbatim transcripts were coded and analysed using an inductive thematic analysis. RESULTS: 11 patients participated and three themes were identified: 1- They were satisfied with the care received within the model; 2- They found APPs to have the appropriate skill set to manage MSKDs and to assume medical-delegated tasks; 3- Timely access to care was a key factor in the acceptability of this model and participants believed physiotherapists were appropriate first-contact practitioners. One participant proposed that the APP model of care should also offer follow-up care. CONCLUSION: Participants had a positive experience of care in this new model. These results support the implementation of APP models of care in EDs as the participants appear receptive to new roles for APPs.


Asunto(s)
Servicio de Urgencia en Hospital , Enfermedades Musculoesqueléticas , Satisfacción del Paciente , Fisioterapeutas , Investigación Cualitativa , Humanos , Enfermedades Musculoesqueléticas/terapia , Enfermedades Musculoesqueléticas/psicología , Masculino , Femenino , Persona de Mediana Edad , Adulto , Fisioterapeutas/psicología , Quebec , Anciano
20.
Musculoskeletal Care ; 22(2): e1908, 2024 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-38898572

RESUMEN

BACKGROUND: First Contact Physiotherapy Practitioners (FCPPs) provide expert care for patients with musculoskeletal (MSK) conditions in General Practice. Access to FCPPs can facilitate timely care and efficient use of health services. However, there is little evidence about patient experiences of accessing FCPP appointments. OBJECTIVE: To explore the experiences of patients with MSK conditions who have accessed an FCPP appointment in a General Practice setting in the UK. DESIGN: Exploratory qualitative design. METHODS: Patients with MSK conditions who had experience of accessing FCPP appointments were recruited via social media. Semi-structured interviews were conducted and recorded via MS Teams. Data were analysed using thematic analysis. RESULTS: Of 13 patients interviewed, there were 10 females and three males, with an age range between 20 and 80 years. The main themes identified were: (1) Awareness of FCPP, (2) Access routes, (3) Facilitators to access, (4) Barriers to access, (5) Likelihood of re-accessing FCPP. Awareness of FCPP was generally low amongst participants. There were a variety of routes to access FCPP appointments; some were felt to be sub-optimal by participants. Facilitators included quick/easy access to FCPP. Barriers included difficulty contacting General Practitioner (GP) surgeries and public perception of needing to see a GP initially. The likelihood of re-consultation with a FCPP was low when participants had disappointing care experiences. CONCLUSION: This study provides new evidence about patient experiences of accessing FCPP. It explores positive and negative aspects of access from patients' perspectives. It also highlights areas for improvement in terms of GP staff/patient awareness and understanding of FCPP.


Asunto(s)
Medicina General , Accesibilidad a los Servicios de Salud , Enfermedades Musculoesqueléticas , Investigación Cualitativa , Humanos , Masculino , Femenino , Persona de Mediana Edad , Adulto , Anciano , Enfermedades Musculoesqueléticas/terapia , Enfermedades Musculoesqueléticas/rehabilitación , Reino Unido , Anciano de 80 o más Años , Citas y Horarios , Adulto Joven , Modalidades de Fisioterapia
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