RESUMEN
Anti-Hu antibodies are associated with autoimmune syndromes, mainly limbic encephalitis, encephalomyelitis, and painful sensory polyneuropathy (Denny-Brown). We report the case of a 15-year-old boy presenting with epilepsia partialis continua (EPC) found to have a right middle frontal gyrus brain lesion without atrophy or contralateral involvement. After partial resection, neuropathology revealed neuronal loss, reactive gliosis and astrocytosis, and perivascular mononuclear inflammatory infiltrate and features of neuronophagia resembling Rasmussen encephalitis. Suboptimal response to antiseizure drugs and surgery prompted further workup with identification of positive serum anti-Hu antibodies and a mediastinal seminoma. The patient was treated with immunotherapy including steroids, IV immunoglobulin, azathioprine, rituximab, plasmapheresis, and mediastinal lesion resection. However, he continued to experience EPC and psychomotor impairment along with left hemiparesis and dysarthria. Given clinical progression with failure to respond to immunotherapy and antiseizure polytherapy, hemispherotomy was attempted and seizure freedom achieved. A review of the literature found only 16 cases of neurologic presentations associated with anti-Hu antibodies in children, confirming the rarity of EPC in these cases. Thus, this report provides a new observation of germ cell mediastinal tumor associated with anti-Hu antibodies in children, broadening the spectrum of anti-Hu-associated neurologic disorders in children and highlighting the importance of considering antineuronal antibody testing in children presenting with EPC and brain lesions suggestive of Rasmussen encephalitis.
Asunto(s)
Encefalitis , Epilepsia Parcial Continua , Neoplasias del Mediastino , Neurología , Seminoma , Neoplasias Testiculares , Adolescente , Humanos , Masculino , Encefalitis/complicaciones , Encefalitis/terapia , Epilepsia Parcial Continua/complicaciones , Imagen por Resonancia Magnética , Neoplasias del Mediastino/complicaciones , Neoplasias del Mediastino/terapia , Seminoma/complicaciones , Neoplasias Testiculares/complicaciones , Neoplasias Testiculares/terapiaRESUMEN
OBJECTIVE: To characterize the duration of seizures and inter-seizure intervals in focal status epilepticus (SE). METHODS: We reviewed consecutive scalp EEG recordings from adult patients who were admitted for a first episode of focal status epilepticus. We identified electrographic seizure duration and inter-seizure intervals in the first diagnostic pretreatment EEG. We also reviewed isolated focal self-limiting seizures in epilepsy patients, as a comparison group for seizure duration. RESULTS: We recorded 307 focal seizures in 100 consecutive focal SE episodes, with a median seizure duration of 107 s (IQR: 54-186), and 134 isolated focal self-limiting seizures in 42 epilepsy patients, with a median duration of 59 s (IQR: 30-90; p < .001). The only clinical feature of SE that significantly increased seizure duration was acute symptomatic etiology. In SE, 15% and 7% of seizures lasted longer than 300 and 600 s, respectively (t1 of the actual definition for tonic-clonic and focal SE), while only 1% of self-limiting seizures lasted longer than 300 s, and none lasted longer than 600 s. The analysis of inter-seizure intervals in SE with multiple seizures showed that 50% of the inter-seizure periods were shorter than 60 s, and 95% were shorter than 540 s (9 min). Patients who had an increase in seizure duration (last versus first) of at least 1.4 times showed an increased 30-day mortality. SIGNIFICANCE: Focal seizures within a SE episode showed a wide range of duration, partly overlapping with the duration of focal self-limiting seizures but with a longer median duration. Inter-seizure intervals within an episode of SE were shorter than 1 min in 50% of the seizures and never lasted more than 10 min. Finally, an increase in seizure duration could represent an "electrophysiological biomarker" of a more severe SE episode, which may require more aggressive and rapid treatment.
Asunto(s)
Epilepsia Parcial Continua , Epilepsia , Estado Epiléptico , Adulto , Humanos , Estado Epiléptico/tratamiento farmacológico , Convulsiones/tratamiento farmacológico , Epilepsia/diagnóstico , Epilepsia Parcial Continua/complicaciones , ElectroencefalografíaRESUMEN
PURPOSE: Hyperglycemia can present as many neurological problems, one of them is seizure. Different brain MRI features can be seen in focal seizures associated with nonketotic hyperglycemia that subcortical T2 hypointensity is the only characteristic one. Finding this MRI feature is highly valuable in early diagnosis and treatment. METHODS: Our patient was a 60-year-old female, a case of type 2 diabetes mellitus. She was brought to Emergency Room (ER) with focal colonic status epilepticus of right face and arm associated with confusion and drowsiness progressed over 2 weeks prior to admission. At first, acyclovir was started alongside anti-seizure medication with doubt of herpes encephalitis but antiviral was discontinued after normal LP result and characteristic MRI features. RESULTS: Subcortical T2 hypointensity in left temporal and insular lobe was seen on first MRI that was resolved on follow up MRI after she was treated. CONCLUSION: Epilepsia partialis continua in the setting of non ketotic hyperglycemia should be differentiated from that in herpes encephalitis in a diabetic patient presenting with subacute confusional state and focal status epilepticus considering characteristic MRI finding of subcortical T2 hypointensity.
Asunto(s)
Diabetes Mellitus Tipo 2 , Encefalitis por Herpes Simple , Epilepsia Parcial Continua , Hiperglucemia , Diabetes Mellitus Tipo 2/complicaciones , Electroencefalografía , Encefalitis por Herpes Simple/complicaciones , Encefalitis por Herpes Simple/diagnóstico por imagen , Epilepsia Parcial Continua/complicaciones , Epilepsia Parcial Continua/etiología , Femenino , Humanos , Hiperglucemia/complicaciones , Hiperglucemia/diagnóstico por imagen , Imagen por Resonancia Magnética , Persona de Mediana EdadRESUMEN
The role of neuroinflammation in epileptogenesis is extensively investigated, but short-term effects of seizures on established CNS pathologies are less studied and less predictable. We describe the case of a woman with previous recurrent episodes of focal cerebral haemorrhage of unknown cause who developed a pseudo-tumoural oedema triggered by provoked focal status epilepticus. A brain biopsy revealed that the underlying condition was primary angiitis of the CNS. Ictal-induced blood-brain barrier dysfunction allows the entry of water and inflammatory molecules that, in the context of CNS inflammatory diseases, may trigger a self-reinforcing process. Caution should be observed when tapering antiepileptic drugs in patients with such conditions.
Asunto(s)
Epilepsia Parcial Continua , Vasculitis del Sistema Nervioso Central , Epilepsia Parcial Continua/complicaciones , Femenino , Humanos , Recurrencia , Vasculitis del Sistema Nervioso Central/patologíaRESUMEN
Epilepsia partialis continua manifests as low-frequency, rhythmic involuntary movements of a focal body part. We report a young man, HIV-positive and with syphilis, who developed right-hand epilepsia partialis continua associated with a small left-sided cortico-subcortical frontal lesion. A pen and paper test provided 'mechanographic' data on frequency, amplitude and rhythmicity of the hand movements, helping distinguish it from other causes of low-frequency repetitive hand movements.
Asunto(s)
Discinesias , Epilepsia Parcial Continua , Discinesias/complicaciones , Electroencefalografía , Epilepsia Parcial Continua/complicaciones , Epilepsia Parcial Continua/diagnóstico por imagen , Mano , Humanos , MasculinoRESUMEN
Epilepsia partialis continua (EPC) of abdominal muscles is a rare entity with variable clinical localization and aetiology. A 25-year-old man presented with sudden onset of intermittent focal myoclonic movements involving the abdominal muscles on the right side exclusively, lasting from 20 minutes to an hour. Brain MRI revealed a ring-enhancing lesion, suggestive of cysticercal granuloma over the left precentral gyrus. The patient fulfilled the revised diagnostic criteria for definitive diagnosis of neurocysticercosis. EEG did not show focal abnormalities during the events. Episodes of EPC were controlled with difficulty using 600 mg oxcarbazepine, 200 mg lacosamide, and 2,000 mg levetiracetam. The patient received antiparasitic therapy with albendazole (15 mg/kg for two weeks) and oral dexamethasone (0.1 mg/kg) for two weeks which was then tapered. The involvement of the primary motor cortex during ictal propagation may account for this curious phenomenon. This is the first report of abdominal EPC in a patient with inflammatory granuloma as a result of neurocysticercosis.
Asunto(s)
Abdomen/fisiopatología , Músculos Abdominales/fisiopatología , Epilepsia Parcial Continua/complicaciones , Neurocisticercosis/complicaciones , Músculos Abdominales/efectos de los fármacos , Adulto , Electroencefalografía/métodos , Epilepsia Parcial Continua/diagnóstico , Epilepsia Parcial Continua/tratamiento farmacológico , Humanos , Levetiracetam/uso terapéutico , Imagen por Resonancia Magnética/métodos , Masculino , Corteza Motora/fisiopatología , Neurocisticercosis/diagnóstico , Neurocisticercosis/fisiopatologíaRESUMEN
BACKGROUND: We describe a patient copresenting with epilepsia partialis continua, tuberculosis, and hemophagocytic lymphohistiocytosis. To our knowledge, this is the first documented case of this triad. CASE PRESENTATION: A 54-year-old black South African woman presented to a hospital in Scotland with an acute history of right-sided facial twitching, breathlessness, and several months of episodic night sweats. Clinical examination revealed pyrexia and continuous, stereotyped, right-sided facial contractions. These worsened with speech and continued through sleep. A clinical diagnosis of epilepsia partialis continua was made, and we provide a video of her seizures. Computed tomographic imaging of the chest and serous fluid analyses were consistent with a diagnosis of disseminated Mycobacterium tuberculosis. An additional diagnosis of hemophagocytic lymphohistiocytosis was made following the identification of pancytopenia and hyperferritinemia in peripheral blood, with hemophagocytosis evident in bone marrow investigation. We provide images of her hematopathology. The patient was extremely unwell and was hospitalized for 6 months, including two admissions to the intensive care unit for ventilatory support. She was treated successfully with high doses of antiepileptic drugs (benzodiazepines, levetiracetam, and phenytoin) and 12 months of oral antituberculosis therapy, and she underwent chemotherapy with 8 weeks of etoposide and dexamethasone for hemophagocytic lymphohistiocytosis, followed by 12 months of cyclosporine and prednisolone. CONCLUSIONS: This combination of pathologies is unusual, and this case report helps educate clinicians on how such a patient may present and be managed. A lack of evidence surrounding the coexpression of this triad may represent absolute rarity, underdiagnosis, or incomplete case ascertainment due to early death caused by untreated tuberculosis or hemophagocytic lymphohistiocytosis. Further research is needed.
Asunto(s)
Epilepsia Parcial Continua/complicaciones , Linfohistiocitosis Hemofagocítica/complicaciones , Tuberculosis/complicaciones , Epilepsia Parcial Continua/tratamiento farmacológico , Femenino , Humanos , Linfohistiocitosis Hemofagocítica/tratamiento farmacológico , Persona de Mediana Edad , Tuberculosis/diagnóstico por imagen , Tuberculosis/tratamiento farmacológicoAsunto(s)
Epilepsia Parcial Continua/complicaciones , Epilepsia/complicaciones , Malformaciones del Desarrollo Cortical de Grupo I/complicaciones , Electroencefalografía , Epilepsia Parcial Continua/cirugía , Epilepsia/cirugía , Humanos , Masculino , Malformaciones del Desarrollo Cortical de Grupo I/cirugía , Persona de Mediana Edad , Proteínas del Tejido Nervioso/metabolismoAsunto(s)
Epilepsia Parcial Continua/diagnóstico por imagen , Epilepsias Parciales/diagnóstico por imagen , Grabación de Cinta de Video , Adolescente , ADN Polimerasa gamma/genética , Electroencefalografía , Epilepsia Parcial Continua/complicaciones , Epilepsias Parciales/complicaciones , Femenino , Humanos , Imagen por Resonancia Magnética , Mutación , NeuroimagenRESUMEN
Epilepsia partialis contina (EPC) in a narrow definition is a variant of simple focal motor status epilepticus in which frequent repetitive muscle jerks, usually arrhythmic, continue over prolonged periods of time. In a broader definition (used in this review) it also includes non-motor manifestations otherwise known as aura continua. EPC may occur as a single episode, repetitive episodes, it may be chronic progressive or non-progressive. It appears as an unusual manifestation of epilepsy in which more typical paroxysmal events are partly or entirely replaced by the sustained repetition of seizure fragments in rapid succession. The minimum duration is defined as one hour but EPC may continue for up to many years. There are multiple possible etiologies which can be local or systemic, including two disease entities, Rasmussen encephalitis and Russian tick-borne spring-summer encephalitis. Among systemic brain disorders, mitochondrial diseases and non-ketotic hyperglycemia are particularly likely to cause EPC whereas stroke is a frequent cause of acute EPC. The symptoms of motor EPC have been interpreted as cortical reflex myocloni but the pathophysiology is probably not uniform for all cases. In pathophysiological terms, EPC seems to represent an oscillation of excitation and inhibition in a feedback loop whose mechanisms are still poorly understood. However, EPC only seems to occur rarely in an otherwise healthy brain. Treatment has to take account of the etiology but, in general, EPC tends to be drug-resistant. Epilepsy surgery is often indicated in Rasmussen encephalitis.
Asunto(s)
Epilepsia Parcial Continua/complicaciones , Epilepsia Parcial Continua/epidemiología , Epilepsia Parcial Continua/etiología , Bases de Datos Factuales/estadística & datos numéricos , Electroencefalografía , Epilepsia Parcial Continua/psicología , HumanosRESUMEN
INTRODUCTION: Tuberculosis is a progressive and disabling infection predominantly seen in low-income and middle-income countries. Immunocompromised patients are at a higher risk of contracting tuberculosis than the healthy population. The presentation may also be atypical, leading to delay in diagnosis. We report the first case of tuberculous cerebral vasculitis presenting with epilepsia partialis continua. CASE PRESENTATION: A 17-year-old adolescent boy of Sri Lankan Moor heritage was taking long-term immunosuppressants for nephrotic syndrome. He presented to hospital with focal fits affecting his left arm. He later developed choreiform movements of the same arm, progressing to epilepsia partialis continua and weakness. The gradually evolving focal neurological signs and underlying immunosuppression raised the possibility of localized cerebral infection or inflammation. Analysis of his cerebrospinal fluid showed lymphocytosis with normal cellular morphology. Magnetic resonance imaging was suggestive of progressive vasculitic infarctions of the cerebral cortex and basal ganglia. There was no evidence of active autoimmune or viral disease on hematological investigations, but molecular amplification detected Mycobacterium tuberculosis in his cerebrospinal fluid. Although our patient had been established on isoniazid preventive treatment for eight months before the episode, tuberculosis was nonetheless considered to be the most likely cause of the cerebral vasculitis. He was treated with a trial of anti-tuberculosis treatment, including streptomycin and adjunctive steroids, and made an uneventful recovery. CONCLUSION: Clinicians should have a high index of suspicion for tuberculosis infection in patients with compromised immunity and other risk factors. The pathophysiological mechanisms underpinning cerebral vasculitis and epilepsia partialis continua are not completely understood. The efficacy of isoniazid prophylaxis in patients with immune suppression warrants further study. We present a regimen that successfully treated tuberculous cerebral vasculitis.
Asunto(s)
Epilepsia Parcial Continua/diagnóstico , Huésped Inmunocomprometido , Inmunosupresores/uso terapéutico , Convulsiones/complicaciones , Tuberculosis/diagnóstico , Vasculitis del Sistema Nervioso Central/diagnóstico , Adolescente , Antituberculosos/uso terapéutico , Encéfalo/microbiología , Encéfalo/patología , Diagnóstico Diferencial , Epilepsia Parcial Continua/complicaciones , Epilepsia Parcial Continua/tratamiento farmacológico , Humanos , Imagen por Resonancia Magnética , Masculino , Síndrome Nefrótico/complicaciones , Síndrome Nefrótico/tratamiento farmacológico , Convulsiones/diagnóstico , Convulsiones/tratamiento farmacológico , Tuberculosis/complicaciones , Tuberculosis/tratamiento farmacológico , Vasculitis del Sistema Nervioso Central/complicaciones , Vasculitis del Sistema Nervioso Central/tratamiento farmacológicoRESUMEN
This article describes clinical cases of 13 year old boy with two non-convulsive status epilepticus which had transient epileptic amnesia as a clinical implication. Status EEG pattern in form of diffuse epileptic activity "benign epileptiform discharge of childhood" type was registered.
Asunto(s)
Amnesia/diagnóstico , Epilepsia Parcial Continua/diagnóstico , Adolescente , Amnesia/etiología , Anticonvulsivantes/administración & dosificación , Diazepam/administración & dosificación , Electroencefalografía , Epilepsia Parcial Continua/complicaciones , Epilepsia Parcial Continua/tratamiento farmacológico , Humanos , Inyecciones Intramusculares , Masculino , Resultado del TratamientoRESUMEN
Argininemia is a rare inherited disorder of the urea cycle because of a deficiency of the enzyme arginase I causing an increase of arginine and guanidino compounds in the blood, urine, and cerebrospinal fluid. The clinical picture is characterized by a mild cognitive dysfunction, progressive asymmetrical paraparesis, and seizures. Here, we describe two cases of argininemia where either epilepsia partialis continua (EPC) or nonconvulsive status epilepticus (NCSE) were the presenting manifestations of epilepsy. This is the first report of EPC in an urea cycle disorder. In both the cases, status epilepticus resolved with anticonvulsive drugs. EPC was successfully treated with levetiracetam, and NCSE with valproic acid. No side effects were observed. Because hyperammonemia and NCSE may have the same features of stupor, a neurophysiological approach might prove useful in differentiating these two conditions. Overall, our results strongly indicate that a correct NCSE diagnosis is mandatory to prevent further deterioration in these patients.
Asunto(s)
Epilepsia Parcial Continua/diagnóstico , Epilepsia Generalizada/diagnóstico , Hiperargininemia/diagnóstico , Niño , Preescolar , Epilepsia Parcial Continua/complicaciones , Epilepsia Generalizada/complicaciones , Humanos , Hiperargininemia/complicaciones , MasculinoRESUMEN
Alpers-Huttenlocher syndrome is an uncommon mitochondrial disease most often associated with mutations in the mitochondrial DNA replicase, polymerase-γ. Alterations in enzyme activity result in reduced levels or deletions in mitochondrial DNA. Phenotypic manifestations occur when the functional content of mitochondrial DNA reaches a critical nadir. The tempo of disease progression and onset varies among patients, even in identical genotypes. The classic clinical triad of seizures, liver degeneration, and progressive developmental regression helps define the disorder, but a wide range of clinical expression occurs. The majority of patients are healthy before disease onset, and seizures herald the disorder in most patients. Seizures can rapidly progress to medical intractability, with frequent episodes of epilepsia partialis continua or status epilepticus. Liver involvement may precede or occur after seizure onset. Regardless, eventual liver failure is common. Both the tempo of disease progression and range of organ involvement vary from patient to patient, and are only partly explained by pathogenic effects of genetic mutations. Diagnosis involves the constellation of organ involvement, not the sequence of signs. This disorder is relentlessly progressive and ultimately fatal.
Asunto(s)
Esclerosis Cerebral Difusa de Schilder/diagnóstico , Epilepsia Parcial Continua/patología , Fallo Hepático/patología , Estado Epiléptico/patología , Esclerosis Cerebral Difusa de Schilder/genética , Esclerosis Cerebral Difusa de Schilder/patología , Progresión de la Enfermedad , Epilepsia Parcial Continua/complicaciones , Epilepsia Parcial Continua/genética , Humanos , Fallo Hepático/complicaciones , Fallo Hepático/genética , Mitocondrias/genética , Mitocondrias/patología , Estado Epiléptico/complicaciones , Estado Epiléptico/genéticaRESUMEN
Schizencephaly is regarded as a malformation of cortical development (due to abnormal neuronal organization) and may be associated with continuous involuntary hand movements. The mechanisms underlying these movements are not clear and both dystonia and epilepsia partialis continua have been considered in previously reported cases. We describe a young patient affected by schizencephaly and continuous involuntary movements of the contralateral hand. Functional MRI showed bilateral cerebral activation, while the subject performed tapping movements with the affected hand and no significant difference in the activation pattern after diazepam infusion. Standard and back-averaged EEG showed no alterations. The results obtained from these investigations and the clinical features of the involuntary movements are not in favor of an epileptic genesis, while support the diagnosis of secondary dystonia.
Asunto(s)
Discinesias/complicaciones , Distonía/complicaciones , Epilepsia Parcial Continua/complicaciones , Mano/fisiopatología , Adulto , Femenino , Lóbulo Frontal/irrigación sanguínea , Lóbulo Frontal/patología , Humanos , Procesamiento de Imagen Asistido por Computador , Imagen por Resonancia Magnética , Oxígeno/sangreRESUMEN
Epilepsia partialis continua (EPC) is clinically defined as a syndrome of continuous focal jerking of a body part, usually a distal limb, occurring over hours, days, or even years. It is considered the status epilepticus equivalent of simple partial motor seizures. A 48-year-old right-handed man with a history of traumatic intracranial hemorrhage was admitted for right-sided hemiplegia and drowsiness after complex partial status epilepticus. An EEG showed periodic lateralized epileptiform discharges over the left hemisphere. Brain MRI revealed extensive multifocal encephalomalaciac changes in the left temporo-parieto-occpital lobe and both frontal lobes with some hemorrhagic residual change. After administration of a loading dose of intravenous phenytoin, his mental status returned to normal. However, his weakness only partially improved. [(18)F]Fluorodeoxyglucose PET (FDG-PET) demonstrated severe hypometabolism in the left cerebral hemisphere, including the basal ganglia and thalamus, with cerebellar diaschisis. At the 3-month follow-up, he complained of symptoms of alien hand phenomenon. Follow-up MRI revealed more extensive encephalomalaciac changes in previously noted regions with thinning of the posterior end of the body of the corpus callosum. Moreover, FDG-PET demonstrated persistent severe hypometabolism over the left cerebral hemisphere. We suggest that the alien hand phenomenon was a result of thinning of the corpus callosum related to EPC.
Asunto(s)
Fenómeno de la Extremidad Ajena , Epilepsia Parcial Continua , Fluorodesoxiglucosa F18 , Imagen por Resonancia Magnética , Tomografía de Emisión de Positrones , Fenómeno de la Extremidad Ajena/diagnóstico por imagen , Fenómeno de la Extremidad Ajena/etiología , Fenómeno de la Extremidad Ajena/patología , Electroencefalografía , Epilepsia Parcial Continua/complicaciones , Epilepsia Parcial Continua/diagnóstico por imagen , Epilepsia Parcial Continua/patología , Humanos , Masculino , Persona de Mediana EdadRESUMEN
Rasmussen encephalitis (RE) is a chronic inflammatory disease leading to unilateral hemispheric atrophy, associated with progressive neurological dysfunction and intractable seizures. The best approach to RE is hemispherectomy. However long-term immunotherapy seems to prevent or slow down hemispheric tissue loss and the associated functional decline. We describe a girl with epilepsia partialis continua (EPC) and progressive neurological dysfunction compatible with RE. The brain MRI showed a lesion that was initially interpreted as focal cortical dysplasia. Combined antiepileptic and immunomodulation were administered for two years with initial beneficial effects. The follow-up MRI, 4 year later showed. atrophic change in right parietal region. The association of antiepileptic and immunomodulation therapies may inhibit pathogenetic mechanisms responsible for neuronal loss in RE, slowing down the progression of the disease.
Asunto(s)
Anticonvulsivantes/administración & dosificación , Encefalitis/terapia , Inmunoglobulinas/administración & dosificación , Anticonvulsivantes/uso terapéutico , Niño , Encefalitis/complicaciones , Encefalitis/diagnóstico , Epilepsia Parcial Continua/complicaciones , Epilepsia Parcial Continua/tratamiento farmacológico , Femenino , Humanos , Inmunoglobulinas/uso terapéutico , Imagen por Resonancia MagnéticaRESUMEN
Epilepsia partialis continua (EPC) is a syndrome clinically defined as continuous spontaneous jerking confined to one part of the body, sometimes aggravated by action or sensory stimuli, occurring over hours, days or even years. In adults the more frequent recognized cause of EPC is an acute cerebrovascular disease. Acute severe hypocalcemia is a highly epileptogenic ionic disturbance, abnormally increasing neuronal excitability. In this short communication we describe the first probable case of acute hypocalcemia-related EPC. Eight months after a left parietal lobe cardioembolic stroke, a 74-year-old woman experienced a generalized tonic-clonic seizure for the first time in her life, at the beginning of a Clostridium difficile enterocolitis. Four days later, while the abdominal symptoms were clinically improving, continuous semi-rhythmic jerks of right face, shoulder and arm began suddenly. Despite several appropriated antiepileptic treatments those involuntary movements did not cease. On routine biochemical examination we noted a total calcium serum level of 1.2 mmol/L (normal range 2.1-2.8 mmol/L), not previously known. After intravenous calcium gluconate supplementation, the jerks started to fade, disappearing completely as a total calcium serum level of 1.9 mmol/L was reached. Two separated CT brain scans did not reveal new cerebral lesions. Neurophysiological studies did not show any cortical activity related to jerks. Taken together, the treatment refractoriness and the clinical improvement after ionic imbalance correction point towards a highly possible role of hypocalcemia in sustaining the activity of a previously silent epileptogenic focus.