RESUMEN
AIM: To present the research results concerning enhanced antimicrobial and release properties of the chitosan derivative with sulfadiazine/hyaluronic acid polyelectrolyte complex (PEC) hydrogel. MATERIAL AND METHODS: The PECs have been prepared from chitosan of different molecular weight, sulfadiazine chitosan derivative and sodium hyaluronate. The complex structure was assessed by FT-IR spectroscopic method and swelling capacity was followed by weighing measurements. RESULTS: It has been establish that chitosan derivative influenced both PEC properties and swelling capacity. CONCLUSIONS: Incorporation in PEC of the sulfadiazine chitosan is a new way to combine bacteriostatic effect of chitosan with that of sulfadiazine, to control properties, antimicrobial activity in the treatment of the wound.
Asunto(s)
Antiinfecciosos/farmacología , Materiales Biocompatibles/farmacología , Quitosano/farmacología , Ácido Hialurónico/farmacología , Sulfadiazina/farmacología , Viscosuplementos/farmacología , Cicatrización de Heridas/efectos de los fármacos , Antiinfecciosos/síntesis química , Antiinfecciosos/química , Vendajes , Materiales Biocompatibles/síntesis química , Materiales Biocompatibles/química , Quitosano/síntesis química , Quitosano/química , Quimioterapia Combinada/métodos , Electrólitos/química , Ácido Hialurónico/síntesis química , Ácido Hialurónico/química , Espectrofotometría Infrarroja/métodos , Sulfadiazina/síntesis química , Sulfadiazina/química , Viscosuplementos/síntesis química , Viscosuplementos/químicaRESUMEN
AIM: This paper is a short review on the state-of-the-art of the use of polyelectrolyte complexes containing polysaccharides for wound and burn healing and treatment using the chitosan/hyaluronic acid polyelectrolyte complex (PEC) hydrogel. RESULTS AND CONCLUSIONS: PEC is suitable for wound healing because a wet treatment can be realized and both components of PEC contribute by their properties to the enhanced antimicrobial activity, promote wound healing and prevent wound damage during treatment.