Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products.
J Biol Chem
; 274(47): 33419-25, 1999 Nov 19.
Article
en En
| MEDLINE
| ID: mdl-10559223
ABSTRACT
Toll-like receptors (TLRs) 2 and 4 are signal transducers for lipopolysaccharide, the major proinflammatory constituent in the outer membrane of Gram-negative bacteria. We observed that membrane lipoproteins/lipopeptides from Borrelia burgdorferi, Treponema pallidum, and Mycoplasma fermentans activated cells heterologously expressing TLR2 but not those expressing TLR1 or TLR4. These TLR2-expressing cells were also stimulated by living motile B. burgdorferi, suggesting that TLR2 recognition of lipoproteins is relevant to natural Borrelia infection. Importantly, a TLR2 antibody inhibited bacterial lipoprotein/lipopeptide-induced tumor necrosis factor release from human peripheral blood mononuclear cells, and TLR2-null Chinese hamster macrophages were insensitive to lipoprotein/lipopeptide challenge. The data suggest a role for the native protein in cellular activation by these ligands. In addition, TLR2-dependent responses were seen using whole Mycobacterium avium and Staphylococcus aureus, demonstrating that this receptor can function as a signal transducer for a wide spectrum of bacterial products. We conclude that diverse pathogens activate cells through TLR2 and propose that this molecule is a central pattern recognition receptor in host immune responses to microbial invasion.
Buscar en Google
Base de datos:
MEDLINE
Asunto principal:
Proteínas Bacterianas
/
Glicoproteínas de Membrana
/
Receptores de Superficie Celular
/
Proteínas de Drosophila
/
Lipoproteínas
Idioma:
En
Revista:
J Biol Chem
Año:
1999
Tipo del documento:
Article