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1.
Genes (Basel) ; 15(8)2024 Aug 02.
Artículo en Inglés | MEDLINE | ID: mdl-39202376

RESUMEN

Cardiac involvement is a major feature of RASopathies, a group of phenotypically overlapping syndromes caused by germline mutations in genes encoding components of the RAS/MAPK (mitogen-activated protein kinase) signaling pathway. In particular, Noonan syndrome (NS) is associated with a wide spectrum of cardiac pathologies ranging from congenital heart disease (CHD), present in approximately 80% of patients, to hypertrophic cardiomyopathy (HCM), observed in approximately 20% of patients. Genotype-cardiac phenotype correlations are frequently described, and they are useful indicators in predicting the prognosis concerning cardiac disease over the lifetime. The aim of this review is to clarify the molecular mechanisms underlying the development of cardiac diseases associated particularly with NS, and to discuss the main morphological and clinical characteristics of the two most frequent cardiac disorders, namely pulmonary valve stenosis (PVS) and HCM. We will also report the genotype-phenotype correlation and its implications for prognosis and treatment. Knowing the molecular mechanisms responsible for the genotype-phenotype correlation is key to developing possible targeted therapies. We will briefly address the first experiences of targeted HCM treatment using RAS/MAPK pathway inhibitors.


Asunto(s)
Síndrome de Noonan , Humanos , Síndrome de Noonan/genética , Síndrome de Noonan/patología , Fenotipo , Cardiomiopatía Hipertrófica/genética , Cardiomiopatía Hipertrófica/patología , Proteínas ras/genética , Proteínas ras/metabolismo , Sistema de Señalización de MAP Quinasas/genética , Estenosis de la Válvula Pulmonar/genética , Estenosis de la Válvula Pulmonar/patología , Estudios de Asociación Genética , Cardiopatías Congénitas/genética , Cardiopatías Congénitas/patología , Mutación
2.
Am J Med Genet A ; 185(5): 1486-1493, 2021 05.
Artículo en Inglés | MEDLINE | ID: mdl-33683002

RESUMEN

The RASopathies are a group of similar genetic syndromes with cardiovascular abnormalities, characteristic facial features, short stature, abnormalities of the skin and musculoskeletal system, and variable neurodevelopmental challenges. The most common cardiovascular abnormalities include pulmonary valvular stenosis and hypertrophic cardiomyopathy. Congenital polyvalvular disease (CPVD) refers to congenital dysplasia of two or more cardiac valves. We diagnosed a RASopathy in two individuals with CPVD and noted that CPVD in RASopathies has rarely been reported in the literature. Thus, we performed a retrospective chart review and literature review to investigate the association and characterize the phenotype of CPVD in the RASopathies. CPVD was present in 2.5% (n = 6/243) of individuals in our RASopathy cohort. Involvement of two cardiac valves, commonly the aortic and pulmonic valves, was seen in the majority of individuals (6/8; 75%) in our cohort, but only 27% (3/11) of reported CPVD and RASopathy cases in the literature. CPVD should be considered an associated cardiovascular phenotype of the RASopathies, which has implications for diagnosis and management.


Asunto(s)
Cardiomiopatía Hipertrófica/genética , Proteína Tirosina Fosfatasa no Receptora Tipo 11/genética , Proteínas Proto-Oncogénicas B-raf/genética , Estenosis de la Válvula Pulmonar/genética , Adolescente , Válvula Aórtica/patología , Cardiomiopatía Hipertrófica/epidemiología , Cardiomiopatía Hipertrófica/patología , Anomalías Cardiovasculares/epidemiología , Anomalías Cardiovasculares/genética , Anomalías Cardiovasculares/patología , Niño , Preescolar , Enanismo/genética , Enanismo/patología , Facies , Femenino , Cardiopatías Congénitas/genética , Cardiopatías Congénitas/patología , Humanos , Lactante , Recién Nacido , Masculino , Anomalías Musculoesqueléticas/epidemiología , Anomalías Musculoesqueléticas/genética , Anomalías Musculoesqueléticas/patología , Síndrome de Noonan , Fenotipo , Estenosis de la Válvula Pulmonar/epidemiología , Estenosis de la Válvula Pulmonar/patología , Anomalías Cutáneas/genética , Anomalías Cutáneas/patología , Proteínas ras/genética
3.
Am J Med Genet C Semin Med Genet ; 184(1): 47-52, 2020 03.
Artículo en Inglés | MEDLINE | ID: mdl-32052942

RESUMEN

Congenital heart disease (CHD) in low-and-middle income countries (LMIC) is often characterized by late presentation resulting from inadequate screening and healthcare access in these regions. Accurate estimates of the burden of CHD among school children are often lacking. The objective of this study was to determine the prevalence and distribution of CHD among school children in two communities (urban and semi-urban) in south western Nigeria. Using clinical assessment and portable echocardiography, 4107 school children aged 5 years to 16 years in Lagos, Nigeria, were selected using a multistage sampling procedure and screened for CHD. Diagnosis of CHD was made after echocardiography. Children identified with CHD were referred to a tertiary hospital for appropriate cardiac care. The 4,107 children screened had a mean age of 11.3 ± 2.7 years and 53.7% were females. Twenty seven children had echocardiography-confirmed CHD, representing a prevalence of CHD among school children in Lagos, Nigeria of 6.6 per 1000 children. Acyanotic CHD constituted 96.3% of detected cases. Two children diagnosed with CHD (Tetralogy of Fallot and severe pulmonary valve stenosis respectively) had successful intervention. The prevalence of previously undiagnosed CHD among school children in Lagos Nigeria is substantial and highlights gaps in the health care system and school health programs. Echocardiographic screening of school children provides an opportunity for missed early diagnosis and treatment of CHD and reduces the prevalence of first-diagnosed CHD in adulthood. Therefore, focused clinical examination of school children followed by echocardiography is a strategy that could bridge this diagnostic and treatment gap in CHD.


Asunto(s)
Cardiopatías Congénitas/epidemiología , Estenosis de la Válvula Pulmonar/diagnóstico , Tetralogía de Fallot/diagnóstico , Adolescente , Adulto , Niño , Preescolar , Ecocardiografía , Femenino , Cardiopatías Congénitas/diagnóstico , Cardiopatías Congénitas/patología , Humanos , Masculino , Nigeria/epidemiología , Estenosis de la Válvula Pulmonar/epidemiología , Estenosis de la Válvula Pulmonar/patología , Instituciones Académicas , Tetralogía de Fallot/epidemiología , Tetralogía de Fallot/patología
5.
Clin Genet ; 97(3): 447-456, 2020 03.
Artículo en Inglés | MEDLINE | ID: mdl-31730227

RESUMEN

Retinal arterial macroaneurysms with supravalvular pulmonic stenosis (RAMSVPS), also known as Familial Retinal Arterial Macroaneurysms (FRAM) syndrome, is a very rare multisystem disorder. Here, we present a case series comprising ophthalmologic and systemic evaluation of patients homozygous for RAMSVPS syndrome causative IGFBP7 variant. New clinical details on 22 previously published and 8 previously unpublished patients are described. Age at first presentation ranged from 1 to 34 years. The classical feature of macroaneurysms and vascular beading involving the retinal arteries was universal. Follow up extending up to 14 years after initial diagnosis revealed recurrent episodes of bleeding and leakage from macroaneurysms in 55% and 59% of patients, respectively. The majority of patients who underwent echocardiography (18/23) showed evidence of heart involvement, most characteristically pulmonary (valvular or supravalvular) stenosis, often requiring surgical correction (12/18). Four patients died in the course of the study from complications of pulmonary stenosis, cerebral hemorrhage, and cardiac complications. Liver involvement (usually cirrhosis) was observed in eight patients. Cerebral vascular involvement was observed in one patient, and stroke was observed in two. We conclude that RAMSVPS is a recognizable syndrome characterized by a high burden of ocular and systemic morbidity, and risk of premature death. Recommendations are proposed for early detection and management of these complications.


Asunto(s)
Predisposición Genética a la Enfermedad , Proteínas de Unión a Factor de Crecimiento Similar a la Insulina/genética , Estenosis de la Válvula Pulmonar/genética , Macroaneurisma Arterial de Retina/genética , Adolescente , Adulto , Niño , Preescolar , Femenino , Angiografía con Fluoresceína , Fondo de Ojo , Homocigoto , Humanos , Lactante , Masculino , Estenosis de la Válvula Pulmonar/complicaciones , Estenosis de la Válvula Pulmonar/diagnóstico por imagen , Estenosis de la Válvula Pulmonar/patología , Macroaneurisma Arterial de Retina/complicaciones , Macroaneurisma Arterial de Retina/diagnóstico por imagen , Macroaneurisma Arterial de Retina/patología , Arteria Retiniana/diagnóstico por imagen , Arteria Retiniana/metabolismo , Arteria Retiniana/patología , Agudeza Visual/genética , Agudeza Visual/fisiología , Adulto Joven
6.
J Vet Cardiol ; 26: 39-50, 2019 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-31794916

RESUMEN

INTRODUCTION/OBJECTIVES: Coronary artery abnormalities are described sporadically in dogs, most commonly with pulmonic stenosis. Computed tomographic angiography (CTA) allows non-invasive assessment of coronary anatomy. Three-dimensional (3D) models improve the understanding and visualization of spatially complex anatomy. The study objective was to evaluate coronary artery anomalies using CTA imaging and using rapid prototyping technology to create life-sized coronary artery models of these studies. ANIMALS, MATERIAL AND METHODS: Combined retrospective case and prospective pilot study. Inclusion criteria were dogs with reported coronary artery anomalies. The CTA data sets were imported into a medical imaging framework for the analysis of the coronary arteries and into a 3D-planning and printing software for creating printable 3D models. The 3D models were printed using fusion deposition modeling technology. RESULTS: Six male dogs with an R2A coronary artery anomaly and pulmonic stenosis diagnosed by CTA were included. Electrocardiogram (ECG)-gated CTA allowed better identification of anomalous coronary arteries than non-gated CTA. In all dogs, the right coronary artery had a smaller diameter than the left and the left coronary artery or its branch had a prepulmonic course. All ECG-gated studies were 3D printed while non-gated studies were not printable due to CTA artifacts. CONCLUSION: In dogs, CTA is effective for diagnosis of coronary artery anomalies. Printed 3D models of ECG-gated CTA studies were of excellent quality and allowed direct visualization of abnormal coronary artery anatomy. The usefulness of these models to improve the understanding of anomalous coronary artery anatomy could be evaluated in future studies.


Asunto(s)
Angiografía por Tomografía Computarizada/veterinaria , Vasos Coronarios/patología , Enfermedades de los Perros/patología , Impresión Tridimensional , Estenosis de la Válvula Pulmonar/veterinaria , Animales , Angiografía Coronaria/métodos , Anomalías de los Vasos Coronarios/veterinaria , Perros , Electrocardiografía/veterinaria , Masculino , Proyectos Piloto , Estenosis de la Válvula Pulmonar/diagnóstico por imagen , Estenosis de la Válvula Pulmonar/patología
7.
J Med Case Rep ; 13(1): 219, 2019 Jul 19.
Artículo en Inglés | MEDLINE | ID: mdl-31319891

RESUMEN

BACKGROUND: Adults with unoperated congenitally corrected transposition of the great arteries are rare but form a distinct group among adults with congenital heart disease. Patients with congenitally corrected transposition of the great arteries often have one or more associated cardiac anomalies that dictate the need for, and timing of, surgical intervention in childhood. However, in a proportion of patients, the hemodynamics does not require surgical attention during childhood, and, in some patients, a correct diagnosis is not established until adulthood. Here we report an adult case of unoperated congenitally corrected transposition of the great arteries with a large ventricular septal defect and probable pulmonary arterial hypertension. CASE PRESENTATION: Our patient was a 46-year-old Korean man. Transthoracic echocardiography and cardiac catheterization demonstrated hemodynamically balanced ventricles with a non-regurgitant systemic atrioventricular valve, normal pulmonary arterial pressure, and a reasonable difference between the oxygen saturation values of the aorta and pulmonary trunk, even with the presence of a large ventricular septal defect. Further morphological assessments using cardiac computed tomography and three-dimensional modeling/printing of his heart revealed that the mitral valve was straddling over the posteriorly positioned ventricular septal defect, which could explain the functional and anatomical subvalvular pulmonary stenosis and a small amount of shunt flow through the large ventricular septal defect. We interpreted this combination of cardiac defects as able to sustain his stable cardiac function. Thus, we decided to maintain his unoperated status. CONCLUSION: A detailed anatomical understanding based on transthoracic echocardiography, cardiac computed tomography, and three-dimensional printing can justify a decision to not operate in cases of congenitally corrected transposition of the great arteries with hemodynamically balanced pulmonary stenosis and a ventricular septal defect, as observed in the present case.


Asunto(s)
Transposición Congénitamente Corregida de las Grandes Arterias/diagnóstico por imagen , Defectos del Tabique Interventricular/diagnóstico por imagen , Estenosis de la Válvula Pulmonar/diagnóstico por imagen , Transposición Congénitamente Corregida de las Grandes Arterias/terapia , Tratamiento Conservador , Ecocardiografía , Defectos del Tabique Interventricular/patología , Defectos del Tabique Interventricular/terapia , Humanos , Imagenología Tridimensional , Masculino , Persona de Mediana Edad , Estenosis de la Válvula Pulmonar/patología , Estenosis de la Válvula Pulmonar/terapia
8.
Dev Biol ; 450(2): 82-89, 2019 06 15.
Artículo en Inglés | MEDLINE | ID: mdl-30951706

RESUMEN

During mouse development, part of the cells derived from the second heart field (SHF) progenitors contributes to the elongation and enlargement of the outflow tract (OFT) that subsequently septates into the trunks of aorta (Ao) and pulmonary artery (PA). Thus, the cardiac progenitor-originated cells are distributed to both Ao and PA. Here, we investigated that how these cells are assigned to the two great arteries during OFT septation through lineage tracing technology. By use of the inducible Mef2c-AHF-CreERT2; Rosa26-mTmG reporter system, two waves of SHF progenitors and their derivatives were identified, and they made differential contribution to the Ao and PA, respectively. While the early wave of cells (at E7.5) was preferentially destined to the Ao, the second wave of cells (from E8.5 till E11.5) made its favorite path to the PA. In addition, we unveiled PDK1 as a critical regulator of the second wave of cells as deletion of Pdk1 resulted in poorly developed PA leading to pulmonary stenosis. Thus, this study provides insights into the understanding of the pre-determined cell fate of the cardiac progenitor-derived cells with preferential contribution to the Ao and PA, as well as of the pathogenesis of pulmonary stenosis.


Asunto(s)
Aorta/metabolismo , Diferenciación Celular , Miocardio/metabolismo , Arteria Pulmonar/metabolismo , Estenosis de la Válvula Pulmonar/metabolismo , Células Madre/metabolismo , Animales , Aorta/patología , Ratones , Ratones Transgénicos , Miocardio/patología , Arteria Pulmonar/patología , Estenosis de la Válvula Pulmonar/patología , Células Madre/patología
9.
Int J Cardiol ; 281: 113-118, 2019 Apr 15.
Artículo en Inglés | MEDLINE | ID: mdl-30732866

RESUMEN

OBJECTIVES: Bioprosthetic pulmonary valve conduits have been reported with an increased risk of endocarditis. Thrombus formation is considered as source of these serious and life-threatening infections. We reviewed a series of explanted valved pulmonary conduits for histological evidence for thrombus formation. MATERIALS AND METHODS: Explanted bioprosthetic pulmonary valves were fixed in formalin and embedded in paraffin or in methylmethacrylate. Standard staining as well as immunohistochemical staining techniques were applied. Native pulmonary valves of German domestic pigs served as controls. RESULTS: 47 valved pulmonary conduits (Hancock n = 23, Homograft n = 7, Contegra n = 7, Melody n = 7, other n = 3) were analyzed histologically. Average time of implantation had been 63 months (6 to 342 months). Indications for explantation included significant obstruction (n = 45), regurgitation (n = 7), and/or endocarditis (n = 6). In 44/47 (93%) specimen, we found accumulation of thrombotic material at the basis of the semilunar valve sinus to a variable degree. 11 patients had been treated with antiplatelet agents, 2 had received anticoagulants at the time of explantation. There was no suspicion of thrombus formation clinically or echocardiographically prior to explantation in any of the patients. Control porcine pulmonary valves (n = 5) did not show any evidence of accumulation of thrombotic material. CONCLUSIONS: In a large series of explanted valved pulmonary conduits, formation of subclinical, mostly non-infectious thrombotic material was an almost ubiquitous finding. We speculate that high incidence of endocarditis in bioprosthetic valves may in part be explained by thrombus apposition at the basis of conduit valve sinus.


Asunto(s)
Bioprótesis/efectos adversos , Prótesis Valvulares Cardíacas/efectos adversos , Estenosis de la Válvula Pulmonar/cirugía , Válvula Pulmonar/cirugía , Trombosis/patología , Adolescente , Adulto , Animales , Bioprótesis/normas , Niño , Preescolar , Femenino , Prótesis Valvulares Cardíacas/normas , Humanos , Lactante , Masculino , Persona de Mediana Edad , Válvula Pulmonar/patología , Estenosis de la Válvula Pulmonar/patología , Porcinos , Trombosis/etiología , Adulto Joven
10.
Circ J ; 82(12): 3064-3068, 2018 11 24.
Artículo en Inglés | MEDLINE | ID: mdl-30298850

RESUMEN

BACKGROUND: We reviewed our revised surgical strategy for tetralogy of Fallot (TOF) total correction to minimize early exposure to significant pulmonary regurgitation (PR) and to avoid right ventriculotomy (RV-tomy). Methods and Results: Since February 2016, we have tried to preserve, first, pulmonary valve (PV) function to minimize PR by extensive commissurotomy with annulus saving; and second, RV infundibular function by avoiding RV-tomy. With this strategy, we performed total correction for 50 consecutive patients with TOF until May 2018. We reviewed the early outcomes of 27 of 50 patients who received follow-up for ≥3 months. Mean patient age at operation was 10.2±5.0 months, and mean body weight was 8.8±1.2 kg. The preoperative pressure gradient at the RV outflow tract and the PV z-score were improved at most recent echocardiography from 82.0±7.1 to 26.8±6.4 mmHg, and from -2.35±0.49 to -0.55±0.54, respectively, during 11.1±1.6 months of follow-up after operation. One patient required re-intervention for residual pulmonary stenosis. Twenty-two patients had less than moderate PR (none, 1; trivial, 8; mild, 13), and 5 patients had moderate PR. There was no free or severe PR. CONCLUSIONS: At 1-year follow-up, the patients who underwent total TOF correction with our revised surgical strategy had acceptable results in terms of PV function. The preserved PV had a tendency to grow on short-term follow-up.


Asunto(s)
Insuficiencia de la Válvula Pulmonar/cirugía , Estenosis de la Válvula Pulmonar/cirugía , Válvula Pulmonar/cirugía , Tetralogía de Fallot/cirugía , Preescolar , Ecocardiografía , Femenino , Estudios de Seguimiento , Humanos , Lactante , Recién Nacido , Masculino , Válvula Pulmonar/diagnóstico por imagen , Válvula Pulmonar/patología , Válvula Pulmonar/fisiopatología , Insuficiencia de la Válvula Pulmonar/diagnóstico por imagen , Insuficiencia de la Válvula Pulmonar/patología , Insuficiencia de la Válvula Pulmonar/fisiopatología , Estenosis de la Válvula Pulmonar/diagnóstico por imagen , Estenosis de la Válvula Pulmonar/patología , Estenosis de la Válvula Pulmonar/fisiopatología , Tetralogía de Fallot/diagnóstico por imagen , Tetralogía de Fallot/patología , Tetralogía de Fallot/fisiopatología
11.
J Vet Intern Med ; 32(5): 1570-1578, 2018 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-30079482

RESUMEN

BACKGROUND: Velocity ratio, velocity time integral (VTI) ratio, and pulmonary valve area indexed to body surface area (iPVA) are methods of assessment of pulmonary valve stenosis (PS) severity that are less dependent on blood flow. Studies evaluating these methods are limited. OBJECTIVES: To determine the effects of butorphanol, atenolol, and balloon valvuloplasty (BV) on velocity ratio, VTI ratio, iPVA, mean PG, and max PG. ANIMALS: Twenty-seven dogs with PS (max PG >50 mm Hg). METHODS: Prospective study. All dogs underwent an echocardiogram at baseline, 5-minutes after administration of butorphanol (0.2-0.25 mg/kg IV), and 2-to-4 weeks after atenolol (1-1.5 mg/kg q12h). Twenty-one of these were evaluated 24-hours after BV. RESULTS: There were no significant differences (P > .05) amongst any of the methods of assessment of PS severity after butorphanol. After atenolol, mean (SD) of mean (57.0 [21.0] mm Hg) and max PG (93.1 [33.8] mm Hg) were significantly decreased (P ≤ .047) compared with baseline (65.2 [26.2] mm Hg and 108 [44.4] mm Hg, respectively). After atenolol, there were no significant (P ≥ .12) differences in velocity ratio (0.29 [0.09]), VTI ratio (0.18 [0.05]), or iPVA (0.43 [0.16] cm2 /m2 ) compared with baseline (0.30 [0.09], 0.19 [0.09], 0.44 [0.17] cm2 /m2 , respectively). CONCLUSIONS AND CLINICAL IMPORTANCE: Atenolol might reduce mean and max PG but does not alter less flow-dependent methods of assessment of PS severity (velocity ratio, VTI ratio, and iPVA) in dogs with PS. Results support an integrative approach to assessment of PS severity that includes less flow-dependent methods, particularly in states of altered flow or right ventricular function.


Asunto(s)
Enfermedades de los Perros/diagnóstico por imagen , Ecocardiografía Doppler , Estenosis de la Válvula Pulmonar/veterinaria , Válvula Pulmonar/diagnóstico por imagen , Animales , Valvuloplastia con Balón/veterinaria , Perros , Femenino , Masculino , Estudios Prospectivos , Válvula Pulmonar/patología , Estenosis de la Válvula Pulmonar/diagnóstico por imagen , Estenosis de la Válvula Pulmonar/patología , Estenosis de la Válvula Pulmonar/terapia
13.
J Small Anim Pract ; 59(1): 38-44, 2018 01.
Artículo en Inglés | MEDLINE | ID: mdl-29193096

RESUMEN

OBJECTIVES: To describe the outcome for nine dogs with pulmonic stenosis treated by open patch grafting using expanded polytetrafluoroethylene under cardiopulmonary bypass. MATERIALS AND METHODS: Data were collected from the hospital records of all dogs that had undergone right ventricular outflow tract grafting with an expanded polytetrafluoroethylene patch under cardiopulmonary bypass between 2006 and 2012 for the treatment of pulmonic stenosis. Echocardiographic images were reviewed and the pressure gradient across the right ventricular outflow tract re-measured. Owners of dogs still alive at the time of writing were invited to return to the hospital for reassessment. RESULTS: Nine dogs met the inclusion criteria. Median pressure gradient preoperatively was 118 mmHg, (range 102 to 259 mmHg) reducing to a median of 20 mmHg (range 7 to 53 mmHg) at 48 hours postoperatively and 14 mmHg (range 10 to 70 mmHg), with a median percentage reduction of 89% (range 41 to 94%) at long-term follow-up. Eight of nine dogs survived surgery, with six of nine surviving to hospital discharge. Two dogs were still alive over 6 and 8 years postoperatively. No long-term deaths were believed to be attributable to pulmonic stenosis. CLINICAL SIGNIFICANCE: Expanded polytetrafluoroethylene patch grafting of the right ventricular outflow tract for treatment of severe pulmonic stenosis in dogs is feasible and can be an effective method to reduce the severity of right ventricular outflow tract obstruction.


Asunto(s)
Puente Cardiopulmonar/veterinaria , Enfermedades de los Perros/cirugía , Estenosis de la Válvula Pulmonar/veterinaria , Animales , Perros , Ecocardiografía/veterinaria , Femenino , Masculino , Complicaciones Posoperatorias/veterinaria , Estenosis de la Válvula Pulmonar/diagnóstico por imagen , Estenosis de la Válvula Pulmonar/patología , Estenosis de la Válvula Pulmonar/cirugía , Estudios Retrospectivos , Resultado del Tratamiento
16.
Chin Med J (Engl) ; 130(9): 1069-1073, 2017 May 05.
Artículo en Inglés | MEDLINE | ID: mdl-28469102

RESUMEN

BACKGROUND: Congenital heart disease (CHD) is the most common congenital malformations with high mortality and morbidity. The prevalence of CHD reported previously ranged from 4 per 1000 live births to 50 per 1000 live births. In this cross-sectional study, we aimed to document the prevalence of CHD in Langfang district of Hebei Province, China by analyzing data collected by hospitals located in 11 the counties of the district, as supported by a public health campaign. METHODS: A total of 67,718 consecutive 3-month-old infants were included from July 19, 2012 to July 18, 2014. Structural abnormalities were diagnosed based on echocardiography findings, including two-dimensional and color Doppler echocardiography results. RESULTS: Of the 67,718 infants, 1554 were found to have cardiac structural abnormalities. The total prevalence of CHD was 22.9 per 1000 live births, a value significantly higher than the previously reported prevalence of 8 cases per 1000 live births. The top five most common cardiac abnormalities were as follows: atrial septal defect (ASD, 605 cases, 8.93‰); ventricular septal defect (550 cases, 8.12‰); patent ductus arteriosus (228 cases, 3.37‰); pulmonary stenosis (66 cases, 0.97‰); and tetralogy of Fallot (32 cases, 0.47‰). The CHD prevalence differed by gender in this study ( χ2 = 23.498,P < 0.001), and the majority of ASD cases were females. Regional differences in prevalence were also found ( χ2 = 24.602,P < 0.001); a higher prevalence was found in urban areas (32.2 cases per 1000 live births) than in rural areas (21.1 cases per 1000 live births). There was a significant difference in the prevalence of CHD in preterm versus full-term infants ( χ2 = 133.443,P < 0.001). Prevalence of CHD in infants of maternal aged 35 years or over was significantly higher ( χ2 = 86.917,P < 0.001). CONCLUSIONS: The prevalence of CHD in Langfang district was within the range reported using echocardiography. Echocardiography can be used to early diagnose the CHD.


Asunto(s)
Cardiopatías Congénitas/patología , China , Estudios Transversales , Conducto Arterial/patología , Ecocardiografía , Femenino , Defectos del Tabique Interatrial/patología , Humanos , Masculino , Prevalencia , Estenosis de la Válvula Pulmonar/patología , Tetralogía de Fallot/patología
17.
J Avian Med Surg ; 31(1): 53-61, 2017 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-28358604

RESUMEN

A 31-year-old female Moluccan cockatoo (Cacatua moluccensis) was examined for intermittent foot clenching of 4 months' duration. Physical examination revealed feather-destructive behavior and clinical findings compatible with hypovitaminosis A. Neurologic examination was unremarkable. Results of radiographs, hematologic testing, plasma biochemical analyses, and measurement of lead and trace element blood concentrations were unremarkable, except for degenerative joint disease of several thoracic intervertebral joints and a low blood copper concentration. Increased dietary copper was recommended. After a 6-month period without clinical signs, the bird presented again for episodes of foot weakness. Radiographic review was suggestive of mild pulmonary trunk enlargement. Echocardiography revealed mild mitral and aortic regurgitation, dilation of the ascending aorta, and a dilated right ventricle with turbulent right ventricular outflow. An electrocardiogram revealed a sinus rhythm and normal-appearing complexes. Nonselective fluoroscopic angiography was performed 3 weeks later because of persistent episodes of foot clenching and weakness. Infundibular pulmonic stenosis, poststenotic dilation of the pulmonic trunk, and proximal main pulmonary arteries were identified, as well as a mild narrowing of the descending aorta compatible with aortic stenosis. The bird was discharged without medication but with dietary recommendations and experienced 2 clenching episodes in the days after the last visit. No recurrence of clinical signs has been reported over the 18-month follow-up period. To our knowledge, this is the first report of infundibular pulmonic stenosis in a bird. This case illustrates the application of basic and advanced diagnostic imaging modalities in evaluating cardiac disease in birds.


Asunto(s)
Enfermedades de las Aves/congénito , Cacatúas , Estenosis de la Válvula Pulmonar/veterinaria , Animales , Enfermedades de las Aves/diagnóstico , Enfermedades de las Aves/patología , Femenino , Estenosis de la Válvula Pulmonar/congénito , Estenosis de la Válvula Pulmonar/diagnóstico , Estenosis de la Válvula Pulmonar/patología
18.
J Vet Cardiol ; 18(4): 418-426, 2016 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-27693045

RESUMEN

Pulmonic stenosis (PS) is the most common congenital cardiac disease in dogs. Boxers and English bulldogs are among the most commonly affected breeds and also commonly associated with an aberrant coronary artery (CA). If an aberrant CA is suspected and balloon valvuloplasty indicated, an intra-operative angiography is recommended prior to the procedure. ECG-gated computed tomography (CT) can be used to screen for CA anomalies in a quick and minimally-invasive way (preventing side effects associated with selective catheter angiography) and allowing early planning of the procedure. The aim of this case series was to report CT findings associated with PS diagnosed by echocardiography. Our database was retrospectively searched for cases of dogs with PS diagnosed by echocardiography, where an ECG-gated CT was performed. A total of six cases were retrieved: all were diagnosed with severe PS. Four dogs had concurrent congenital defects: two dogs had a patent ductus arteriosus, one dog had a ventricular septal defect and an overriding aorta, one dog had an aberrant CA. Detailed CT findings of all cases were reported, including one case of a patent ductus arteriosus and an overriding aorta not identified by transthoracic echocardiography. In addition, an abnormal single left coronary ostium, with a pre-pulmonic right CA was described. In conclusion, despite echocardiography remaining the gold standard for diagnosis and assessment of PS, ECG-gated-CT angiography is a complementary diagnostic method that may provide additional relevant information, shorten surgery/anaesthesia time and reduce the amount of radiation to which the clinician is subjected.


Asunto(s)
Angiografía/veterinaria , Anomalías de los Vasos Coronarios/veterinaria , Perros/anomalías , Ecocardiografía/veterinaria , Estenosis de la Válvula Pulmonar/veterinaria , Angiografía/métodos , Animales , Técnicas de Imagen Sincronizada Cardíacas/veterinaria , Angiografía por Tomografía Computarizada/veterinaria , Ecocardiografía/métodos , Femenino , Estenosis de la Válvula Pulmonar/patología , Estudios Retrospectivos
19.
Heart ; 102(3): 216-22, 2016 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-26701967

RESUMEN

OBJECTIVE: Patients with unoperated single ventricle (SV) rarely survive into adulthood with good functional status and may develop Eisenmenger's syndrome (ES). We report outcomes of a 30-year cohort of such patients. METHODS: Adult patients with unoperated SV were identified by searching the Mayo Clinic medical record from 1984 to 2014. Clinical data were collected and compared between patients with pulmonary stenosis (PS) and ES. RESULTS: 24 patients were identified (median peak-age 56 (31-77) years (11 ES, 13 PS); 22 had left ventricular morphology. 50-year transplant-free survival was 65% (95% CI 43 to 81). Median age at death was 55 years (31-77 years); 15 deaths (62%) occurred before oral pulmonary vasodilators were commercially available. Two-thirds of the cohort demonstrated preserved New York Heart Association functional class and median EF was 60% (49% to 62%). The majority of patients to survive into the fifth decade exhibited anatomy of double-inlet LV (DILV) with PS. CONCLUSION: Selected patients with unoperated SV with PS and ES can survive with good functional class up to the eighth decade with good medical management. DILV/PS appears to be the ideal phenotype for advanced survival. Our outcomes may be considered when such patients with SV having 'balanced' physiology are evaluated for Fontan palliation. However, additional prospective study will be necessary to verify this assertion.


Asunto(s)
Estimulación Cardíaca Artificial/métodos , Complejo de Eisenmenger/terapia , Estenosis de la Válvula Pulmonar/terapia , Vasodilatadores/uso terapéutico , Adulto , Anciano , Estudios de Cohortes , Complejo de Eisenmenger/mortalidad , Complejo de Eisenmenger/patología , Antagonistas de los Receptores de Endotelina/uso terapéutico , Femenino , Cardiopatías Congénitas/mortalidad , Cardiopatías Congénitas/patología , Cardiopatías Congénitas/terapia , Humanos , Masculino , Persona de Mediana Edad , Inhibidores de Fosfodiesterasa 5/uso terapéutico , Prostaglandinas I/uso terapéutico , Estenosis de la Válvula Pulmonar/mortalidad , Estenosis de la Válvula Pulmonar/patología , Estudios Retrospectivos , Volumen Sistólico , Tasa de Supervivencia
20.
Am J Med Genet A ; 170(3): 665-9, 2016 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-26686981

RESUMEN

Noonan syndrome (NS) is the second most frequent hereditary syndrome with cardiac involvement. Pulmonary valve stenosis and hypertrophic cardiomyopathy are the most prevalent cardiovascular abnormalities. We report on a 14-year-old girl with NS due to SOS1 mutation with pulmonary stenosis and idiopathic coronary ectasia. To the best of our knowledge, this is the first report describing coronary ectasia in a patient with NS secondary to a SOS1 mutation. We include a literature review of this rare association.


Asunto(s)
Cardiomiopatía Hipertrófica/genética , Enfermedad de la Arteria Coronaria/genética , Mutación , Síndrome de Noonan/genética , Estenosis de la Válvula Pulmonar/genética , Proteína SOS1/genética , Adolescente , Cardiomiopatía Hipertrófica/complicaciones , Cardiomiopatía Hipertrófica/diagnóstico , Cardiomiopatía Hipertrófica/patología , Enfermedad de la Arteria Coronaria/complicaciones , Enfermedad de la Arteria Coronaria/diagnóstico , Enfermedad de la Arteria Coronaria/patología , Femenino , Expresión Génica , Humanos , Síndrome de Noonan/complicaciones , Síndrome de Noonan/diagnóstico , Síndrome de Noonan/patología , Estenosis de la Válvula Pulmonar/complicaciones , Estenosis de la Válvula Pulmonar/diagnóstico , Estenosis de la Válvula Pulmonar/patología
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