Asunto(s)
Malformaciones Vasculares del Sistema Nervioso Central/diagnóstico por imagen , Hemorragia Cerebral/diagnóstico por imagen , Demencia/diagnóstico , Enfermedades Talámicas/diagnóstico por imagen , Malformaciones Vasculares del Sistema Nervioso Central/complicaciones , Malformaciones Vasculares del Sistema Nervioso Central/diagnóstico , Angiografía Cerebral , Hemorragia Cerebral/etiología , Hemorragia Cerebral/fisiopatología , Angiografía por Tomografía Computarizada , Diagnóstico Tardío , Demencia/etiología , Demencia/fisiopatología , Progresión de la Enfermedad , Humanos , Imagen por Resonancia Magnética , Masculino , Persona de Mediana Edad , Enfermedades Talámicas/etiología , Enfermedades Talámicas/fisiopatología , Tomografía Computarizada por Rayos XAsunto(s)
Arteria Carótida Interna/diagnóstico por imagen , Malformaciones Vasculares del Sistema Nervioso Central/diagnóstico por imagen , Venas Cerebrales/diagnóstico por imagen , Enfermedades Talámicas/diagnóstico por imagen , Anciano , Anhedonia/fisiología , Afasia de Broca/fisiopatología , Malformaciones Vasculares del Sistema Nervioso Central/complicaciones , Malformaciones Vasculares del Sistema Nervioso Central/cirugía , Angiografía Cerebral , Demencia/fisiopatología , Ataxia de la Marcha/fisiopatología , Humanos , Angiografía por Resonancia Magnética , Imagen por Resonancia Magnética , Masculino , Trastornos de la Memoria/fisiopatología , Enfermedades Talámicas/etiología , Enfermedades Talámicas/fisiopatologíaRESUMEN
Infarcts involving the thalamus can yield many deficits, including sensory syndromes, altered consciousness, and cognitive disturbances, depending on the thalamic vascular territory involved. Isolated truncal contrapulsion due to pure thalamic infarct has been rarely reported. Truncal lateropulsion is a compelling sensation of being pulled toward one side that cannot be explained by weakness or limb ataxia. It is commonly reported in lateral medullary infarcts. It may occur with lesions that involve the peripheral vestibular system, brainstem, cerebellum, basal ganglia, ponto-mesencephalic, and thalamic lesions. We hereby report a 64-year-old woman who presented with truncal contrapulsion as the sole manifestation of an acute right lateral thalamic infarct.
Asunto(s)
Infarto Cerebral/diagnóstico , Trastornos Psicomotores/etiología , Enfermedades Talámicas/fisiopatología , Tálamo/patología , Infarto Cerebral/clasificación , Infarto Cerebral/complicaciones , Femenino , Humanos , Persona de Mediana Edad , Postura , Tálamo/irrigación sanguíneaRESUMEN
Congenital Zika virus syndrome (CZVS) is associated with severe neurological deficits. Clinical characteristics of epilepsy and the electroencephalographic (EEG) pattern in CZVS were documented in infancy. In this study, we aimed to describe the EEG findings observed during the follow-up of children with CZVS. Seventy-six EEGs of 55 children (60% female; mean age = 50 months) with confirmed CZVS were analyzed, considering the background, interictal, and ictal epileptiform discharges. Continuous (or almost continuous) epileptiform discharges during non-rapid eye movement sleep were identified in 22 (40%) patients. In 20 (90.1%) patients, the pattern was symmetrical, with an anterior predominance of the epileptiform activity. All patients with this pattern had epilepsy, which was severe in 15 (68.2%) and demanded polytherapy in 19 (86.4%). Subcortical calcifications (77.3%) and multifocal EEGs (72.8%) in earlier ages occurred more often in patients with this pattern. Other unspecific interictal EEG patterns were focal epileptiform discharges in 23 (41.8%) and multifocal activity in six (10.9%). In CZVS, continuous (or almost continuous) epileptiform discharges during sleep emerge as a pattern after the second year of life. This was associated with severe and drug-resistant epilepsy, but not necessarily with an apparent regression. Subcortical calcifications and multifocal epileptiform discharges in infancy are associated with this pattern.
Asunto(s)
Encéfalo/fisiopatología , Epilepsia/fisiopatología , Malformaciones del Desarrollo Cortical/fisiopatología , Sueño , Infección por el Virus Zika/congénito , Infección por el Virus Zika/fisiopatología , Anticonvulsivantes/uso terapéutico , Enfermedades de los Ganglios Basales/diagnóstico por imagen , Enfermedades de los Ganglios Basales/fisiopatología , Encéfalo/diagnóstico por imagen , Tronco Encefálico/diagnóstico por imagen , Tronco Encefálico/patología , Calcinosis/diagnóstico por imagen , Calcinosis/fisiopatología , Cerebelo/diagnóstico por imagen , Cerebelo/patología , Preescolar , Progresión de la Enfermedad , Epilepsia Refractaria/diagnóstico por imagen , Epilepsia Refractaria/tratamiento farmacológico , Epilepsia Refractaria/fisiopatología , Electroencefalografía , Epilepsias Parciales/diagnóstico por imagen , Epilepsias Parciales/tratamiento farmacológico , Epilepsias Parciales/fisiopatología , Epilepsia/diagnóstico por imagen , Epilepsia/tratamiento farmacológico , Femenino , Humanos , Masculino , Malformaciones del Desarrollo Cortical/diagnóstico por imagen , Tamaño de los Órganos , Polimicrogiria/diagnóstico por imagen , Polimicrogiria/fisiopatología , Índice de Severidad de la Enfermedad , Síndrome , Enfermedades Talámicas/diagnóstico por imagen , Enfermedades Talámicas/fisiopatología , Infección por el Virus Zika/diagnóstico por imagenAsunto(s)
Infecciones por Coronavirus/complicaciones , Hemorragias Intracraneales/complicaciones , Enfermedad de Moyamoya/complicaciones , Neumonía Viral/complicaciones , Enfermedades Talámicas/complicaciones , Enfermedad Aguda , Angiografía de Substracción Digital , Betacoronavirus , COVID-19 , Angiografía Cerebral , Disfunción Cognitiva/etiología , Disfunción Cognitiva/fisiopatología , Disfunción Cognitiva/psicología , Infecciones por Coronavirus/diagnóstico , Femenino , Humanos , Hemorragias Intracraneales/diagnóstico por imagen , Hemorragias Intracraneales/fisiopatología , Hemorragias Intracraneales/psicología , Imagen por Resonancia Magnética , Enfermedad de Moyamoya/diagnóstico por imagen , Enfermedad de Moyamoya/fisiopatología , Enfermedad de Moyamoya/psicología , Pandemias , Neumonía Viral/diagnóstico , SARS-CoV-2 , Enfermedades Talámicas/diagnóstico por imagen , Enfermedades Talámicas/fisiopatología , Enfermedades Talámicas/psicología , Adulto JovenRESUMEN
BACKGROUND: Various radiologic patterns of posterior reversible encephalopathy syndrome (PRES) have been reported. Among them, PRES involving brainstem, thalamus, or deep white matter and lacking parieto-occipital edema is rare. Although PRES in general has a benign course, PRES-related intracranial hemorrhage has been associated with a poor prognosis. We report a case of variant type of PRES associated with deep brain hemorrhage and discuss the characteristics of PRES-related intracranial hemorrhage via a literature review. CASE DESCRIPTION: A woman aged 41 years with a history of untreated hypertension presented to our hospital complaining of severe headache and with an elevated blood pressure of 237/142 mmHg. Computed tomography revealed a hemorrhage in the left thalamus and basal ganglia. Magnetic resonance imaging revealed remarkable hyperintensity in the left cerebellum, pons, bilateral temporal lobes, bilateral basal ganglia, and bilateral cerebral white matter on fluid-attenuated inversion recovery imaging, which represented vasogenic edema. The parieto-occipital regions were unremarkable. Given this clinical presentation, PRES associated with deep brain hemorrhage was suspected. The patient received strict blood pressure control treatment, which resulted in gradual symptom improvement. Magnetic resonance images obtained 1 month after admission demonstrated an almost complete resolution of the edema. CONCLUSIONS: Although hemorrhage in the thalamus, basal ganglia, or brainstem is uncommon in patients with PRES, it may occur in patients with variant type of PRES involving these lesions. It is important to recognize the presence of variant patterns of clinical features and radiologic findings of PRES to allow for early identification and appropriate treatment.
Asunto(s)
Hemorragia de los Ganglios Basales/diagnóstico por imagen , Síndrome de Leucoencefalopatía Posterior/diagnóstico por imagen , Enfermedades Talámicas/diagnóstico por imagen , Adulto , Antihipertensivos/uso terapéutico , Hemorragia de los Ganglios Basales/complicaciones , Hemorragia de los Ganglios Basales/fisiopatología , Hemorragia Cerebral/complicaciones , Hemorragia Cerebral/diagnóstico por imagen , Hemorragia Cerebral/fisiopatología , Femenino , Humanos , Hipertensión/complicaciones , Hipertensión/tratamiento farmacológico , Imagen por Resonancia Magnética , Síndrome de Leucoencefalopatía Posterior/complicaciones , Síndrome de Leucoencefalopatía Posterior/fisiopatología , Enfermedades Talámicas/complicaciones , Enfermedades Talámicas/fisiopatología , Tomografía Computarizada por Rayos XRESUMEN
Odor detection, recognition, and identification were assessed in 19 acute ischemic stroke patients who had no magnetic resonance imaging-detectable thalamic lesions but in whom technetium-99m ethyl cysteinate dimer single photon emission tomography revealed thalamic hypoperfusion. Although these patients were unaware of reduced olfactory function, they exhibited significantly lower scores in tests for odor identification and recognition threshold as compared with 9 ischemic stroke controls that had normal thalamic hypoperfusion. However, absolute odor detection thresholds were similar in the 2 groups. These results demonstrate the usefulness of cerebral perfusion scintigraphy in assessing sensory loss after ischemic stroke and provide further evidence for the role of the thalamus in olfaction.
Asunto(s)
Accidente Cerebrovascular Isquémico/fisiopatología , Trastornos del Olfato/fisiopatología , Enfermedades Talámicas/fisiopatología , Anciano , Femenino , Humanos , Accidente Cerebrovascular Isquémico/diagnóstico por imagen , Masculino , Odorantes/análisis , Trastornos del Olfato/diagnóstico por imagen , Enfermedades Talámicas/diagnóstico por imagen , Tomografía Computarizada de Emisión de Fotón ÚnicoRESUMEN
Study design: Case Report. Purpose: Stroke is the most common cause of long-term disability. Dysesthesia, an unpleasant sensory disturbance, is common following thalamic stroke and evidence-based interventions for this impairment are limited. The purpose of this case report was to describe a decrease in dysesthesia following manual therapy intervention in a patient with history of right lacunar thalamic stroke. Case description: A 66-year-old female presented with tingling and dysesthesia in left hemisensory distribution including left trunk and upper/lower extremities, limiting function. Decreased left shoulder active range of motion, positive sensory symptoms but no sensory loss in light touch was found. She denied pain and moderate shoulder muscular weakness was demonstrated. Laterality testing revealed right/left limb discrimination deficits and neglect-like symptoms were reported. Passive accessory joint motion assessment of glenohumeral and thoracic spine revealed hypomobility and provoked dysesthesia. Interventions included passive oscillatory joint mobilization of glenohumeral joint, thoracic spine, ribs and shoulder strengthening. Results: After six sessions, shoulder function, active range of motion, strength improved and dysesthesia decreased. Global Rating of Change Scale was +5 and QuickDASH score decreased from 45% to 22% disability. Laterality testing was unchanged. Conclusion: Manual therapy may be a beneficial intervention in management of thalamic stroke-related dysesthesia. Implications for Rehabilitation While pain is common following thalamic stroke, patients may present with chronic paresthesia or dysesthesia, often in a hemisensory distribution. Passive movement may promote inhibition of hyperexcitable cortical pathways, which may diminish aberrant sensations. Passive oscillatory manual therapy may be an effective way to treat sensory disturbances such as paresthesias or dysesthesia.
Asunto(s)
Terapia Pasiva Continua de Movimiento/métodos , Debilidad Muscular , Manipulaciones Musculoesqueléticas/métodos , Parestesia/rehabilitación , Accidente Cerebrovascular/complicaciones , Enfermedades Talámicas , Actividades Cotidianas , Anciano , Femenino , Humanos , Debilidad Muscular/etiología , Debilidad Muscular/rehabilitación , Rango del Movimiento Articular , Recuperación de la Función , Rehabilitación de Accidente Cerebrovascular/métodos , Enfermedades Talámicas/etiología , Enfermedades Talámicas/fisiopatología , Enfermedades Talámicas/rehabilitaciónAsunto(s)
Hemorragia Cerebral/diagnóstico por imagen , Corea/diagnóstico por imagen , Mano , Enfermedades Talámicas/diagnóstico por imagen , Hemorragia Cerebral/complicaciones , Hemorragia Cerebral/fisiopatología , Corea/etiología , Corea/fisiopatología , Femenino , Mano/fisiopatología , Humanos , Persona de Mediana Edad , Enfermedades Talámicas/complicaciones , Enfermedades Talámicas/fisiopatología , Factores de TiempoRESUMEN
BACKGROUND AND PURPOSE: Ipsilateral thalamic diaschisis (ITD) describes the reduction of thalamic function, metabolism, and perfusion resulting from a distant lesion of the ipsilateral hemisphere. Our aim was to evaluate the perfusion characteristics and clinical impact of ITD in acute middle cerebral artery stroke, which does not directly affect the thalamus. METHODS: One hundred twenty-four patients with middle cerebral artery infarction were selected from a prospectively acquired cohort of 1644 patients who underwent multiparametric computed tomography (CT), including CT perfusion for suspected stroke. Two blinded readers evaluated the occurrence of ITD, defined as ipsilateral thalamic hypoperfusion present on ≥2 CT perfusion maps. Perfusion alterations were defined according to the Alberta Stroke Program Early CT Score regions. Final infarction volume and subacute complications were assessed on follow-up imaging. Clinical outcome was quantified using the modified Rankin Scale. Multivariable linear and ordinal logistic regression analysis were applied to identify independent associations. RESULTS: ITD was present in 25/124 subjects (20.2%, ITD+). In ITD+ subjects, perfusion of the caudate nucleus, internal capsule, and lentiform nucleus was more frequently affected than in ITD- patients (each with P<0.001). In the ITD+ group, larger cerebral blood flow (P=0.002) and cerebral blood volume (P<0.001) deficit volumes, as well as smaller cerebral blood flow-cerebral blood volume mismatch (P=0.021) were observed. There was no independent association of ITD with final infarction volume or clinical outcome at discharge in treatment subgroups (each with P>0.05). ITD had no influence on the development of subacute stroke complications. CONCLUSIONS: ITD in the form of thalamic hypoperfusion is a frequent CT perfusion finding in the acute phase in middle cerebral artery stroke patients with marked involvement of subcortical areas. ITD does not result in thalamic infarction and had no independent impact on patient outcome. Notably, ITD was misclassified as part of the ischemic core by automated software, which might affect patient selection in CT perfusion-based trials.
Asunto(s)
Isquemia Encefálica/diagnóstico por imagen , Infarto de la Arteria Cerebral Media/diagnóstico por imagen , Enfermedades Talámicas/diagnóstico por imagen , Anciano , Anciano de 80 o más Años , Isquemia Encefálica/etiología , Isquemia Encefálica/fisiopatología , Estudios de Casos y Controles , Núcleo Caudado/irrigación sanguínea , Núcleo Caudado/diagnóstico por imagen , Circulación Cerebrovascular , Cuerpo Estriado/irrigación sanguínea , Cuerpo Estriado/diagnóstico por imagen , Femenino , Humanos , Infarto de la Arteria Cerebral Media/complicaciones , Infarto de la Arteria Cerebral Media/fisiopatología , Cápsula Interna/irrigación sanguínea , Cápsula Interna/diagnóstico por imagen , Modelos Lineales , Modelos Logísticos , Masculino , Persona de Mediana Edad , Análisis Multivariante , Imagen de Perfusión , Accidente Cerebrovascular/complicaciones , Accidente Cerebrovascular/diagnóstico por imagen , Accidente Cerebrovascular/fisiopatología , Enfermedades Talámicas/etiología , Enfermedades Talámicas/fisiopatología , Tálamo/irrigación sanguínea , Tálamo/diagnóstico por imagen , Tomografía Computarizada por Rayos XRESUMEN
BACKGROUND/AIMS: Patients who suffer from Dejerine-Roussy syndrome commonly experience severe poststroke hemibody pain which has historically been attributed to thalamic lesions. Despite pharmacological treatment, a significant proportion of the population is resistant to traditional therapy. Deep brain stimulation is often appropriate for the treatment of resistant populations. In this review we aim to summarize the targets that are used to treat Dejerine-Roussy syndrome and provide insight into their clinical efficacy. METHODS: In reviewing the literature, we defined stimulation success as achievement of a minimum of 50% pain relief. RESULTS: Contemporary targets for deep brain stimulation are the ventral posterior medial/ventral posterior lateral thalamic nuclei, periaqueductal/periventricular gray matter, the ventral striatum/anterior limb of the internal capsule, left centromedian thalamic nuclei, the nucleus ventrocaudalis parvocellularis internis, and the posterior limb of the internal capsule. CONCLUSIONS: Due to technological advancements in deep brain stimulation, its therapeutic effects must be reevaluated. Despite a lack of controlled evidence, deep brain stimulation has been effectively used as a therapeutic in clinical pain management. Further clinical investigation is needed to definitively evaluate the therapeutic efficacy of deep brain stimulation in treating the drug-resistant patient population.
Asunto(s)
Estimulación Encefálica Profunda/métodos , Manejo del Dolor/métodos , Enfermedades Talámicas/terapia , Femenino , Humanos , Cápsula Interna/fisiopatología , Masculino , Persona de Mediana Edad , Dolor/epidemiología , Dolor/fisiopatología , Enfermedades Talámicas/epidemiología , Enfermedades Talámicas/fisiopatología , Resultado del Tratamiento , Núcleos Talámicos Ventrales/fisiopatologíaRESUMEN
OBJECTIVE: We aimed to report a novel case of hyperacute computed tomography (CT) perfusion imaging abnormalities in artery of Percheron infarction. METHODS: We described a case of a 74-year-old man who presented acutely to the emergency room with witnessed sudden onset altered level of consciousness. RESULTS: Although initial hyperacute CT brain imaging was reported as normal, subsequent magnetic resonance imaging revealed bilateral paramedian thalamic infarction. A retrospective review of CT perfusion imaging revealed perfusion mismatch in the bilateral thalami, which was not recognized in the hyperacute setting. CONCLUSION: Artery of Percheron occlusion is a well-described cause of bilateral paramedian thalamic infarction, but to date, we have not identified any reports of perfusion imaging abnormalities in the hyperacute setting. This case emphasizes the important role of perfusion imaging when clinical presentation is not typical for ischemic stroke, but is suspected, given an acute onset; its recognition may have led to the consideration of thrombolysis acutely in this case (stroke chameleon).
Asunto(s)
Infarto Encefálico/diagnóstico por imagen , Enfermedades Arteriales Cerebrales/diagnóstico por imagen , Arterias Cerebrales/diagnóstico por imagen , Circulación Cerebrovascular , Imagen de Perfusión/métodos , Enfermedades Talámicas/diagnóstico por imagen , Tomografía Computarizada por Rayos X , Anciano , Infarto Encefálico/fisiopatología , Enfermedades Arteriales Cerebrales/fisiopatología , Arterias Cerebrales/fisiopatología , Constricción Patológica , Imagen de Difusión por Resonancia Magnética , Humanos , Masculino , Valor Predictivo de las Pruebas , Enfermedades Talámicas/fisiopatologíaRESUMEN
BACKGROUND: In patients with cerebral infarction, identifying the distribution of infarction and the relevant artery is essential for ascertaining the underlying vascular pathophysiological mechanisms and preventing subsequent stroke. However, visualization of the basal perforating arteries (BPAs) has had limited success, and simultaneous viewing of background anatomical structures has only rarely been attempted in living human brains. Our study aimed at identifying the BPAs with 7T MRI and evaluating their distribution in the subcortical structures, thereby showing the clinical significance of the technique. METHODS: Twenty healthy subjects and 1 patient with cerebral infarction involving the posterior limb of the internal capsule (ICpost) and thalamus underwent 3-dimensional fast spoiled gradient-echo sequence as time-of-flight magnetic resonance angiography (MRA) at 7T with a submillimeter resolution. The MRA was modified to detect inflow signals from BPAs, while preserving the background anatomical signals. BPA stems and branches in the subcortical structures and their origins were identified on images, using partial maximum intensity projection in 3 dimensions. RESULTS: A branch of the left posterior cerebral artery (PCA) in the patient ran through both the infarcted thalamus and ICpost and was clearly the relevant artery. In 40 intact hemispheres in healthy subjects, 571 stems and 1,421 branches of BPAs were detected in the subcortical structures. No significant differences in the numbers of stems and branches were observed between the intact hemispheres. The numbers deviated even less across subjects. The distribution analysis showed that the subcortical structures of the telencephalon, such as the caudate nucleus, anterior limb of the internal capsule, and lenticular nucleus, were predominantly supplied by BPAs from the anterior circulation. In contrast, the thalamus, belonging to the diencephalon, was mostly fed by BPAs from the posterior circulation. However, compared with other subcortical structures, the ICpost, which marks the anatomical boundary between the telencephalon and the diencephalon, was supplied by BPAs with significantly more diverse origins. These BPAs originated from the internal carotid artery (23.1%), middle cerebral artery (38.5%), PCA (17.3%), and the posterior communicating artery (21.1%). CONCLUSIONS: The modified MRI method allowed the detection of the relevant BPA within the infarcted area in the stroke survivor as well as the BPAs in the subcortical structures of living human brains. Based on in vivo BPA distribution analyses, the ICpost is the transitional zone of the anterior and posterior cerebral circulations.
Asunto(s)
Arteria Cerebral Anterior/diagnóstico por imagen , Angiografía Cerebral/métodos , Circulación Cerebrovascular , Infarto de la Arteria Cerebral Anterior/diagnóstico por imagen , Infarto de la Arteria Cerebral Posterior/diagnóstico por imagen , Cápsula Interna/diagnóstico por imagen , Angiografía por Resonancia Magnética , Arteria Cerebral Posterior/diagnóstico por imagen , Enfermedades Talámicas/diagnóstico por imagen , Tálamo/diagnóstico por imagen , Adulto , Anciano de 80 o más Años , Arteria Cerebral Anterior/fisiopatología , Arteria Carótida Interna/diagnóstico por imagen , Arteria Carótida Interna/fisiopatología , Estudios de Casos y Controles , Femenino , Humanos , Infarto de la Arteria Cerebral Anterior/fisiopatología , Infarto de la Arteria Cerebral Posterior/fisiopatología , Cápsula Interna/irrigación sanguínea , Arteria Cerebral Media/diagnóstico por imagen , Arteria Cerebral Media/fisiopatología , Arteria Cerebral Posterior/fisiopatología , Valor Predictivo de las Pruebas , Enfermedades Talámicas/fisiopatología , Tálamo/irrigación sanguínea , Adulto JovenRESUMEN
BACKGROUND: Bilateral paramedian thalamic stroke is characterized by hypersomnia, vertical gaze palsy, amnestic alteration, and apathic state. Combined lesion of the paramedian thalamus and mesencephalon bilaterally is extremely rare. Little is known about the breathing disturbances of the particular region due to the lesion. The following describes the specific case of a woman, age 62, with bilateral paramedian thalamic and mesencephalic stroke. Initially, the patient's complaints exhibited altered vigilance and vertical gaze palsy. Notably, following the acute phase, fluctuating hypersomnia was detected. The MRI (brain) revealed an ischemic lesion in the medial part of the mesencephalon and paramedian thalamus, bilaterally. AIMS: The aim of the present study is to elucidate the involvement and characteristics of sleep-related breathing abnormalities in the clinical manifestation of the combined paramedian thalamic and mesencephalic stroke. METHODS: Polysomnographic recordings were accomplished seven times with 1-week interval between the consecutive recordings, toward investigating the early changes of sleep and sleep-related breathing abnormalities. RESULTS: Sleep structure examination featured a decrease in N3 and REM ratio and an increase in N1 and N2 ratio with minimal improvement during the recovery period. In contrast, significant changes were found in the breathing pattern: the initial central apnea dominance was followed by obstructive apneas with a gradual decrease of the total pathological respiratory events. CONCLUSION: In addition to the structural abnormality of the sleep regulating network, sleep-disordered breathing is another possible cause of hypersomnia in patients afflicted with the present localization of the lesion.
Asunto(s)
Dominancia Cerebral/fisiología , Mesencéfalo/fisiopatología , Síndromes de la Apnea del Sueño/diagnóstico , Síndromes de la Apnea del Sueño/fisiopatología , Accidente Cerebrovascular/fisiopatología , Enfermedades Talámicas/fisiopatología , Tálamo/fisiopatología , Nivel de Alerta/fisiología , Comorbilidad , Trastornos de Somnolencia Excesiva/diagnóstico , Trastornos de Somnolencia Excesiva/fisiopatología , Femenino , Estudios de Seguimiento , Humanos , Persona de Mediana Edad , Oftalmoplejía/diagnóstico , Oftalmoplejía/fisiopatología , PolisomnografíaRESUMEN
BACKGROUND: Spinal cord stimulation (SCS) is an established procedure for treatment of chronic neuropathic pain of peripheral origin. The efficacy of SCS in case of central poststroke pain (CPSP), especially thalamic pain, has not been adequately proven. OBJECTIVES: The efficacy of SCS as an extracranial neurostimulation method for the management of central pain syndrome was investigated. MATERIALS AND METHODS: In this study, relevant pharmacological and nonpharmacological measures for central pain management were reviewed. A case of successful SCS for thalamic pain after ischemic insult is presented. Explanatory approaches of pathophysiological processes and a review of the current literature underline our results. RESULTS: In the case presented, SCS was found effective in the treatment of thalamic pain. CONCLUSION: The efficacy of SCS might be caused by segmental and supraspinal processes and collaboration of activating and inhibiting pathways. The integrity of the spinothalamic tract is mandatory. SCS is a treatment option for central pain syndrome, especially thalamic pain. Comparable studies confirm the potency of this technique. In contrast to other neuromodulation procedures spinal cord stimulation is less invasive, has a lower perioperative risk and is often less expensive. Further studies are needed to define its potential and role in the treatment of thalamic pain.
Asunto(s)
Manejo del Dolor/métodos , Dolor/fisiopatología , Estimulación de la Médula Espinal/métodos , Enfermedades Talámicas/fisiopatología , Enfermedades Talámicas/terapia , Isquemia Encefálica/complicaciones , Isquemia Encefálica/fisiopatología , Isquemia Encefálica/terapia , Terapia Combinada , Humanos , Tractos Espinotalámicos/fisiopatologíaRESUMEN
The anterior and mediodorsal thalamic nuclei form neuroanatomical networks supporting memory along with the mammillary body, medial temporal structures, prefrontal cortices and posterior cingulate cortex. In this review article, we discuss human diencephalic amnesic syndromes, including Wernicke-Korsakoff syndrome and amnesia associated with thalamic infarcts, and animal neuropsychological studies from a neuroanatomical network perspective. In addition, we suggest future research directions for understanding the functional roles of the anterior and mediodorsal thalamic nuclei in memory function based on findings from recent animal studies.
Asunto(s)
Amnesia/fisiopatología , Trastornos de la Memoria/fisiopatología , Memoria/fisiología , Enfermedades Talámicas/fisiopatología , Tálamo/anatomía & histología , Animales , Humanos , Pruebas NeuropsicológicasRESUMEN
BACKGROUND: Cognitive, affective, and behavioural disturbances are commonly reported following thalamic strokes. Conversely, sleep disorders are rarely reported in this context. OBSERVATIONS: Herein, we report the cases of two young patients admitted for an ischemic stroke located in the territories of the left pre-mammillary and paramedian arteries. Together with aphasia, memory complaint, impaired attention and executive functions, they reported lucid dreams with catastrophic content or conflicting situations. CONCLUSION: Lucid dreams are an atypical presentation in thalamic strokes. These cases enlarge the clinical spectrum of sleep-wake disturbances potentially observed after an acute cerebrovascular event.
Asunto(s)
Sueños/psicología , Trastornos del Sueño-Vigilia/etiología , Trastornos del Sueño-Vigilia/patología , Accidente Cerebrovascular/complicaciones , Accidente Cerebrovascular/patología , Enfermedades Talámicas/fisiopatología , Adulto , Atención , Arterias Cerebrales/patología , Trastornos del Conocimiento/etiología , Trastornos del Conocimiento/psicología , Imagen de Difusión por Resonancia Magnética , Función Ejecutiva , Femenino , Humanos , Masculino , Pruebas Neuropsicológicas , Trastornos del Sueño-Vigilia/psicología , Accidente Cerebrovascular/psicología , Enfermedades Talámicas/psicologíaRESUMEN
OBJECTIVES: Cumulative head trauma may alter brain structure and function. We explored the relationship between exposure variables, cognition and MRI brain structural measures in a cohort of professional combatants. METHODS: 224 fighters (131 mixed martial arts fighters and 93 boxers) participating in the Professional Fighters Brain Health Study, a longitudinal cohort study of licensed professional combatants, were recruited, as were 22 controls. Each participant underwent computerised cognitive testing and volumetric brain MRI. Fighting history including years of fighting and fights per year was obtained from self-report and published records. Statistical analyses of the baseline evaluations were applied cross-sectionally to determine the relationship between fight exposure variables and volumes of the hippocampus, amygdala, thalamus, caudate, putamen. Moreover, the relationship between exposure and brain volumes with cognitive function was assessed. RESULTS: Increasing exposure to repetitive head trauma measured by number of professional fights, years of fighting, or a Fight Exposure Score (FES) was associated with lower brain volumes, particularly the thalamus and caudate. In addition, speed of processing decreased with decreased thalamic volumes and with increasing fight exposure. Higher scores on a FES used to reflect exposure to repetitive head trauma were associated with greater likelihood of having cognitive impairment. CONCLUSIONS: Greater exposure to repetitive head trauma is associated with lower brain volumes and lower processing speed in active professional fighters.
Asunto(s)
Boxeo/lesiones , Trastornos del Conocimiento/patología , Traumatismos Craneocerebrales/patología , Artes Marciales/lesiones , Procesos Mentales/fisiología , Enfermedades Talámicas/patología , Tálamo/patología , Adolescente , Adulto , Trastornos del Conocimiento/etiología , Trastornos del Conocimiento/fisiopatología , Traumatismos Craneocerebrales/fisiopatología , Humanos , Masculino , Tamaño de los Órganos , Enfermedades Talámicas/etiología , Enfermedades Talámicas/fisiopatología , Adulto JovenAsunto(s)
Enfermedad de Leigh , Síndrome MERRF , Enfermedades Talámicas , Adolescente , Humanos , Enfermedad de Leigh/genética , Enfermedad de Leigh/patología , Enfermedad de Leigh/fisiopatología , Síndrome MERRF/genética , Síndrome MERRF/patología , Síndrome MERRF/fisiopatología , Masculino , Mutación , Fenotipo , Enfermedades Talámicas/genética , Enfermedades Talámicas/patología , Enfermedades Talámicas/fisiopatologíaRESUMEN
The success of device-based research in the clinical neurosciences has overshadowed a critical and emerging problem in the biomedical research environment in the United States. Neuroprosthetic devices, such as deep brain stimulation (DBS), have been shown in humans to be promising technologies for scientific exploration of neural pathways and as powerful treatments. Large device companies have, over the past several decades, funded and developed major research programs. However, both the structure of clinical trial funding and the current regulation of device research threaten investigator-initiated efforts in neurologic disorders. The current atmosphere dissuades clinical investigators from pursuing formal and prospective research with novel devices or novel indications. We review our experience in conducting a federally funded, investigator-initiated, device-based clinical trial that utilized DBS for thalamic pain syndrome. We also explore barriers that clinical investigators face in conducting device-based clinical trials, particularly in early-stage studies or small disease populations. We discuss 5 specific areas for potential reform and integration: (1) alternative pathways for device approval; (2) eliminating right of reference requirements; (3) combining federal grant awards with regulatory approval; (4) consolidation of oversight for human subjects research; and (5) private insurance coverage for clinical trials. Careful reformulation of regulatory policy and funding mechanisms is critical for expanding investigator-initiated device research, which has great potential to benefit science, industry, and, most importantly, patients.