RESUMEN
Due to its intrinsic complexity and the principle of collective solidarity that governs it, solid organ transplantation (SOT) seems to have been spared from the increase in litigation related to medical activity. Litigation relating to solid organ transplantation that took place in the 29 units of the Assistance Publique-Hôpitaux de Paris and was the subject of a judicial decision between 2015 and 2022 was studied. A total of 52 cases of SOT were recorded, all in adults, representing 1.1% of all cases and increasing from 0.71% to 1.5% over 7 years. The organs transplanted were 25 kidneys (48%), 19 livers (37%), 5 hearts (9%) and 3 lungs (6%). For kidney transplants, 11 complaints (44%) were related to living donor procedures and 6 to donors. The main causes of complaints were early post-operative complications in 31 cases (60%) and late complications in 13 cases (25%). The verdicts were in favour of the institution in 41 cases (79%). Solid organ transplants are increasingly the subject of litigation. Although the medical institution was not held liable in almost 80% of cases, this study makes a strong case for patients, living donors and their relatives to be better informed about SOT.
Asunto(s)
Hospitales Universitarios , Trasplante de Órganos , Humanos , Trasplante de Órganos/legislación & jurisprudencia , Hospitales Universitarios/legislación & jurisprudencia , Adulto , Masculino , Femenino , Complicaciones Posoperatorias , Donadores Vivos/legislación & jurisprudencia , Persona de Mediana Edad , Trasplante de Hígado/legislación & jurisprudencia , Trasplante de Hígado/efectos adversos , Trasplante de Riñón/legislación & jurisprudencia , Europa (Continente) , Trasplante de Pulmón/legislación & jurisprudenciaRESUMEN
The first living donor kidney transplant in Syria was performed 44 years ago; by the end of 2022, 6265 renal transplants had been performed in Syria. Kidney, bone marrow, cornea, and stem cells are the only organs or tissues that can be transplanted in Syria. Although 3 heart transplants from deceased donors were performed in the late 1980s, cardiac transplant activities have since discontinued. In 2003, national Syrian legislation was enacted authorizing the use of organs from living unrelated and deceased donors. This important law was preceded by another big stride: the acceptance by the higher Islamic religious authorities in Syria in 2001 of the principle of procurement of organs from deceased donors, provided that consent is given by a first- or second-degree relative. After the law was enacted, kidney transplant rates increased from 7 per million population in 2002 to 17 per million population in 2007. Kidney transplants performed abroad for Syrian patients declined from 25% in 2002 to <2% in 2007. Rates plateaued through 2010, before the political crisis started in 2011. Forty-four years after the first successful kidney transplant in Syria, patients needing an organ transplant rely on living donors only. Moreover, 20 years after the law authorizing use of organs from deceased donors, a program is still not in place in Syria. The war, limited resources, and lack of public awareness about the importance of organ donation and transplant appear to be factors inhibiting initiation of a deceased donor program in Syria. A concerted and ongoing education campaign is needed to increase awareness of organ donation, change negative public attitudes, and gain societal acceptance. Every effort must be made to initiate a deceased donor program to lessen the burden on living donors and to enable national self-sufficiency in organs for transplant.
Asunto(s)
Donadores Vivos , Trasplante de Órganos , Donantes de Tejidos , Obtención de Tejidos y Órganos , Humanos , Siria , Obtención de Tejidos y Órganos/legislación & jurisprudencia , Obtención de Tejidos y Órganos/tendencias , Trasplante de Órganos/legislación & jurisprudencia , Trasplante de Órganos/tendencias , Donadores Vivos/provisión & distribución , Donadores Vivos/legislación & jurisprudencia , Donantes de Tejidos/provisión & distribución , Donantes de Tejidos/legislación & jurisprudencia , Religión y Medicina , Trasplante de Riñón/legislación & jurisprudencia , Islamismo , Factores de Tiempo , Política de Salud/legislación & jurisprudencia , Regulación GubernamentalAsunto(s)
Trasplante de Riñón , Motivación , Donantes de Tejidos/psicología , Obtención de Tejidos y Órganos , Altruismo , Accesibilidad a los Servicios de Salud/economía , Accesibilidad a los Servicios de Salud/legislación & jurisprudencia , Necesidades y Demandas de Servicios de Salud/economía , Necesidades y Demandas de Servicios de Salud/legislación & jurisprudencia , Humanos , Trasplante de Riñón/economía , Trasplante de Riñón/legislación & jurisprudencia , Obtención de Tejidos y Órganos/economía , Obtención de Tejidos y Órganos/legislación & jurisprudencia , Estados UnidosRESUMEN
BACKGROUND: Although a shortage in organ donation is a critical problem in Japan, understanding of and attitude toward organ transplantation in medical students have not been sufficiently reported. METHODS: Between 2013 and 2018, we surveyed 702 medical students in the fifth-year clinical training in our urology department. The survey concerned (1) knowledge of Japanese transplantation law, which was amended in 2010, and (2) whether the respondents had an organ donor card and had agreed to be a brain-dead donor or a living donor in kidney transplantation with specific reasons for their choices. RESULTS: All 702 students answered the survey. Of 657 students who provided valid answers to the first section, 402 (61%) recognized the amendment to the Japanese transplantation law, and only 11 (1.7%) fully understood its contents. Of 702 students, 194 (28%) had a donor card, 384 (55%) agreed to be a brain-dead donor, and 529 (75%) agreed to be a living donor in kidney transplantation. As the specific reasons for their choices, only a few medical students wrote reasons based on their medical standpoint, and more students wrote emotional reasons. CONCLUSIONS: The understanding of and attitude toward organ transplantation were not remarkably high in the fifth-year medical students in Japan. To solve the donor shortage problem, education about organ transplantation may need to be more effective.
Asunto(s)
Actitud , Muerte Encefálica , Trasplante de Riñón/legislación & jurisprudencia , Donadores Vivos/provisión & distribución , Estudiantes de Medicina/estadística & datos numéricos , Adulto , Estudios Transversales , Emociones , Humanos , Japón , Estudiantes de Medicina/psicología , Obtención de Tejidos y Órganos , Adulto JovenAsunto(s)
Cooperación Internacional/historia , Fallo Renal Crónico/cirugía , Trasplante de Riñón/legislación & jurisprudencia , Obtención de Tejidos y Órganos/organización & administración , Adulto , Australia , Femenino , Francia , Supervivencia de Injerto , Historia del Siglo XXI , Humanos , Trasplante de Riñón/historia , Masculino , Turismo Médico/historia , Persona de Mediana Edad , Nueva Caledonia , Factores de Tiempo , Donantes de Tejidos , Obtención de Tejidos y Órganos/historia , Obtención de Tejidos y Órganos/legislación & jurisprudenciaRESUMEN
The prevalence of end-stage renal disease (ESRD) morbidity and mortality is mounting. Kidney transplantation offers a good means of survival and improves longevity of patients with ESRD. However, not everyone is fortunate to benefit from this lifesaving renal replacement therapy due to the lack of available kidneys, one of the many reasons. It eventually expands the number of patients on waiting list of kidney transplantation. At present, deceased and living-related kidney donor transplantation models are widely used, but with limited success to keep up with the pace of burgeoning ESRD. A debate over the legalization of unrelated living kidney donor transplantation has erupted lately. This short review articles focuses on issues surrounding kidney transplantation in Pakistan and draws an informed conclusion regarding pragmatic legalization of unrelated living kidney donor transplantation in exceptional circumstances. Finally, this article also offers a food for thought for countries facing analogous picture in the field of kidney transplantation.
Asunto(s)
Selección de Donante/legislación & jurisprudencia , Accesibilidad a los Servicios de Salud/legislación & jurisprudencia , Fallo Renal Crónico/cirugía , Trasplante de Riñón/legislación & jurisprudencia , Donadores Vivos/legislación & jurisprudencia , Formulación de Políticas , Donante no Emparentado/legislación & jurisprudencia , Regulación Gubernamental , Humanos , Fallo Renal Crónico/mortalidad , Donadores Vivos/provisión & distribución , Pakistán/epidemiología , Donante no Emparentado/provisión & distribuciónRESUMEN
Human immunodeficiency virus (HIV) infection was traditionally considered an absolute contraindication for kidney transplantation. After the introduction of ART, several studies have demonstrated comparable patient and graft outcomes between HIV-negative and HIV-positive kidney recipients. The US Congress passed the HIV Organ Policy Equity (HOPE) Act in 2013, which permits research in the area of HIV-positive to HIV-positive transplantation. HIV-infected living donation is also permitted under the HOPE Act. However, there is a concern regarding the safety of kidney donation in an HIV-infected person, given the risk of renal disease associated with HIV infection. We report here the case of successful kidney transplantation from HIV-positive living donor to HIV-positive recipient performed in our center on July 2012. To the best of our knowledge, this is the earliest case done in this medical context to be reported in the literature, therefore, potentially carrying several important messages to the transplantation community. In the present case, the living-donor kidney transplant was performed between a married couple infected with same strain of HIV-1, both on effective ART with efficiently suppressed viral replication and satisfactory pre-transplantation immune status.
Asunto(s)
Nefropatía Asociada a SIDA/cirugía , Lesión Renal Aguda/cirugía , Seropositividad para VIH/diagnóstico , Trasplante de Riñón/métodos , Donadores Vivos , Nefropatía Asociada a SIDA/complicaciones , Nefropatía Asociada a SIDA/inmunología , Nefropatía Asociada a SIDA/virología , Lesión Renal Aguda/etiología , Fármacos Anti-VIH/administración & dosificación , Estudios de Seguimiento , Seropositividad para VIH/tratamiento farmacológico , Seropositividad para VIH/virología , VIH-1/aislamiento & purificación , Humanos , Trasplante de Riñón/legislación & jurisprudencia , Masculino , Persona de Mediana Edad , Cuidados Preoperatorios/métodos , Esposos , Obtención de Tejidos y Órganos/legislación & jurisprudencia , Resultado del Tratamiento , Carga Viral/efectos de los fármacos , Replicación Viral/efectos de los fármacosRESUMEN
Although live kidney donation (LD) has become an increasingly common procedure, European and US transplant centres disagree as to whether minors and young adults should qualify as donor candidates. Therefore, we aimed to better understand the attitudes and viewpoints of transplant professionals. We conducted fourteen in-depth interviews with a purposive sample of international transplant professionals from various professional backgrounds. Data analysis was guided by QUAGOL, a systematic approach based on the constant-comparative method. Professionals expressed a cautionary view, worrying about the uncertain long-term medical and psychosocial consequences of LD at a young age. They also worried that young individuals' decisions are more likely to be influenced by their psychosocial developmental stage or family pressure. As these concerns were more significant for minors as compared to young adults, minors were deemed ineligible for LD except for in highly exceptional circumstances. Professionals' attitudes were also influenced by the expected benefits for the recipient and the availability of therapeutic alternatives, as well as the strength of the donor-recipient relationship. More prospective research on the long-term medical and psychological outcomes in young adult donors is likely to shed more light on the acceptability of LD by adolescents and young adults.
Asunto(s)
Trasplante de Riñón/ética , Trasplante de Riñón/legislación & jurisprudencia , Trasplante de Riñón/psicología , Donadores Vivos , Obtención de Tejidos y Órganos/ética , Obtención de Tejidos y Órganos/legislación & jurisprudencia , Adolescente , Adulto , Anciano , Niño , Toma de Decisiones , Femenino , Humanos , Cooperación Internacional , Riñón/cirugía , Masculino , Persona de Mediana Edad , Menores , Nefrectomía , Estudios Prospectivos , Investigación Cualitativa , Encuestas y Cuestionarios , Resultado del Tratamiento , Adulto JovenRESUMEN
PURPOSE OF REVIEW: We report the current state of HIV+ to HIV+ kidney transplantation in the United States and remaining challenges in implementing this practice nationally. RECENT FINDINGS: The HIV Organ Policy Equity (HOPE) Act, which was the first step in unlocking the potential of HIV+ organ donors, mandates clinical research on HIV+ to HIV+ transplantation. As of March 2019, there have been 57 HOPE donors, including both true and false positive HOPE donors resulting in more than 120 transplants. SUMMARY: The HOPE Act, signed in 2013, reversed the federal ban on the transplantation of organs from HIV+ donors into HIV+ recipients. Ongoing national studies are exploring the safety, feasibility, and efficacy of both kidney and liver transplantation in this population. If successfully and fully implemented, HIV+ to HIV+ transplantation could attenuate the organ shortage for everyone waiting, resulting in a far-reaching public health impact.
Asunto(s)
Trasplante de Riñón/efectos adversos , Trasplante de Riñón/legislación & jurisprudencia , Obtención de Tejidos y Órganos/legislación & jurisprudencia , Humanos , Estados UnidosRESUMEN
Over recent decades, numerous clinical advances and policy changes have affected outcomes for candidates of kidney transplantation in the United States. We examined the national Scientific Registry for Transplant Recipients for adult (18+) solitary kidney transplant candidates placed on the waiting list for primary listing from 2001 to 2015. We evaluated rates of mortality, transplantation, and waitlist removal. Among 340 115 candidates there were significant declines in mortality (52 deaths/1000 patient years in 2001-04 vs 38 deaths/1000 patient years in 2012-15) and transplant rates (304 transplants/1000 patient years in 2001-04 vs 212 transplants/1000 patient years in 2012-15) and increases in waitlist removals (15 removals/1000 patient years in 2001-04 vs 25/1000 patient years in 2012-15) within the first year after listing. At 5 years an estimated 37% of candidates listed in 2012-15 were alive without transplant as compared to 22% in 2001-04. Declines in mortality over time were significantly more pronounced among African Americans, candidates with longer dialysis duration, and those with diabetes (P < .001). Cumulatively, results indicate dramatic changes in prognoses for adult kidney transplant candidates, likely impacted by selection criteria, donor availability, regulatory oversight, and clinical care. These trends are important considerations for prospective policy development and research, clinical and patient decision-making, and evaluating the impact on access to care.
Asunto(s)
Trasplante de Riñón/mortalidad , Mortalidad/tendencias , Selección de Paciente , Asignación de Recursos , Receptores de Trasplantes/estadística & datos numéricos , Listas de Espera/mortalidad , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Femenino , Estudios de Seguimiento , Humanos , Trasplante de Riñón/legislación & jurisprudencia , Masculino , Persona de Mediana Edad , Pronóstico , Sistema de Registros , Donantes de Tejidos , Obtención de Tejidos y Órganos , Estados Unidos , Adulto JovenRESUMEN
BACKGROUND: Previous simultaneous liver-kidney (SLK) transplant allocation was based on serum creatinine, a metric that disadvantaged women relative to men. A recent SLK transplant policy change uses estimated glomerular filtration rate (eGFR), which accounts for sex-based differences in creatinine. METHODS: To understand the impact of this new policy, we analyzed nonstatus 1 adults listed for liver transplantation (LT) from May 2007 to July 2014, excluding those with exceptions. We defined patients who met the new SLK policy as having an eGFR <60 mL/min for 90 days, with a final eGFR <30 mL/min. RESULTS: Of 40979 candidates, 1683 would have met only the new criteria (N-SLK), 2452 would have met only the old criteria (O-SLK), and 1878 would have met both criteria (B-SLK). Compared to those in the B-SLK or O-SLK groups, those in the N-SLK group were significantly more likely to be female (52% versus 36% versus 39%, P < 0.001). Cox-regression analysis demonstrated that in adjusted analysis those in the N-SLK group were significantly less likely to die postliver transplant (hazard ratio [HR], 0.0; P < 0.001). Further, in Cox regression subgroup analyses, both in women (HR 0.04; P < 0.001) and in men (HR, 0.02, P < 0.001) those in the N-SLK group who underwent liver transplant were significantly less likely to die postliver transplant, even after adjustment for confounders. CONCLUSIONS: We anticipate that implementation of the new SLK policy will increase the proportion of women and decrease the proportion of men who are listed for SLK but may not improve posttransplant survival. Our data highlight the need for monitoring of SLK outcomes after implementation of the new policy.
Asunto(s)
Enfermedad Hepática en Estado Terminal/cirugía , Fallo Renal Crónico/cirugía , Trasplante de Riñón/legislación & jurisprudencia , Trasplante de Hígado/legislación & jurisprudencia , Asignación de Recursos/legislación & jurisprudencia , Adulto , Creatinina/sangre , Enfermedad Hepática en Estado Terminal/sangre , Enfermedad Hepática en Estado Terminal/mortalidad , Femenino , Estudios de Seguimiento , Tasa de Filtración Glomerular , Implementación de Plan de Salud/estadística & datos numéricos , Humanos , Estimación de Kaplan-Meier , Fallo Renal Crónico/sangre , Fallo Renal Crónico/mortalidad , Trasplante de Riñón/estadística & datos numéricos , Trasplante de Hígado/estadística & datos numéricos , Masculino , Persona de Mediana Edad , Selección de Paciente , Políticas , Sistema de Registros/estadística & datos numéricos , Asignación de Recursos/organización & administración , Asignación de Recursos/estadística & datos numéricos , Factores de Riesgo , Factores Sexuales , Obtención de Tejidos y Órganos/legislación & jurisprudencia , Estados Unidos/epidemiología , Listas de EsperaRESUMEN
Kidney transplantation is the gold standard for end-stage renal disease. All over the world there are several challenges preventing sufficient organ donation to meet the growing needs of patients on the waiting list. One major challenge which is common to most countries is the shortage of organs from willing living donors. Many countries, especially, the developed countries, have devised several models of expanding their donor pools to meet the growing needs of patients on the waiting list. Nigeria, a developing country has very low kidney transplantation rate even though some progress have been made in making the procedure feasible in about a dozen hospitals in Nigeria. One very major challenge has been the shortage of donor organ supply. This paper intends to proffer suggestions on how to expand the organ donor pool in Nigeria.
Asunto(s)
Fallo Renal Crónico/cirugía , Trasplante de Riñón/métodos , Donadores Vivos/provisión & distribución , Obtención de Tejidos y Órganos , Prestación Integrada de Atención de Salud , Educación en Salud/métodos , Conocimientos, Actitudes y Práctica en Salud , Política de Salud , Humanos , Fallo Renal Crónico/diagnóstico , Fallo Renal Crónico/epidemiología , Trasplante de Riñón/legislación & jurisprudencia , Donadores Vivos/legislación & jurisprudencia , Nigeria/epidemiología , Formulación de Políticas , Sistema de Registros , Obtención de Tejidos y Órganos/legislación & jurisprudencia , Listas de EsperaAsunto(s)
Gastos en Salud/estadística & datos numéricos , Fallo Renal Crónico/cirugía , Trasplante de Riñón/estadística & datos numéricos , Complicaciones Posoperatorias/epidemiología , Obtención de Tejidos y Órganos/legislación & jurisprudencia , Adulto , Femenino , Historia del Siglo XX , Historia del Siglo XXI , Humanos , Fallo Renal Crónico/economía , Fallo Renal Crónico/epidemiología , Trasplante de Riñón/efectos adversos , Trasplante de Riñón/economía , Trasplante de Riñón/legislación & jurisprudencia , Donadores Vivos , Masculino , Complicaciones Posoperatorias/etiología , Estudios Retrospectivos , Sudán/epidemiología , Obtención de Tejidos y Órganos/métodos , Obtención de Tejidos y Órganos/estadística & datos numéricos , Adulto JovenRESUMEN
Living donors are the preferred source of organs for kidney transplantation, which is the treatment modality of choice for end-stage kidney disease. Health care systems widely promote living kidney donation. However, women are consistently overrepresented among living donors. The reasons behind the sex-based disparity in living kidney donation remain poorly understood. Compared to women, men possess a greater amount of kidney function, and the higher deceased donation rate among men reflects their higher overall kidney quality. A plausible medical explanation for the sex-based disparity in living kidney donation includes an uncompromising emphasis on preserving donor health, with less emphasis placed on organ quality, which is the main criterion in deceased donor selection. On the other hand, consent to deceased donation is also greater in women, indicating their greater desire to donate even though fewer women actually become deceased donors. Therefore, nonmedical reasons for the sex disparity in living donation must be sought. Increased empathic distress or emotional memory; a greater sense of responsibility, urgency, and impulsiveness with increased reaction to empathy; a different body image; and a different social status may all contribute to greater living kidney donation in women. Economic inequity may be the singular explanation when personal worth links to economic worth. To better understand the sex disparity in living kidney donation, we need better data on the reasons behind both nondonation and donor rejection after evaluation in clinical practice. Nondirected living kidney donation provides unique opportunities to minimize factors such as emotional distress, empathy, and impulsiveness. More liberal acceptance criteria for donors with isolated medical abnormalities and testing legitimate donor reimbursement strategies based on actual income levels rather than a fixed amount can assist in both ascertaining the reasons behind the sex disparity in living kidney donation and increasing overall living kidney donation rates.