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1.
BMJ Case Rep ; 17(6)2024 Jun 19.
Artículo en Inglés | MEDLINE | ID: mdl-38901851

RESUMEN

This case report describes a man in his 20s presenting with bilateral crypto-orchidism, micropenis and underdeveloped secondary sexual characteristics. The patient also exhibited hyposmia, eunuchoid stature and gynecomastia. Biochemical investigations revealed low levels of testosterone, luteinising hormone and follicle-stimulating hormone. Hence, he was diagnosed with Kallmann syndrome. Imaging studies showed an absent right kidney and cystic dilatation of the distal ureteric bud, seminal vesicle and absent/hypoplastic ejaculatory duct. The association of hypogonadotropic hypogonadism with Zinner syndrome, a rare condition characterised by renal agenesis, seminal vesicle cyst and ejaculatory duct obstruction, was noted.


Asunto(s)
Hipogonadismo , Síndrome de Kallmann , Humanos , Masculino , Hipogonadismo/complicaciones , Hipogonadismo/diagnóstico , Síndrome de Kallmann/complicaciones , Síndrome de Kallmann/diagnóstico , Vesículas Seminales/anomalías , Vesículas Seminales/diagnóstico por imagen , Riñón/anomalías , Conductos Eyaculadores/anomalías , Conductos Eyaculadores/diagnóstico por imagen , Adulto , Pene/anomalías
2.
J Pediatr Urol ; 20(4): 705.e1-705.e7, 2024 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-38945789

RESUMEN

INTRODUCTION: Zinner Syndrome (ZS), a rare congenital malformation of the mesonephric duct, combines seminal vesicle cyst (SVC) with ipsilateral upper urinary tract abnormalities. Typically asymptomatic in childhood, ZS manifests between 2nd to 4th decades with bladder symptoms, perineal pain and infertility. Diagnostic confirmation with additional imaging is needed when either renal or seminal abnormalities are identified. MATERIALS AND METHODS: A retrospective study spanning 22 years identified 20 pediatric ZS cases through clinical analytics. Demographic, clinical, and radiological data were analyzed, including presenting complaints, imaging modalities (ultrasound, CT, MRI), and surgical findings. The study was HIPAA-compliant and IRB-approved. RESULTS: Among 20 cases (mean age: 7.3 years), clinical presentations included asymptomatic cases, urinary symptoms, and abdominal pain. Imaging revealed renal anomalies (agenesis, multicystic dysplastic kidney) and seminal vesicle abnormalities. Surgical interventions (n = 12) addressed symptomatic cases, often involving robotic or laparoscopic procedures. DISCUSSION: ZS, though rare, presents with varied clinical features, necessitating a multidisciplinary approach. Early diagnosis is facilitated by prenatal identification of renal abnormalities. Surgical intervention is reserved for symptomatic cases, with techniques such as vesiculectomy and resection of remnant structures employed. CONCLUSION: This study highlights ZS's diverse clinical and radiological spectrum, emphasizing the need for vigilance in detecting overlapping entities. Timely identification, utilizing advanced imaging techniques, is crucial for accurate diagnosis and appropriate management of Zinner Syndrome in the pediatric population.


Asunto(s)
Vesículas Seminales , Humanos , Estudios Retrospectivos , Masculino , Niño , Vesículas Seminales/anomalías , Vesículas Seminales/diagnóstico por imagen , Preescolar , Síndrome , Femenino , Adolescente , Anomalías Múltiples/diagnóstico , Conductos Mesonéfricos/anomalías , Quistes/diagnóstico , Quistes/cirugía , Lactante
3.
J Radiol Case Rep ; 17(8): 57-64, 2023 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-38090641

RESUMEN

Zinner's syndrome is a rare congenital malformation characterized by the association of unilateral renal agenesis with ipsilateral seminal vesicle cyst and ejaculatory duct obstruction. Most patients are asymptomatic until the third or fourth decade of life when the syndrome is associated with dysuria, perineal pain, infertility, and painful ejaculation. In this report, we present the common imaging findings of this rare developmental anomaly involving the mesonephric duct in a 48-year-old male patient experiencing pelvic pain, recurrent dysuria, and pollakiuria.


Asunto(s)
Enfermedades de los Genitales Masculinos , Riñón , Masculino , Humanos , Persona de Mediana Edad , Riñón/diagnóstico por imagen , Riñón/anomalías , Disuria , Vesículas Seminales/diagnóstico por imagen , Vesículas Seminales/anomalías , Conductos Mesonéfricos/diagnóstico por imagen , Conductos Mesonéfricos/anomalías , Síndrome
4.
Curr Med Imaging ; 18(1): 78-81, 2022.
Artículo en Inglés | MEDLINE | ID: mdl-34102980

RESUMEN

INTRODUCTION: Zinner syndrome is a rare congenital abnormality defined by a clinical triad of unilateral renal agenesis, ipsilateral seminal vesicle cyst, and ipsilateral ejaculatory duct obstruction. CASE PRESENTATION: Most patients are asymptomatic, but if the cystic dilatation of the seminal vesicle becomes significant, it can result in urinary symptoms such as dysuria and urinary retention. This rare developmental anomaly related to mesonephric duct can also present with other abnormalities. CONCLUSION: Here, we report our experience of Zinner syndrome with bladder outlet obstruction and an ectopic ureter remnant.


Asunto(s)
Quistes , Enfermedades de los Genitales Masculinos , Uréter , Enfermedades de los Genitales Masculinos/diagnóstico , Humanos , Riñón/anomalías , Riñón/diagnóstico por imagen , Masculino , Vesículas Seminales/anomalías , Vesículas Seminales/diagnóstico por imagen , Síndrome , Uréter/anomalías , Uréter/diagnóstico por imagen
5.
BMJ Case Rep ; 14(1)2021 Jan 18.
Artículo en Inglés | MEDLINE | ID: mdl-33462046

RESUMEN

Congenital malformations of the seminal vesicles (SVs) are rare and are associated with abnormalities of the ipsilateral urinary tracts as embryologically both the ureteral buds and SVs arise from the mesonephric ducts. The triad of SV cysts, ipsilateral renal agenesis and ejaculatory duct obstruction is known as the Zinner syndrome. We, herein, present three very rare presentations of Zinner syndrome. Case 1 presented with haematuria, and was found to have a large SV cyst with stones and underwent a robotic cyst excision. Case 2 presented with primary infertility, and was found to have a variant of Zinner syndrome. Case 3 was a known case of chronic kidney disease on maintenance haemodialysis who presented with fever and oliguria. He was found to have Zinner syndrome and underwent aspiration of SV abscess. To the best of our knowledge, such varying presentations of Zinner syndrome have been rarely reported thus far.


Asunto(s)
Anomalías Congénitas/diagnóstico , Conductos Eyaculadores/anomalías , Enfermedades Renales/congénito , Riñón/anomalías , Vesículas Seminales/anomalías , Adulto , Humanos , Enfermedades Renales/complicaciones , Enfermedades Renales/diagnóstico , Masculino , Persona de Mediana Edad , Síndrome , Adulto Joven
6.
Andrologia ; 52(1): e13397, 2020 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-31729082

RESUMEN

This study aims to emphasise the importance of imaging in the diagnosis and treatment decision-making in Zinner syndrome and provide a classification for seminal vesicle cysts. The data of six patients with Zinner syndrome in a single institution were collected. All patients underwent a contrast-enhanced computed tomography (CT) exam. Among these patients, five patients also underwent an magnetic resonance imaging (MRI). These results were combined with the review of available literature to classify the seminal vesicle cysts. Among these patients, two patients had urinary urgency and frequency, while four patients had no urinary symptoms. No reproductive-system symptoms were revealed. The imaging revealed left-sided involvement in two patients and right-sided involvement in four patients. The associated features included ipsilateral renal agenesis, seminal vesicle cyst or agenesis, and ejaculatory duct obstruction. Either an ipsilateral ureterocele or an ipsilateral small testis was noted. The seminal vesicle cysts demonstrated varying attenuation or intensity in the imaging. Imaging (CT and especially MRI) can be critical in the noninvasive diagnosis of Zinner syndrome and in allowing aberrant anatomy to be displayed for possible surgery. The proposed seminal vesicle cyst imaging classification could potentially contribute to clinical decision-making.


Asunto(s)
Quistes/diagnóstico por imagen , Enfermedades de los Genitales Masculinos/diagnóstico por imagen , Vesículas Seminales/anomalías , Adolescente , Adulto , Toma de Decisiones Clínicas , Quistes/patología , Quistes/cirugía , Enfermedades de los Genitales Masculinos/patología , Enfermedades de los Genitales Masculinos/cirugía , Humanos , Imagen por Resonancia Magnética , Masculino , Persona de Mediana Edad , Estudios Retrospectivos , Vesículas Seminales/diagnóstico por imagen , Vesículas Seminales/cirugía , Síndrome , Tomografía Computarizada por Rayos X
7.
BMJ Case Rep ; 12(12)2019 Dec 17.
Artículo en Inglés | MEDLINE | ID: mdl-31852695

RESUMEN

The rarity of primary seminal vesical adenocarcinoma (PSVA) coupled with mostly late and advanced presentation with high mortality makes it an unanticipated malignancy with poor prognosis. Although there has been sporadic reporting of cases, the dearth of literature makes standardised care a challenge. The detection has incorporated immunohistochemistry for establishing the site of origin as well as the differentiation of primary from metastatic cancer. Surgical management with seminal vesiculectomy continues to be the mainstay of treatment, but difficult anatomy and delayed intervention do lead to an increased chance of residual disease that may warrant further adjuvant chemoradiation. We present a case report where PSVA developed in a patient with Zinner syndrome-an observation that is extremely rare with a literature review of PSVA including the various aspects of management including contemporary diagnosis techniques.


Asunto(s)
Adenocarcinoma/diagnóstico por imagen , Neoplasias de los Genitales Masculinos/diagnóstico por imagen , Vesículas Seminales/patología , Adenocarcinoma/patología , Adenocarcinoma/terapia , Adulto , Quimioterapia Adyuvante , Neoplasias de los Genitales Masculinos/patología , Neoplasias de los Genitales Masculinos/terapia , Humanos , Laparoscopía , Masculino , Vesículas Seminales/anomalías , Vesículas Seminales/diagnóstico por imagen , Vesículas Seminales/cirugía , Riñón Único/diagnóstico por imagen , Tomografía Computarizada por Rayos X , Resultado del Tratamiento
8.
BMJ Case Rep ; 12(5)2019 May 06.
Artículo en Inglés | MEDLINE | ID: mdl-31061196

RESUMEN

Congenital unilateral renal agenesis is a relatively frequent condition at birth diagnosed mostly incidentally. Despite the excellent prognosis, unilateral renal agenesis is associated with an increased risk of other structural abnormalities, including genital malformations. The authors present two cases of asymptomatic adolescents with known congenital unilateral renal agenesis and associated genital malformations solely diagnosed during puberty-a man with Zinner syndrome and a female with Mayer-Rokitansky-Küster-Hauser syndrome.


Asunto(s)
Trastornos del Desarrollo Sexual 46, XX/diagnóstico por imagen , Anomalías Congénitas/diagnóstico por imagen , Enfermedades Renales/congénito , Riñón/anomalías , Vesículas Seminales/anomalías , Maduración Sexual/fisiología , Ultrasonografía , Anomalías Urogenitales/diagnóstico , Vagina/anomalías , Trastornos del Desarrollo Sexual 46, XX/fisiopatología , Trastornos del Desarrollo Sexual 46, XX/terapia , Adolescente , Niño , Femenino , Humanos , Riñón/diagnóstico por imagen , Enfermedades Renales/diagnóstico por imagen , Masculino , Salpingectomía , Vesículas Seminales/diagnóstico por imagen , Vagina/diagnóstico por imagen , Espera Vigilante
9.
Arch Ital Urol Androl ; 91(1): 58-59, 2019 Mar 29.
Artículo en Inglés | MEDLINE | ID: mdl-30932434

RESUMEN

INTRODUCTION: Zinner syndrome is a rare developmental anomaly of the Wolffian (mesonephric) duct which is characterized by a triad of obstruction of the ejaculatory duct, the ipsilateral seminal vesicle cyst, and the ipsilateral renal agenesis. Usually is totally asymptomatic, however it can also determine symptoms such as lower urinary tract symptoms, perineal pain, ejaculatory disorders such as painful ejaculation or hematospermia, and infertility. CASE REPORT: We present a case of a 51 years old men with a 3-year history of lower urinary tract symptoms, perineal pain, obstructed defecation, recurrent urinary tract infections and infertility. CT scan showed a voluminous cystic neoformation of the left seminal vesicle, hypoplasia of the left kidney and ipsilateral ureteronephrosis. The mass was removed using laparoscopic "en block" seminal vesiculectomy with associated ipsilateral nephroureterectomy. No post-operative complications occurred. At 2-month post-operative control the patient reported an improvement of urinary and rectal symptoms.


Asunto(s)
Riñón/cirugía , Laparoscopía/métodos , Nefroureterectomía/métodos , Vesículas Seminales/anomalías , Quistes/cirugía , Estudios de Seguimiento , Humanos , Infertilidad Masculina/etiología , Riñón/anomalías , Síntomas del Sistema Urinario Inferior/etiología , Masculino , Persona de Mediana Edad , Procedimientos Quirúrgicos Mínimamente Invasivos/métodos , Vesículas Seminales/cirugía , Síndrome , Tomografía Computarizada por Rayos X , Infecciones Urinarias/etiología , Conductos Mesonéfricos/anomalías
10.
Mil Med Res ; 6(1): 4, 2019 02 14.
Artículo en Inglés | MEDLINE | ID: mdl-30760330

RESUMEN

BACKGROUND: Zinner syndrome represents a rare congenital malformation of the urinary tract. It comprises a constellation of Wolffian duct anomalies and is almost exclusively encountered as a classic triad of seminal vesicle cysts, ejaculatory duct obstruction and renal agenesis. Patients can be either asymptomatic or symptomatic. Recently, minimally invasive surgical techniques have emerged, superseding traditional surgery for select symptomatic cases. Our case highlights the finding of a rare clinical syndrome that was incidentally detected during a routine mass screening of military recruits in the Greek Armed Forces. CASE PRESENTATION: Herein, we present a case of a 19-year-old male who reported having a solitary right kidney when examined in a military training center of Northern Greece. No additional clinical information was available; thus, referral to a tertiary urology department for further investigation ensued. Imaging studies, namely, computed tomography and magnetic resonance imaging, revealed left renal aplasia, multiple left seminal vesicle cysts, and ejaculatory duct obstruction. Laboratory values and urinalysis were within normal range. Semen analysis was significant for cryptozoospermia. Our patient remained asymptomatic during the entire hospitalization. Long-term follow-up was recommended. Nevertheless, he declined further investigation and sought treatment in a private practice setting. CONCLUSIONS: This article aims to present the incidental diagnosis of a rare syndrome in a military setting. Population screening conducted in the armed forces permits the identification of undiagnosed diseases that warrant further investigation. To the best of our knowledge, this was the first report of Zinner syndrome in a military recruit and the second case cited of a Greek patient in the published literature. Regular follow-up is the key to timely intervention in conservatively managed cases.


Asunto(s)
Personal Militar , Vesículas Seminales/anomalías , Anomalías Urogenitales/complicaciones , Anomalías Congénitas/genética , Anomalías Congénitas/fisiopatología , Grecia , Humanos , Hallazgos Incidentales , Riñón/anomalías , Riñón/fisiopatología , Masculino , Análisis de Semen , Riñón Único/complicaciones , Riñón Único/fisiopatología , Tomografía Computarizada por Rayos X/métodos , Anomalías Urogenitales/diagnóstico , Anomalías Urogenitales/etiología , Anomalías Urogenitales/genética , Anomalías Urogenitales/fisiopatología , Adulto Joven
12.
Pesqui. vet. bras ; Pesqui. vet. bras;38(6): 1038-1042, jun. 2018. tab, graf
Artículo en Portugués | LILACS, VETINDEX | ID: biblio-955444

RESUMEN

A vesiculite é um processo inflamatório das glândulas vesiculares, podendo ser unilateral ou bilateral, que acomete reprodutores. O objetivo do presente trabalho foi avaliar a utilização da ultrassonografia como meio de diagnóstico precoce das alterações das vesículas seminais em touros. O presente trabalho foi realizado no município de Videira, Santa Catarina. Analisou-se um total 42 reprodutores, com média de idade de 15 meses, das raças Aberdeen Angus e Polled Hereford em semi-confinamento. Foi realizado exame clinico do estado geral dos animais e exame andrológico dos reprodutores. As amostras de sêmen para a realização do exame das características físicas do ejaculado foram obtidas por eletroejaculação. Através da palpação retal, realizou-se a avaliação das glândulas vesiculares por ultrassonografia. A análise estatística dos dados foi realizada por meio de análise de variância (ANOVA) para comparação entre médias com nível de significância de 5%. A presença de vesiculite foi observada em 31 animais (73,8%) dos 42 analisados. Dos 31 animais portadores 11 animais (35,5%) apresentaram vesiculite bilateral e 20 apresentaram vesiculite unilateral (64,5%; P<0,05). Animais com perímetro escrotal maior tendem a desenvolver vesiculite unilateral, tal fato pode ser explicado pela precocidade sexual agravado pela sodomia entre os animais. O uso do ultrassom auxilia de forma preventiva a detecção de animais portadores de vesiculite em reprodutores.(AU)


The vesiculite is an inflammatory process of the vesicular glands, unilateral or bilateral, that affects bulls. The purpose of this study was to evaluate the use of ultrasound as a complementary method for early detection of changes in seminal vesicles in bulls. This study was conducted in the municipality of Videira, Santa Catarina. We evaluated 42 bulls, with an average age of 15 months, Aberdeen Angus and Polled Hereford breeds and in semi-confinement. Clinical animal examination and andrological exam were performed in all animals. Semen samples were obtained by electroejaculation and physical characteristics of the ejaculate were performed. Rectal palpation was performed by ultrasonography to evaluate vesicular glands changes. Statistical analysis of the data was performed using analysis of variance (ANOVA) for comparison between means with significance level of 5%. The presence of vesiculitis was observed in 31 (73.8%) from the 42 analyzed bulls. Of the 31 animals, 11 animals (35.5%) presented bilateral vesiculitis and 20 showed unilateral vesiculitis (64.5%; P<0.05). Animals with a larger scrotal perimeter tend to develop unilateral vesiculitis, which can be explained by the sexual precocity observed by sodomy among animals. In this way, the use of ultrasound helps preventively to detect animals with vesiculitis in breeding animals.(AU)


Asunto(s)
Animales , Masculino , Bovinos , Vesículas Seminales/anomalías , Bovinos/anomalías , Ultrasonografía/veterinaria
13.
Int. braz. j. urol ; 44(1): 86-94, Jan.-Feb. 2018. tab, graf
Artículo en Inglés | LILACS | ID: biblio-892945

RESUMEN

ABSTRACT Purpose Congenital and acquired pathologies of the seminal vesicles (SV) are rare diseases. The diagnosis of SV anomalies is frequently delayed or wrong due to the rarity of these diseases and the lack of adequate evaluation of SV pathology. For this reason, we aimed to comprehensively evaluate SV pathologies and accompanying genitourinary system abnormalities. Materials and Methods Between March 2012 and December 2015, 1455 male patients with different provisional diagnosis underwent MRI. Congenital and acquired pathology of the SV was identified in 42 of these patients. The patients were categorized according to their SV pathologies. The patients were analyzed in terms of genitourinary system findings associated with SV pathologies. Results SV pathologies were accompanied by other genitourinary system findings. Congenital SV pathologies were bilateral or predominantly in the left SV. Patients with bilateral SV hypoplasia were diagnosed at an earlier age compared to patients with unilateral SV agenesis. There was a significant association between abnormal signal intensity in the SV and benign prostate hypertrophy (BPH) and patient age. Conclusion SV pathologies are rare diseases of the genitourinary system. The association between seminal vesicle pathology and other genitourinary system diseases requires complete genitourinary system evaluation that includes the seminal vesicles.


Asunto(s)
Humanos , Masculino , Adulto , Anciano , Adulto Joven , Vesículas Seminales/anomalías , Vesículas Seminales/diagnóstico por imagen , Enfermedades Urológicas/diagnóstico por imagen , Vesículas Seminales/patología , Enfermedades Urológicas/patología , Anomalías Congénitas/patología , Anomalías Congénitas/diagnóstico por imagen , Imagen por Resonancia Magnética , Persona de Mediana Edad
14.
Int Braz J Urol ; 44(1): 86-94, 2018.
Artículo en Inglés | MEDLINE | ID: mdl-28853814

RESUMEN

PURPOSE: Congenital and acquired pathologies of the seminal vesicles (SV) are rare diseases. The diagnosis of SV anomalies is frequently delayed or wrong due to the rarity of these diseases and the lack of adequate evaluation of SV pathology. For this reason, we aimed to comprehensively evaluate SV pathologies and accompanying genitourinary system abnormalities. MATERIALS AND METHODS: Between March 2012 and December 2015, 1455 male patients with different provisional diagnosis underwent MRI. Congenital and acquired pathology of the SV was identified in 42 of these patients. The patients were categorized according to their SV pathologies. The patients were analyzed in terms of genitourinary system findings associated with SV pathologies. RESULTS: SV pathologies were accompanied by other genitourinary system findings. Congenital SV pathologies were bilateral or predominantly in the left SV. Patients with bilateral SV hypoplasia were diagnosed at an earlier age compared to patients with unilateral SV agenesis. There was a significant association between abnormal signal intensity in the SV and benign prostate hypertrophy (BPH) and patient age. CONCLUSION: SV pathologies are rare diseases of the genitourinary system. The association between seminal vesicle pathology and other genitourinary system diseases requires complete genitourinary system evaluation that includes the seminal vesicles.


Asunto(s)
Vesículas Seminales/anomalías , Vesículas Seminales/diagnóstico por imagen , Enfermedades Urológicas/diagnóstico por imagen , Adulto , Anciano , Anomalías Congénitas/diagnóstico por imagen , Anomalías Congénitas/patología , Humanos , Imagen por Resonancia Magnética , Masculino , Persona de Mediana Edad , Vesículas Seminales/patología , Enfermedades Urológicas/patología , Adulto Joven
15.
Urol Int ; 99(3): 338-342, 2017.
Artículo en Inglés | MEDLINE | ID: mdl-28407634

RESUMEN

OBJECTIVES: We reviewed the clinical presentation and approach for the treatment of symptomatic seminal vesicle cyst associated with ipsilateral renal agenesis while presenting our experience with a series of 5 patients treated with minimally invasive surgery for Zinner syndrome. MATERIALS AND METHODS: Between the years 2008 and 2016, we operated on 5 patients who presented with symptomatic seminal vesicle cyst and ipsilateral renal agenesis. Patients' charts and medical records were reviewed and compared with past published minimally invasive series. RESULTS: Four patients were treated in a laparoscopic approach and one was treated with robotic-assisted seminal vesicle cyst excision. In all cases, the cystic complex was drained and excised with marsupialization of the remaining cyst walls to prevent cystic recurrence. The mean operating time was 3:47 h and mean hospitalization time was 7 days (4-14). The mean follow-up period was 3.2 years (range 1.7-4.8 years). All patients reported a resolution of symptoms during postoperative follow-up. CONCLUSIONS: Seminal vesicle cyst with ipsilateral renal agenesis should be suspected in young male patients presenting with pelvic cystic masses. Treatment is reserved for symptomatic patients and the preferred approach is minimally invasive surgery. This approach is feasible and effective while providing advantages both for the patient and the surgeon.


Asunto(s)
Anomalías Congénitas , Quistes/cirugía , Enfermedades de los Genitales Masculinos/cirugía , Enfermedades Renales/congénito , Riñón/anomalías , Laparoscopía , Procedimientos Quirúrgicos Robotizados , Vesículas Seminales/cirugía , Procedimientos Quirúrgicos Urológicos Masculinos/métodos , Adolescente , Anomalías Congénitas/diagnóstico por imagen , Anomalías Congénitas/genética , Quistes/congénito , Quistes/diagnóstico por imagen , Enfermedades de los Genitales Masculinos/congénito , Enfermedades de los Genitales Masculinos/diagnóstico por imagen , Humanos , Riñón/diagnóstico por imagen , Enfermedades Renales/diagnóstico por imagen , Enfermedades Renales/genética , Laparoscopía/efectos adversos , Tiempo de Internación , Imagen por Resonancia Magnética , Masculino , Tempo Operativo , Complicaciones Posoperatorias/etiología , Procedimientos Quirúrgicos Robotizados/efectos adversos , Vesículas Seminales/anomalías , Vesículas Seminales/diagnóstico por imagen , Factores de Tiempo , Resultado del Tratamiento , Procedimientos Quirúrgicos Urológicos Masculinos/efectos adversos , Adulto Joven
16.
Scand J Urol ; 51(1): 81-84, 2017 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-27905212

RESUMEN

The association of ipsilateral renal agenesis and cystic seminal vesicle is a rare congenital syndrome described by Zinner in 1914. The cases of two patients with this syndrome are presented, one of them associated with infertility, the other with cryptorchidism and testicular pain. A brief review of the literature is undertaken, regarding the main clinical and imaging implications, and the developmental anomalies that are involved in this unusual congenital anomaly are analyzed.


Asunto(s)
Anomalías Congénitas/diagnóstico por imagen , Conductos Eyaculadores/diagnóstico por imagen , Enfermedades Renales/congénito , Riñón/anomalías , Vesículas Seminales/diagnóstico por imagen , Anomalías Urogenitales/diagnóstico por imagen , Adulto , Criptorquidismo/complicaciones , Criptorquidismo/cirugía , Conductos Eyaculadores/anomalías , Humanos , Infertilidad Masculina/etiología , Riñón/diagnóstico por imagen , Enfermedades Renales/complicaciones , Enfermedades Renales/diagnóstico por imagen , Imagen por Resonancia Magnética , Masculino , Vesículas Seminales/anomalías , Síndrome , Tomografía Computarizada por Rayos X , Ultrasonografía , Anomalías Urogenitales/complicaciones
19.
Sci Rep ; 4: 6959, 2014 Nov 07.
Artículo en Inglés | MEDLINE | ID: mdl-25376241

RESUMEN

Wnt/ß-catenin signalling regulates numerous developmental and homeostatic processes. Ctnnb1 (also known as ß-catenin) is the only protein that transmits signals from various Wnt ligands to downstream genes. In this study, we report that our newly established mouse strain, which harbours a Cys429 to Ser missense mutation in the ß-catenin gene, exhibited specific organ defects in contrast to mice with broadly functioning Wnt/ß-catenin signalling. Both homozygous mutant males and females produced normal gametes but were infertile because of abnormal seminal vesicle and vaginal morphogenesis. An ins-TOPGAL transgenic reporter spatiotemporally sustained Wnt/ß-catenin signalling during the corresponding organogenesis. Therefore, ß-catenin(C429S) should provide new insights into ß-catenin as a universal component of Wnt/ß-catenin signal transduction.


Asunto(s)
Infertilidad Femenina/genética , Infertilidad Masculina/genética , Mutación , Vesículas Seminales/metabolismo , Vagina/metabolismo , Vía de Señalización Wnt , beta Catenina/genética , Animales , Embrión de Mamíferos , Femenino , Genes Reporteros , Homocigoto , Masculino , Ratones , Ratones Endogámicos C57BL , Ratones Transgénicos , Óvulo/crecimiento & desarrollo , Óvulo/metabolismo , Vesículas Seminales/anomalías , Vesículas Seminales/crecimiento & desarrollo , Espermatozoides/crecimiento & desarrollo , Espermatozoides/metabolismo , Vagina/anomalías , Vagina/crecimiento & desarrollo , Proteínas Wnt/genética , Proteínas Wnt/metabolismo , beta Catenina/metabolismo
20.
Urology ; 84(3): e7, 2014 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-25053522

RESUMEN

Renal agenesis is a rare condition of unknown etiology frequently seen together with ipsilateral seminal vesicle and vas deferens anomalies because of common embryologic development. However, no cases of contralateral seminal vesicle hypoplasia accompanying renal agenesis have previously been reported. We describe a case of contralateral seminal vesicle hypoplasia accompanying renal agenesis incidentally detected in a 27-year-old presenting to the urology clinic with pelvic pain.


Asunto(s)
Anomalías Congénitas/fisiopatología , Enfermedades Renales/congénito , Riñón/anomalías , Vesículas Seminales/anomalías , Anomalías Múltiples , Adulto , Comorbilidad , Humanos , Riñón/fisiopatología , Enfermedades Renales/fisiopatología , Imagen por Resonancia Magnética , Masculino
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