Eugenics and the misuse of Mendel.

Highlighting the Distinguished Speakers Symposium on "The Future of Human Genetics and Genomics," this collection of articles is based on presentations at the ASHG 2023 Annual Meeting in Washington, DC, in celebration of all our field has accomplished in the past 75 years, since the founding of ASHG in 1948.

Confronting the Legacy of Eugenics and Ableism: Towards Anti-Ableist Bioscience Education.

Society and education are inherently ableist. Disabled people are routinely excluded from education, or have poorer outcomes within educational systems. Improving educational experiences and outcomes for people of color has required educators to design antiracist curricula that explicitly address racial inequality. Here, we explore parallel antiableist approaches to bioscience education in an essay coauthored by a disabled bioscience student and able-bodied faculty member in bioscience. Our work is underpinned by Critical Disability Theory and draws on disability and pedagogical scholarship as well as our own experiences. The biosciences has a unique need to confront its history in the discredited pseudoscience of eugenics, which has led to discrimination and human rights abuses against disabled people. We provide a brief history of the relationship between biological sciences research and eugenics and explore how this legacy impacts bioscience education today. We then present a recommended structure for antiableist biology education. Our approach goes beyond providing disability access, to a model that educates all students about disability issues and empowers them to challenge ableist narratives and practices.

[Obstetric interventionism and maternalization ofwomen in childbirth care in Uruguay, 1920-1940]. / Intervencionismo obstétrico y maternalización de las mujeres en la atención del parto en Uruguay, 1920-1940.

This article analyzes the speeches of leading doctors in the creation of the specialty in childbirth care: gynecotology. Between 1920 and 1940, under the influence of eugenic and maternalist thinking, in a context of valuing the well-being of children, medicine built a new obstetric interventionism under the foundation of improving fetal viability. The supposed female "maternal instinct" was, thus, appealed to improve acceptance of the medical mandate. At the same time, doctors recognized their difficulties in providing adequate care. They did not wait long enough and tended to intervene in unnecessary physiological processes.

En este artículo se analizan discursos de médicos de referencia en la creación de la especialidad en la atención del parto: la ginecotocología. Entre 1920 y 1940, bajo la influencia del pensamiento eugenésico y maternalista, en un contexto de valorización del bienestar de la infancia, la medicina construyó un nuevo intervencionismo obstétrico bajo el fundamento de mejorar la viabilidad fetal. En ese marco se apeló al supuesto "instinto maternal" femenino para mejorar la aceptación del mandato médico. A la vez, los médicos reconocieron sus dificultades para asistir de forma adecuada. No esperaban el tiempo suficiente y tendían a intervenir más de lo necesario en procesos fisiológicos que no lo requerían.

"Four Corners and a Void": Idiocy and Childhood Disability in Nineteenth-Century America.

Over the second half of the nineteenth century, thousands of Americans were admitted to schools for so-called idiotic children, later known as institutions for the feebleminded and linked to the Eugenics movement. While idiocy is often presumed to be the antecedent of intellectual disability, an analysis of the stories of three hundred children admitted to one such institution over a forty-year period demonstrates an unexpected diversity of appearances, abilities, and behaviors. Within the walls of the institution, idiocy was composed of children whose perceived abilities deviated from the expectations of their social position. Families further shaped the diagnosis of idiocy by negotiating the timing of admission for their children, influenced not only by personal factors, but by shifting educational and employment opportunities, and cultural tolerance of diversity. Consequently, idiocy became the broadest descriptor of disability during the nineteenth century.

"Prototypic personality disorder" and the social issue: The category of psychopathy in Polish psychiatry in the interwar period.

The category of psychopathy has a long history, and its meaning has undergone a notable evolution since its conception in the 19th century. The history of psychopathy has been concentrating mainly on English- and German-speaking psychopathology. This article investigates definitions of psychopathy, its classification, and social issues associated with this category in Polish psychiatry in the interwar period. Polish definitions of psychopathy were influenced predominantly by Ernst Kretschmer's constitutional theory as well as by Eugen Kahn's, William Stern's, and Kurt Schneider's ideas. The term was generally understood as a borderline category denoting states between health and mental illness. As those states could manifest differently, it was thought to be many psychopathies. Two Polish psychiatrists, Maurycy Bornsztajn and Jakub Frostig, presented comprehensive classifications of psychopathies. Social issues associated with the category of psychopathy concentrated on three topics: psychopathy in children as a problem of the prevention of mental disorders; psychopathy as a problem of the justice system, the penitentiary, and military systems; and psychopathy as an issue of eugenics and social usefulness. Polish psychiatrists highlighted the need for the development of national institutions for the care of psychopathic children. Issues of accountability and insanity of psychopaths from the point of view of forensic psychiatry were also discussed. In conclusion, psychopathy in interwar Polish psychiatry was not just one of the personality disorders-it denoted the whole spectrum of characterological disturbances; thus, it rather corresponds to the modern category of personality disorders than to the contemporary understanding of psychopathy. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

[To benefit tomorrow's children: female participation in Brazilian eugenics, 1918-1936]. / Em benefício dos filhos de amanhã: participação feminina na eugenia brasileira, 1918-1936.

This text analyzes female participation in Brazilian eugenics and medical discourse on the roles and social functions of the sexes during the first half of the twentieth century. In examining the production of two women, Ítala Silva de Oliveira and Eunice Penna Kehl, we maintain that certain women were effectively engaged in the eugenics movement and worked to bring women closer to eugenics. This analysis makes it possible to explore a pedagogical dimension of eugenics and of the popularization of this movement by attempting to form a hygienist and eugenist consciousness among women.

O texto analisa a participação feminina na eugenia brasileira e os discursos médicos acerca dos papéis e funções sociais dos sexos na primeira metade do século XX. A partir da análise da produção de duas mulheres, Ítala Silva de Oliveira e Eunice Penna Kehl, o objetivo principal é argumentar que determinadas mulheres se engajaram efetivamente no movimento eugênico, trabalhando em prol da aproximação feminina com a eugenia. Tal análise permite explorar uma dimensão pedagógica e de popularização da eugenia por meio da tentativa de formação de uma consciência higiênica e eugênica nas mulheres.

Telling a scientific story and governing the population: The Kallikak story and the historical mutations of the eugenic discourse.

In this article, we follow the trails of 20th-century psychologist Henry Herbert Goddard's influential study of the Kallikak family. Goddard's study is treated as a scientific story with two interlocking dimensions: One is the actual story of the Kallikak family, with literary elements such as setting, plot, and characters. The other dimension is the broader eugenic discourse, a powerful scientific narrative that calls for action in relation to society and the population. The purpose of the article is twofold. Firstly, to analyze the forming and articulations of this story and to explore some of the consequences for governing the population that it has made possible. Secondly, to explore some aspects of what a Foucauldian analytics of government can contribute with in relation to Goddard's work and the eugenic discourse from the early 20th century to today. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Reflections on assortative mating, social stratification, and genetics.

A recent report by G. Clark points to a sustained persistence of social status in England that extends vertically across several generations and horizontally across many levels of kinship. We seek to put his findings in historical perspective. We do so by relating them to two lines of thinking related to biological inheritance. One predated the rediscovery of Mendel's work and led to the field of quantitative genetics, which dealt on the whole with quasi-continuously varying traits. The other is based on the rediscovery itself and led to a reconciliation between quantitative genetics and discrete Mendelian elements of heredity. Both were enmeshed with the supposed need for, and societal consequences of, eugenics and assortative mating. Also on both issues, the significant ideas can be traced to R. A. Fisher, inspired in one case by F. Galton and in the other by J. A. Cobb, with strong support for Galton and Cobb coming from Karl Pearson. Clark's findings point to societal stratification, and assortative mating for wealth is a straightforward hypothesis to account for it. However, it should be noted that the findings support, but do not prove, the hypothesis.

Thorny entanglements: feminism, eugenics and the Abortion Law Reform Association's (ALRA) campaign for safe, accessible abortion in Britain, 1936-1967.

For the past two decades anti-abortionists in the Global North have been aggressively instrumentalising disability in order to undermine women's social autonomy, asserting, falsely, there is an insuperable conflict between disability rights and reproductive rights. The utilisation of disability in struggles over abortion access is not new, it has a history dating back to the interwar era. Indeed, decades before anti-abortionists' campaign, feminists invoked disability to expand access to safe abortion. This paper examines the feminist eugenics in the first organisation dedicated to liberalising restrictive abortion laws, the Abortion Law Reform Association (ALRA), established in England in 1936. ALRA played a vital role in the passage of the Abortion Act 1967 (or the Act) that greatly expanded the grounds for legal abortion, a hugely important gain for women in Britain and beyond seeking legal, safe abortions. In addition, the Act permitted eugenic abortion, which also had transnational effects: within a decade, jurisdictions in numerous Commonwealth countries passed abortion laws that incorporated the Act's eugenics clause, sometimes verbatim. This essay analyses ALRA's role in codifying eugenics in the Abortion Act 1967 and argues that from the outset, ALRA was simultaneously a feminist and eugenist association. Initially, ALRA prioritized their feminist commitment to 'voluntary motherhood' in their campaign whereas starting in the 1940s, they subordinated feminism to negative eugenics, a shift that was simultaneously strategic and a reflection of genuine concern to prevent the birth of children with disabilities.

Revisiting Emil Kraepelin's eugenic arguments.

It is widely recognized that Emil Kraepelin explicitly advocated for eugenic ideas in his academic works. Given the renewed interest in related concepts such as self-domestication and neo-Lamarckism in different contexts, this article revisits his eugenic arguments by scrutinizing a section of his seminal work, the 8th edition of his textbook published in 1909. Our analysis reveals that Kraepelin's arguments consisted of multiple theories and ideas prevalent at the time (i.e. self-domestication hypothesis, neo-Lamarckism, degeneration theory, social Darwinism, racism and ethnic nationalism), each of which presented individual fundamental claims. Nevertheless, Kraepelin amalgamated them into one combined narrative, which crystallized into an anti-humanistic psychiatry in the next generation. This paper cautions that a similar 'packaging of ideas' might be emerging now.

"At a Glance:" The Role of Diagrammatic Representations in Eugenics Appropriations of the "Infamous Juke Family".

The case of the Juke family is one of the most notable episodes of the history of eugenics in the USA. The Jukes were initially brought to the fore in the 1870s by a famous investigation that aimed at estimating the interplay of heredity and environment in determining the problems of poverty and crime. This inquiry triggered a harsh confrontation between two polar interpretations of the study, an "environmentalist" one and a "hereditarian" one. It was with the later reassessment of the case made by the Eugenics American Office (ERO) in the 1910s that the controversy was considered closed with the victory of the eugenicists' hereditarian stance. As a result, the family was made a living proof of the alleged hereditary nature of crime and pauperism and a case study in support of the eugenicists' plea for the sterilization of people deemed the bearers of hereditary defectiveness. In this article, I explore the role played by pedigrees and other diagrammatic representations in the eugenicists' appropriation of the meaning of the case of the Juke family and the role played by this appropriation in asserting the superiority of the ERO's method of work over rival approaches.

Bruno Schulz's 1936 book "Methodology of medical genetic research particularly with regard to psychiatry".

In 1936, Bruno Schulz published the first detailed, book-length review of the methodology of psychiatric genetic research, based on his experiences at the German Research Institute of Psychiatry. Emphasis is placed on proper selection of relatives and the ascertainment corrections required for Mendelian transmission models. Twin studies are considered as is the impact of reduced fertility on patterns of risk. For the field work, Schulz emphasizes the importance of trust-building, confidentiality, collateral informants, and the use of medical and other administrative records, all ideally stored in personal files. Several methods of age-correction are reviewed. Schulz provides detailed algebraic treatments of these and other problems, including tests for etiologic homogeneity, with worked examples. He emphasizes two fundamental concerns in psychiatric genetics research: (i) its inter-dependency with the optimal diagnostic boundaries, which are rarely known and (ii) the genetic homogeneity of clinical samples. Given these problems, he is pessimistic about finding Mendelian transmission patterns. He assesses the predominant 19th-century method of psychiatric genetic investigation-"hereditary burden"-to be crude and biased by family size. Although written at a time of consolidation of Nazi power in Germany, this book nowhere endorses their racial/eugenic policies and can be seen as subtly questioning them.

"A Vigorous Campaign against Abortion": Views of American Leaders of Eugenics v. Supreme Court Distortions.

The Supreme Court decided Box v. Planned Parenthood of Indiana and Kentucky in 2019. Justice Clarence Thomas's opinion in the case claimed there was a direct connection between the legalization of abortion, in the late 20th Century, and the beginnings of the birth control movement a full three quarters of a century earlier. "Many eugenicists," Thomas argued, "supported legalizing abortion."Justice Samuel Alito highlighted similar claims in Dobbs v. Jackson Women's Health, citing a brief entitled "The Eugenic Era Lives on through the Abortion Movement." That brief was an echo of Justice Thomas' misguided attempt at history in the Box opinion. Similar claims reoccur in Judge Matthew Kacsmaryk's opinion in the Texas mifepristone case, Alliance for Hippocratic Medicine v. U.S. Food and Drug Administration.These false claims are the focus of this article. There is no evidence that early leaders of the eugenics movement supported abortion as part of the movement for birth control. It is accurate to describe those leaders as anti-abortion, and their followers as people who condemned abortion for moral, legal, and medical reasons.

Past: Imperfect; Future: Tense.

How should the field of bioethics grapple with a history that includes ethicists who supported eugenics, scientific racism, and even Nazi medicine and also ethicists who created the salutary policy and practice responses to those heinous aspects of medical history? Learning humility from studying historical errors is one path to improvement; finding courage from studying historical strengths is another, but these can be in tension. This commentary lays out these paths and seeks to apply them both to a contemporary challenge facing the field: why hasn't bioethics been more at the forefront of efforts to address inequities in health and health care?

Addressing the paradox: Health expansion threatening sustainable healthcare.

We need to address the paradox that health expansion threatens sustainable healthcare as anti-aging drugs are on the trail from trial to the market and come together with health enhancement measures changing demography and the health of populations. This poses global, social, and professional problems, and challenges clinical medicine as well as health policy. To handle the emerging challenges, we need to address four crucial issues: (1) injustice (access), (2) sustainability, (3) basic human rights, and (4) eugenics. To do so we need to differentiate between health improvements and health enhancements and reinforce medicine's strongest moral appeal: to reduce suffering.

"Not by a Decree of Fate:" Ellen Richards, Euthenics, and the Environment in the Progressive Era.

In 1904, Ellen Richards introduced "euthenics." By 1912, Lewellys Barker, director of medicine and physician-in-chief at Johns Hopkins Hospital, would tell the New York Times that the "task of eugenics" and the "task of euthenics" was the "Task for the Nation." Alongside the emergence of hereditarian eugenics, where fate was firmly rooted in heredity, this article places euthenics into the same Progressive Era demands for the scientific management over environmental issues like life and labor, health and hygiene, sewage and sanitation. I argue that euthenics not only heralded women as leaders in the quest for what Richards and eugenicists termed "racial improvement," but also aimed to make reforms through environmental and educational changes rather than hereditary interventions. Seeking to recuperate the figure of Ellen Richards in the history of science, I place Richards and her euthenics more into the debate over eugenics rather than over the emergence of home economics. Building on the work of Donald Opitz, Staffan Bergwik, and Brigette Van Tiggelen, this article shows, first, how Richards' career threads the needle between the home and the laboratory as sites of science making, not as separate spheres but as overlapping realms, and helps recover how domestic concerns shaped the focus of the life sciences. Second, this article shows how euthenics shaped eugenics by looking at the writings of American eugenicists Charles Davenport, Paul Popenoe, and David Starr Jordan. Third, the article describes how euthenics took root in new academic departments of domestic science, home economics, and departments child welfare and family life in the 1920 and 1930s, most notably the department of euthenics at the Kansas State Agricultural College from 1926 and the Institute of Euthenics at Vassar College after 1923.

Between scientific dissemination and late-stage eugenics: ruptures and continuations in the intellectual trajectory of Salvador de Toledo Piza Jr., 1898-1988. / Entre a divulgação científica e a eugenia tardia: rupturas e permanências na trajetória intelectual de Salvador de Toledo Piza Jr., 1898-1988.

This article analyzes the ruptures from and continuations of eugenicist ideology in the work of Salvador de Toledo Piza Jr., a geneticist and professor at the Escola Superior de Agricultura "Luiz de Queiroz." Documentary research involving articles, correspondence, and notes from this former director of the Boletim de Eugenia investigates the reshaping of eugenics in the post-1945 context, a time when Piza Jr. began to publicize evolutionism. While Piza Jr. stopped publicly defending eugenics in latter half of the twentieth century, he maintained his racialized notions into the 1950s, corresponded with eugenicist groups in the 1960s, and supported a hierarchical interpretation of human evolution until the late 1980s.

O artigo analisa as rupturas e permanências do ideário eugênico na obra de Salvador de Toledo Piza Jr., professor e geneticista da Escola Superior de Agricultura "Luiz de Queiroz". A partir da pesquisa documental sobre artigos, correspondências e anotações do ex-diretor do Boletim de Eugenia , investiga-se a reconfiguração da eugenia no contexto pós-1945, momento em que Piza Jr. passou a atuar como divulgador do evolucionismo. Conclui-se que Piza Jr. deixou de defender publicamente a eugenia na segunda metade do século XX, mas manteve a concepção racializada nos anos 1950, correspondeu-se com sociedades eugenistas nos anos 1960 e sustentou a interpretação hierarquizada de evolução humana até final dos anos 1980.

Nursing and eugenics in the early 20th century United States.

BACKGROUND: Research has documented how ideas about race, class, ethnicity, ableism, and structural hierarchies determine health outcomes and disparities today. The historical role of nursing practice and education needs further exploration. PURPOSE: This study aims to better understand how some nurses thought about and interacted with eugenics in the early 20th century. METHODS: Historical analysis of primary and secondary sources. DISCUSSION: In the early 20th century, reformers of the day, including some nurses, demonstrated much ambiguity of thinking as they pushed for eugenic improvement of the "human race" while also enhancing environmental changes, such as good nutrition and clean, safe housing. CONCLUSION: Nursing's past relationship with eugenics sheds light on the history and construction of the system leading to health disparities among marginalized groups. Nurses must acknowledge the historical roots and context of their education and practice as we engage in critical conversations about social inequities.

Choosing the best apple: counselling leaflets and technologies of communication in the history of reproduction.

Historians have shown how the establishment of human genetic counselling in West Germany was characterised by several sociohistorical factors, in particular the impact of the legacies of Nazi biopolitics. These accounts have reconstructed continuities on an intellectual level which delayed a turn towards non-directive approaches, emphasising individual (emotional) well-being and voluntariness, and instead have prolonged a discourse that defined disability as an economic and social burden. However, while the distinct legacies of eugenics and racial hygienics are well researched, other factors that constituted counselling encounters, such as the ways of communicating reproduction and material objects' roles in transformations of concepts, actors and their relations, have not been examined in detail. Drawing on the archives of a Marburg-based charity, this paper aimed to reconstruct these factors at the example of the production and circulation of a major family planning leaflet, Our Child Shall Be Healthy, developed ca 1977. In doing so, I want to suggest that connections between science, politics and economy were a key element in technologies of communicating reproduction. This essay approaches counselling as a communicative practice that was in continual productive engagement with different concepts of reproductive health. First, it argues that the communicative and paper technologies used in counselling interactions in West Germany changed in the aftermath of the worldwide thalidomide tragedy. Second, it argues that a novel approach to reproductive health emerged that focused on individual decision making as the basis of prosperity and emotional well-being. Taking a family planning leaflet as a site for reconstructing how people of different organisations, with different stakes and expertise converged in the design of a counselling encounter, this paper targets the crossroads of economic, political and scientific activities in the history of communicating reproductive health and reproductive risks.