RESUMEN
RATIONALE: Paraneoplastic neurological syndrome with anti-Hu antibody (Hu-PNS) is a neurological disorder that occur in patients with malignancy. The syndrome has a wide range of presentations and can present before diagnosis of primary malignancy. Familiarity with these paraneoplastic neurological syndromes can help early recognition and take appropriate regimens. PATIENTS CONCERNS: Diagnosis and treatment of Hu-PNS. DIAGNOSES: This is retrospective study that analyzed the clinical data of this case. Through retrospective analysis and targeted antibody screening, serum anti-Hu antibody was detected. Subsequent spinal imaging revealed a mass in the paraspinal region, which was confirmed as ganglioneuroblastoma by pathologic examination. INTERVENTIONS: The child was treated with a course of intravenous immunoglobulin and radical surgical operation without chemotherapy. OUTCOMES: The neurological symptoms were gradually improved and no signs indicate disease progression or tumor recurrence. LESSONS: Hu-PNS has rarely been reported in children with ganglioneuroblastomas. They can mimic non-neoplastic processes, making detection and diagnosis difficult. Serum and/or cerebrospinal fluid onconeural antibody can strongly indicate occult cancers. Early detection of paraneoplastic neurological syndromes can help take appropriate regimens and improve prognosis.
Asunto(s)
Ganglioneuroblastoma , Síndromes Paraneoplásicos del Sistema Nervioso , Humanos , Ganglioneuroblastoma/inmunología , Ganglioneuroblastoma/complicaciones , Síndromes Paraneoplásicos del Sistema Nervioso/inmunología , Síndromes Paraneoplásicos del Sistema Nervioso/diagnóstico , Masculino , Proteínas ELAV/inmunología , Autoanticuerpos/sangre , Autoanticuerpos/inmunología , Preescolar , Estudios RetrospectivosRESUMEN
ABSTRACT: Coexistence of Langerhans cell histiocytosis and ganglioneuroblastoma is rare and seldom reported in the literature. A 3-year-old girl with Langerhans cell histiocytosis underwent 18 F-FDG PET/CT imaging for staging, which demonstrated significant 18 F-FDG accumulation in the mandibles. Unexpectedly, a mild hypermetabolic soft mass was detected in the upper retroperitoneum. Results of surgical pathology of the abdominal mass were consistent with ganglioneuroblastoma.
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Ganglioneuroblastoma , Histiocitosis de Células de Langerhans , Femenino , Humanos , Niño , Preescolar , Fluorodesoxiglucosa F18 , Ganglioneuroblastoma/complicaciones , Ganglioneuroblastoma/diagnóstico por imagen , Tomografía Computarizada por Tomografía de Emisión de Positrones , Tomografía de Emisión de Positrones , Histiocitosis de Células de Langerhans/complicaciones , Histiocitosis de Células de Langerhans/diagnóstico por imagenRESUMEN
We performed a 68Ga-DOTATOC PET/CT scan on a 25-mo-old female patient who presented with opsoclonus myoclonus ataxia syndrome and had negative initial anatomic imaging. The scan showed a somatostatin receptor-overexpressing cervical tumor in favor of a cervical neuroendocrine tumor, with subsequent histopathologic findings of ganglioneuroblastoma.
Asunto(s)
Ganglioneuroblastoma , Tumores Neuroendocrinos , Síndrome de Opsoclonía-Mioclonía , Compuestos Organometálicos , Humanos , Femenino , Niño , Tomografía Computarizada por Tomografía de Emisión de Positrones/métodos , Radioisótopos de Galio , Síndrome de Opsoclonía-Mioclonía/complicaciones , Síndrome de Opsoclonía-Mioclonía/diagnóstico por imagen , Ganglioneuroblastoma/complicaciones , Ganglioneuroblastoma/diagnóstico por imagen , Radiofármacos , Octreótido , Tumores Neuroendocrinos/patologíaRESUMEN
BACKGROUND: Neuroblastomas are the most common extracranial solid malignancy in children with variable manifestations and complications depending on the presence of paraneoplastic syndromes. MATERIALS AND METHODS: We performed a single institution retrospective cohort study of all patients less than 18 years old diagnosed with neuroblastoma or ganglioneuroblastoma between January 2002 and July 2022. Patients were identified through the pathology and cancer registry and cross-referenced with pediatric records. Patient demographics, clinical presentation, treatment, and outcomes were collected. A univariate descriptive analysis of the collected data was conducted. RESULTS: In our study period, 130 children were diagnosed with neuroblastoma, and 15 were diagnosed with ganglioneuroblastoma. There were 12 children with a paraneoplastic syndrome identified, 8 with NBL and 4 with ganglioneuroblastoma (GNBL). The average age at diagnosis was 22 months. All but 1 underwent resection prior to treatment of paraneoplastic syndrome, and 4 children required neoadjuvant therapy. Neurological complications were the most common with 10 children (83%). The average time from symptom onset to diagnosis was 0.7 months. Eight children had complete resolution of their symptoms after treatment and resection, 2 children recently started treatment within a year, 1 had partial resolution, and 1 died during treatment. The presence of tumor-infiltrating lymphocytes occurred in 4 children with neurologic paraneoplastic syndromes. Six children had neuropil rich tumors. CONCLUSION: The histological profile of paraneoplastic syndromes of neuroblastoma and ganglioneuroblastoma and their treatment across a single institution can be highly variable. The presence of tumor-infiltrating lymphocytes and neuropil may have an impact on paraneoplastic pathology.
Asunto(s)
Ganglioneuroblastoma , Enfermedades del Sistema Nervioso , Neuroblastoma , Síndromes Paraneoplásicos , Humanos , Niño , Lactante , Adolescente , Ganglioneuroblastoma/complicaciones , Ganglioneuroblastoma/diagnóstico , Ganglioneuroblastoma/cirugía , Estudios Retrospectivos , Neuroblastoma/complicaciones , Neuroblastoma/terapia , Neuroblastoma/patología , Síndromes Paraneoplásicos/terapia , Síndromes Paraneoplásicos/complicacionesRESUMEN
A 1-year-old boy presented with a 4-month history of hypertension, ptosis of the right upper eyelid, left hemifacial sweating, and flushing. He was diagnosed with Harlequin syndrome associated with Horner syndrome. Computed tomography revealed a mass lesion in the right superior mediastinum. Therefore, the patient underwent total tumor resection. Histological examination demonstrated ganglioneuroblastoma. The MYCN oncogene was not amplified, and the mitosis-karyorrhexis index was low. Accordingly, radiation and chemotherapy were not performed. No recurrence was observed within 8 months after surgery, and the patient's blood pressure was normalized. However, the ptosis, hemifacial sweating, and flushing persisted.
Asunto(s)
Ganglioneuroblastoma , Síndrome de Horner , Enfermedades del Sistema Nervioso Autónomo , Rubor/etiología , Ganglioneuroblastoma/complicaciones , Ganglioneuroblastoma/diagnóstico por imagen , Ganglioneuroblastoma/cirugía , Síndrome de Horner/etiología , Humanos , Hipohidrosis , Lactante , Masculino , Recurrencia Local de NeoplasiaRESUMEN
CONTEXT: Rapid-onset obesity with hypothalamic dysfunction, hypoventilation, autonomic dysregulation and neural crest tumor (ROHHHAD[NET]) is a rare and potentially fatal disease. No specific diagnostic biomarker is currently available, making prompt diagnosis challenging. Since its first definition in 2007, a complete clinical analysis leading to specific diagnosis and follow-up recommendations is still missing. OBJECTIVE: The purpose of this work is to describe the clinical timeline of symptoms of ROHHAD(NET) and propose recommendations for diagnosis and follow-up. DESIGN: We conducted a systematic review of all ROHHAD(NET) case studies and report a new ROHHAD patient with early diagnosis and multidisciplinary care. METHODS: All the articles that meet the definition of ROHHAD(NET) and provide chronological clinical data were reviewed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis individual patient data guidelines. The data were grouped into 7 categories: hypothalamic dysfunction, autonomic dysregulation, hypoventilation, NET, psychiatric symptoms, other clinical manifestations, and outcome. RESULTS: Forty-three individual patient data descriptions were analyzed. The timeline of the disease shows rapid-onset obesity followed shortly by hypothalamic dysfunction. Dysautonomia was reported at a median age of 4.95 years and hypoventilation at 5.33 years, or 2.2 years after the initial obesity. A NET was reported in 56% of the patients, and 70% of these tumors were diagnosed within 2 years after initial weight gain. CONCLUSION: Because early diagnosis improves the clinical management and the prognosis in ROHHAD(NET), this diagnosis should be considered for any child with rapid and early obesity. We propose guidance for systematic follow-up and advise multidisciplinary management with the aim of improving prognosis and life expectancy.
Asunto(s)
Neoplasias de las Glándulas Suprarrenales/diagnóstico , Enfermedades del Sistema Nervioso Autónomo/diagnóstico , Ganglioneuroblastoma/diagnóstico , Ganglioneuroma/diagnóstico , Enfermedades Hipotalámicas/diagnóstico , Hipoventilación/diagnóstico , Obesidad/diagnóstico , Neoplasias de las Glándulas Suprarrenales/complicaciones , Enfermedades del Sistema Nervioso Autónomo/complicaciones , Ganglioneuroblastoma/complicaciones , Ganglioneuroma/complicaciones , Humanos , Enfermedades Hipotalámicas/complicaciones , Hipoventilación/complicaciones , Obesidad/complicaciones , Pronóstico , SíndromeAsunto(s)
Ganglioneuroblastoma/terapia , Síndrome de Opsoclonía-Mioclonía/terapia , Síndromes Paraneoplásicos del Sistema Nervioso/terapia , Terapia Combinada , Femenino , Ganglioneuroblastoma/complicaciones , Ganglioneuroblastoma/patología , Humanos , Lactante , Síndrome de Opsoclonía-Mioclonía/complicaciones , Síndrome de Opsoclonía-Mioclonía/patología , Síndromes Paraneoplásicos del Sistema Nervioso/complicaciones , Síndromes Paraneoplásicos del Sistema Nervioso/patología , Resultado del TratamientoRESUMEN
BACKGROUND: Mycobacterium tuberculosis (M. tuberculosis) disease is a generally well-known problem among immunocompromised adults and children. In pediatric oncology, only few cases of M. tuberculosis disease are reported so far. CASE PRESENTATION: We report a case of concomitant lymphnode tuberculosis in a 4-year-old German boy with relapsed ganglioneuroblastoma. 18 months after the initial diagnosis, relapse with new paravertebral lesions and new lesions in the left lower lobe of the lung and in the perihilar lymphnodes suspicious of metastases of the ganglioneuroblastoma were detected. While relapse in the tumor was confirmed, unexpectedly, pathologic examination revealed morphological diagnosis of lymphnode tuberculosis. The boy was of German background without previous history of tuberculosis exposure. Both, antituberculostatic and relapse treatment were immediately initiated. Three months on, MRI revealed regressive findings in the lung and lymphnodes and partial response in the tumor. The patient underwent second MiBG therapy and haploidentical stem cell transplantation. CONCLUSION: The diagnosis of lymphnode tuberculosis in a 4-year-old German boy with relapsed ganglioneuroblastoma was only made by chance, but most likely saved his life. Pediatric oncologist should be aware of tuberculosis as the incidence might increase over time and the timely diagnosis of a potentially preventable M. tuberculosis disease is irreplaceable. Further studies are needed to explore the incidence of M. tuberculosis infections and the value of IGRA, testing for latent tuberculosis infection prior to chemotherapy in children with underlying malignancies.
Asunto(s)
Ganglioneuroblastoma/diagnóstico , Tuberculosis Ganglionar/diagnóstico , Antituberculosos/farmacología , Preescolar , Ganglioneuroblastoma/complicaciones , Humanos , Huésped Inmunocomprometido , Interferón gamma/metabolismo , Pulmón/diagnóstico por imagen , Ganglios Linfáticos/diagnóstico por imagen , Imagen por Resonancia Magnética , Masculino , Mycobacterium tuberculosis/aislamiento & purificación , Recurrencia Local de Neoplasia , Tuberculosis Ganglionar/complicaciones , Tuberculosis Ganglionar/tratamiento farmacológico , Tuberculosis Ganglionar/microbiologíaRESUMEN
A series of I-MIBG scanning was performed in a 33-year-old woman with a history of ganglioneuroblastoma and a known left renal cyst. The initial studies did not reveal any MIBG activity in the renal cyst. However, increased MIBG activity was noted in the same renal cyst in the subsequent follow-up scans.
Asunto(s)
3-Yodobencilguanidina , Quistes/diagnóstico por imagen , Neoplasias Renales/diagnóstico por imagen , Adulto , Quistes/complicaciones , Femenino , Ganglioneuroblastoma/complicaciones , Humanos , Neoplasias Renales/complicacionesRESUMEN
Resumen: El neuroblastoma es un tumor maligno del sistema nervioso simpático periférico con presentación y curso clínico heterogéneo. Es el tercer tumor pediátrico más frecuente y el 90% de los casos se diagnostica antes de los 5 años. Los síntomas más comunes se deben a la compresión por la masa tumoral o al dolor óseo causado por la metástasis. La diarrea como síntoma principal es rara por lo que es difícil de diagnosticar en la etapa temprana de la enfermedad. Se presenta el caso clínico de una paciente de 2 años en la que luego de 8 meses de estudio por diarrea crónica se diagnóstica ganglioneuroblastoma secretor de VIP. Se debe plantear como diagnóstico diferencial en los pacientes menores de 3 años con diarrea crónica intratable luego de haber descartado otras etiologías.
Summary: Neuroblastoma is a malignant tumor of the peripheral sympathetic nervous system with heterogeneous clinical presentation and course. It is the third most frequent pediatric tumor and in 90% of cases it is diagnosed before 5 years of age. The most typical symptoms result from the tumor compression or bone pain caused by methastasis. Diarrhea as the main symptom is unusual, and thus it is hard to diagnose in early stages of the disease. We report the case of a 2-year-old patient who, after 8 months of study for chronic diarrhea was diagnosed with VIP-secreting ganglioneuroblastoma. It is necessary for this condition to be considered as a differential diagnosis in patients younger than 3 years old with chronic diarrhea with no evolution, after other etiologies are ruled out.
Asunto(s)
Humanos , Ganglioneuroblastoma/diagnóstico , Disentería/etiología , Péptido Intestinal Vasoactivo/metabolismo , Ganglioneuroblastoma/complicaciones , Diagnóstico DiferencialRESUMEN
OBJECTIVE: Adrenal tumors are rare in children. The aim of this study is to review and analyze clinical data on the diagnosis and management of adrenal tumors in children. METHODS: Between 2001 and 2015, 48 pediatric patients (<14 years old) admitted to our institute with adrenal tumors were reviewed. Clinical features, imaging studies, surgical approaches, as well as pathological diagnoses were recorded. RESULTS: The series comprised 28 males and 20 females. Adrenomedullary tumors were 37, including 24 cases of neuroblastoma, 10 cases of ganglioneuroma, 2 cases of ganglioneuroblastoma, and 1 case of pheochromocytoma. Adrenocortical tumors were 10: 9 cases of cortical adenoma and 1 case of cortical cancer. The other one was hematoma. Fever, pain, and abdominal distention were the main clinical manifestations of adrenomedullary tumors, while Cushing syndrome was the most frequent presenting symptom of adrenocortical tumors. Both computed tomography and magnetic resonance imaging showed a high diagnostic yield. Some patients had an elevated hormone level. Open adrenalectomy was performed in 40 patients (83.3%), while a laparoscopic approach was employed in eight patients (16.7%). RESULTS: Adrenal tumors in children have various types,as well as clinical manifestations. Imaging and laboratory data could be useful for differentiation of malignant from benign tumor. Final diagnosis depends on pathology. Surgical excision of the adrenal tumors is the standard of care.
Asunto(s)
Adenoma Corticosuprarrenal , Carcinoma Corticosuprarrenal , Ganglioneuroblastoma , Ganglioneuroma , Feocromocitoma , Adolescente , Adrenalectomía , Adenoma Corticosuprarrenal/complicaciones , Adenoma Corticosuprarrenal/diagnóstico por imagen , Adenoma Corticosuprarrenal/cirugía , Carcinoma Corticosuprarrenal/complicaciones , Carcinoma Corticosuprarrenal/diagnóstico por imagen , Carcinoma Corticosuprarrenal/cirugía , Dolor en Cáncer/etiología , Niño , Preescolar , Síndrome de Cushing/etiología , Femenino , Fiebre/etiología , Ganglioneuroblastoma/complicaciones , Ganglioneuroblastoma/diagnóstico por imagen , Ganglioneuroblastoma/cirugía , Ganglioneuroma/complicaciones , Ganglioneuroma/diagnóstico por imagen , Ganglioneuroma/cirugía , Humanos , Lactante , Imagen por Resonancia Magnética , Masculino , Feocromocitoma/complicaciones , Feocromocitoma/diagnóstico por imagen , Feocromocitoma/cirugía , Estudios Retrospectivos , Tomografía Computarizada por Rayos XRESUMEN
RATIONALE: Intracranial ganglioneuroblastoma represents a rare subtype of primitive neuroectodermal tumor. Here, we report a hippocampal ganglioneuroblastoma and a literature review of cerebral anglioneuroblastoma is carried out. PATIENT CONCERNS: We report a 16-year-old male patient presenting with absence seizure and high-infiltration hippocampal ganglioneuroblastoma. INTERVENTIONS: Magnetic resonance imaging (MRI) indicates a space-occupying lesion with a well-defined margin in the right temporal lobe and hippocampus. However, hyper-signal on flair and diffusion-weighted imaging (DWI) with a low apparent diffusion coefficient (ADC) value is detected, which prompts high tumoral invasiveness. INTERVENTIONS: A total resection of tumor and subsequent chemotherapy combing with radiotherapy is performed. OUTCOMES: For a follow-up period of 60 months, no evidence of recurrence and further seizures are detected. LESSONS: High-infiltration hippocampal ganglioneuroblastoma is a rare event. MRI examination often showed features of low-grade gliomas, while hyper-signal lesion on DWI with a low ADC value can be detected. Complete resection combined with fractionated radiotherapy and chemotherapy was the optimal treatment for cerebral ganglioneuroblastoma.
Asunto(s)
Neoplasias Encefálicas/diagnóstico , Ganglioneuroblastoma/diagnóstico , Adolescente , Neoplasias Encefálicas/complicaciones , Neoplasias Encefálicas/diagnóstico por imagen , Neoplasias Encefálicas/terapia , Terapia Combinada , Diagnóstico Diferencial , Ganglioneuroblastoma/complicaciones , Ganglioneuroblastoma/diagnóstico por imagen , Ganglioneuroblastoma/terapia , Hipocampo , Humanos , Imagen por Resonancia Magnética , Masculino , Convulsiones/etiologíaRESUMEN
We report a patient with stage 3 ganglioneuroblastoma who initially presented with clinical and laboratory features consistent with mucopolysaccharidosis including coarse facial features, developmental delay, and an elevated quantitative urine glycosaminoglycan (GAG) level. All mucopolysaccharidosis features resolved following successful treatment of neuroblastoma. High GAG levels have been documented in the pediatric oncology literature, yet not as a potential marker of malignancy or other target for clinical utility. This patient prompts further investigation into the relationship between neuroblastoma and elevated GAG levels.
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Ganglioneuroblastoma/complicaciones , Glicosaminoglicanos/orina , Mucopolisacaridosis/etiología , Ganglioneuroblastoma/terapia , Humanos , LactanteRESUMEN
PURPOSE: To report a rare case of ganglioneuroblastoma encountered rarely in adults, especially during pregnancy. Materials and METHODS: The authors present a case of ganglioneuroblastoma relapse during the third trimester of pregnancy in a patient previously treated for ganglioneuroblastoma who had a eight-year disease-free interval. Late manifestation of neurological symptoms (vestibular syndrome, nystagmus, slightly right motor deficit) was perhaps influenced by the hormonal pregnancy effects. In this case the option was for caesarean section under general anesthesia at 36 weeks. RESULTS: Based on MRI result, the neurosurgical consultation stated the need of postpartum brain tumor excision. Recovery of the mother was complication-free with persistent, constant postoperative neurological symptoms. It resulted in a healthy newborn, not requiring special follow-up. CONCLUSIONS: Pregnancy and brain tumor have mutual negative effect on the patient. Therapeutic management in this case was a medical dilemma regarding mode setting and timing of delivery, taking into account the maternal-fetal risk-benefit.
Asunto(s)
Neoplasias Encefálicas/patología , Cesárea , Ganglioneuroblastoma/patología , Recurrencia Local de Neoplasia/patología , Complicaciones Neoplásicas del Embarazo/patología , Anestesia General , Neoplasias Encefálicas/complicaciones , Manejo de la Enfermedad , Femenino , Ganglioneuroblastoma/complicaciones , Humanos , Recién Nacido , Imagen por Resonancia Magnética , Recurrencia Local de Neoplasia/complicaciones , Nistagmo Patológico/etiología , Embarazo , Tercer Trimestre del Embarazo , Enfermedades Vestibulares/etiología , Adulto JovenAsunto(s)
Enfermedades del Sistema Nervioso Autónomo/etiología , Rubor/etiología , Ganglioneuroblastoma/complicaciones , Síndrome de Horner/etiología , Hipohidrosis/etiología , Enfermedades del Iris/etiología , Neoplasias del Mediastino/complicaciones , Trastornos de la Pigmentación/etiología , Adulto , Enfermedades del Sistema Nervioso Autónomo/diagnóstico , Diagnóstico Diferencial , Femenino , Rubor/diagnóstico , Ganglioneuroblastoma/diagnóstico , Síndrome de Horner/diagnóstico , Humanos , Hipohidrosis/diagnóstico , Enfermedades del Iris/diagnóstico , Neoplasias del Mediastino/diagnóstico , Trastornos de la Pigmentación/diagnósticoRESUMEN
INTRODUCTION: Opsoclonus-myoclonus syndrome (OMS) is a paraneoplastic neurological disorder associated with neuroblastic tumor (NT) in childhood. Half of patients have neurological sequelae after the neurological and oncological treatment. We reviewed the neurological and oncological outcomes of NT with OMS, and discussed whether the treatment of NT would contribute to improving the neurological prognosis. METHODS: We retrospectively assessed NT patients with OMS from January 2001 to December 2013 at a single institution in Japan. Demographic data, neurological and oncological status, histopathology, treatments, prognosis, and diagnosis and treatment timing were retrospectively reviewed from the records. The timings assessed were the interval between OMS onset and NT detection, initial NT therapy, and initial OMS therapy, the interval between NT therapy and OMS remission, and duration of OMS. RESULTS: A total of 73 patients with NT were treated during the study period, and 5 of 73 patients were diagnosed as having NT with OMS. The median age at onset of OMS was 22 months (range, 18-30 months). The median age at detection of NT was 29 months (range, 21-33 months). Three of five cases showed no uptake on meta-iodobenzylguanidine scintigraphy. The tumor histopathology was neuroblastoma in two patients, ganglioneuroblastoma in two patients, and ganglioneuroma in one patient. Primary resection was performed in three cases. All patients survived. Two of five cases presented with atypical neurological symptoms without opsoclonus. The initial neurological therapy was started within a mean of 20 days (range, 3-76 days) from the onset of OMS in all cases. Four patients received intravenous immunoglobulin, and one with persistent neurological problems received rituximab. Neurological symptoms resolved in three cases. The mean interval between the onset of OMS and the detection of NT in case without neurological sequelae was 57 days (range, 25-113 days), while in case with neurological sequelae it was 365 days (range, 271-458 days). The mean interval between onset of OMS and initial therapy for NT in case without neurological sequelae was 88 days (range, 47-145 days), while in case with neurological sequelae it was 389 days (range, 292-486 days). CONCLUSION: The interval between the onset of OMS and the detection and initial therapy of NT tended to be longer in patients with neurological sequelae than in those without neurological sequelae. This study suggested that early detection and treatment of NT with OMS might improve the neurological outcomes.
Asunto(s)
Detección Precoz del Cáncer , Ganglioneuroma/diagnóstico , Ganglioneuroma/cirugía , Neuroblastoma/diagnóstico , Neuroblastoma/cirugía , Síndrome de Opsoclonía-Mioclonía/etiología , Neoplasias de las Glándulas Suprarrenales/complicaciones , Neoplasias de las Glándulas Suprarrenales/diagnóstico , Neoplasias de las Glándulas Suprarrenales/cirugía , Preescolar , Femenino , Estudios de Seguimiento , Ganglioneuroblastoma/complicaciones , Ganglioneuroblastoma/diagnóstico , Ganglioneuroblastoma/cirugía , Ganglioneuroma/complicaciones , Humanos , Lactante , Japón , Masculino , Neuroblastoma/complicaciones , Neoplasias Pélvicas/complicaciones , Neoplasias Pélvicas/diagnóstico , Neoplasias Pélvicas/cirugía , Neoplasias Retroperitoneales/complicaciones , Neoplasias Retroperitoneales/diagnóstico , Neoplasias Retroperitoneales/cirugía , Estudios Retrospectivos , Resultado del TratamientoRESUMEN
We describe a 4-year-old girl with acute onset headaches and transient blindness who underwent surgical intervention, chemotherapy, and radiotherapy for an intracranial mass. This mass was pathologically confirmed as a primary intracranial ganglioneuroblastoma, a rare finding in the pediatric population. The literature on pediatric primary intracranial ganglioneuroblastoma is reviewed.