Slow clearance of Plasmodium vivax with chloroquine amongst children younger than six months of age in the Brazilian Amazon
Mem. Inst. Oswaldo Cruz
; 109(5): 540-545, 19/08/2014. tab, graf
Article
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| LILACS
| ID: lil-720423
Biblioteca responsable:
BR1.1
ABSTRACT
Plasmodium vivax is the most widespread parasite causing malaria, being especially prevalent in the Americas and Southeast Asia. Children are one of the most affected populations, especially in highly endemic areas. However, there are few studies evaluating the therapeutic response of infants with vivax malaria. This study retrospectively evaluated the parasitaemia clearance in children diagnosed with vivax malaria during the first five days of exclusive treatment with chloroquine (CQ). Infants aged less than six months old had a significantly slower parasitaemia clearance time compared to the group of infants and children between six months and 12 years old (Kaplan-Meier survival analysis; Wilcoxon test; p = 0.004). The impaired clearance of parasitaemia in younger children with vivax malaria is shown for the first time in Latin America. It is speculated that CQ pharmacokinetics in young children with vivax malaria is distinct, but this specific population may also allow the detection of CQ-resistant parasites during follow-up, due to the lack of previous immunity. .
Palabras clave
Texto completo:
1
Base de datos:
LILACS
Asunto principal:
Plasmodium vivax
/
Cloroquina
/
Malaria Vivax
/
Parasitemia
/
Antimaláricos
Tipo de estudio:
Observational_studies
País/Región como asunto:
America do sul
/
Brasil
Idioma:
En
Revista:
Mem. Inst. Oswaldo Cruz
Asunto de la revista:
MEDICINA TROPICAL
/
PARASITOLOGIA
Año:
2014
Tipo del documento:
Article