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1.
N Engl J Med ; 389(9): 795-807, 2023 Aug 31.
Artículo en Inglés | MEDLINE | ID: mdl-37646677

RESUMEN

BACKGROUND: Among infants with isolated cleft palate, whether primary surgery at 6 months of age is more beneficial than surgery at 12 months of age with respect to speech outcomes, hearing outcomes, dentofacial development, and safety is unknown. METHODS: We randomly assigned infants with nonsyndromic isolated cleft palate, in a 1:1 ratio, to undergo standardized primary surgery at 6 months of age (6-month group) or at 12 months of age (12-month group) for closure of the cleft. Standardized assessments of quality-checked video and audio recordings at 1, 3, and 5 years of age were performed independently by speech and language therapists who were unaware of the trial-group assignments. The primary outcome was velopharyngeal insufficiency at 5 years of age, defined as a velopharyngeal composite summary score of at least 4 (scores range from 0 to 6, with higher scores indicating greater severity). Secondary outcomes included speech development, postoperative complications, hearing sensitivity, dentofacial development, and growth. RESULTS: We randomly assigned 558 infants at 23 centers across Europe and South America to undergo surgery at 6 months of age (281 infants) or at 12 months of age (277 infants). Speech recordings from 235 infants (83.6%) in the 6-month group and 226 (81.6%) in the 12-month group were analyzable. Insufficient velopharyngeal function at 5 years of age was observed in 21 of 235 infants (8.9%) in the 6-month group as compared with 34 of 226 (15.0%) in the 12-month group (risk ratio, 0.59; 95% confidence interval, 0.36 to 0.99; P = 0.04). Postoperative complications were infrequent and similar in the 6-month and 12-month groups. Four serious adverse events were reported (three in the 6-month group and one in the 12-month group) and had resolved at follow-up. CONCLUSIONS: Medically fit infants who underwent primary surgery for isolated cleft palate in adequately resourced settings at 6 months of age were less likely to have velopharyngeal insufficiency at the age of 5 years than those who had surgery at 12 months of age. (Funded by the National Institute of Dental and Craniofacial Research; TOPS ClinicalTrials.gov number, NCT00993551.).


Asunto(s)
Fisura del Paladar , Insuficiencia Velofaríngea , Preescolar , Humanos , Lactante , Técnicos Medios en Salud , Fisura del Paladar/complicaciones , Fisura del Paladar/cirugía , Europa (Continente) , Complicaciones Posoperatorias/epidemiología , Insuficiencia Velofaríngea/diagnóstico , Insuficiencia Velofaríngea/etiología , América del Sur , Técnicas de Diagnóstico Quirúrgico
2.
Rev. medica electron ; 43(6): 1547-1558, dic. 2021.
Artículo en Español | LILACS, CUMED | ID: biblio-1409678

RESUMEN

RESUMEN Introducción: el síndrome subacromial es una afección caracterizada por el pinzamiento tendinoso intraarticular por osteofitos o estrechamiento del espacio. Objetivos: evaluar la técnica de Neer en el tratamiento de pacientes con síndrome subacromial y los factores y actividades que favorecen esta afección. Materiales y métodos: se realizó un estudio observacional, descriptivo, prospectivo a pacientes con síndrome subacromial tratados con acromioplastia por la técnica de Neer. El universo lo conformaron 66 pacientes mayores de 20 años, que presentaron síndrome subacromial con síntomas por más de seis meses, y que fueron tratados con la técnica de Neer. Resultados: el sexo más afectado fue el femenino, con 65,2 %. Predominó el grupo etario de 41 a 50 años. El dolor en etapa prequirúrgica fue de moderado a severo en un 77,2 %, y nulo o leve después de la operación. La función en etapa prequirúrgica estuvo afectada de moderada a severa en un 68,1 %, y nula o leve después del tratamiento quirúrgico. La flexión anterior activa estuvo por debajo de 90º en un 83,1 % antes de ser operados, y por encima de 90º en un 80,3 % en el posquirúrgico. La fuerza muscular era mala o regular en etapa prequirúrgica en un 77,2 %, resultando ser excelente o buena después de la operación. Conclusiones: una vez aplicada la técnica de Neer, el dolor fue leve o nulo en la mayoría del universo, la función del hombro fue buena, la flexión anterior adecuada, y buena la fuerza muscular. Se recomienda emplear esta técnica quirúrgica en esta afección (AU).


ABSTRACT Introduction: subacromial syndrome is a condition characterized by intra-articular tendinous impingement by osteophytes or narrowing of space. Objective: to evaluate Neer's technique in the treatment of patients with subacromial syndrome and the factors and activities favoring this condition. Materials end methods: an observational, descriptive, prospective study was performed in patients with subacromial syndrome treated with acromioplasty using Neer's technique. The universe was formed by 66 patients aged over 20 years, who presented subacromial syndrome with symptoms for more than 6 months, and were treated with Neer's technique. Results: the most affected sex was the female one, with 65.2 %. The age group aged 41 to 50 years predominated. In pre-surgical stage, pain ranged from moderate to severe in 77.2 %, and from null to mild after surgery. Preoperative function was moderate to severe in 68.1 % and null or mild after surgical treatment. The previous active flexion was below 90° in 83.1 % before being operated, and above 90° in 80.3 % after surgery. Muscle strength was poor or regular in pre-surgical stage in 77.2 %, being excellent or good after surgery. Conclusions: once Neer's technique was applied, the pain was mild or null in most of the universe, the shoulder function was good, the anterior flexion adequate, and the muscle strength good (AU).


Asunto(s)
Humanos , Masculino , Femenino , Síndrome de Abducción Dolorosa del Hombro/cirugía , Técnicas de Diagnóstico Quirúrgico/normas , Acromion/cirugía , Síndrome de Abducción Dolorosa del Hombro/diagnóstico , Síndrome de Abducción Dolorosa del Hombro/terapia , Osteofito/cirugía
3.
Rev. méd. hondur ; 89(2): 131-135, jul.-dic. 2021. ilus, tab.
Artículo en Español | LILACS, BIMENA | ID: biblio-1359452

RESUMEN

Antecedentes: La exposición ósea puede ser consecuencia de fracturas traumáticas abiertas o cerradas con complicaciones, así como secundarias a procesos infecciosos. La cobertura del miembro inferior con defecto cutáneo se basa en la preservación de la perfusión sanguínea y nerviosa para favorecer la consolidación ósea y así el salvamento del miembro. Descripción de los casos: Se describe la reconstrucción con colgajo muscular rotacional pediculado de sóleo y/o gastrocnemio en 16 pacientes con complicaciones asociadas a fracturas expuestas en miembros inferiores con defectos de partes blandas y pérdida de cobertura cutánea, realizados en el Servicio de Ortopedia y Traumatología del Hospital Escuela (HE) durante el período 2012-2015. Se realizó colocación de colgajo con sóleo en 50.0% (8/16) y gastrocnemio en 50.0% (8/16). El éxito terapéutico calificado quirúrgica y funcionalmente fue del 87.5% (14/16). Conclusión: Con la técnica de reconstrucción realizada a estos pacientes se logró disminuir la frecuencia de complicaciones y por consiguiente evitar la amputación de la extremidad afectada...(AU)


Asunto(s)
Humanos , Masculino , Adulto , Persona de Mediana Edad , Anciano , Colgajos Quirúrgicos , Fracturas Óseas/complicaciones , Músculo Esquelético/cirugía , Técnicas de Diagnóstico Quirúrgico
4.
Ann R Coll Surg Engl ; 103(6): 412-414, 2021 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-33851881

RESUMEN

INTRODUCTION: Two group and save (G&S) samples are routinely collected from patients undergoing diagnostic laparoscopy and/or emergency appendicectomy. We aimed to identify the necessity of this practice by looking at the perioperative transfusion rates. METHODS: Data were obtained from our electronic theatre system for all patients who underwent emergency laparoscopic surgery (specifically diagnostic laparoscopy and/or laparoscopic appendicectomy) between January 2017 and December 2018. Records were reviewed for the number of G&S samples sent and perioperative transfusion rates. RESULTS: A total of 451 patients were included in the study. The numbers of procedures performed in 2017 and 2018 were 202 (44.8%) and 249 (55.2%), respectively. The total number of samples sent was 930. Only 786 (84.5%) samples were processed and the rest were rejected for various reasons. Of the 451 patients included in the study, 308 (68.3%) had two G&S samples sent, whereas 41 patients (9.1%) had only one G&S sample sent. Fifty-six (12.4%) and 20 (4.4%) patients had three and four G&S samples sent, respectively. Only two patients required transfusion perioperatively (0.4%), and the indication in both was irrelevant to the primary operation. CONCLUSIONS: These results demonstrate a near-zero transfusion rate in this patient cohort. Omitting G&S is safe and potentially saves time and resources.


Asunto(s)
Tipificación y Pruebas Cruzadas Sanguíneas/estadística & datos numéricos , Laparoscopía/estadística & datos numéricos , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Apendicectomía/estadística & datos numéricos , Tipificación y Pruebas Cruzadas Sanguíneas/economía , Tipificación y Pruebas Cruzadas Sanguíneas/normas , Transfusión Sanguínea/estadística & datos numéricos , Niño , Técnicas de Diagnóstico Quirúrgico/estadística & datos numéricos , Urgencias Médicas , Femenino , Humanos , Masculino , Persona de Mediana Edad , Guías de Práctica Clínica como Asunto , Adulto Joven
6.
Arch Dis Child ; 106(3): 291-293, 2021 03.
Artículo en Inglés | MEDLINE | ID: mdl-32349979

RESUMEN

AIM: To provide a further insight into the usefulness of lung biopsy in children. METHODS: Lung biopsies in children from January 2007 to December 2017 were reviewed (n=39). The histology results were categorised as: definitive diagnosis, normal lung parenchyma, inconclusive. RESULTS: Lung biopsy provided a definitive diagnosis in 25 (64%) cases. A suspected diagnosis was confirmed in 16 (41%) and a new diagnosis was found in 9 (23%) children. Histology was inconclusive in 11 (28%) cases and normal in 3 (8%). Fifteen (38%) children had treatment altered due to the biopsy result. CONCLUSION: Lung biopsy mostly confirmed the suspected diagnosis and was associated with a low procedure related morbidity (n=1) and mortality (n=0). Importantly, the biopsy result identified a pathology which altered treatment in over one third of patients. However, in a number of cases the histology was inconclusive, therefore careful patient selection is recommended to maximise diagnostic yield.


Asunto(s)
Biopsia/métodos , Técnicas de Diagnóstico Quirúrgico/mortalidad , Pulmón/patología , Selección de Paciente/ética , Adolescente , Biopsia/efectos adversos , Biopsia/estadística & datos numéricos , Niño , Preescolar , Técnicas de Diagnóstico Quirúrgico/efectos adversos , Femenino , Humanos , Lactante , Recién Nacido , Masculino , Tempo Operativo , Patólogos/estadística & datos numéricos , Derivación y Consulta/estadística & datos numéricos , Toracoscopía/métodos , Toracoscopía/estadística & datos numéricos
7.
Eur J Surg Oncol ; 47(6): 1441-1448, 2021 06.
Artículo en Inglés | MEDLINE | ID: mdl-33234483

RESUMEN

BACKGROUND: Studies on the value of a staging laparoscopy in detecting metastases in gastric cancer patients show great variation. This study investigates the avoidable surgery rate in patients with and without a staging laparoscopy scheduled for surgery with curative intent. METHODS: This population-based cohort study included all patients with an intentional resection for a potentially curable gastric adenocarcinoma, between 2011 and 2016, registered in the Dutch Upper GI Cancer audit. Patients with and without a staging laparoscopy were compared. The primary outcome was the avoidable surgery rate (detection of metastases and/or locoregional non-resectable tumor during intentional gastrectomy). Secondary outcomes were the negative predictive value, postoperative morbidity and pathology parameters. RESULTS: 2849 patients who underwent an intentional gastrectomy were included. 414 of 2849 (14.5%) patients underwent a staging laparoscopy before initiation of treatment. The avoidable surgery rate was 16.2% in the staging laparoscopy group, compared to 8.5% in the non-staging group (P < 0.001), resulting in a negative predictive value of 83.8%. The avoidable surgery rate remained significantly different after correction for possible confounders. The main reason for not executing the gastrectomy was the presence of distant metastasis in both groups. cT and cN stage were significantly higher in patients who underwent a staging laparoscopy. CONCLUSIONS: The staging laparoscopy group had a higher cTN and pTN stage, implicating selection of patients with more advanced disease for a staging laparoscopy. Despite the staging laparoscopy, a higher rate of avoidable surgery was found, suggesting a low sensitivity for detecting metastases or locoregional non-resectability in this patient group.


Asunto(s)
Adenocarcinoma/secundario , Adenocarcinoma/cirugía , Gastrectomía/estadística & datos numéricos , Estadificación de Neoplasias , Neoplasias Gástricas/patología , Neoplasias Gástricas/cirugía , Procedimientos Innecesarios/estadística & datos numéricos , Contraindicaciones de los Procedimientos , Técnicas de Diagnóstico Quirúrgico , Femenino , Gastrectomía/efectos adversos , Humanos , Laparoscopía , Masculino , Persona de Mediana Edad , Valor Predictivo de las Pruebas , Estudios Retrospectivos , Factores de Riesgo
8.
J Laparoendosc Adv Surg Tech A ; 31(3): 326-330, 2021 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-32706645

RESUMEN

Background: Balloon-assisted stone extraction (BASE) can be applied to remove the common bile duct (CBD) stones during laparoscopic CBD exploration (LCBDE). This study aimed to analyze the efficacy of BASE. Methods: A retrospective analysis of patients with CBD stone who underwent LCBDE using BASE from 2001 to 2017 was conducted. The outcomes of BASE and potential factor for failure of technique were also evaluated. Results: A total of 163 patients underwent LCBDE using BASE were enrolled. Success rate of BASE was 88.3% (144/163) and 19 (11.7%) patients with failed BASE underwent basket for lithotripsy additionally. The reason for aborting BASE were stone impaction (n = 6), small stone (n = 4), migration into intrahepatic duct (IHD) (n = 3), and others (n = 6). The overall success rate of stone clearance was 98.2% (160/163). The mean CBD diameter was 15.8 mm (range 7-34 mm), and the largest stone size was 13.8 mm (range 3-36 mm). The overall rate of complication related with procedure was 4.9% (8/163), including bile leakage in 2 patients (1.2%), bleeding in 2 patients (1.2%), and pancreatitis in 4 patients (2.4%). There was no procedure-related mortality. Conclusions: BASE for CBD stone is safe and effective technique for the treatment of CBD stones.


Asunto(s)
Coledocolitiasis/cirugía , Cálculos Biliares/cirugía , Laparoscopía/métodos , Hemorragia Posoperatoria/etiología , Adulto , Anciano , Anciano de 80 o más Años , Conducto Colédoco/patología , Conducto Colédoco/cirugía , Técnicas de Diagnóstico Quirúrgico , Femenino , Cálculos Biliares/diagnóstico , Humanos , Laparoscopía/efectos adversos , Litotricia , Masculino , Persona de Mediana Edad , Pancreatitis/etiología , Estudios Retrospectivos , Insuficiencia del Tratamiento , Adulto Joven
9.
BMC Urol ; 20(1): 186, 2020 Nov 23.
Artículo en Inglés | MEDLINE | ID: mdl-33225931

RESUMEN

BACKGROUND: Complications in the urinary tract related to congenital Zika syndrome have recently been reported. One complication, cryptorchidism, has been reported by the Microcephaly Epidemic Research Group/MERG, in Pernambuco/Brazil. The present article describes for the first time the surgical findings in a case series of boys with Zika-related microcephaly and cryptorchidism, who underwent surgical testicular exploration as a contribution to better understand the possible mechanisms involved in gonads formation and descent. METHODS: A total of 7 children (11 testicular units), aged 3 to 4 years, were submitted to inguinal or scrotal orchidopexy for the treatment of palpable cryptorchidism between August 2019 and January 2020. Characteristics of the gonads and its annexes related to appendixes, testis-epididymis dissociation, gubernacular insertion, and associated hydroceles and/or hernias were described. Measures in centimetres were taken for volume calculate. RESULTS: We found a low prevalence of testicular and epididymal appendix (66.7%), a high prevalence of testis-epididymis dissociation (55.6%), low mean testicular volume for their ages (lower for older boys) and ectopic gubernacular insertion in all cases. There was no evidence of associated hydroceles and/or hernias in any case. No surgical complication was registered or reported, and all explored gonads were properly placed in the scrotal sac. CONCLUSIONS: We herein describe the surgical findings of these children's orchidopexies and discuss the possible mechanisms of viral action in embryogenesis and postnatal growth and development of the testes and annexes. These children need to be followed over time due to the higher risk of testicular atrophy and malignancy. Surgical timing seems to be relevant to avoid loss of testicular volume.


Asunto(s)
Criptorquidismo/complicaciones , Criptorquidismo/cirugía , Microcefalia/complicaciones , Orquidopexia , Infección por el Virus Zika/complicaciones , Preescolar , Criptorquidismo/diagnóstico , Técnicas de Diagnóstico Quirúrgico , Humanos , Masculino , Enfermedades Testiculares/complicaciones , Enfermedades Testiculares/diagnóstico
10.
Dan Med J ; 67(7)2020 Jul 01.
Artículo en Inglés | MEDLINE | ID: mdl-32734884

RESUMEN

INTRODUCTION: Obstruction of the gastrointestinal tract is a frequent surgical emergency experienced by patients with advanced cancers. We aimed to evaluate factors associated with resumption of post-operative chemotherapy in patients with advanced cancer undergoing explorative laparotomy for bowel obstruction. METHODS: This retrospective cohort study was conducted between 2009 and 2013 at Herlev Hospital, Denmark. All patients with advanced cancer were identified from a local electronic database containing all emergency laparotomies. Adult patients with mechanical bowel obstruction were included if they had any kind of cancer and had been under active oncological treatment within the last eight weeks prior to surgery. Demographic, clinical, pre-, and post-operative data were collected and reviewed manually. Multivariate logistic regression analysis was performed to identify predictors for resuming oncological treatment. RESULTS: A total of 76 patients admitted with bowel obstruction and undergoing oncological treatment within eight weeks before surgery were included. Post-operatively, cancer treatment was resumed in 58% of patients. An American Society of Anesthesiologists (ASA) score less-than III (odds ratio = 12.6 (95% confidence interval (CI): 2.9-54.6); p = 0.001) and a performance status less-than 3 (odds ratio = 9.7 (95% CI: 1.4-67.2); p = 0.021) were associated with resuming post-operative cancer treatment. CONCLUSIONS: We found that ASA score and performance status are associated with resumption of cancer treatment post-operatively and should be taken into consideration when considering the treatment strategy for patients with advanced cancer and malignant bowel obstruction. FUNDING: The authors received no financial support for the research, authorship, and/or publication of this article. TRIAL REGISTRATION: not relevant.


Asunto(s)
Procedimientos Quirúrgicos del Sistema Digestivo/estadística & datos numéricos , Obstrucción Intestinal/diagnóstico , Laparotomía/estadística & datos numéricos , Oncología Médica/métodos , Neoplasias/tratamiento farmacológico , Adulto , Anciano , Anciano de 80 o más Años , Antineoplásicos/administración & dosificación , Bases de Datos Factuales , Técnicas de Diagnóstico Quirúrgico , Esquema de Medicación , Femenino , Tracto Gastrointestinal/cirugía , Humanos , Obstrucción Intestinal/etiología , Modelos Logísticos , Masculino , Persona de Mediana Edad , Neoplasias/complicaciones , Oportunidad Relativa , Periodo Posoperatorio , Estudios Retrospectivos
11.
Surg Oncol ; 33: 135-140, 2020 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-32561078

RESUMEN

BACKGROUND: Despite its widespread use, computed tomography (CT) is not perfect for evaluating peritoneal metastases of colorectal origin before cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS + HIPEC). We therefore evaluated the value of adding diagnostic laparoscopy to CT when assessing patient eligibility for CRS + HIPEC. METHODS: This was a retrospective study of a consecutive series of 112 patients evaluated systematically by diagnostic laparoscopy and CT between January 2012 and January 2018. Patient eligibility for CRS + HIPEC was assessed by the peritoneal cancer index (PCI) both at the time of initial diagnostic laparoscopy and during the retrospective review of CT images. Two experienced radiologists who were blinded to the PCI result at laparoscopy then independently estimated the PCI based on CT imaging. The primary outcome was the number of patients eligible for CRS + HIPEC by each method. RESULTS: We identified 112 patients, of whom 95 (85%) were eligible for CRS + HIPEC based on diagnostic laparoscopy and 84 underwent CRS + HIPEC. Overall, 14 patients (17%) experienced an "open-and-close" procedure. In contrast to diagnostic laparoscopy, 100 patients (89%) were identified as being eligible for CRS + HIPEC by CT (p = 0.13), which would have resulted in an additional five open-and-close procedures. CONCLUSIONS: Adding diagnostic laparoscopy to CT produced a clinically relevant, but statistically non-significant, reduction in the number of patients eligible for CRS + HIPEC. We conclude that diagnostic laparoscopy may be of use in preoperative assessments when systematic analysis by CT scores the PCI as greater than ten. Future research should focus on the cost-effectiveness of this approach.


Asunto(s)
Carcinoma/terapia , Neoplasias Colorrectales/patología , Procedimientos Quirúrgicos de Citorreducción , Técnicas de Diagnóstico Quirúrgico , Quimioterapia Intraperitoneal Hipertérmica , Laparoscopía , Selección de Paciente , Neoplasias Peritoneales/terapia , Adulto , Anciano , Carcinoma/diagnóstico por imagen , Carcinoma/secundario , Estudios de Cohortes , Neoplasias Colorrectales/diagnóstico por imagen , Femenino , Humanos , Masculino , Persona de Mediana Edad , Neoplasias Peritoneales/diagnóstico por imagen , Neoplasias Peritoneales/secundario , Estudios Retrospectivos , Tomografía Computarizada por Rayos X
12.
Respirology ; 25(9): 987-996, 2020 09.
Artículo en Inglés | MEDLINE | ID: mdl-32307854

RESUMEN

Diagnosing ILD can be complex, and despite detailed evaluation and HRCT imaging, many patients require lung biopsy to help classify their disease. SLB has served as the reference standard for histopathology in ILD, since initial classification schemes were created more than 50 years ago. Frequently, patients are too unwell to undertake SLB and remain unclassifiable, despite the input of expert MDD. This can limit access to therapy and establishment of prognosis. TBLC is an emerging procedure for sampling lung tissue with promising results in research and clinical settings. Although diagnostic yield is not as high as SLB, the risk profile looks to be more acceptable and the accuracy appears to be good. There is increasing evidence for the utility of cryobiopsy in ILD diagnosis, particularly within the MDD. Cryobiopsy serves as an important adjunct for the diagnosis of ILD, enhancing the diagnostic confidence of treating clinicians.


Asunto(s)
Biopsia Guiada por Imagen/métodos , Enfermedades Pulmonares Intersticiales/diagnóstico , Enfermedades Pulmonares Intersticiales/patología , Grupo de Atención al Paciente , Broncoscopía , Técnicas de Diagnóstico Quirúrgico , Fluoroscopía , Humanos , Biopsia Guiada por Imagen/efectos adversos , Pulmón/patología , Enfermedades Pulmonares Intersticiales/tratamiento farmacológico , Pronóstico , Tomografía Computarizada por Rayos X
13.
World J Urol ; 38(12): 3169-3176, 2020 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-32130476

RESUMEN

BACKGROUND: To evaluate the surgical safety of en bloc resection of bladder tumor (ERBT) and the effectiveness of ERBT combined with near-infrared (NIR) imaging technique in the diagnosis and treatment of non-muscle invasive bladder cancer (NMIBC). METHODS: From October 2017 to June 2018, 26 patients newly diagnosed with single NMIBC were included in this retrospectively trial. All patients received ERBT with monopolar current. After surgery, the fresh specimen was incubated with anti-CD47-Alexa Fluor 790, and then imaged under NIR imaging technique. Operative details, intraoperative and postoperative complications of ERBT regarded as safety outcomes, the mean fluorescence intensity (MFI) of tumor tissue and adjacent normal background tissue, and 12 months follow-up data were analyzed. RESULTS: Of 26 collected patients, obturator nerve reflex was occurred in six patients during tumor resection, and only one patient was observed with bladder perforation. In NIR gray image, the gray scale of MFI of tumor tissue were 132.31 ± 6.67 and the adjacent normal background tissue were 52.27 ± 12.09. The result showed a significantly higher MFI signals in tumor tissue compared to adjacent normal background tissue (P < 0.001). The recurrence-free survival rate at 12 month was 96.15%. CONCLUSIONS: ERBT with monopolar current is a safe and feasible technique to treat patients with NMIBC. A integrated bladder tumor tissue-bound anti-CD47-Alexa Fluor 790 was detected under NIR light, and the NIR image indicates that higher MFI signals in surgical margin is a predictive factor for residual tumor in patients with NMIBC after ERBT.


Asunto(s)
Cistectomía/métodos , Neoplasias de la Vejiga Urinaria/diagnóstico por imagen , Neoplasias de la Vejiga Urinaria/cirugía , Anciano , Cistectomía/efectos adversos , Técnicas de Diagnóstico Quirúrgico , Femenino , Humanos , Masculino , Persona de Mediana Edad , Imagen Molecular , Invasividad Neoplásica , Estudios Retrospectivos , Resultado del Tratamiento , Neoplasias de la Vejiga Urinaria/patología
14.
Laryngoscope ; 130(12): E963-E969, 2020 12.
Artículo en Inglés | MEDLINE | ID: mdl-32065406

RESUMEN

OBJECTIVE: To determine whether advanced imaging is cost-effective compared to primary bilateral neck exploration in the management of non-localizing primary hyperparathyroidism. STUDY DESIGN: Cost-effectiveness analysis. METHODS: Cost-effectiveness analysis based on decision tree model and available Medicare financial data using data from 347 consecutive patients having parathyroidectomy for primary hyperparathyroidism with either 1) positive, concordant ultrasound and sestamibi or 2) negative sestamibi and negative ultrasound. RESULTS: Bilateral neck exploration (BNE) costs $9578 and has a success rate of 97.3%. Single photon emission computed tomography (SPECT) + minimally invasive parathyroidectomy (MIP) was modeled to have a total cost of $8197 with a success rate of 98.6%. SPECT/computed tomography (CT) + MIP was modeled to have a total cost of $8271 and a 98.9% success rate. Four-dimensional (4D)-CT + MIP was modeled to cost $8146 with a success rate of 99%. Incremental cost-effectiveness ratios (IECR) (as compared to BNE) were -536.1, -605.5, and -701.6 ($/percent cure rate) for SPECT, SPECT/CT, and 4D-CT respectively. One-way sensitivity analyses demonstrate the change in IECR and cut-off points (IECR = 0) for four major variables. CONCLUSIONS: In patients with non-localizing primary hyperparathyroidism, advanced imaging is associated with cost-savings compared to routine bilateral neck exploration. Increased cost-savings were predicted with increased imaging accuracy and decreased imaging costs. Increasing time for BNE or decreasing time for MIP were associated with increased cost savings. LEVEL OF EVIDENCE: III Laryngoscope, 2020.


Asunto(s)
Hiperparatiroidismo Primario/diagnóstico por imagen , Hiperparatiroidismo Primario/cirugía , Paratiroidectomía/economía , Análisis Costo-Beneficio , Árboles de Decisión , Técnicas de Diagnóstico Quirúrgico , Humanos , Procedimientos Quirúrgicos Mínimamente Invasivos , Modelos Económicos , Paratiroidectomía/métodos , Radiofármacos , Tecnecio Tc 99m Sestamibi , Tomografía Computarizada de Emisión de Fotón Único/métodos , Tomografía Computarizada por Rayos X , Ultrasonografía
15.
Hepatobiliary Pancreat Dis Int ; 19(2): 157-162, 2020 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-32088126

RESUMEN

BACKGROUND: The Bismuth-Corlette (BC) classification is used to categorize hilar cholangiocarcinoma by proximal extension along the biliary tree. As the right hepatic artery crosses just behind the left bile duct, we hypothesized that BC IIIb tumors would have a higher likelihood of local unresectability due to involvement of the contralateral artery. METHODS: A retrospective review of a prospectively maintained database identified patients with hilar cholangiocarcinoma taken to the operating room for intended curative resection between April 2008 and September 2016. Cases were assigned BC stages based on preoperative imaging. RESULTS: Sixty-eight patients were included in the study. All underwent staging laparoscopy after which 16 cases were aborted for metastatic disease. Of the remaining 52 cases, 14 cases were explored and aborted for locally advanced disease. Thirty-eight underwent attempt at curative resection. After excluding cases aborted for metastatic disease, the chance of proceeding with resection was 55.6% for BC IIIb staged lesions compared to 80.0% of BC IIIa lesions and to 82.4% for BC I-IIIa staged lesions (P < 0.05). About 44.4% of BC IIIb lesions were aborted for locally advanced disease versus 17.6% of remaining BC stages. CONCLUSIONS: When hilar cholangiocarcinoma is preoperatively staged as BC IIIb, surgeons should anticipate higher rates of locally unresectable disease, likely involving the right hepatic artery.


Asunto(s)
Neoplasias de los Conductos Biliares/clasificación , Neoplasias de los Conductos Biliares/cirugía , Tumor de Klatskin/clasificación , Tumor de Klatskin/cirugía , Neoplasias de los Conductos Biliares/patología , Técnicas de Diagnóstico Quirúrgico/efectos adversos , Supervivencia sin Enfermedad , Hepatectomía/efectos adversos , Arteria Hepática/patología , Humanos , Tumor de Klatskin/patología , Laparoscopía/efectos adversos , Tiempo de Internación , Estadificación de Neoplasias , Pancreaticoduodenectomía/efectos adversos , Complicaciones Posoperatorias/etiología , Pronóstico , Estudios Retrospectivos , Tasa de Supervivencia
16.
World J Surg ; 44(5): 1673-1680, 2020 05.
Artículo en Inglés | MEDLINE | ID: mdl-31933039

RESUMEN

BACKGROUND: There is evidence in favor of using the ultrasound as the primary screening tool in looking for an occult cardiac injury. We report on a prospective single-center study to determine the diagnostic accuracy of chest ultrasound for the diagnosis of occult penetrating cardiac wounds in a low-resource hospital from a middle-income country. METHODS: Data were collected prospectively. We included all consecutive patients 14 years and older who presented to the Emergency Trauma Unit with (1) penetrating injuries to the precordial area and (2) a systolic blood pressure ≥ 90 mmHg (hemodynamically stable). The main outcome measures were sensitivity, specificity, and positive and negative predictive values of ultrasound compared with those of the pericardial window, which was the standard test. RESULTS: A total of 141 patients met the inclusion criteria. Our results showed that for diagnosing an occult cardiac injury, the sensitivity of the chest ultrasonography was 79.31%, and the specificity was 92.86%. Of the 110 patients with a normal or negative ultrasound, six had a positive pericardial window. All of these patients had left hemothoraces. None of them required further cardiac surgical interventions. CONCLUSION: We found that ultrasound was 79% sensitive and 92% specific for the diagnosis of occult penetrating cardiac wounds. However, it should be used with caution in patients with injuries to the cardiac zone and simultaneous left hemothorax.


Asunto(s)
Lesiones Cardíacas/diagnóstico por imagen , Ultrasonografía , Heridas Penetrantes/diagnóstico por imagen , Adulto , Presión Sanguínea , Procedimientos Quirúrgicos Cardíacos , Técnicas de Diagnóstico Quirúrgico , Servicio de Urgencia en Hospital , Reacciones Falso Negativas , Femenino , Lesiones Cardíacas/fisiopatología , Lesiones Cardíacas/cirugía , Hemotórax/complicaciones , Hemotórax/diagnóstico por imagen , Humanos , Masculino , Técnicas de Ventana Pericárdica , Valor Predictivo de las Pruebas , Estudios Prospectivos , Heridas Penetrantes/fisiopatología , Heridas Penetrantes/cirugía , Adulto Joven
18.
J Knee Surg ; 33(8): 810-817, 2020 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-31067591

RESUMEN

A cross-sectional analysis of data derived from patients undergoing knee surgery at a single institution was conducted. The objectives of the study were to (1) compare how the Patient-Reported Outcomes Measurement Information System physical function (PROMIS PF) computer adaptive test performs against the International Knee Documentation Committee (IKDC) Subjective Knee Form in evaluating functional status, and (2) to determine demographic, clinical, and psychosocial correlates of each outcome measure in an urban population undergoing a variety of knee surgeries. We hypothesized that there would be a strong correlation between PROMIS PF and IKDC, with minimal floor and ceiling effects, and similar clinical correlates. The sample consisted of 412 patients undergoing knee surgery. Bivariate and multivariable statistical analyses were performed to identify significant independent predictors. The PROMIS PF and IKDC scores were strongly correlated (r s = 0.71, p < 0.001), and neither exhibited floor nor ceiling effects. Lower body mass index, no preoperative opioid use, lower Charlson comorbidity index score, employment, and lower income were found to be significant independent predictors for better scores on both PROMIS PF and IKDC. Patients undergoing total knee arthroplasty had significantly lower PROMIS PF and IKDC scores (p < 0.05). Potential explanations for these findings are presented, and clinical implications are discussed.


Asunto(s)
Diagnóstico por Computador/métodos , Técnicas de Diagnóstico Quirúrgico , Traumatismos de la Rodilla/rehabilitación , Traumatismos de la Rodilla/cirugía , Procedimientos Ortopédicos/rehabilitación , Medición de Resultados Informados por el Paciente , Adulto , Estudios Transversales , Femenino , Indicadores de Salud , Encuestas Epidemiológicas , Humanos , Rodilla/cirugía , Traumatismos de la Rodilla/diagnóstico , Articulación de la Rodilla/cirugía , Masculino , Persona de Mediana Edad , Recuperación de la Función , Población Urbana , Adulto Joven
19.
Nursing (Ed. bras., Impr.) ; 22(253): 2995-2998, jun.2019.
Artículo en Portugués | BDENF, LILACS | ID: biblio-1025730

RESUMEN

Objetivo: Relatar a experiência de usuária do Sistema Único de Saúde em hospital situado em Piabetá/ Magé, distrito situado no Estado do Rio de Janeiro, na qual a cliente alega incapacitantes dores pélvicas. Método: Houve relato de experiência através de coleta de dados de prontuário, além de entrevista com a usuária. Resultados: A usuária com 48 anos de idade e funcionária de uma companhia de limpeza apresentava dores pélvicas paroxísticas, em meio a questões de ordem social e psicológicas desfavoráveis. Insistiu com a equipe que seu sofrimento advinha de afecções uterinas, em detrimento de mioma detectado em ultrassonografia e menorragia. Seu caso evoluiu à conduta cirúrgica com extirpação de útero e ovários. Conclusão: A análise histopatológica revelara mioma e salpingite, podendo esta ter motivado suas dores, devido às aderências. As dores, porém, persistiram com igual gravidade, tendo sido sanadas após procedimento urológico devido à litíase. Conclui-se que o singular, o sentimento da cliente relacionando a origem da dor à afecção do sistema reprodutor norteia seu primeiro tratamento cirúrgico, o que não lhe trouxe a almejada cura de imediato. O singular, assim, norteou a conduta do relato em tela. A resolutividade para a cliente poderia ter sido superior, caso a unidade hospitalar relevasse o enfermeiro em suas equipes multidisciplinares.(AU)


Objective: To report the experience of users of the Unified Health System in a hospital located in Piabetá/Magé, a district located in the Rio de Janeiro State, in which the client claims incapacitating pelvic pain. Method: There was an experience report through the collection of data from the medical record, as well as an interview with the user. Results: The 48-year-old female wearer and employee of a cleaning company had paroxysmal pelvic pain during unfavorable social and psychological issues. She insisted with the team that her suffering came from uterine affections, to the detriment of myoma detected on ultrasonography and menorrhagia. Her case evolved surgical procedure with extirpation of the uterus and ovaries. Conclsion: The histopathological analysis revealed myoma and salpingitis, which may have motivated her pain due to adhesions. The pains, however, persisted with the same severity, having been healed after a urological procedure due to lithiasis. It is concluded that the singular, the client's feeling relating the origin of the pain to the affection of the reproductive system guided its first surgical treatment, which did not bring him the desired cure immediately. The singular, thus, guided the conduct of the story on screen. The resoluteness for the client could have been superior if the hospital unit were to show the nurse in their multidisciplinary teams.


Objetivo: Informar de la experiencia de usuaria del Sistema Único de Salud en un hospital situado en Piabetá/Magé, distrito situado en el estado de Río de Janeiro, en el que la cliente alega incapacitantes dolores pélvicos. Método: Hubo relato de experiencia a través de recolección de datos de prontuario, además de entrevista con la usuária. Resultado: La usuaria con 48 años de edad y funcionaria de una compañía de limpieza presentaba dolores pélvicos paroxísticos, en medio de cuestiones de orden social y psicológicas desfavorables. Insistió con el equipo que su sufrimiento provenía de afecciones uterinas, en detrimento de mioma detectado en ultrasonografía y menorragia. Su caso evolucionó a la conducta quirúrgica con extirpación de útero y ovarios. Conclusión: El análisis histopatológico reveló mioma y salpingitis, pudiendo ésta haber motivado sus dolores, debido a las adherencias. Los dolores, sin embargo, persistieron con igual gravedad, habiendo sido sanados después del procedimiento urológico debido a la litiasis. Se concluye que el singular, el sentimiento de la cliente relacionando el origen del dolor a la afección del sistema reproductor comunica su primer tratamiento quirúrgico, lo que no le traía la ansiada cura de inmediato. El singular, así, orientó la conducta del relato en tela. La resolución para la cliente podría haber sido superior, si la unidad hospitalaria relevara al enfermero en sus equipos multidisciplinares.(AU)


Asunto(s)
Humanos , Femenino , Persona de Mediana Edad , Factores de Riesgo , Dolor Pélvico , Técnicas de Diagnóstico Quirúrgico , Quimioterapia , Sistema Único de Salud
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