Comparision effects of solifenacin, darifenacin, propiverine on ocular parameters in eyes: A prospective study
Int. braz. j. urol
; 46(2): 185-193, Mar.-Apr. 2020. tab, graf
Article
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| LILACS
| ID: biblio-1090573
Biblioteca responsable:
BR1.1
ABSTRACT
ABSTRACT Objective To evaluate the effects of solifenacin, darifenacin, and propiverine on nasal-, subfoveal-, temporal choroidal thicknesses (NCT, SFCT, TCT), intraocular pressure (IOP) and pupil diameter (PD). Materials and Methods Patients with overactive bladder (OAB) diagnosed according to The International Continence Society were administered with solifenacin, darifenacin or propiverine on a daily basis between November 2017 and May 2018. NCT, SFCT, TCT, IOP, and PD of these patients were measured and compared as initial, fourth and twelfth weeks. Results A total of 165 patients (330 eyes) with OAB were evaluated. Solifenacin (n=140) significantly reduced IOP from 17.30±2.72 mmHg to 16.67±2.56 mmHg (p=0.006) and 16.57±2.41 mmHg (p=0.002), at the fourth and twelfth weeks, respectively. Darifenacin (n=110) significantly reduced NCT from 258.70±23.96 μm to 257.51±22.66 μm (p=0.002) and 255.36±19.69 μm (p=0.038), at the fourth and twelfth weeks, respectively. Propiverine (n=80) significantly increased PD from 4.04±0.48 mm to 4.08±0.44 mm (p=0.009) and 4.09±0.45 mm (p=0.001), at the fourth and twelfth weeks, respectively. Conclusion These findings can help to decide appropriate anticholinergic drug choice in OAB patients. We finally suggest further well-designed randomized prospective studies with a larger population to evaluate the anticholinergic-related complications in eyes.
Palabras clave
Texto completo:
1
Base de datos:
LILACS
Asunto principal:
Pirrolidinas
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Bencilatos
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Benzofuranos
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Pupila
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Coroides
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Antagonistas Muscarínicos
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Succinato de Solifenacina
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Presión Intraocular
Tipo de estudio:
Clinical_trials
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Observational_studies
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Prognostic_studies
Idioma:
En
Revista:
Int. braz. j. urol
Asunto de la revista:
UROLOGIA
Año:
2020
Tipo del documento:
Article