Benign phyllodes tumour in a transgender woman receiving hormonal therapy.

We present a case of a transwoman taking hormonal feminisation therapy for over 20 years, who underwent surgical excision of a benign phyllodes tumour of the breast. Hormones progesterone and oestrogen act on breast epithelium to increase proliferation. For ciswomen, endogenous and exogenous oestrogen exposure over a lifetime is associated with increased risk for certain benign and malignant breast pathologies. Transwomen taking hormonal therapy may also be at an increased risk of breast disease.

A Case of Benign Phyllodes Tumor in a Transgender Woman Receiving Cross-Sex Hormones.

Phyllodes tumor is a relatively uncommon fibroepithelial neoplasm of the breast characterized by proliferation of both stromal and epithelial elements. Benign phyllodes tumors are distinguished from fibroadenomas by their prominent leaf-like architecture and exaggerated intracanalicular stromal growth pattern. Typically, these lesions affect older natal females; however, we present what we believe is the first reported case of benign phyllodes tumor in a hormonally treated transgender woman.

A phyllodes tumor of the urinary bladder in a rat.

AIM: The aim of this short communication was to describe a case of phyllodes tumor of the urinary bladder discovered in a female Fisher 344 rat that died during an experimental protocol to induce and study urothelial lesions by N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN). METHODOLOGY: From a group of several female rats exposed to BBN via drinking water over the course of 20 weeks, one animal died. At necropsy, a solid mass was identified in the urinary bladder lumen, with a diameter of 0.8 x 0.7 cm. This tumor was processed for histopathological examination and Feulgen coloration. RESULTS: Microscopically, the mass in the bladder was observed to be a phyllodes tumor. DNA content measured by image analysis of a Feulgen-stained section of the tumor and stroma cells displayed diploid DNA content in both components of the tumor. CONCLUSION: This is the first reported phyllodes tumor in a rat's urinary bladder. The exact prognosis and histogenesis of phyllodes tumors of the urinary bladder remains to be determined by the accumulation of data from additional cases.

Phyllodes tumor in epileptics: a report of two cases.

Phyllodes tumor is an uncommon breast neoplasm characterized by a proliferation of both stromal and epithelial elements. In 1989, two young patients with phyllodes tumors were referred to our surgical department because of the detection of breast lumps. Interestingly, both patients also had epilepsy and had been taking anticonvulsants. An analytical case control study revealed that no significant difference between the control group and phyllodes group was found for various categories. In addition, no anticonvulsant medication had been prescribed in either the control group or the phyllodes group except for these two cases. We herein report two cases of phyllodes tumors occurring in two young epileptic patients.

Malignant cystosarcoma phyllodes in a man treated with polyestradiolphosphate. Case report.

Cystosarcoma phyllodes is a rare breast tumor and only five cases have been previously reported in males. A case of cystosarcoma phyllodes in a man treated with polyestradiolphosphate for prostatic carcinoma and by radiation because of breast tenderness is presented. The tumor showed a malignant stroma histologically and the epithelial component was similar to a ductal carcinoma in situ. Electron microscopy revealed several cell types. The possible relationship to radiation and estrogen therapy is discussed.

Fibroadenoma of the female breast. Some epidemiologic surprises.

In a study of 70 cases of fibroadenoma of the female breast, two ages of peak incidence were recorded, one of them in the late 20s to early 30s and a second in the late 40s to early 50s. At the time of diagnosis, the lesions usually were less than 3.0 cm in diameter. Almost two thirds of the tumors were situated in the lateral quadrants of the breast. Incidence of fibroadenoma was significantly higher among parous females tham among nulliparas. Review of family histories showed a remarkably high incidence of breast disease of all types in the mothers and sisters of the patients studied. An inordinately high proportion of patients under 40 years of age were nonwhite. Recurrences and multiple lesions were much more frequent in patients over 40. "Recurrences" are undoubtedly serial presentations of multicentric lesions.

PIP: A retrospective study of 70 cases of mammary fibroadenomata in women 18-73 years of age is presented. They were observed for 1-3 years after excision of the tumors. Of these, 42 were less than 40-years-old. In 1 0% of cases, multiple fibroadenomas were present in 1 or both breasts. In 63%, the tumors were situated in the lateral quadrants of the breast. 74% of the younger patients and 93% of the older ones had had 1 or more children. Only 18 of the total were nulliparous. Nipple discharge had been noted in 11% of the younger patients. A history of previous breast trauma was obtained from only a few. Breast disease among mothers and sisters of patients had occurred in 57%. Of these, 24% had been cancer. History of an unremoved lump had been frequent among these relatives. Fibroadenoma had been diagnosed in 27% of relatives. Among the 70 patients recurrence rate of fibroadenomata was 34%. Recurrences occurred at intervals of several months to 15 years, with an average of 3.3 years in younger patients and 4 years in the older ones. The number of nonwhite patients was more than in the general population, especially in the group under age 40. Oral contraceptives had been taken by 42 patients (60%). In only 5 instances (7%) had the oral contraceptive main component been progesterone. Malignant or benign pelvic disease was also present in 3% of patients. Recurrences of adenomata are thought to be serial presentations of multicentric lesions.