Intercalation of multilayered Ti3C2Tx electrode doped with vanadium for highly sensitive electrochemical detection of dopamine in biological samples.

The electrochemical detection characteristics of the layered Ti3C2Tx material were enhanced by modifying its surface. Ti3C2Tx is used as the Ti - F chemical bond weakens with increasing pH levels. Ti3C2Tx is alkalinized by KOH, and F is substituted for - OH. The surface hydroxyl groups can be eliminated by intercalating K+. This study elaborates on the hydrothermal production of vanadium-doped layered Ti3C2Tx nanosheets intercalated with K+. The development of a sensitive dopamine electrochemical sensor is outlined by intercalating a vanadium-doped multilayered K+ Ti3C2Tx electrode. The chemical, surface, and structural composition of the synthesized electrode for dopamine detection was investigated and confirmed. The sensor exhibits a linear range (1-10 µM), a low detection limit (8.4 nM), and a high sensitivity of 2.746 µAµM-1cm-2 under optimal electrochemical testing conditions. The sensor also demonstrates exceptional anti-interference capabilities and stability. The sensor was applied to detection of dopamine in (spiked) rat brains, human serum, and urine samples. This study introduces a novel approach by utilizing K+ intercalation of vanadium-doped Ti3C2Tx-based electrochemical sensors and an innovative method for dopamine detection. The dopamine detection revealed the potential of (V0.05) K+ Ti3C2Tx-GCE for practical application in pharmaceutical sample analysis.

A refreshing approach to understanding the action on DNA of vanadium (IV) and (V) complexes derived from the anticancer VCp2Cl2.

A computational study based on derivatives of the anticancer VCp2Cl2 compound and their interaction with representative models of deoxyribonucleic acid (DNA) is presented. The derivatives were obtained by substituting the cyclopentadienes of VCp2Cl2 with H2O, NH3, OH-, Cl-, O2- and C2O42- ligands. The oxidation states IV and V of vanadium were considered, so a total of 20 derivative complexes are included. The complexes interactions with DNA were studied using two different models, the first model considers the interactions of the complexes with the pair Guanine-Cytosine (G-C) and the second involves the interaction of the complexes with adjacent pairs, that is, d(GG). This study compares methodologies based on density functional theory with coupled cluster like calculations (DLPNO-CCSD(T)), the gold standard of electronic structure methods. Furthermore, the change in the electron density of the hydrogen bonds that keep bonded the G-C pair and d(GG) pairs, due to the presence of vanadium (IV) and (V) complexes is rationalize. To this aim, quantities obtained from the topology of the electron densities are inspected, particularly the value of the electron density at the hydrogen bond critical points. The approach allowed to identify vanadium complexes that lead to significant changes in the hydrogen bonds indicated above, a key aspect in the understanding, development, and proposal of mechanisms of action between metal complexes and DNA.

Spatial distribution of PAHs, nickel, and vanadium in sediments from a large coastal lagoon near a petroleum extraction area in the southern Gulf of Mexico.

One of the world's crucial areas for crude oil exploration and extraction is the southern Gulf of Mexico, where Terminos Lagoon (TL) is located. Sediments from the TL region were used to assess the spatial patterns, origins, and ecotoxicological risks associated with 16 priority polycyclic aromatic hydrocarbons (PAHs; 3.1-248.9 ng⸳g-1 dry weight basis, dw) and trace metals (Ni = 11.0-104.0 mg⸳kg-1; V = 2.0-35.0 mg⸳kg-1 dw) linked to anthropogenic activities. Although origin indices based on PAHs and metals concentrations indicate no crude oil pollution in the region, sources of pyrogenic PAHs were identified. A chemometric approach demonstrated associations between organic matter and PAHs, and that metal accumulation depends mostly by the input of lithogenic materials. Ecotoxicological risk estimations showed a higher risk of possible adverse effects in sites near swamps and mangrove zones, highlighting the need of future monitoring. This study provides a reference for policymakers to conserve Mexico's largest coastal lagoon and other oil-impacted coastal areas worldwide.

Promoting C-Cl Bond Activation via a Preoccupied Anchoring Strategy on Vanadia-Based Catalysts for Multi-Pollutant Control of NOx and Chlorinated Aromatics.

Regulating vanadia-based oxides has been widely utilized for fabricating effective difunctional catalysts for the simultaneous elimination of NOx and chlorobenzene (CB). However, the notorious accumulation of polychlorinated species and excessively strong NH3 adsorption on the catalysts lead to the deterioration of multipollutant control (MPC) activity. Herein, protonated sulfate (-HSO4) supported on vanadium-titanium catalysts via a preoccupied anchoring strategy are designed to prevent polychlorinated species and alleviate NH3 adsorption for the multipollutant control. The obtained catalysts with -HSO4 modification achieve an excellent NOx and CB conversion with turnover frequency values of ∼ 3.63 and 17.7 times higher than those of the pristine, respectively. The protonated sulfate promotes the formation of polymeric vanadyl with a higher chemical state and d-band center of V. The modulated catalysts not only substantially alleviate the competitive adsorption of multipollutant via the "V 3d-O 2p-S 3p" network, but also distinctly strengthen the Brønsted acid sites. Besides, the introduced proton donor of the -HSO4 connecting polymeric structure could markedly reduce the reaction barrier of breaking the C-Cl bond. This work paves an advanced way for low-loading vanadium SCR catalysts to achieve highly efficient NOx and CB oxidation at a low temperature.

Silibinin Mitigates Vanadium-induced Lung Injury via the TLR4/MAPK/NF-κB Pathway in Mice.

BACKGROUND/AIM: Silibinin, has been investigated for its potential benefits and mechanisms in addressing vanadium pentoxide (V2O5)-induced pulmonary inflammation. This study explored the anti-inflammatory activity of silibinin and elucidate the mechanisms by which it operates in a mouse model of vanadium-induced lung injury. MATERIALS AND METHODS: Eight-week-old male BALB/c mice were exposed to V2O5 to induce lung injury. Mice were pretreated with silibinin at doses of 50 mg/kg and 100 mg/kg. Histological analyses were performed to assess cell viability and infiltration of inflammatory cells. The expression of pro-inflammatory cytokines (TNF-α, IL-6, IL-1ß) and activation of the MAPK and NF-[Formula: see text]B signaling pathways, as well as the NLRP3 inflammasome, were evaluated using real-time PCR, western blot analysis, and immunohistochemistry. Whole blood analysis was conducted to measure white blood cell counts. RESULTS: Silibinin treatment significantly improved cell viability, reduced inflammatory cell infiltration, and decreased the expression of pro-inflammatory cytokines in V2O5-induced lung injury. It also notably suppressed the activation of the MAPK and NF-[Formula: see text]B signaling pathways, along with a marked reduction in NLRP3 inflammasome expression levels in lung tissues. Additionally, silibinin-treated groups exhibited a significant decrease in white blood cell counts, including neutrophils, lymphocytes, and eosinophils. CONCLUSION: These findings underscore the potent anti-inflammatory effects of silibinin in mice with V2O5-induced lung inflammation, highlighting its therapeutic potential. The study not only confirms the efficacy of silibinin in mitigating inflammatory responses but also provides a foundational understanding of its role in modulating key inflammatory pathways, paving the way for future therapeutic strategies against pulmonary inflammation induced by environmental pollutants.

Vanadium-Based Metal-Organic Frameworks with Peroxidase-like Activity as a Colorimetric Sensing Platform for Direct Detection of Organophosphorus Pesticides.

Colorimetry based on the bioenzyme inhibition strategy holds promising application prospects in the field of organophosphorus pesticide (OPs) detection. However, overcoming the challenges of the high cost and low stability of bioenzymes remains crucial. In this study, we successfully synthesized a peroxidase vanadium-based metal-organic framework (MOF) nanozyme named MIL-88B(V) and employed its mediated bioenzyme-free colorimetric strategy for direct OPs detection. The experimental results demonstrated that MIL-88B(V) exhibited a remarkable affinity and a remarkable catalytic rate. When the OPs target is added, it can be anchored on the MOF surface through a V-O-P bond, effectively inhibiting the MOF's activity. Subsequently, leveraging the advantages of smartphones such as convenience, speed, and sensitivity, we developed a paper sensor integrated into a smartphone for efficient OPs detection. The as-designed nanozyme-based colorimetric assay and paper sensor presented herein offer notable advantages, including affordability, speed, stability, wide adaptability, low cost, and accuracy in detecting OPs, thus providing a versatile and promising analytical approach for real sample analysis and allowing new applications of V-based MOF nanozymes.

Enhancement of Mineralization Ability and Water Resistance of Vanadium-Based Catalysts for Catalytic Oxidation of Chlorobenzene by Platinum Loading.

The design of a catalyst with multifunctional sites is one of the effective methods for low-temperature catalytic oxidation of chlorinated volatile organic compounds (CVOCs). The loss of redox sites and competitive adsorption of H2O prevalent in the treatment of industrial exhaust gases are the main reasons for the weak mineralization ability and poor water vapor resistance of V-based catalysts. In this work, platinum (Pt) is selected to combine with the V/CeO2 catalyst, which provides more redox sites and H2O dissociative activation sites and further enhances its catalytic performance. The results show that PtV/CeO2 achieves 90% of the CO2 yield at 318 °C and maintains excellent catalytic activity rather than continuous deactivation within 15 h after water vapor injection. The formation of Pt-O-V bonds enhances the redox ability and promotes deep oxidation of polychlorinated intermediates, accounting for the significantly improved mineralization ability of PtV/CeO2. The dissociative activation effect of Pt on H2O molecules strengthens the migration and activation of V-adsorbed H2O, precluding V-poisoning and notably improving water resistance. This study lays a solid foundation for the efficient degradation of chlorobenzene under humid conditions.

Distinguishing contributions of diverse sediment components to vanadium transport, immobilization and transformation in aquifer.

Vanadium (V) occurs in environment naturally and anthropogenically, but little has been understood about its environmental behavior in groundwater aquifer with sediments. This study investigated the pentavalent V [V(V)] transport and transformation under the influence of different sediment components (minerals, organic matter, and microorganisms) through column experiments. All these components played pivotal roles in V immobilization. The synergistic effects of sediment components enhanced V retention compared to individual component. Mineral components, particularly those containing carbonates and metal oxides, predominantly influenced V(V) transport as indicated by XRD analysis. Organic matter, especially under low pH conditions, induced particle aggregation, thereby inhibiting the transport of V(V). The V K-edge X-ray absorption near-edge structure spectroscopy revealed the formation of tetravalent V[V(IV)] in treatments involving organic matter and microorganisms. Notably, organic matter exhibited the capability to directly reduce V(V). The introduction of microorganisms restricted V(V) transfer. V(V) reducing genera (e.g., Brevundimonas, Arenimonas, Xanthobacter) were detected, achieving V(V) reduction to insoluble V(IV). V(V) bioreduction was improved by minerals that promote microbial metabolism with enhanced electron transfer, or by organic matter that increases levels of intracellular nicotinamide adenine dinucleotide and extracellular polymeric substances. This study specifies the contributions of different sediment components to the transportation and transformation of V, deepening our understanding of V biogeochemistry in groundwater aquifer.

A sustainable bioremediation of vanadium from marine environment and value-addition using potential thraustochytrids.

Rising concerns about global environmental degradation underscore the pressing need for effective solutions to combat heavy metal pollution. Industries such as semiconductor and steel production discharge vanadium into marine ecosystems, posing significant risks to both marine life and human health. The current study investigates efficacy of utilizing marine thraustochytrid for efficient vanadium removal outcompeting other microbial sources. By optimizing pH and temperature conditions during harvesting, achieved a remarkable 50.80 % enhancement in vanadium removal efficiency, from 19.31 to 29.12 mg/L. Furthermore, chelating agents EDTA and citric acid supplementation demonstrated promising enhancements, reaching up to 31.21 and 32.59 mg/L, respectively. Notably, vanadium-treated biomass supplemented with citric acid exhibited maximum enhancement in lipid content, from 58.47 to 75.34 %, indicating thraustochytrid's potential for biofuel production. This study presents a sustainable approach for industrial-scale vanadium bioremediation, aligning with Sustainable Development Goals focused on dual benefits of environmental protection and renewable energy.

Performance of V-Fe based catalysts on the oxidation of dibenzothiophenes.

To obtain fossil fuels with ultra-low S levels at friendly conditions, different V oxides formulations on alumina modified with Fe were characterized and selected to oxidize dibenzothiophene (DBT), 4-methyl DBT and 4,6-dimethyl DBT prevailing in diesel fuel. V-Fe based catalysts (5 or 10 wt% of V) were obtained by impregnation of ammonium metavanadate solutions on Fe-modified alumina, obtained by impregnation of Mohr salt on pseudoboehmite (2 wt% of Fe). The catalysts were calcined in air atmosphere, and after were partially reduced with H2 flux to obtain a mix of several oxidation states of V and Fe species, to evaluate the interaction of Fe in VOx/Al2O3 catalysts and determine its effect on the oxidation processes. The structural and optical properties, as well as surface species, were determined by SEM-EDS, TPR, XRD, Raman, ATR-FTIR, photoluminescence, UV-Vis diffuse reflectance, and XPS spectroscopy. The catalytic performance was evaluated in oxidative desulfurization (ODS) and photocatalytic ODS (PODS) processes. The experimental results showed the addition of Fe promoted the catalytic activity of both ODS and PODS reactions. ODS activities of V-Fe catalysts increase up to 7.5 times with respect to V catalysts without Fe, and the most active catalyst (V5Fer) presents a characteristic oxidation time of 50 min for 4,6-DMDBT. The PODS activity of V10Fec was like ODS activity, showing it is possible to oxidize the dibenzothiophenes under friendly conditions to obtain lower S levels. The promoting effect of Fe was due to the interaction of Fe2+ and Fe3+ with the catalytic support, favoring the distribution of surface V3+ and V4+ species. Additionally, Fe improved the optical properties of the catalysts since the bandgap energy decrease and low recombination rate of the electron-hole pair were observed. Therefore, V-Fe based catalysts are photocatalytically actives to be used in PODS processes.

Synthesis and Characterization of Vanadium Nitride/Carbon Nanocomposites.

The present work focuses on the synthesis of a vanadium nitride (VN)/carbon nanocomposite material via the thermal decomposition of vanadyl phthalocyanine (VOPC). The morphology and chemical structure of the synthesized compounds were characterized using scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy dispersive spectroscopy (EDS), Fourier transformed infrared spectroscopy (FTIR), X-ray diffraction (XRD), and X-ray photoemission spectroscopy (XPS). The successful syntheses of the VOPC and non-metalated phthalocyanine (H2PC) precursors were confirmed using FTIR and XRD. The VN particles present a needle-like morphology in the VN synthesized by the sol-gel method. The morphology of the VN/C composite material exhibited small clusters of VN particles. The XRD analysis of the thermally decomposed VOPC indicated a mixture of amorphous carbon and VN nanoparticles (VN(TD)) with a cubic structure in the space group FM-3M consistent with that of VN. The XPS results confirmed the presence of V(III)-N bonds in the resultant material, indicating the formation of a VN/C nanocomposite. The VN/C nanocomposite synthesized through thermal decomposition exhibited a high carbon content and a cluster-like distribution of VN particles. The VN/C nanocomposite was used as an anode material in LIBs, which delivered a specific capacity of 307 mAh g-1 after 100 cycles and an excellent Coulombic efficiency of 99.8 at the 100th cycle.

Phallusia nigra-mediated vanadium removal from brine: Assessment and optimization.

The rejected brines from desalination plants contain significant amounts of heavy metals. In this study, we evaluated the effectiveness of Phallusia nigra Savigny, 1816 (P. nigra) in removing vanadium from the rejected brines of desalination plants through the bioaccumulation process. Initial assessments revealed a remarkably high accumulation rate of vanadium in P. nigra with a bioaccumulation factor exceeding 4.7 × 104 in the tunic and 5.1 × 105 in the mantle body. Acclimation experiments demonstrated that P. nigra could survive salinities up to 56 practical salinity units (psu), temperatures of ≤32 °C, and pH of 6.5-8.5. We employed the L-16 Taguchi approach in experimental design to optimize environmental conditions for vanadium removal by P.nigra. Our results indicated that temperature has the most significant effect on increasing vanadium bioaccumulation in P. nigra, followed by salinity and pH. Under optimal conditions, the vanadium concentration reached 1892.30 ppm in the entire body of P. nigra compared to 350 ppm in natural conditions. Considering that, a high concentration of vanadium is toxic to the environment and the conventional methods of its removal from brine are costly and include the use of chemicals that pollute the environment, therefore, vanadium removal from brine using P. nigra can be considered a cost-effective and environmentally friendly method in the future, as opposed to some chemical methods.

Construction of dual Z-scheme Ag3VO4-BiVO4/InVO4 photocatalysts using vanadium source from spent catalysts for contaminated water treatment and bacterial inactivation.

Vanadate-based photocatalysts have recently attracted substantial attention owing to their outstanding photocatalytic activity for degrading organic pollutants and generating energy via photocatalytic processes. However, the relatively high price of vanadium has hindered the development of vanadate-based photocatalysts for various applications. Spent catalysts obtained from oil refineries typically contain a significant quantity of vanadium, making them valuable for recovery and utilization as precursors for the production of high-value-added photocatalysts. In this study, we transformed the V present in spent catalysts produced by the petrochemical industry into ternary vanadate-based photocatalysts [BiVO4/InVO4/Ag3VO4 (BVO/IVO/AVO, respectively)] designed for water remediation. The ternary composites revealed an enhanced photocatalytic capability, which was 1.42 and 5.1 times higher than those of the binary BVO/IVO and pristine AVO due to the facilitated charge separation. The ternary photocatalysts not only effectively treated wastewater containing various organic dyes, such as methylene blue (MB), rhodamine 6G (R6G), and brilliant green (BG), but also exhibited remarkable photocatalytic performance in the degradation of antibiotics, reduction of Cr(VI), and bacterial inactivation. This paper proposes a feasible route for recycling industrial waste as a source of vanadium to produce highly efficient vanadate-based photocatalysts.

Emulsion liquid membrane (ELM) enhanced by nanoparticles and ionic liquid for extracting vanadium ions from wastewater.

Emulsion liquid membrane (ELM) stands out as an extraction process that has drawn much attention due to its promising prospects in industrial wastewater treatment technology. Nevertheless, the pivotal challenge is to reach high membrane stability to overcome the obstacle of applying ELM at the industrial scale. In this study, ELM was boosted by using nanoparticles (superparamagnetic iron oxide (Fe2O3)) in the stripping phase (W1) and ionic liquid (1-methyl-3-octyl-imidazolium-hexafluorophosphate [OMIM][PF6) in the oil phase (O) for recovering/extracting vanadium from synthetic wastewater to near completion and at the same time enhancing emulsion stability to be appropriate for industrial application. The vanadium recovery/extraction percentage has been raised significantly in 3 min to 99.6% when adding 0.01% (w/w) Fe2O3 NPs (20 to 50 nm in size) in the internal phase (W1) and 5% (v/v) [OMIM]PF6 ionic liquid in the oil phase (O). Also, the emulsion stability was considerably improved, and the leakage percentage was reduced to 16% after 3 days. The results of this study could be used in the future to remove additional heavy metal ions from industrial effluents.

Deep-sea microorganisms-driven V5+ and Cd2+ removal from vanadium smelting wastewater: Bacterial screening, performance and mechanism.

The disorderly discharge of industrial wastewater containing heavy metals has caused serious water pollution and ecological environmental risks, ultimately threatening human life and health. Biological treatment methods have obvious advantages, but the existing microorganisms exhibit issues such as poor resistance, adaptability, colonization ability, and low activity. However, a wide variety of microorganisms in deep-sea hydrothermal vent areas are tolerant to heavy metals, possessing the potential for efficient treatment of heavy metal wastewater. Based on this, the study obtained a group of deep-sea microbial communities dominated by Burkholderia-Caballeronia-Paraburkholderia through shake flask experiments from the sediments of deep-sea hydrothermal vents, which can simultaneously achieve the synchronous removal of vanadium and cadmium heavy metals through bioreduction, biosorption, and biomineralization. Through SEM-EDS, XRD, XPS, and FT-IR analyses, it was found that V(V) was reduced to V(IV) through a reduction process and subsequently precipitated. Glucose oxidation accelerated this process. Cd(II) underwent biomineralization to form precipitates such as cadmium hydroxide and cadmium carbonate. Functional groups on the microbial cell surface, such as -CH2, C=O, N-H, -COOH, phosphate groups, amino groups, and M-O moieties, participated in the bioadsorption processes of V(V) and Cd(II) heavy metals. Under optimal conditions, namely a temperature of 40 °C, pH value of 7.5, inoculation amount of 10%, salinity of 4%, COD concentration of 600 mg/L, V5+ concentration of 300 mg/L, and Cd2+ concentration of 40 mg/L, the OD600 can reach its highest at 72 h, with the removal efficiency of V5+, Cd2+, and COD in simulated vanadium smelting wastewater reaching 86.32%, 59.13%, and 61.63%, respectively. This study provides theoretical insights and practical evidence for understanding the dynamic changes in microbial community structure under heavy metal stress, as well as the resistance mechanisms of microbial treatment of industrial heavy metal wastewater.

Biomimetic synergistic effect of redox site and Lewis acid for construction of efficient artificial enzyme.

In enzymatic catalysis, the redox site and Lewis acid are the two main roles played by metal to assist amino acids. However, the reported enzyme mimics only focus on the redox-active metal as redox site, while the redox-inert metal as Lewis acid has, to the best of our knowledge, not been studied, presenting a bottleneck of enzyme mimics construction. Based on this, a series of highly efficient MxV2O5·nH2O peroxidase mimics with vanadium as redox site and alkaline-earth metal ion (M2+) as Lewis acid are reported. Experimental results and theoretical calculations indicate the peroxidase-mimicking activity of MxV2O5·nH2O show a periodic change with the Lewis acidity (ion potential) of M2+, revealing the mechanism of redox-inert M2+ regulating electron transfer of V-O through non-covalent polarization and thus promoting H2O2 adsorbate dissociation. The biomimetic synergetic effect of redox site and Lewis acid is expected to provide an inspiration for design of enzyme mimics.

Unique regulatory network of dragon fruit simultaneously mitigates the effect of vanadium pollutant and environmental factors.

Under changing climatic conditions, plants are simultaneously facing conflicting stresses in nature. Plants can sense different stresses, induce systematic ROS signals, and regulate transcriptomic, hormonal, and stomatal responses. We performed transcriptome analysis to reveal the integrative stress response regulatory mechanism underlying heavy metal stress alone or in combination with heat and drought conditions in pitaya (dragon fruit). A total of 70 genes were identified from 31,130 transcripts with conserved differential expression. Furthermore, weighted gene co-expression network analysis (WGCNA) identified trait-associated modules. By integrating information from three modules and protein-protein interaction (PPI) networks, we identified 10 interconnected genes associated with the multifaceted defense mechanism employed by pitaya against co-occurring stresses. To further confirm the reliability of the results, we performed a comparative analysis of 350 genes identified by three trait modules and 70 conserved genes exhibiting their dynamic expression under all treatments. Differential expression pattern of genes and comparative analysis, have proven instrumental in identifying ten putative structural genes. These ten genes were annotated as PLAT/LH2, CAT, MLP, HSP, PB1, PLA, NAC, HMA, and CER1 transcription factors involved in antioxidant activity, defense response, MAPK signaling, detoxification of metals and regulating the crosstalk between the complex pathways. Predictive analysis of putative candidate genes, potentially governing single, double, and multifactorial stress response, by several signaling systems and molecular patterns. These findings represent a valuable resource for pitaya breeding programs, offering the potential to develop resilient "super pitaya" plants.

Regioselective Halogenation of Lavanducyanin by a Site-Selective Vanadium-Dependent Chloroperoxidase.

Halogenated phenazine meroterpenoids are a structurally unusual family of marine actinobacterial natural products that exhibit antibiotic, antibiofilm, and cytotoxic bioactivities. Despite a lack of established phenazine halogenation biochemistry, genomic analysis of Streptomyces sp. CNZ-289, a prolific lavanducyanin and C2-halogenated derivative producer, suggested the involvement of vanadium-dependent haloperoxidases. We subsequently discovered lavanducyanin halogenase (LvcH), characterized it in vitro as a regioselective vanadium-dependent chloroperoxidase, and applied it in late-stage chemoenzymatic synthesis.

Vanadium toxicity was alleviated by supplementation of silicon in tomato seedlings: Upregulating antioxidative enzymes and glyoxalase system.

The primary goal of this research is to investigate the mitigating effect of silicon (Si; 2 mM) on the growth of tomato seedlings under vanadium (V; 40 mg) stress. V stress caused higher V uptake in leaf, and enhanced concentration of leaf anthocyanin, H2O2, O2•-, and MDA, but a decreased in plant biomass, root architecture system, leaf pigments content, mineral elements, and Fv/Fm (PSII maximum efficiency). Si application increased the concentrations of crucial antioxidant molecules such as AsA and GSH, as well as the action of key antioxidant enzymes comprising APX, GR, DHAR, and MDHAR. Importantly, oxidative damage was remarkably alleviated by upregulation of these antioxidant enzymes genes. Moreover, Si application enhanced the accumulation of secondary metabolites as well as the expression their related-genes, and these secondary metabolites may restricted the excessive accumulation of H2O2. In addition, Si rescued tomato plants against the damaging effects of MG by boosting the Gly enzymes activity. The results confirmed that spraying Si to plants might diminish the V accessibility to plants, along with promotion of V stress resistance.

Hydrazone-flavonol based oxidovanadium(V) complexes: Synthesis, characterization and antihyperglycemic activity of chloro derivative in vivo.

Wet synthesis approach afforded four new heteroleptic mononuclear neutral diamagnetic oxidovanadium(V) complexes, comprising salicylaldehyde-based 2-furoic acid hydrazones and a flavonol coligand of the general composition [VO(fla)(L-ONO)]. The complexes were comprehensively characterized, including chemical analysis, conductometry, infrared, electronic, and mass spectroscopy, as well as 1D 1H and proton-decoupled 13C(1H) NMR spectroscopy, alongside extensive 2D 1H1H COSY, 1H13C HMQC, and 1H13C HMBC NMR analyses. Additionally, the quantum chemical properties of the complexes were studied using Gaussian at the B3LYP, HF, and M062X levels on the 6-31++g(d,p) basis sets. The interaction of these hydrolytically inert vanadium complexes and the BSA was investigated through spectrofluorimetric titration, synchronous fluorimetry, and FRET analysis in a temperature-dependent manner, providing valuable thermodynamic insights into van der Waals interactions and hydrogen bonding. Molecular docking was conducted to gain further understanding of the specific binding sites of the complexes to BSA. Complex 2, featuring a 5-chloro-substituted salicylaldehyde component of the hydrazone, was extensively examined for its biological activity in vivo. The effects of complex administration on biochemical and hematological parameters were evaluated in both healthy and diabetic Wistar rats, revealing antihyperglycemic activity at millimolar concentration. Furthermore, histopathological analysis and bioaccumulation studies of the complex in the brain, kidneys, and livers of healthy and diabetic rats revealed the potential for further development of vanadium(V) hydrazone complexes as antidiabetic and insulin-mimetic agents.