1a, 25(OH)2D3 induces capacitative calcium entry involving a TRPC3 protein in skeletal muscle and osteoblastic cells
Biol. Res
; 37(4): 647-651, 2004. ilus, graf
Article
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| LILACS
| ID: lil-437521
Biblioteca responsable:
CL1.1
ABSTRACT
This work describes the involvement of TRPC proteins in capacitative calcium entry (CCE) induced by 1a,25-dihydroxy-vitamin-D3 [1a,25(OH)2D3] in chick skeletal muscle and in rat osteoblast-like cells (ROS 17/2.8) and the role of the vitamin D receptor (VDR) in this non-genomic rapid response mediated by the hormone. We propose that an endogenous TRPC3 protein mediates 1a,25(OH)2D3 modulation of CCE in these cells, which seems to implicate VDR-TRPC3 association and the participation of an INAD-like scaffold protein.
Texto completo:
1
Base de datos:
LILACS
Asunto principal:
Osteoblastos
/
Calcitriol
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Calcio
/
Músculo Esquelético
/
Canales Iónicos
Idioma:
En
Revista:
Biol. Res
Asunto de la revista:
BIOLOGIA
Año:
2004
Tipo del documento:
Article