Use of breath hydrogen testing to detect experimentally induced disaccharide malabsorption in healthy adult dogs.
Am J Vet Res
; 60(7): 836-40, 1999 Jul.
Article
en En
| MEDLINE
| ID: mdl-10407476
ABSTRACT
OBJECTIVE:
To develop a noninvasive method to detect disaccharide malabsorption in dogs by measuring hydrogen concentration ([H2]) in exhaled breath before and after experimentally induced disaccharide malabsorption. ANIMALS 8 healthy mixed-breed dogs. PROCEDURE [H2] was measured every 30 minutes for 8 hours after administration of disaccharide solutions (lactose, 0.5 g/kg of body weight; lactose, 1.0 g/kg; sucrose, 2.0 g/kg; maltose, 1.5 g/kg; and lactose [0.5 g/kg] and sucrose [2.0 g/kg]) to determine reference ranges of [H2] for each solution, which were compared with [H2] in dogs with experimentally induced disaccharide malabsorption. To induce disaccharide malabsorption, dogs were given a mild overdose of lactose (1.5 g/kg) or a disaccharidase inhibitor. In the latter experiment, acarbose (10 mg/kg, PO) was given with the combination of lactose (0.5 g/kg) and sucrose (2 g/kg), and with maltose (1.5 g/kg).RESULTS:
Overdosing with lactose resulted in [H2] persistently outside the reference range for lactose in 5 of 8 dogs. Acarbose administration resulted in [H2] persistently outside the reference range in 7 of 8 dogs that received a combination of sucrose and lactose but did not consistently affect [H2] after administration of maltose.CONCLUSIONS:
Disaccharide malabsorption resulted in [H2] outside the reference ranges in most of the adult dogs studied, suggesting that the technique may be useful in detecting naturally occurring disaccharidase deficiency.
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Base de datos:
MEDLINE
Asunto principal:
Pruebas Respiratorias
/
Perros
/
Hidrógeno
/
Intolerancia a la Lactosa
Tipo de estudio:
Observational_studies
/
Prognostic_studies
Idioma:
En
Revista:
Am J Vet Res
Año:
1999
Tipo del documento:
Article