Infection by Mycobacterium leprae of household contacts of lepromatous leprosy patients from a post-elimination leprosy region of Colombia
Mem. Inst. Oswaldo Cruz
; 100(7): 703-707, Nov. 2005. tab
Article
en En
| LILACS
| ID: lil-419691
Biblioteca responsable:
BR1.1
RESUMO
The Leprosy Control Program of Antioquia, (post-elimination leprosy state of Colombia), had registered by 1999, 56 lepromatous leprosy patients and their household contacts (HHC). Our interest was to detect Mycobacterium leprae infection in these HHC. Clinical examination, acid-fast bacillary staining (AFB) in nasal secretions, and slit skin samples, IgM anti-PGL-I in serum and Lepromine A (Mitsuda) reactivity were tested. Two hundred forty eight HHC were studied, 49 percent were male. After clinical examination, two HHC were diagnosed as multi bacillary patients; 13 percent showed positive IgM anti-PGL-I titers; Mitsuda reaction (> 4 mm) was positive in 59 percent; AFB was negative in all samples, except in the two new patients. HHC were classified according to test results.Group 1 two new multi bacillary patients. Group 2 15 HHC seropositive, Mitsuda-negative. Group 3 13 HHC seropositive, Mitsuda-positive. Group 4 130 HHC seronegative, Mitsuda-positive. Group 5 88 HHC seronegative, Mitsuda-negative. These results are an indication that the transmission of the infection is still happening in a region considered in the post elimination phase. The two new patients represent an infection source for others contacts, and groups 2 and 3 are infected HHC that could develop the disease in future. Follow up of high risk population is necessary to achieve real elimination of leprosy.
Texto completo:
1
Base de datos:
LILACS
Asunto principal:
Glucolípidos
/
Lepra Lepromatosa
/
Lepromina
/
Anticuerpos Antibacterianos
/
Mycobacterium leprae
/
Antígenos Bacterianos
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
País/Región como asunto:
America do sul
/
Colombia
Idioma:
En
Revista:
Mem. Inst. Oswaldo Cruz
Asunto de la revista:
MEDICINA TROPICAL
/
PARASITOLOGIA
Año:
2005
Tipo del documento:
Article