Asunto(s)
Dermatitis Alérgica por Contacto/epidemiología , Tiocarbamatos/efectos adversos , Ziram/análogos & derivados , Ziram/efectos adversos , Adulto , Reacciones Cruzadas , Dermatitis Alérgica por Contacto/etiología , Dermatología , Femenino , Alemania/epidemiología , Humanos , Masculino , Pruebas del ParcheRESUMEN
Current pesticide exposure levels can induce a state of sensitization in exposed workers and only in exceptional situations cause severe intoxication. Three cases are reported--one suffering from urticaria/angio-edema, one from asthma and the other from oculo-rhinitis. Only one subject was atopical. The substances to which sensitization was found were Cynoxamil, Mancozeb, Thiophanate, Seccatutto for the first case, Paraquat for the second and Dodine for the third subject. The results suggest the need to extend allergological tests also to pesticides when workers, or subjects in any case exposed, show clinical signs with suspected immunological pathogenesis. Furthermore, in order to reduce the number of new cases of pesticide allergy, a more severe control also of subjects exposed to low doses is proposed.
Asunto(s)
Hipersensibilidad a las Drogas/etiología , Enfermedades Profesionales/inducido químicamente , Plaguicidas/efectos adversos , Angioedema/inducido químicamente , Asma/inducido químicamente , Oftalmopatías/inducido químicamente , Fungicidas Industriales/efectos adversos , Guanidinas/efectos adversos , Herbicidas/efectos adversos , Humanos , Masculino , Maneb/efectos adversos , Persona de Mediana Edad , Paraquat/efectos adversos , Rinitis/inducido químicamente , Tiofanato/efectos adversos , Urticaria/inducido químicamente , Zineb/efectos adversos , Ziram/efectos adversosRESUMEN
3 cases of allergic contact dermatitis from industrial rubber products were investigated using a combination of patch testing in patients and chemical analysis of causative rubber products by gas chromatography (GC), GC-mass spectrometry (GC-MS) and high-performance liquid chromatography (HPLC). Our studies revealed N-isopropyl-N'-phenyl-p-phenylenediamine (IPPD), a typical rubber allergen, as a causative chemical in a case from a brand of heavy-duty rubber gloves and a case from a black rubber ring for car manufacture, and zinc ethylphenyldithiocarbamate (ZEPC), a dithiocarbamate (DTC)-type accelerator, as a causative chemical in a case from a brand of rubber work gloves: both IPPD and ZEPC, which showed positive patch test reactions, were confirmed in the extracts of the causative rubber products by GC, GC-MS and/or HPLC.
Asunto(s)
Dermatitis Alérgica por Contacto/diagnóstico , Dermatitis Alérgica por Contacto/etiología , Dermatitis Profesional/diagnóstico , Dermatitis Profesional/etiología , Pruebas del Parche , Goma/efectos adversos , Goma/análisis , Adulto , Antioxidantes/efectos adversos , Antioxidantes/análisis , Automóviles , Dimetilaminas/efectos adversos , Dimetilaminas/análisis , Ditiocarba/efectos adversos , Ditiocarba/análogos & derivados , Ditiocarba/análisis , Femenino , Guantes Protectores , Humanos , Masculino , Persona de Mediana Edad , Pruebas del Parche/métodos , Fenilendiaminas/efectos adversos , Fenilendiaminas/análisis , Ziram/efectos adversos , Ziram/análisisAsunto(s)
Contaminantes Ocupacionales del Aire/efectos adversos , Neoplasias/inducido químicamente , Enfermedades Profesionales/inducido químicamente , Exposición Profesional/efectos adversos , Ziram/efectos adversos , Contaminantes Ocupacionales del Aire/farmacocinética , Animales , Pruebas de Carcinogenicidad , Comparación Transcultural , Humanos , Concentración Máxima Admisible , Pruebas de Mutagenicidad , Residuos de Plaguicidas/efectos adversos , Ziram/farmacocinéticaAsunto(s)
Dermatitis por Contacto/etiología , Dermatitis Profesional/inducido químicamente , Maneb/efectos adversos , Tiocarbamatos/efectos adversos , Ziram/efectos adversos , Adulto , Anciano , Enfermedades de los Trabajadores Agrícolas/inducido químicamente , Femenino , Humanos , Italia , MasculinoRESUMEN
The cytogenetic activity of some substances formed in agricultural plants during metabolism of pesticides of four classes of chemical compounds was studied in the culture of human peripheric blood lymphocytes. Metabolites were shown either to have mutagenic properties similar to those of the initial compounds (ziramtetramethylthiourea, both being mutagens; captan-phthalimide, both possessing no cytogenetic activity) or to be considerably transformed in comparison with them as a result of deactivation (benomile-MBC) or activation (betanal-MHPC) processes. The latter variant if being determined for the genetic hazard of the pesticide necessitates to take into account data on the mutagenic character of those metabolites which really might enter the human organism.